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Leukocyte immunoglobulin-like receptor, subfamily B

ILT5, LIR3, Pirb, HL9, LILRB3
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PIR, CAN, HAD, IL-4, ERK1
Papers on ILT5
Allele-specific recognition by LILRB3 and LILRA6 of a cytokeratin 8 - associated ligand on necrotic glandular epithelial cells.
New
Trowsdale et al., Cambridge, United Kingdom. In Oncotarget, Feb 2016
We found that specific allelic variants of two related members of the LILR family, LILRB3 and LILRA6, interact with a ligand exposed on necrotic glandular epithelial cells.
A Genome Wide Study of Copy Number Variation Associated with Nasopharyngeal Carcinoma in Malaysian Chinese Identifies CNVs at 11q14.3 and 6p21.3 as Candidate Loci.
New
Ng et al., Kuala Lumpur, Malaysia. In Plos One, Dec 2015
RESULTS: Six putative CNVRs overlapping GRM5, MICA/HCP5/HCG26, LILRB3/LILRA6, DPY19L2, RNase3/RNase2 and GOLPH3 genes were jointly identified by PennCNV and cnvPartition.
ANGPTL2/LILRB2 signaling promotes the propagation of lung cancer cells.
New
Zheng et al., Shanghai, China. In Oncotarget, Sep 2015
Recently we demonstrated that leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) and its murine homolog, paired immunoglobulin-like receptor B (PIRB), are expressed on hematopoietic stem cells and acute myeloid leukemia stem cells and function in maintenance of stemness.
The landscape of copy number variations in Finnish families with autism spectrum disorders.
New
Järvelä et al., Helsinki, Finland. In Autism Res, Jul 2015
Additionally, several novel candidate genes (BDKRB1, BDKRB2, AP2M1, SPTA1, PTH1R, CYP2E1, PLCD3, F2RL1, UQCRC2, LILRB3, RPS9, and COL11A2) were identified through gene prioritization.
Multilayered HIV-1 gag-specific T-cell responses contribute to slow progression in HLA-A*30-B*13-C*06-positive patients.
New
Shang et al., Zhengzhou, China. In Aids, Jul 2015
A new epitope [HQPISPRTL (Gag144-152, HL9)] within OLP-15 and OLP-16 was identified.
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.
New
Sawalha et al., Ann Arbor, United States. In Arthritis Rheumatol, May 2015
RESULTS: We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)).
HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats.
Renner et al., Zürich, Switzerland. In Plos One, 2014
HD5 blocked cell-surface interaction of B272 with immune regulatory receptors KIR3DL2, LILRB2 and Pirb.
Paired immunoglobulin-like receptor B regulates platelet activation.
Liu et al., Shanghai, China. In Blood, 2014
Murine paired immunoglobulin-like receptors B (PIRB), as the ortholog of human leukocyte immunoglobulin-like receptor B2 (LILRB2), is involved in a variety of biological functions.
Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development.
Impact
Munitz et al., Tel Aviv-Yafo, Israel. In Nat Immunol, 2014
Subsequently, Pirb(-/-) mice displayed impaired aeroallergen-induced lung eosinophilia and induction of lung TH2 cell responses.
Expression of phosphocitrate-targeted genes in osteoarthritis menisci.
Hanley et al., Charlotte, United States. In Biomed Res Int, 2013
We found that PC downregulated the expression of numerous genes classified in immune response, inflammatory response, and angiogenesis, including chemokine (C-C motif) ligand 5, Fc fragment of IgG, low affinity IIIb receptor (FCGR3B), and leukocyte immunoglobulin-like receptor, subfamily B member 3 (LILRB3).
Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development.
Impact
Zhang et al., Dallas, United States. In Nature, 2012
Here we show that the immune-inhibitory receptor human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse orthologue paired immunoglobulin-like receptor (PIRB) are receptors for several ANGPTLs.
Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells.
Impact
Chen et al., New York City, United States. In Immunity, 2011
Herein, we investigate the potential function of paired immunoglobulin-like receptor B (PIR-B), also known as leukocyte immunoglobulin-like receptor subfamily B member 3 (LILRB3) in MDSC differentiation, and its role in tumor-induced immunity.
Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers.
GeneRIF
Yu et al., Boston, United States. In J Virol, 2010
Blockade of LILRB1 and LILRB3 receptors by monoclonal antibodies or short interfering RNA (siRNA) abrogated the specific antigen-presenting properties of dendritic cells, implying an important regulatory role of these molecules.
Immune proteins in brain development and synaptic plasticity.
Review
Boulanger, Princeton, United States. In Neuron, 2009
These include proinflammatory cytokines (e.g., TNFalpha, IL-6), proteins of the innate immune system (e.g., complement C1q and C3, pentraxins, Dscam), members of the major histocompatibility complex class I (MHCI) family, and MHCI-binding immunoreceptors and their components (e.g., PIRB, Ly49, DAP12, CD3zeta).
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.
GeneRIF
Takai et al., Sendai, Japan. In J Immunol, 2008
LILRB3 is expressed on cultured osteoclast precursor cells derived from peripheral blood monocytes and plays a regulatory role in the development of osteoclasts.
Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells.
GeneRIF
Arm et al., Sydney, Australia. In J Leukoc Biol, 2008
Progenitor mast cells expressed cell surface inhibitory LILRB3. Mature cord-blood-derived mast cells had detectable mRNA encoding multiple LILRs, none were expressed on the cell surface.
Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition.
GeneRIF
Arm et al., Boston, United States. In Blood, 2004
Coligation of LIR3 to LIR7 or to FcepsilonRI by means of a second monoclonal antibody significantly inhibited net histamine release, cysLT production, and IL-4 generation. LIR3 is counter-regulatory for both adaptive and innate receptors suggests.
Exacerbated graft-versus-host disease in Pirb-/- mice.
Impact
Takai et al., Sendai, Japan. In Nat Immunol, 2004
Immune responses are often regulated by opposing receptor pairs that recognize the same ligand but deliver either activating or inhibitory signals.
The genomic context of natural killer receptor extended gene families.
Review
Wilson et al., Cambridge, United Kingdom. In Immunol Rev, 2001
A few ILT loci, such as ILT5 and ILT8, are polymorphic, but only ILT6 exhibits presence/absence variation.
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