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Interleukin 9 receptor

IL-9R, interleukin-9 receptor
The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-9, IL-4, Interleukin-2, CD25, V1a
Papers on IL-9R
IL-9 signaling affects central nervous system resident cells during inflammatory stimuli.
Rostami et al., Philadelphia, United States. In Exp Mol Pathol, Dec 2015
In the present study, we found that the IL-9 receptor (IL-9R) was highly expressed in astrocytes, oligodendrocyte progenitor cells (OPCs), oligodendrocytes and microglia cells, and that its expression was significantly upregulated in brain and spinal cord during EAE.
Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis.
Triolo et al., Pavia, Italy. In Rheumatology (oxford), Dec 2015
METHODS: IL-9, IL-9R, PU.1, IL-9, thymic stromal lymphopoietin (TSLP), IL-4 and TGF-β expression was assessed by real-time-PCR in the synovial tissues of RA and OA patients.
Difference in the expression of IL-9 and IL-17 correlates with different histological pattern of vascular wall injury in giant cell arteritis.
Triolo et al., Palermo, Italy. In Rheumatology (oxford), Sep 2015
IL-8, IL-9, IL-9R, IL-17, IL-4, TGF-β and thymic stromal lymphopoietin expression was evaluated by RT-PCR and immunohistochemistry on artery biopsy specimens.
High expression of IL-9R promotes the progression of human hepatocellular carcinoma and indicates a poor clinical outcome.
Tong et al., Hefei, China. In Oncol Rep, Aug 2015
Interleukin-9 receptor (IL-9R) overexpression has a pivotal role in human hematological malignancies.
IL-9 aggravates the development of atherosclerosis in ApoE-/- mice.
Cheng et al., Wuhan, China. In Cardiovasc Res, Jul 2015
METHODS AND RESULTS: IL-9R was expressed in mouse aortic endothelial cells (MAECs) and aortic tissues, and IL-9 levels were elevated in plasma and aortic arches in Apolipoprotein E-deficient (ApoE-/-) mice.
IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes: A plausible mechanism of IL-9R in atopic dermatitis.
Lee et al., Kao-hsiung, Taiwan. In J Dermatol Sci, Jun 2015
Its role in atopic dermatitis (AD) was examined in just a few studies, including nucleotide polymorphisms, increased transcriptional levels of IL-9 and IL-9R in diseased skin, and an association of blood IL-9 levels with clinical severity.
IL-9 and its receptor are predominantly involved in the pathogenesis of UC.
Mudter et al., Erlangen, Germany. In Gut, May 2015
DESIGN: We investigated the expression of IL-9 and IL-9R by using peripheral blood, biopsies and surgical samples.
Expression and regulation of interleukin-9 in chronic rhinosinusitis.
Lin et al., Shanghai, China. In Am J Rhinol Allergy, 2015
Recent evidence has suggested that interleukin (IL)-9 is vital in eliciting inflammatory response, stimulating cell proliferation and preventing apoptosis, through binding to the IL-9 receptor (IL-9R).
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
Flemington et al., New Orleans, United States. In J Virol, 2015
Analysis of HTLV-1 integrations in two cell lines, HuT 102 and MJ, identified 14 and 66 transcriptionally active integration sites with potentially activating integrations in immune regulatory genes, including interleukin-15 (IL-15), IL-6ST, STAT5B, HIVEP1, and IL-9R.
Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells.
Bodnár et al., Debrecen, Hungary. In Chemphyschem, 2015
The interleukin-9 receptor (IL-9R) consists of an α subunit and a γ(c) chain that are shared with other cytokine receptors, including interleukin-2 receptor (IL-2R), an important regulator of T cells.
Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen.
Khan et al., Miami, United States. In Front Immunol, 2014
MZ B-cells possessed the most distinct transcriptome including down-regulation of CD45 phosphatase-associated protein (CD45-AP/PTPRC-AP), as well as upregulation of IL-9R and innate molecules TLR3, TLR7, and bactericidal Perforin-2 (MPEG1).
GATA-3 dose-dependent checkpoints in early T cell commitment.
Rothenberg et al., Pasadena, United States. In J Immunol, 2014
Gene expression analyses (quantitative PCR, RNA sequencing) showed that GATA-3-deficient DN2 cells quickly upregulated genes, including Spi1 (PU.1) and Bcl11a, and downregulated genes, including Cpa3, Ets1, Zfpm1, Bcl11b, Il9r, and Il17rb with gene-specific kinetics and dose dependencies.
Interleukin-9 receptor gene is transcriptionally regulated by nucleolin in T-cell lymphoma cells.
Shimada et al., Chiba, Japan. In Mol Carcinog, 2012
Data indicate that increased expression of interleukin-9 receptor (Il9R) is associated with an increased binding of nucleolin.
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
Kupper et al., Boston, United States. In Nat Med, 2012
Il9r(-/-) mice showed accelerated tumor growth, and administration of recombinant IL-9 (rIL-9) to tumor-bearing WT and Rag1(-/-) mice inhibited melanoma as well as lung carcinoma growth.
The gamma-chain cytokine/receptor system in fish: more ligands and receptors.
Secombes et al., Aberdeen, United Kingdom. In Fish Shellfish Immunol, 2011
In recent years, aided by the availability of sequenced fish genomes and expressed sequence tag databases, five of the six mammalian γC cytokines and their cognate receptors have been discovered in fish, with only the IL-9/IL-9R homologues apparently absent.
An association between IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population.
Yang et al., Cleveland, United States. In J Dermatol Sci, 2011
analysis of IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population
Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis.
Ahnert et al., Leipzig, Germany. In J Rheumatol, 2009
There is an association of at least 2 X-chromosomal genes with rheumatoid arthritis: TIMP1 and IL9R.
T(H)2 cytokines modulate the IL-9R expression on human neutrophils.
Gounni et al., Winnipeg, Canada. In Biochem Biophys Res Commun, 2009
These results reveal a regulatory function for IFN-gamma and IL-10 on modulating the inducible IL-9Ralpha expression levels on peripheral blood neutrophils by T(H)2 cytokines.
Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers.
Renauld et al., Brussels, Belgium. In J Biol Chem, 2009
IL-9Ralpha and IL-2Rbeta homodimers efficiently mediate constitutive activation of ALL-associated JAK1 mutants.
Multiple gamma c-dependent cytokines regulate T-cell development.
He et al., Miami, United States. In Immunol Today, 1999
gamma c contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2-receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R.
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