GATA-3 dose-dependent checkpoints in early T cell commitment.
Pasadena, United States. In J Immunol, 2014
Gene expression analyses (quantitative PCR, RNA sequencing) showed that GATA-3-deficient DN2 cells quickly upregulated genes, including Spi1 (PU.1) and Bcl11a, and downregulated genes, including Cpa3, Ets1, Zfpm1, Bcl11b, Il9r, and Il17rb with gene-specific kinetics and dose dependencies.
The gamma-chain cytokine/receptor system in fish: more ligands and receptors.
Aberdeen, United Kingdom. In Fish Shellfish Immunol, 2011
In recent years, aided by the availability of sequenced fish genomes and expressed sequence tag databases, five of the six mammalian γC cytokines and their cognate receptors have been discovered in fish, with only the IL-9/IL-9R homologues apparently absent.