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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Inosine 5'-phosphate dehydrogenase 2

IMPDH, IMD2
Top mentioned proteins: ACID, CAN, STEP, XMP, HAD
Papers on IMPDH
Bicyclol promotes toll-like 2 receptor recruiting inosine 5'-monophosphate dehydrogenase II to exert its anti-inflammatory effect.
New
Zhang et al., Beijing, China. In J Asian Nat Prod Res, Feb 2016
Tar-Fis-Dock, virtual molecular docking system, showed that inosine 5'-monophosphate dehydrogenase II (IMPDH II) has the highest probability of binding to bicyclol.
Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton.
New
Heuckeroth et al., Saint Louis, United States. In Dev Biol, Feb 2016
Two IMPDH isoforms are ubiquitously expressed in the embryo, but only IMPDH2 is required for life.
Purine metabolism in response to hypoxic conditions associated with breath-hold diving and exercise in erythrocytes and plasma from bottlenose dolphins (Tursiops truncatus).
New
Zenteno-Savín et al., La Paz, Mexico. In Comp Biochem Physiol A Mol Integr Physiol, Jan 2016
Activity of enzymes involved in purine metabolism (hypoxanthine guanine phosphoribosyl transferase (HGPRT), inosine monophosphate deshydrogenase (IMPDH), xanthine oxidase (XO), purine nucleoside phosphorylase (PNP)), and purine metabolite (hypoxanthine (HX), xanthine (X), uric acid (UA), inosine monophosphate (IMP), inosine, nicotinamide adenine dinucleotide (NAD(+)), adenosine, adenosine monophosphate (AMP), adenosine diphosphate (ADP), ATP, guanosine diphosphate (GDP), guanosine triphosphate (GTP)) concentrations were quantified in erythrocyte and plasma samples.
Pharmacokinetics and pharmacodynamics of mycophenolic acid in Nagase analbuminemic rats: Evaluation of protein binding effects using the modeling and simulation approach.
New
Matsubara et al., Kyoto, Japan. In Drug Metab Pharmacokinet, Dec 2015
This study aimed to examine the pharmacokinetics and pharmacodynamics of mycophenolic acid (MPA) in Nagase analbuminemic rats (NARs) to evaluate the effect of protein binding on the associated inosine-5'-monophosphate dehydrogenase (IMPDH) activity.
Differential Sensitivities of Fast- and Slow-cycling Cancer Cells to Inosine Monophosphate Dehydrogenase 2 Inhibition by Mycophenolic Acid.
New
Pan et al., Rotterdam, Netherlands. In Mol Med, Nov 2015
Here we explored the notion that intrinsic differences in cancer cell cycle velocity are important in the resistance towards inhibition of inosine monophosphate dehydrogenase (IMPDH) by mycophenolic acid (MPA).
Drug target molecules to guide immunosuppression.
New
Vethe et al., Oslo, Norway. In Clin Biochem, Nov 2015
For drugs such as MPA and mTOR inhibitors, there are candidates such as IMPDH activity expression and p70SK6 phosphorylation status, respectively.
Lower tacrolimus trough levels are associated with subsequently higher acute rejection risk during the first 12 months after kidney transplantation.
New
Burke et al., Miami, United States. In Transpl Int, Nov 2015
Using our prospectively followed cohort of 528 adult, primary kidney transplant recipients (pooled across four randomized trials) who received reduced TAC dosing plus an IMPDH inhibitor, TAC trough levels measured at seven time points, 7, 14 days, 1, 2, 3, 6 and 9 months post-transplant, were utilized along with Cox's model to determine the multivariable significance of TAC level(t) (a continuous time-dependent covariate equaling the most recently measured TAC level prior to time t) on the hazard rate of developing first BPAR during the first 12 months post-transplant.
Synthesis of the inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors.
Review
Dzierzbicka et al., Gdańsk, Poland. In J Enzyme Inhib Med Chem, 2014
Inosine 5'-monophosphate dehydrogenase (IMPDH) is important molecular target for potential anticancer, antiviral, antibacterial and immunosuppressive agents.
Inosine 5'-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives.
Review
Kharkar et al., Mumbai, India. In Future Med Chem, 2014
Inosine 5'-monophosphate dehydrogenase (IMPDH), a crucial enzyme required for de novo synthesis of guanine nucleotides, is an important target for cancer, bacterial, parasitic and viral infections and autoimmune disorders.
Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases.
Revuelta et al., Salamanca, Spain. In Nat Commun, 2014
Inosine-5'-monophosphate dehydrogenase (IMPDH) plays key roles in purine nucleotide metabolism and cell proliferation.
Identification of Novel Laminin- and Fibronectin-binding Proteins by Far-Western Blot: Capturing the Adhesins of Streptococcus suis Type 2.
Zhang et al., Nanjing, China. In Front Cell Infect Microbiol, 2014
Nine newly identified proteins, including oligopeptide-binding protein OppA precursor (OppA), elongation factor Tu (EF-Tu), enolase, lactate dehydrogenase (LDH), fructose-bisphosphate aldolase (FBA), 3-ketoacyl-ACP reductase (KAR), Gly ceraldehyde-3-phosphate dehydrogenase (GAPDH), Inosine 5'-monophosphate dehydrogenase (IMPDH), and amino acid ABC transporter permease (ABC) were cloned, expressed, purified and further confirmed by Far-Western blotting and ELISA.
Pharmacology and toxicology of mycophenolate in organ transplant recipients: an update.
Review
Tett et al., Brisbane, Australia. In Arch Toxicol, 2014
MPA is a competitive, selective and reversible inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), an important rate-limiting enzyme in purine synthesis.
Mycophenolate mofetil--a new atheropreventive drug?
Review
Zapolska-Downar et al., In Acta Pol Pharm, 2014
Mycophenolate mofetil (MMF) is an inhibitor of inosine monophosphate dehydrogenase (IMPDH), that exerts anti-proliferative and pro-apototic effects, particularly on activated T-lymphocytes.
[The basic functions of inosine 5'-monophosphate dehydrogenase and its application in drug discovery].
Review
Sun et al., In Yao Xue Xue Bao, 2014
Inosine 5'-monophosphate dehydrogenase (IMPDH) is a key enzyme of de novo GMP biosynthesis.
Metabolic enzyme IMPDH is also a transcription factor regulated by cellular state.
GeneRIF
Verrijzer et al., Rotterdam, Netherlands. In Mol Cell, 2012
Data show that inosine monophosphate dehydrogenase (IMPDH) binds sequence specifically to single-stranded, CT-rich DNA elements.
Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells.
GeneRIF
Boutros et al., Heidelberg, Germany. In Embo J, 2011
Ectopic Ras/MAPK pathway activation results in the suppression of Drosophila IMD/NF-kappaB signalling.
A drosophila model for EGFR-Ras and PI3K-dependent human glioma.
GeneRIF
Thomas et al., Los Angeles, United States. In Plos Genet, 2009
Constitutive coactivation of EGFR-Ras and PI3K pathways in glia and glial precursors gives rise to neoplastic, invasive glial cells.
Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1.
GeneRIF
Sekimizu et al., Tokyo, Japan. In Genes Cells, 2008
Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1
Properties of an intergenic terminator and start site switch that regulate IMD2 transcription in yeast.
GeneRIF
Reines et al., Atlanta, United States. In Mol Cell Biol, 2008
analysis of an intergenic terminator and start site switch that regulate IMD2 transcription in S. cerevisiae
Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.
Impact
Wilson et al., Cambridge, United States. In Cell, 1996
The structure of inosine-5'-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction.
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