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IMP2 inner mitochondrial membrane peptidase-like

IMMP2L, inner mitochondrial membrane peptidase 2-like
This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: HAD, DOCK4, AGE, CAN, FOXP2
Papers on IMMP2L
The Immp2l mutation causes age-dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment.
Lu et al., China. In Aging Cell, Feb 2016
We recently showed that mice with a mutation in the Inner Mitochondrial Membrane Peptidase 2-like (Immp2l) gene had elevated levels of mitochondrial superoxide, impaired fertility and age-associated phenotypes, including kyphosis and ataxia.
Genome-wide association study of schizophrenia in Ashkenazi Jews.
Pulver et al., Jerusalem, Israel. In Am J Med Genet B Neuropsychiatr Genet, Dec 2015
Supportive evidence (meta P < 1 × 10(-4) ) was also found for several previously identified genome-wide significant findings, including the HLA region, CNTN4, IMMP2L, and GRIN2A.
Prevalence of chromosomal rearrangements involving non-ETS genes in prostate cancer.
Minner et al., Hamburg, Germany. In Int J Oncol, Apr 2015
One rearranged tumor sample was observed for each of VCL, ZNF578, IMMP2L, SLC16A12, PANK1, GPHN, LRP1 and ZHX2.
Superoxide overproduction and kidney fibrosis: a new animal model.
Andersson et al., São Paulo, Brazil. In Einstein (sao Paulo), 2015
OBJECTIVE: To establish whether the mutation in the Immp2L gene induces renal fibrosis and whether aging exacerbates renal morphology in mice.
Intragenic deletions affecting two alternative transcripts of the IMMP2L gene in patients with Tourette syndrome.
Tümer et al., Glostrup, Denmark. In Eur J Hum Genet, 2014
IMMP2L (inner mitochondrial membrane peptidase, subunit 2) located on chromosome 7q31 is one of the genes suggested as a susceptibility factor in disease pathogenesis.
Homozygous microdeletion of exon 5 in ZNF277 in a girl with specific language impairment.
Newbury et al., Bologna, Italy. In Eur J Hum Genet, 2014
Moreover, ZNF277 is adjacent to the DOCK4 and IMMP2L genes, which have been implicated in ASD.
Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice.
Lu et al., Winston-Salem, United States. In Redox Biol, 2014
Inner mitochondrial membrane peptidase 2-like (IMMP2L) protein is a mitochondrial inner membrane peptidase that cleaves the signal peptide sequences of cytochrome c1 (CYC1) and mitochondrial glycerol phosphate dehydrogenase (GPD2).
Family-based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to autism in a northeastern Chinese Han population.
Tomoda et al., Harbin, China. In J Zhejiang Univ Sci B, 2014
OBJECTIVE: A study in a Caucasian population has identified two single-nucleotide polymorphisms (SNPs) in ZNF533, one in DOCK4, and two in IMMP2L, which were all significantly associated with autism.
Interstitial 7q31.1 copy number variations disrupting IMMP2L gene are associated with a wide spectrum of neurodevelopmental disorders.
Tassano et al., Genève, Switzerland. In Mol Cytogenet, 2013
RESULTS: We present the clinical and molecular description of four unrelated patients affected by neurodevelopmental disorders and overlapping 7q31.1 microdeletion/microduplication, identified by array-CGH and involving only part of the IMMP2L gene.
Genome-wide association study on differentiated thyroid cancer.
Försti et al., Heidelberg, Germany. In J Clin Endocrinol Metab, 2013
Additionally, in the combined analysis of the Italian series, suggestive associations were attained with rs10238549 and rs7800391 in IMMP2L (OR = 1.27,
Prenatal diagnosis and molecular cytogenetic characterization of a de novo interstitial deletion of 7q (7q22.1→q31.1).
Wang et al., Taipei, Taiwan. In Gene, 2013
We discuss the genotype-phenotype correlation and the consequence of haploinsufficiency of ZKSCAN5, ARPC1A, CYP3A43, RELN, LAMB1, IMMP2L and DOCK4 in this case.
The role of nitric oxide signaling in food intake; insights from the inner mitochondrial membrane peptidase 2 mutant mice.
Lu et al., Winston-Salem, United States. In Redox Biol, 2012
We previously reported that Immp2l mutation in mice causes excessive mitochondrial superoxide generation, which causes infertility and early signs of aging.
Deficiency in the inner mitochondrial membrane peptidase 2-like (Immp21) gene increases ischemic brain damage and impairs mitochondrial function.
Li et al., Durham, United States. In Neurobiol Dis, 2011
This study demomistrated that Immp2l deficiency increases ischemic brain damage by enhancing O(2)(-) production and damaging mitochondrial functional performance.
Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal.
Lu et al., Winston-Salem, United States. In Aging Cell, 2011
Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal
High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.
IMGSAC et al., Bologna, Italy. In Mol Psychiatry, 2010
AUTS1/AUTS5 linkage to immp2l-dock4 may be involved in autism susceptibility
[Knockout mice in the service of reproduction].
Escalier, Le Kremlin-Bicêtre, France. In Gynecol Obstet Fertil, 2008
They concern the female meiosis (Brca1), primordial follicles (Lhx8), granulosa cells (Lrh1), and, for both sexes, mitochondria (Immp2l) and meiosis (Ubb).
Non-random inactivation of large common fragile site genes in different cancers.
Smith et al., Rochester, United States. In Cytogenet Genome Res, 2006
To determine if there was selection for the inactivation of different large CFS genes in different cancers, we examined the expression of 13 of the 20 known large CFS genes: FHIT, WWOX, PARK2, GRID2, NBEA, DLG2, RORA isoforms 1 and 4, DAB1, CNTNAP2, DMD, IL1RAPL1, IMMP2L and LARGE in breast, ovarian, endometrial and brain cancers using real-time RT-PCR analysis.
The genetics of autism.
Rapin et al., New York City, United States. In Pediatrics, 2004
Among other candidate genes are the FOXP2, RAY1/ST7, IMMP2L, and RELN genes at 7q22-q33 and the GABA(A) receptor subunit and UBE3A genes on chromosome 15q11-q13.
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