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Importin 8

IMP-8, importin 8, IPO8, RanBP8
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: HAD, importin, pFGE, POLYMERASE, GAPDH
Papers on IMP-8
Sorting nexin 9 differentiates ligand-activated Smad3 from Smad2 for nuclear import and transforming growth factor β signaling.
New
Leof et al., Rochester, United States. In Mol Biol Cell, Dec 2015
Although SNX9 does not bind nucleoporins Nup153 or Nup214 or some β importins (Imp7 or Impβ), it mediates the association of pSmad3 with Imp8 and the nuclear membrane.
Validation of endogenous control reference genes for normalizing gene expression studies in endometrial carcinoma.
New
Konje et al., Doha, Qatar. In Mol Hum Reprod, Sep 2015
The mathematical software packages geNorm qBasePLUS identified Pumilio homolog 1 (Drosophila) (PUM1), ubiquitin C (UBC), phosphoglycerate kinase (PGK1), mitochondrial ribosomal protein L19 (MRPL19) and peptidylpropyl isomerase A (cyclophilin A) (PPIA) as the best reference gene combination, whilst NormFinder identified MRPL19 as the best single reference gene, with importin 8 (IPO8) and PPIA being the best combination of two reference genes.
Reference gene selection for real-time quantitative PCR analysis on ovarian cryopreservation by vitrification in mice.
New
Xiuying et al., Yinchuan, China. In J Assist Reprod Genet, Aug 2015
METHODS: GeNorm, NormFinder, comparative Delta-CT, and BestKeeper were used to analyze the expression and stability of the 14 reference genes GAPDH, ABL1, ACTB, CDKN1A, GPER, GUSB, HPRT1, HSP90AB1, IPO8, PPIA, RPL4, RPL30, TBP, and UPAR.
Characterization of pKP-M1144, a Novel ColE1-Like Plasmid Encoding IMP-8, GES-5, and BEL-1 β-Lactamases, from a Klebsiella pneumoniae Sequence Type 252 Isolate.
New
Gniadkowski et al., Brno, Czech Republic. In Antimicrob Agents Chemother, Aug 2015
IMP-8 metallo-β-lactamase was identified in Klebsiella pneumoniae sequence type 252 (ST252), isolated in a Portuguese hospital in 2009.
Analysis of a long-term outbreak of XDR Pseudomonas aeruginosa: a molecular epidemiological study.
New
Peter et al., Barcelona, Spain. In J Antimicrob Chemother, May 2015
RESULTS: By using conventional infection control methods we identified 49 P. aeruginosa strains, including eight environmental isolates that belonged to ST308 (by MLST) and carried the metallo-β-lactamase IMP-8.
Clinical features of patients with carbapenem nonsusceptible Klebsiella pneumoniae and Escherichia coli in intensive care units: a nationwide multicenter study in Taiwan.
New
Fung et al., Taipei, Taiwan. In J Microbiol Immunol Infect, Apr 2015
Nineteen isolates had genes that encoded carbapenemases (28.8%), including Klebsiella pneumoniae carbapenemase-2 (KPC-2) (n = 14), imipenemase-8 (IMP-8) (n = 1), Verona integron-encoded metallo-β-lactamase (VIM) (n = 3), and New Delhi metallo-β-lactamase-1 (NDM-1) (n = 1).
Lessons from an outbreak of metallo-β-lactamase-producing Klebsiella oxytoca in an intensive care unit: the importance of time at risk and combination therapy.
New
Rodríguez-Baño et al., Sevilla, Spain. In J Hosp Infect, Feb 2015
AIM: To investigate the risk factors for the acquisition of clonal multidrug-resistant Klebsiella oxytoca (MDRKO) producing the metallo-β-lactamase IMP-8 and hyperproducing chromosomal OXY-2 β-lactamase during a well-characterized outbreak, and to describe the clinical features of infections due to MDRKO.
Carbapenem-nonsusceptible Enterobacteriaceae in Taiwan.
Chang et al., Taipei, Taiwan. In Plos One, 2014
oxytoca), 37 IMP-8 (26 Enterobacter cloacae, 4 Citrobacter freundii, 4 Raoultella planticola, 1 K. pneumoniae, 1 E. coli and 1 K. oxytoca), and 2 VIM-1 (1 E. cloacae, 1 E. coli).
Emergence of OXA-48-Producing Klebsiella pneumoniae in Taiwan.
Lu et al., Taiwan. In Plos One, 2014
Carbapenemases were detected in 210 CnSKP isolates (27.6%), including 162 KPC-2 (n = 1), KPC-3, KPC-17, and NDM-1 (n = 1 each), OXA-48 (n = 4), IMP-8 (n = 18), and VIM-1 (n = 24).
Joint eQTL assessment of whole blood and dura mater tissue from individuals with Chiari type I malformation.
Ashley-Koch et al., Durham, United States. In Bmc Genomics, 2014
Several identified eQTLs were novel and these implicate genes involved in bone development (IPO8, XYLT1, and PRKAR1A), and ribosomal pathways related to marrow and bone dysfunction, as potential candidates in the development of CMI.
High prevalence of metallo-β-lactamase among carbapenem-resistant Klebsiella pneumoniae in a teaching hospital in China.
Cao et al., Fuzhou, China. In Can J Microbiol, 2014
IMP-4, IMP-8, NDM-1, and KPC-2 were identified in 14 (35.0%),
[Cloning of IPO8 promoter and analysis of its transcription activity].
Li et al., Jiujiang, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2014
OBJECTIVE: To clone 5' untranslated region of human IPO8 gene and determine its transcription activity.
Emergence of Citrobacter freundii carrying IMP-8 metallo-β-lactamase in Germany.
Willmann et al., Tübingen, Germany. In New Microbes New Infect, 2014
This report describes the isolation of Citrobacter freundii carrying IMP-8 MBL from three patients during the period from March 2012 until March 2013 in Germany.
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.
Impact
GeneRIF
Meister et al., Martinsried, Germany. In Cell, 2009
Study provides evidence that Imp8 is required for cytoplasmic miRNA-guided gene silencing and affects nuclear localization of Ago proteins.
Preferential utilization of Imp7/8 in nuclear import of Smads.
GeneRIF
Xu et al., Worcester, United States. In J Biol Chem, 2008
TGF-beta-induced and basal state spontaneous nuclear import of Smad4 require importin 7 and 8.
Identification of importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens.
GeneRIF
Calvo et al., Pamplona, Spain. In Bmc Mol Biol, 2007
IPO8 is the most accurate reference gene for clinical lung specimens.
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