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Interleukin 1 receptor accessory protein-like 2

IL1RAPL2, Interleukin 1 Receptor Accessory Protein-Like-2, three immunoglobulin domain-containing IL-1 receptor-related, IL-1R9, TIGIRR-1
The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-1beta, IL-1ra, IL-18, SIGIRR, IL-18BP
Papers on IL1RAPL2
Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula.
Lau et al., Hong Kong, Hong Kong. In Plos One, 2014
After 16 h incubation of NF3, other sets of genes were shown with differential expression in HUVEC, e.g., IL1RAPL2 and NR1H4 in anti-inflammation; miR28 in anti-tumorogenesis; GRIN1 and LCN1 in anti-oxidation; EPB41 in intracellular signal transduction; PRL and TFAP2A in cell proliferation; miR28, PRL and SCG2 in cell migration; PRL in tubular formation; and miR28, NR1H4 and PRL in angiogenesis.
Molecular patterns of subclinical and clinical rejection of kidney allograft: quantity matters.
Viklicky et al., Praha, Czech Republic. In Kidney Blood Press Res, 2014
RESULTS: Clinical inflammation group showed a increased expression of genes for chemotaxis mediating cytokines (CCL1, CCL17, CCL24, CCL25, CCL26), cytokine receptors (CCR1, CCRL2, IL1RAPL2, CXCR5), proinflammatory cytokines (IL12A, LTA), inflammatory mediator (PTAFR), complement protein C3, executioner protein of apoptosis (CASP7), growth factor (TGFA), colony stimulating factor (CSF-2), proteins involved in dendritic cells differentiation and interaction (CD209, LAMP3), regulation of immune response (LILRB2, LILBRB4).
An emerging phenotype of Xq22 microdeletions in females with severe intellectual disability, hypotonia and behavioral abnormalities.
Stefanova et al., Tokyo, Japan. In J Hum Genet, 2014
The possible candidate region responsible for such distinctive features has been narrowed down to the neighboring region for PLP1, including the interleukin 1 receptor accessory protein-like 2 (IL1RAPL2) gene and the clustered brain expressed X-linked (BEX) genes.
Negative regulatory receptors of the IL-1 family.
Mantovani et al., Rozzano, Italy. In Semin Immunol, 2014
In this review, the negative regulation mediated by decoy receptors are presented and include IL-1R2 and IL-IL-18BP as well as atypical receptors, which include TIR8/SIGIRR, IL-1RAcPb, TIGIRR-1 and IL-1RAPL.
The interleukin-1 receptor family.
Tagliabue et al., Napoli, Italy. In Semin Immunol, 2014
Presently there are two orphan receptors, IL-1R9 and IL-1R10, which have no known function.
Decoys and Regulatory "Receptors" of the IL-1/Toll-Like Receptor Superfamily.
Mantovani et al., Rozzano, Italy. In Front Immunol, 2012
Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function.
X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma.
Gershwin et al., Davis, United States. In Clin Exp Immunol, 2012
Identified genes include transcription factors (ARX, HSFX1, ZBED1, ZNF41) and surface antigens (IL1RAPL2, PGRMC1), and pathway analysis suggests their involvement in cell proliferation (PGK1, SMS, UTP14A, SSR4), apoptosis (MTM1), inflammation (ARAF) and oxidative stress (ENOX2).
The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2.
Sala et al., Milano, Italy. In Hum Mol Genet, 2012
We also found that the IL1RAPL1 paralog, IL1RAPL2, interacts with PTPδ and induces excitatory synapse and dendritic spine formation.
Marfanoid hypermobility caused by an 862 kb deletion of Xq22.3 in a patient with Sotos syndrome.
Yamamoto et al., Tokyo, Japan. In Am J Med Genet A, 2011
Severe developmental delay seen in the patient may be derived from position effect of the deletion for neighboring interleukin 1 receptor accessory protein-like 2 gene (IL1RAPL2), which is a candidate gene for X-linked mental retardation.
Identification of ChIP-seq mapped targets of HP1β due to bombesin/GRP receptor activation.
Benya et al., Chicago, United States. In Clin Epigenetics, 2011
Of these, genomic PCR of immunoprecipitated chromatin demonstrated that GRPR signaling affected the expression of IL1RAPL2, FAM13A, GBE1, PLK3, and SLCO1B3.
Fine mapping of Xq11.1-q21.33 and mutation screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for autism spectrum disorders (ASD).
Järvelä et al., Helsinki, Finland. In Autism Res, 2011
A total of six novel and 11 known single nucleotide polymorphisms were identified. Further studies are warranted to analyze the candidate genes at Xq11.1-q21.33.
Mutations in the calcium-related gene IL1RAPL1 are associated with autism.
Rouleau et al., Montréal, Canada. In Hum Mol Genet, 2009
We also sequenced the coding region of the close related member IL1RAPL2 and of NCS-1/FREQ, which physically interacts with IL1RAPL1, in a cohort of subjects with autism.
Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies.
Lundberg et al., Stockholm, Sweden. In Arthritis Rheum, 2007
The increased expression of IL-1 receptor and the colocalization with reciprocal ligands in patients with myositis but not in healthy controls support the hypothesis of a crucial role of IL-1 in the pathogenesis of polymyositis and dermatomyositis.
Construction of a high-density and high-resolution human chromosome X array for comparative genomic hybridization analysis.
Inazawa et al., Tokyo, Japan. In J Hum Genet, 2006
Furthermore, array-CGH in a patient with atypical Schinzel-Giedion syndrome disclosed a 1.1-Mb duplication at Xq22.3 including a part of the IL1RAPL2 gene as a likely causative aberration.
Analysis of interleukin (IL)-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and IL-1 accessory protein in HCV-associated lymphoproliferative disorders.
Nicoletti et al., Catania, Italy. In Oncol Rep, 2006
Increased circulating levels of IL-1 accessory protein is associated with Hepatitis C virus positive patients
Regulation of expression of the novel IL-1 receptor family members in the mouse brain.
Rothwell et al., Manchester, United Kingdom. In J Neurochem, 2005
The discovery of new orphan members of the IL-1 receptor superfamily (including ST2/T1, IL-1Rrp2, TIGIRR1 and -2, SIGGIR, IL-18Ralpha and IL-18Rbeta) has increased speculation that alternative IL-1 ligands signalling pathways exist in the brain.
IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system.
Franco et al., Milano, Italy. In Gene, 2001
This new transcript was cloned by analysis of genomic sequences from the Xq22 region and was named IL1RAPL2 (Interleukin 1 Receptor Accessory Protein-Like-2).
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