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Neurofilament, medium polypeptide

INa, NF-M, Neurofilament
neuronal intermediate filament protein; important component of the cytoskeleton [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: NF-L, CAN, NF-H, HAD, ACID
Papers using INa antibodies
A guided tour into subcellular colocalization analysis in light microscopy.
Klymkowsky Michael, In PLoS ONE, 2005
... 594 conjugate (Invitrogen Molecular Probes, 1/1000), Synaptophysin (monoclonal, Zymed, 1/5), Rapsyn (clone 1234, Sigma-Aldrich, 1/40), Neurofilament (polyclonal, Chemicon, 1/2000), HA.11 (clone 16B12 and polyclonal, Eurogentec, 1/1000), HA (polyclonal, Sigma, ...
SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level
Brown Anthony et al., In The Journal of Cell Biology, 2002
... The neurofilament protein constructs were all created by cloning mouse NFL and NFM cDNAs into pEGFP-C or pEGFP-N plasmids (Clontech Laboratories, Inc.) ...
Papers on INa
Nav1.5 N-Terminal Domain Binding to α1-Syntrophin Increases Membrane Density of Human Kir2.1, Kir2.2 and Nav1.5 Channels.
Delpón et al., Madrid, Spain. In Cardiovasc Res, Feb 2016
Nav1.5 N-terminal domain, by itself (the 132 aa peptide) (Nter), exerts a "chaperone-like" effect that increases sodium (INa) and inward rectifier potassium (IK1) currents by enhancing the expression of Nav1.5, Kir2.1, and Kir2.2 channels as demonstrated in Chinese hamster ovary (CHO) cells and in rat cardiomyocytes.
Serum neurofilament light chain in early relapsing remitting MS is increased and correlates with CSF levels and with MRI measures of disease severity.
Granziera et al., Basel, Switzerland. In Mult Scler, Feb 2016
BACKGROUND/OBJECTIVES: Neurofilament light chain (NfL) levels in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients correlate with the degree of neuronal injury.
Pathophysiology of Pruritus in Primary Localised Cutaneous Amyloidosis.
Yosipovitch et al., Singapore, Singapore. In Br J Dermatol, Feb 2016
Patients' biopsies revealed lower IENF counts (p<0.001 using PGP9.5, ΒIII-tubulin and Neurofilament-200 stains) and increased epidermal expression of OSMRβ (p<0.001) and IL-31RA (p=0.002).
The cardiac sodium channel gene SCN5A and its gene product NaV1.5: Role in physiology and pathophysiology.
Lodder et al., Amsterdam, Netherlands. In Gene, Jan 2016
This channel predominates the cardiac sodium current, INa, which underlies the fast upstroke of the cardiac action potential.
Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role.
Deschênes et al., Cleveland, United States. In Plos One, Dec 2015
In addition, cells with reduced KChIP2 also displayed lowered INa from reduced Nav1.5 protein.
Neurofilament dynamics and involvement in neurological disorders.
Durham et al., Montréal, Canada. In Cell Tissue Res, Jun 2015
Disruption of neurofilament organization and expression or metabolism of neurofilament proteins is characteristic of certain neurological syndromes including Amyotrophic Lateral Sclerosis, Charcot-Marie-Tooth sensorimotor neuropathies and Giant Axonal Neuropathy.
Neurofilament assembly and function during neuronal development.
Beck et al., Tel Aviv-Yafo, Israel. In Curr Opin Cell Biol, Feb 2015
Studies on the assembly of neuronal intermediate filaments (IFs) date back to the early work of Alzheimer.
An emerging antiarrhythmic target: late sodium current.
Izu et al., Debrecen, Hungary. In Curr Pharm Des, 2014
The cardiac late sodium current (INa,L) has been in the focus of research in the recent decade.
Supernormal Conduction and Suppression of Spatially Discordant Alternans of Cardiac Action Potentials.
Patwardhan et al., Lexington, United States. In Front Physiol, 2014
To illustrate this subtlety, we simulated this phenomenon using two approaches; (1) by using the standard, i.e., S1S2 protocol to quantify restitution and disabling the slow inactivation gate j of the sodium current (INa), and (2) by using the dynamic, i.e., S1S1 protocol for quantification of restitution and increasing INa at different cycle lengths (CL).
The clinical implications and biologic relevance of neurofilament expression in gastroenteropancreatic neuroendocrine neoplasms.
Modlin et al., New Haven, United States. In Cancer, 2012
INA may provide additional biologic information relevant to delineation of both pancreatic neuroendocrine neoplasms (NEN) tumor phenotypes and clinical behavior.
Expansion of neurofilament medium C terminus increases axonal diameter independent of increases in conduction velocity or myelin thickness.
Garcia et al., Columbia, United States. In J Neurosci, 2012
Computational modeling predicted that an expanded NF-M C terminus extended farther from the neurofilament core independent of lysine-serine-proline (KSP) phosphorylation.
Neurofilament proteins in axonal regeneration and neurodegenerative diseases.
Li et al., Changchun, China. In Neural Regen Res, 2012
Neurofilament protein is a component of the mature neuronal cytoskeleton, and it interacts with the zygosome, which is mediated by neurofilament-related proteins.
Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine-vulval attachment in Caenorhabditis elegans.
Sherwood et al., Durham, United States. In Nat Cell Biol, 2011
Further, an RNA interference and expression screen identifies the integrin INA-1/PAT-3 and VAB-19, homologue of the tumour suppressor Kank, as regulators of basement membrane opening.
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
Turck et al., München, Germany. In J Psychiatr Res, 2010
This protein has been found differentially expressed in thalami from patients with schizophrenia.
Quantitative phosphoproteomic analysis of neuronal intermediate filament proteins (NF-M/H) in Alzheimer's disease by iTRAQ.
Pant et al., Bethesda, United States. In Faseb J, 2010
direct evidence that NF-M/H are hyperphosphorylated in Alzheimer disease
Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.
Turck et al., München, Germany. In J Psychiatr Res, 2010
This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia
Gel-expanded to gel-condensed transition in neurofilament networks revealed by direct force measurements.
Safinya et al., Santa Barbara, United States. In Nat Mater, 2010
These findings, which delineate the distinct roles of NF-M and NF-H in regulating neurofilament interactions, shed light on possible mechanisms for disruptions of optimal mechanical network properties.
Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis.
Wekerle et al., Martinsried, Germany. In Nat Med, 2009
We report that in Mog-deficient mice (Mog-/-), the autoimmune response by transgenic T cells is redirected to a neuronal cytoskeletal self antigen, neurofilament-M (NF-M).
Direct visualization of protein interactions in plant cells.
Brisson et al., Montréal, Canada. In Nat Biotechnol, 2001
We demonstrate that the interaction between Arabidopsis NPR1/NIM1 and the bZIP factor TGA2 is induced by the regulators of SAR, salicylic acid (SA), and its analog 2,6-dichloroisonicotinic acid (INA) with distinct species-specific responses.
Phosphatidylinositol as a Component of the Ice Nucleating Site of Pseudomonas syringae and Erwinia herbiola.
Westaway et al., In Science, 1984
Plant lectins binding to inositol and a highly purified phosphatidylinositol-specific hydrolase (a C(II) lipase) inhibited or decreased the efficiency of the ice nucleating activity (INA) of both bacteria.
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