Predominant intracellular localization of the type I transforming growth factor-β receptor and increased nuclear accumulation after growth arrest
In The Journal of Cell Biology, 1999
... ), using antibodies against the Xpress epitope tag, EGFR, c-Jun, c-Fos, c-Myc, cyclin E, and importin β (Santa Cruz Biotechnology, Inc.), phospho-c-Jun (New England ...
The impact of genetic factors on response to glucocorticoids therapy in IBD.
Poznań, Poland. In Scand J Gastroenterol, Feb 2016
To those genes belong: NR3C1 - responsible for the synthesis of GC receptor (GR); Hsp90, HSP70, STIP1, FKB5 - genes of GR protein complex; ABCB1 and IPO13 coding glycoprotein p170; and importin 13 - involved in GCs transport; IL1A, IL1B, IL2, IL4, IL8, IL10, TNF, and MIF - genes of the epithelial pro-inflammatory factors synthesis, which excessive activation causes steroid resistance as well as CYP3A4 and CYP3A5 - encoding GCs biotransformation enzymes.
The GTPase RAN regulates multiple steps of the centrosome life cycle.
Roma, Italy. In Chromosome Res, Feb 2016
In parallel, RAN also regulates the capacity of centrosomes to nucleate and organize functional microtubules, and this predominanlty involves importin vectors: many factors regulating microtubule nucleation or function harbor nuclear localization sequences that interact with importin molecules and such interaction inhibits their activity.
Structural Biology and Regulation of Protein Import into the Nucleus.
Australia. In J Mol Biol, Nov 2015
The pathways involve transport factors that are members of the β-karyopherin family, which can bind cargo directly (e.g., importin-β, transportin-1, transportin-3, importin-13) or through adaptor proteins (e.g., importin-α, snurportin-1, symportin-1), as well as unrelated transport factors such as Hikeshi, involved in the transport of heat-shock proteins, and NTF2, involved in the transport of RanGDP.
Nuclear Import of Yeast Proteasomes.
Toronto, Canada. In Cells, 2014
This pathway uses canonical nuclear localisation signals within proteasomal subunits and Srp1/Kap95, and the canonical import receptor, named importin/karyopherin αβ.
Axon-soma communication in neuronal injury.
Israel. In Nat Rev Neurosci, 2014
This has included the discovery of a priming role for early calcium waves; confirmation of central roles for mitogen-activated protein kinase signalling effectors, the importin family of nucleocytoplasmic transport factors and molecular motors such as dynein; and demonstration of the importance of local translation as a key regulatory mechanism.