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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Mar 2015.

Interleukin 8

IL-8, Interleukin-8, NaF
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-6, CAN, IL-10, HAD, V1a
Papers using IL-8 antibodies
Agents Classified by the IARC Monographs, Volumes 1–102.
Fry Rebecca C. et al., In Environmental Health Perspectives, 2009
An OptEIA™ human IL-8 enzyme-linked immunosorbent assay (ELISA) (BD Biosciences, San Jose, CA) was ...
Cystic Fibrosis Airway Epithelial Ca2+i Signaling: the mechanism for the larger agonist-mediated Ca2+i signals in human cystic fibrosis airway epithelia.
Zhou Wen-Liang, In PLoS ONE, 2004
... IL-6 and IL-8 ELISA kits were obtained from eBioscience (San Diego, CA), and ...
A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
Moser Bernhard et al., In The Journal of Experimental Medicine, 2002
IL-6 (AS12), IL-8 (AS14), TNF-α (6401.1111),
Natural-killer like cells in the sheep: Functional characterization and regulation by pregnancy-associated proteins
Hansen Peter J et al., In BMC Cell Biology, 2001
... was from Anaspec (San Jose, CA) and the ELISA MAX™ Set Deluxe kit for human IL-8 was obtained from BioLegend (San Diego, CA) ...
Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells
Shimizu Tadamichi et al., In Mediators of Inflammation, 2001
... (CA); Paeoniflorin was from LKT Laboratories, Inc.; MIF, IL-6, and IL-8 ELISA kits were obtained from R&D Systems (Minneapolis); and the Western blot detection system was obtained from Cell Signaling Technology (Beverly, MA) ...
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Papers on IL-8
Proinflammatory status in the aqueous humor of high myopic cataract eyes.
Lu et al., Shanghai, China. In Exp Eye Res, 21 Apr 2015
The cytokine antibody array showed that the expression level of interleukin-1 receptor antagonist (IL-1ra) in the AH was higher in ARC than in HMC, whereas opposite trends were found for monocyte chemoattractant protein-1 (MCP-1), regulated on activation, normal T-cell expressed and presumably secreted (RANTES), IL-8, platelet-derived growth factor-BB, and IL-6 (all P < 0.05).
The biological functions of IL-17 in different clinical expressions of H. pylori-infection.
Razavi et al., Tehrān, Iran. In Microb Pathog, 12 Apr 2015
IL-17 usually causes secretion of IL-8 through activation of ERK 1/2 MAP kinase pathway.
The role of infections in Behçet disease and neuro-Behçet syndrome.
Giovannoni et al., Porto, Portugal. In Autoimmun Rev, 10 Apr 2015
Raised levels of serum IL-8 in some BD patients did not reflect clinical activity or severity.
Dynamic contrast-enhanced computed tomography to assess early activity of cetuximab in squamous cell carcinoma of the head and neck.
Machiels et al., Brussels, Belgium. In Radiol Oncol, 31 Mar 2015
Plasmatic VEGF, PDGF-BB and IL-8 decreased as early as 2 hours after cetuximab infusion.
Orostachys japonicus Inhibits Expression of the TLR4, NOD2, iNOS, and COX-2 Genes in LPS-Stimulated Human PMA-Differentiated THP-1 Cells by Inhibiting NF-κB and MAPK Activation.
Kim et al., Seoul, South Korea. In Evid Based Complement Alternat Med, Dec 2014
O. japonicus inhibited LPS-induced TLR4 and NOD2 mRNA levels, suppressed LPS-induced iNOS and COX-2 transcription and translocation, and downregulated LPS-induced proinflammatory cytokine (IL-1β, IL-6, IL-8, and TNF-α) mRNA levels.
Sudden infant death syndrome and the genetics of inflammation.
Opdal et al., Oslo, Norway. In Front Immunol, Dec 2014
The pro-inflammatory cytokines favor inflammation; the most important of these are IL-1α, IL-1β, IL-6, IL-8, IL-12, IL-18, TNF-α, and IFN-γ.
Virus Infections and Sudden Death in Infancy: The Role of Interferon-γ.
Blackwell et al., Newcastle, Australia. In Front Immunol, Dec 2014
For PBMC, IFN-γ enhanced interleukin (IL)-1β, IL-6, and tumor necrosis factor-α responses but reduced IL-8 and IL-10 responses.
Cytokine changes in tears and relationship to contact lens discomfort.
Lazon de la Jara et al., Sydney, Australia. In Mol Vis, Dec 2014
For the remaining 15 cytokines, interleukin-8 (IL-8) was the only cytokine that changed in both groups during the day without (reduced by >-0.5 Log pg/ml, p<0.001) or with lens wear (reduced by >-0.2 Log pg/ml, p<0.001).
Aqueous Cytokines as Predictors of Macular Edema in Patients with Diabetes following Uncomplicated Phacoemulsification Cataract Surgery.
Tang et al., Beijing, China. In Biomed Res Int, Dec 2014
Compared to the ME (-) patients, the concentrations of interleukin-1β (IL-1β) (P < 0.001), IL-6 (P < 0.001), IL-8 (P < 0.001), interferon-induced protein-10 (IP-10) (P = 0.003), monocyte chemotactic protein-1 (MCP-1) (P < 0.001), and vascular endothelial growth factor (VEGF) (P < 0.001) in the ME (+) patients were significantly higher.
Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants.
Hayday et al., London, United Kingdom. In Nat Med, Oct 2014
Here we demonstrate that a major T cell effector function in human newborns is interleukin-8 (CXCL8) production, which has the potential to activate antimicrobial neutrophils and γδ T cells.
γδT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer.
Huang et al., Hangzhou, China. In Immunity, Jun 2014
Activated inf-DCs induced γδT17 cells to secrete IL-8, tumor necrosis factor alpha, and GM-CSF with a concomitant accumulation of immunosuppressive PMN-MDSCs in the tumor.
α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling.
Ma et al., Houston, United States. In Nat Cell Biol, Mar 2014
This stabilization in turn prevents nuclear localization of RelA and p50, leading to decreased expression of TNF-α, IL-8 and RelB.
Neuroinflammation in Alzheimer's disease: chemokines produced by astrocytes and chemokine receptors.
Guo et al., Shanghai, China. In Int J Clin Exp Pathol, 2013
Clarification of the involvement of chemokines and their receptors, such as MCP-1/CCR2, fractalkine/CX3CR1, SDF-1α/CXCR4, MIP-1α/CCR5, IP-10/CXCR3, IL-8/CXCR1, CXCR2, and RANTES/CCR1, CCR3, CCR5, will provide a new strategy and more specific targets for the treatment of Alzheimer's disease.
Biological features of novel avian influenza A (H7N9) virus.
Shu et al., Beijing, China. In Nature, 2013
In acute serum samples of H7N9-infected patients, increased levels of the chemokines and cytokines IP-10, MIG, MIP-1β, MCP-1, IL-6, IL-8 and IFN-α were detected.
A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells.
Metcalfe et al., Bethesda, United States. In Immunity, 2013
In addition, gene targeting of t-FcεRIβ attenuated microtubule formation, degranulation, and IL-8 production downstream of Ca2+ signals.
Seminal plasma induces angiogenic chemokine expression in cervical cancer cells and regulates vascular function.
Katz et al., Cape Town, South Africa. In Biochim Biophys Acta, 2012
Seminal plasma rapidly enhanced the expression of the angiogenic chemokines, interleukin (IL)-8 and growth regulated oncogene alpha (GRO) in HeLa cells.
Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells.
Akiyama et al., Tokushima, Japan. In Oncol Rep, 2012
The enzymatic activity of thymidine phosphorylase was required for the enhanced expression of IL-8 in human cancer cells.
The lL-8 and IL-13 gene polymorphisms in inflammatory bowel disease and colorectal cancer.
Majsterek et al., Łódź, Poland. In Dna Cell Biol, 2012
data showed that the IL-8 -251 T/A and IL-13 -1112 C/T polymorphisms might be associated with the inflammatory bowel disease and colorectal cancer occurrence
Role of mechanical stretching and lipopolysaccharide in early apoptosis and IL-8 of alveolar epithelial type II cells A549.
Zhao et al., Haikou, China. In Asian Pac J Trop Med, 2012
Mechanical stretch can induce early apoptosis and IL-8 secretion. Mechanical stretch and lipopolysaccharide have an additive effect on early apoptosis and IL-8 production in human alveolar type 2 cells.
IL8 and serum soluble TRAIL levels following anti-VEGF monoclonal antibody treatment in patients with metastatic colon cancer.
Gorczynski et al., Denizli, Turkey. In Clin Lab, 2011
In BevacizumAb therapy, serum IL8 levels were decreased in all patients, and thus, changes in such levels were not correlated with disease outcome.
More papers using IL-8 antibodies
Microarray analysis of eosinophils reveals a number of candidate survival and apoptosis genes
Kankaanranta Hannu et al., In Journal of Inflammation (London, England), 2000
... (Miltenyi Biotec Ltd., Surrey, UK), human recombinant IL-5, GM-CSF and DuoSet ELISA Development System for IL-8 and MCP-1 (R&D system Europe, Abingdon, UK), May-Grünwald (Merck, Darmstadt, Germany), and Giemsa ...
NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100.
Kyprianou Natasha, In PLoS ONE, 2000
... To examine the effect of IL-8 on radiation responses, LNCaP cells were pretreated with IL-8 (BD Biosciences) at concentrations of 0 to ...
Assay for redox-sensitive transcription factor.
Hartl Dominik, In PLoS ONE, 1999
... Human IL-6 and IL-8 ELISA kits were from Diaclone (Stamford, CT) and R&D ...
Thrombin and leukocyte recruitment in endotoxemia.
Woodman Richard C et al., In BMC Immunology, 1999
... fetal bovine serum (FBS) (Cansera International Inc., Toronto, ON), tumour necrosis factor (TNF) and interleukin-8 (IL-8) (Research Diagnostics Inc.,Flandere,NJ); HTMT dimaleate (6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)-heptanecarboxamide) ...
TNF-α and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAP kinase-dependent pathway
Pilette Charles et al., In Journal of Biomedicine and Biotechnology, 1999
... After washing, neutrophils were resuspended in RPMI-1640 and activated by 20 ng/ml IL-8 (R&D System, Minneapolis, MN) for 5 min followed by 1 nM formyl-Methionyl-Leucyl-Phenylalanine (fMLP) (Sigma Aldrich, Saint Louis, MO) for ...
Interleukin-1α producing synovial sarcoma with prolonged fever: a case report
Sugitani Masahiko et al., In Acta Histochemica et Cytochemica, 1997
... Next, we immunohistochemically examined the localization of the proinflammatory cytokine, IL-8 (Abcam Ltd, Cambridge, UK), using ...
A prospective study of maternal and fetal outcome in acute Lassa fever infection during pregnancy
Garry Robert F et al., In Virology Journal, 1987
... indicators (Abaxis, Inc.) and serum cytokine levels (Cambridge Biomedical [IL-1b, IL-10], BD Biosciences [IL-2, IL-4, IL-8, IL-12p70], R&D Systems [IL-5, IL-6], Thermo Scientific [TNF-α], BioVendor [TNF-β, IFN-γ]) ...
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