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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 9

IL-9, Interleukin-9
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-4, IL-13, Interleukin-2, IL-5, TH2
Papers using IL-9 antibodies
IL-9– and mast cell–mediated intestinal permeability predisposes to oral antigen hypersensitivity
Supplier
Hogan Simon P. et al., In The Journal of Experimental Medicine, 2005
... Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice ...
Feedback regulation of murine Ly-1 B cell development
Supplier
Renauld Jean-Christophe et al., In The Journal of Experimental Medicine, 1988
... express large amounts of IL-9 message in all organs, and high levels of biologically active IL-9 (± 1 μg/ml) have been detected in the serum of transgenic but not control mice ...
Papers on IL-9
Effect of TH2 cytokines and interferon gamma on beat frequency of human respiratory cilia.
New
Omran et al., Münster, Germany. In Pediatr Res, Feb 2016
METHODS: Nasal respiratory epithelial cells of 21 patients were used to prepare multicellular cells (spheroids) in presence of the TH2 cytokines interleukin (IL)-4, IL-5, IL-9 and IL-13 and the TH1 cytokine interferon gamma (IFN-γ).
Decidual Control of Trophoblast Invasion.
Review
New
Modi et al., Mumbai, India. In Am J Reprod Immunol, Feb 2016
The decidual secretions contain high amounts of pro-invasive factors that include IL-1β, IL-5, IL-6, IL-7, IL-8, IL-9, IL-13, IL-15, Eotaxin CCL11, IP-10 and RANTES, and anti-invasive factors IL-10, IL-12 and VEGF.
IL-9, a local growth factor for synovial T cells in inflammatory arthritis.
New
Raychaudhuri et al., Sacramento, United States. In Cytokine, Feb 2016
OBJECTIVE: The regulatory role of the Th9 cells along with its signature cytokine IL-9 in human immune system and its aberrant activation in autoimmune diseases is currently under investigation.
IL-10- and TGFβ-mediated Th9 Responses in a Human Helminth Infection.
New
Babu et al., Chennai, India. In Plos Negl Trop Dis, Jan 2016
BACKGROUND: Th9 cells are a subset of CD4+ T cells that express the protoypical cytokine, IL-9.
Common gamma chain cytokines in combinatorial immune strategies against cancer.
Review
New
Shanker et al., Nashville, United States. In Immunol Lett, Jan 2016
Common γ chain (γC) cytokines, namely IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 are important for the proliferation, differentiation, and survival of lymphocytes that display antitumor activity, thus stimulating considerable interest for the use of cytokines in cancer immunotherapy.
New insights of common gamma chain in hematological malignancies.
New
Hong et al., Yangsan, South Korea. In Cytokine, Jan 2016
UNASSIGNED: The common gamma chain (γc) receptor family of cytokines including interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21 has the common feature of sharing γc signaling subunit of their receptors.
A deleterious role for Th9/IL-9 in hepatic fibrogenesis.
New
Zhou et al., Nanning, China. In Sci Rep, Dec 2015
We aimed to investigate the role of Th9/interleukin-9 (IL-9) in the pathogenesis of hepatic fibrosis.
A novel cell-penetrating peptide suppresses breast tumorigenesis by inhibiting β-catenin/LEF-1 signaling.
New
Tsai et al., Kao-hsiung, Taiwan. In Sci Rep, Dec 2015
Furthermore, the human global gene expression profiles and Ingenuity Pathway Analysis software showed that the TAT-NLS-BLBD-6 downstream target genes were associated with the HER-2 and IL-9 signaling pathways.
Licensed to Ill: IL-9 Generation in Immature Mast Cells Permits Food-Elicited Anaphylaxis.
New
Impact
Austen et al., Boston, United States. In Immunity, Nov 2015
Chen et al. (2015) demonstrate that food-elicited reactions require an immature mast cell that generates IL-9 to induce its own maturation.
Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy.
New
Impact
Wang et al., Cincinnati, United States. In Immunity, Nov 2015
Experimental IgE-mediated food allergy depends on intestinal anaphylaxis driven by interleukin-9 (IL-9).
The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells.
New
Impact
Chen et al., Bethesda, United States. In Nat Immunol, Oct 2015
The molecular mechanisms by which signaling via transforming growth factor-β (TGF-β) and interleukin 4 (IL-4) control the differentiation of CD4(+) IL-9-producing helper T cells (TH9 cells) remain incompletely understood.
Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells.
New
Impact
Kang et al., Seoul, South Korea. In Nat Med, Sep 2015
IL-4 receptor knockout (Il4ra(-/-)) mice, which have reduced expression of IL-9, were resistant to tumor growth inhibition by DTA-1.
Role of Innate Lymphoid Cells in Lung Disease.
Review
New
Velayati et al., Tehrān, Iran. In Iran J Allergy Asthma Immunol, Aug 2015
ILC1 cells encompass natural killer (NK) cells and interferon (IFN)-g releasing cells; ILC2 cells release the Th2 cytokines, IL-5, IL-9 and IL-13 in response to IL-25 and IL-33; and ILC3 cells which release IL-17 and IL-22.
Type 2 cytokines: mechanisms and therapeutic strategies.
Review
New
Impact
Wynn, Bethesda, United States. In Nat Rev Immunol, May 2015
Type 2 immune responses are defined by the cytokines interleukin-4 (IL-4), IL-5, IL-9 and IL-13, which can either be host protective or have pathogenic activity.
Group 2 innate lymphoid cells: new players in human allergic diseases.
Review
Broide et al., In J Investig Allergol Clin Immunol, 2014
Production of TH2 cytokines including IL-4, IL-5, IL-9, and IL-13 has mainly been attributed to CD4+T(H)2 cells.
Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells.
Impact
GeneRIF
Khoury et al., Boston, United States. In Immunity, 2012
propose that Notch and Smad3 cooperate to induce IL-9 and participate in regulating the immune response
The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma.
GeneRIF
Schmitt et al., České Budějovice, Czech Republic. In J Immunol, 2012
data suggest that sialostatin L can prevent experimental asthma, most likely by inhibiting the IL-9 production of Th9 cells
STAT6-dependent regulation of Th9 development.
GeneRIF
Kaplan et al., Indianapolis, United States. In J Immunol, 2012
data established a transcription factor network that regulates IL-9
IL-9 contributes to immunosuppression mediated by regulatory T cells and mast cells in B-cell non-hodgkin's lymphoma.
GeneRIF
Wang et al., Jinan, China. In J Clin Immunol, 2011
contributes to immunosuppression mediated by regulatory T cells and mast cells in B-cell non-hodgkin's lymphoma
An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation.
Impact
GeneRIF
Stockinger et al., United Kingdom. In Nat Immunol, 2011
production is largely restricted to innate lymphoid cells in experimental lung inflammation
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