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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Solute carrier family 35

Inactive
The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, AGE, Renin
Papers on Inactive
Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.
New
Liu et al., In Cancer Discov, Feb 2016
These studies provide convincing evidence that the KRAS G12C mutation generates a "hyperexcitable" rather than a "statically active" state and that targeting the inactive, GDP-bound form is a promising approach for generating novel anti-RAS therapeutics.
A profile of inactive information seekers on influenza prevention: a survey of health care workers in Central Kentucky.
New
Real et al., Lexington, United States. In Health Info Libr J, Feb 2016
OBJECTIVE: This study developed a profile of inactive information seekers by characterising how they are different from active seekers, identifying possible determinants of inactive seekers and understanding characteristics of frequently asked influenza-related questions.
Ciliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila.
New
Moon et al., Seoul, South Korea. In Cell Rep, Jan 2016
Mutations in dInpp5e lead to hearing deficits due to the mislocalization of dTULP and mechanotransduction channels, Inactive and NOMPC, in chordotonal cilia.
Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.
New
Impact
Zhou et al., Xiamen, China. In Nat Immunol, Nov 2015
Inactive forms of Rac, including the human Rac2(D57N) mutant, disrupted the TRAF6-ECSIT complex by sequestering TRAF6 and substantially diminished ROS production and enhanced susceptibility to bacterial infection.
Meta-Analyses of the Effects of Habitual Running on Indices of Health in Physically Inactive Adults.
Review
New
Verhagen et al., Amsterdam, Netherlands. In Sports Med, Oct 2015
OBJECTIVE: The aim was to summarise the literature on the effects of endurance running on biomedical indices of health in physically inactive adults.
Prevalence and severity of depression in chronic viral hepatitis in Iran.
Review
New
Shahbazi et al., Tehrān, Iran. In Gastroenterol Rep (oxf), Aug 2015
However, CHB and CHC patients did not differ significantly in their depression prevalence after excluding inactive hepatitis B surface antigen (HBsAg) carriers (29.3% vs. 35.9%;
Targeting the Inactive Conformation of JAK2 in Hematological Malignancies.
New
Impact
Hubbard et al., Tampere, Finland. In Cancer Cell, Aug 2015
Activating JAK2 mutants cause hematological malignancies.
Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions.
New
Impact
Waterman et al., Bethesda, United States. In Nat Cell Biol, Jul 2015
Inactive vinculin localizes to the lower integrin signalling layer in FAs by binding to phospho-paxillin.
Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors.
Review
New
Roskoski, United States. In Pharmacol Res, Apr 2015
Inactive Src is stabilized by SH2 and SH3 domains on the rear of the kinase domain where they form an immobilizing and inhibitory clamp.
A kinase-independent role for EGF receptor in autophagy initiation.
New
Impact
Anderson et al., Madison, United States. In Cell, Feb 2015
Here, we report an unanticipated role for the inactive EGFR in autophagy initiation.
Vessel Wall Inflammation of Takayasu Arteritis Detected by Contrast-Enhanced Magnetic Resonance Imaging: Association with Disease Distribution and Activity.
Isobe et al., Tokyo, Japan. In Plos One, 2014
Patients were divided into Active (n = 19) and Inactive disease (n = 30) groups.
The association between three IL-6 polymorphisms and HBV-related liver diseases: a meta-analysis.
Liu et al., Wuhan, China. In Int J Clin Exp Med, 2014
However, IL-6 polymorphisms (-572G/C) were not related to Inactive Carrier (IC), Liver Cirrhosis (LC) and Hepatocellular Carcinoma (HCC) risk in this study.
Inactive fibrotic lesions versus pulmonary tuberculosis with negative bacteriology.
Review
Altet Gómez et al., Barcelona, Spain. In Arch Bronconeumol, 2014
This article analyzes the concept of inactive fibrotic lesions of presumed tuberculous origin (old healed tuberculosis), defined by radiological characteristics and a positive tuberculin skin test (TST), and we examine the evidence-based foundation for the indication of treatment of latent tuberculosis infection in these cases.
G protein-coupled receptor mutations and human genetic disease.
Review
Cole et al., Toronto, Canada. In Methods Mol Biol, 2013
Inactive, overactive, or constitutively active receptors have been identified that result in pathology.
Architecture and membrane interactions of the EGF receptor.
Impact
Shaw et al., New York City, United States. In Cell, 2013
Inactive EGFR can exist as both monomers and dimers, suggesting that the mechanism regulating EGFR activity may be subtle.
Loss of gene function as a consequence of human papillomavirus DNA integration.
GeneRIF
Dürst et al., Jena, Germany. In Int J Cancer, 2012
Papillomavirus DNA integration is associated with loss of CASZ1 gene and thus cervical carcinogenesis.
Characterization of critical domains within the tumor suppressor CASZ1 required for transcriptional regulation and growth suppression.
GeneRIF
Liu et al., Bethesda, United States. In Mol Cell Biol, 2012
This study identifies key domains needed for CASZ1b to regulate gene transcription; a link between loss of CASZ1b transcriptional activity and attenuation of CASZ1b-mediated inhibition of neuroblastoma growth and tumorigenicity
EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR.
GeneRIF
Thiele et al., Bethesda, United States. In Cancer Res, 2012
determined that the tumor suppressors CLU, NGFR, and RUNX3 were also directly repressed by EZH2 like CASZ1 in NB cells
Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.
GeneRIF
Luque et al., Córdoba, Spain. In Endocrinology, 2011
the role of endogenous CST is different from SST; CST exerted an unexpected stimulatory role on prolactin secretion
Attenuation of kidney injuries maintains serum sulfatide levels dependent on hepatic synthetic ability: a possible involvement of oxidative stress.
GeneRIF
Hara et al., Matsumoto, Japan. In Tohoku J Exp Med, 2011
Protein-overload mice exhibited marked kidney injuries, enhancement of hepatic oxidative stress, decreased levels of serum and hepatic sulfatides, and decreased expression of hepatic cerebroside sulfotransferase.
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