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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Karyopherin alpha 4

importin alpha3, Qip1, KPNA4
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: importin, CAN, SRP1, importin-alpha3, Alpha-1
Papers on importin alpha3
Karyopherin α 3 and karyopherin α 4 proteins mediate the nuclear import of methyl-CpG binding protein 2.
New
Zoghbi et al., Houston, United States. In J Biol Chem, Oct 2015
To clarify the mechanism of MeCP2 nuclear import, we isolated proteins that interact with the NLS and identified karyopherin α 3 (KPNA3 or Kap-α3) and karyopherin α 4 (KPNA4 or Kap-α4) as key binding partners of MeCP2.
Genomic profiling screens small molecules of metastatic prostate carcinoma.
New
Sun et al., Beijing, China. In Oncol Lett, Sep 2015
In addition, KPNA4, SYT1, PLCB1, SPRED1, MBNL2, RNF165, MEF2C, MBNL1, ZFP36L1 and CELF2, were found to be likely to play significant roles in the process of metastatic prostate carcinoma.
Postgenomics biomarkers for rabies—the next decade of proteomics.
Review
New
Chowdhary et al., Mumbai, India. In Omics, Feb 2015
An interesting observation is that certain molecules, such as KPNA4, could be potential diagnostic markers for rabies.
TDP-43 Inhibits NF-κB Activity by Blocking p65 Nuclear Translocation.
Jia et al., Vancouver, Canada. In Plos One, 2014
The inhibition by TDP-43 does not occur through preventing IκB degradation but probably by competing for the nuclear transporter-importin α3 (KPNA4).
Upregulation of miR-181s reverses mesenchymal transition by targeting KPNA4 in glioblastoma.
Jiang et al., Harbin, China. In Sci Rep, 2014
Furthermore, miR-181b was validated to suppress EMT by targeting KPNA4 and was associated with survival outcome in the TCGA and CGGA datasets and in another independent cohort.
Clinical application of genetics to guide prevention and treatment of oral diseases.
Review
Polverini et al., Waltham, United States. In Clin Genet, 2014
Dental caries' GWAS identified significant signals in LYZL2, AJAp1, and KPNA4; and efforts are ongoing to identify genetic factors for multiple caries phenotypes.
Oxidative stress impairs multiple regulatory events to drive persistent cytokine-stimulated STAT3 phosphorylation.
Bogoyevitch et al., In Biochim Biophys Acta, 2014
In exploring the nuclear import/ export pathways, we observed disruption of nuclear/cytoplasmic distributions of Ran and importin-alpha3 in cells exposed to H2O2 and the resultant reduced nuclear trafficking of Classical importin-alpha/3-dependent protein cargoes.
Expressional regulation of genes linked to immunity & programmed development in human early placental villi.
Ghosh et al., New Delhi, India. In Indian J Med Res, 2014
Transcriptional integration supportive of programmed development was observed in first trimester placental villi and it included regulation of apoptosis and cell cycle progression (ARRB1, ATR, BLM, CHRNA7, CHRNB1, FYN, KPNA4, and MTOR/FRAP), autophagy (ATG4B, ATG14, BAD, and BCL2), cell adhesion (CD9 and FN1) and epithelial-to-mesenchymal transition (CALD1, FN1, HEY1, MMP2, and WNT3A).
Integration of mRNA expression profile, copy number alterations, and microRNA expression levels in breast cancer to improve grade definition.
Castiglioni et al., Milano, Italy. In Plos One, 2013
The combination of mRNA profile analysis and copy number data with microRNA expression levels led to the identification of two gene signatures of 42 and 4 altered genes (FOXM1, KPNA4, H2AFV and DDX19A) respectively, the latter obtained through a meta-analytical procedure.
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
Shaffer et al., In Caries Res, 2013
We detected genome-wide significant signals in KPNA4 (p value = 2.0E-9), and suggestive signals in ITGAL (p value = 2.1E-7) and PLUNC family genes (p value = 2.0E-6), thus nominating these novel loci as putative caries susceptibility genes.
Dissection of the C-terminal region of E1A redefines the roles of CtBP and other cellular targets in oncogenic transformation.
Mymryk et al., London, Canada. In J Virol, 2013
Interaction of E1A with importin α3/Qip1, dual-specificity tyrosine-regulated kinase 1A (DYRK1A), HAN11, and CtBP influenced transformation with E1B-55K.
Convergent findings for abnormalities of the NF-κB signaling pathway in schizophrenia.
Haroutunian et al., New York City, United States. In Neuropsychopharmacology, 2013
The gene expression levels of an NF-κB-associated importin (KPNA4: one of the proteins responsible for the translocation of NF-κB to the nucleus) was decreased in SZ and an SNP within the KPNA4 locus was associated with susceptibility to SZ, reduced KPNA4 expression levels and attenuated PPI of the startle reflex in healthy control subjects.
Quantitative proteomics for identifying biomarkers for Rabies.
Shankar et al., Baltimore, United States. In Clin Proteomics, 2012
The differentially expressed molecules included karyopherin alpha 4 (KPNA4), which was overexpressed only in paralytic rabies, calcium calmodulin dependent kinase 2 alpha (CAMK2A), which was upregulated in paralytic rabies group and glutamate ammonia ligase (GLUL), which was overexpressed in paralytic as well as encephalitic rabies.
Importin α3/Qip1 is involved in multiplication of mutant influenza virus with alanine mutation at amino acid 9 independently of nuclear transport function.
Aida et al., Wako, Japan. In Plos One, 2012
Although NP binds to importin α isoforms Rch1, Qip1 and NPI-1, the role of each individual isoform during the nuclear transport of NP and replication of the influenza virus remains unknown.
Calcitriol decreases expression of importin α3 and attenuates RelA translocation in human bronchial smooth muscle cells.
Agrawal et al., Omaha, United States. In J Clin Immunol, 2012
The nuclear import of activated NF-кB p50/RelA subunit is dependent on importin α3 (KPNA4) and importin α4 (KPNA3).
Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication.
GeneRIF
Yao et al., Winnipeg, Canada. In J Virol, 2010
Impalpha3 is an HIV integrase-interacting cofactor and is required for efficient HIV-1 nuclear import and replication.
Common importin alpha specificity for papillomavirus E2 proteins.
GeneRIF
Wilson et al., College Station, United States. In Virus Res, 2010
The papillomavirus E2 proteins preferentially interacted with alpha importins 3 and 5, and showed very weak or no interaction with the other three widely expressed alpha importins (alpha1, alpha 4, and alpha 7).
Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-alpha3 binding.
GeneRIF
Moll et al., Stony Brook, United States. In Cell Death Differ, 2010
stress-induced accumulation of non-ubiquitinated p53 in the cytoplasm promotes interaction with importin-alpha3 and rapid import
Prohibitin inhibits tumor necrosis factor alpha-induced nuclear factor-kappa B nuclear translocation via the novel mechanism of decreasing importin alpha3 expression.
GeneRIF
Sitaraman et al., Atlanta, United States. In Mol Biol Cell, 2009
Expression of importin alpha3, a protein involved in p50/p65 nuclear import, was decreased in cells overexpressing PHB.
Daxx contains two nuclear localization signals and interacts with importin alpha3.
GeneRIF
Chen et al., United States. In J Cell Biochem, 2008
Daxx interacts selectively with importin alpha3 through its NLS1 and NLS2 sequences. Conversely, importin alpha3 utilizes two NLS-binding sites for Daxx interaction, suggesting that it mediates nuclear import of Daxx.
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