GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Interleukin 8
IL-8, Interleukin-8, NaF
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers using
IL-8
antibodies
Agents Classified by the IARC Monographs, Volumes 1–102.
Supplier
In Environmental Health Perspectives, 2009
An OptEIA™ human IL-8 enzyme-linked immunosorbent assay (ELISA) (BD Biosciences, San Jose, CA) was ...
Cystic Fibrosis Airway Epithelial Ca2+i Signaling: the mechanism for the larger agonist-mediated Ca2+i signals in human cystic fibrosis airway epithelia.
Supplier
In PLoS ONE, 2004
... IL-6 and IL-8 ELISA kits were obtained from eBioscience (San Diego, CA), and ...
A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
Supplier
In The Journal of Experimental Medicine, 2002
IL-6 (AS12), IL-8 (AS14), TNF-α (6401.1111),
Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells
Supplier
In Mediators of Inflammation, 2001
Natural-killer like cells in the sheep: Functional characterization and regulation by pregnancy-associated proteins
more suppliersSupplier
In BMC Cell Biology, 2001
... was from Anaspec (San Jose, CA) and the ELISA MAX™ Set Deluxe kit for human IL-8 was obtained from BioLegend (San Diego, CA) ...
Papers on
IL-8
Vital Exhaustion and Markers of Low-Grade Inflammation in Healthy Adults: The Amsterdam Growth and Health Longitudinal Study.
New
Amsterdam, Netherlands. In Stress Health, 08 Apr 2013
Markers of low-grade inflammation included interleukin-6, interleukin-8 and tumour necrosis factor-α.
Dietary phytophenols reduce infection-induced inflammatory pathways in human gestational tissues.
New
Melbourne, Australia. In Mol Hum Reprod, 07 Apr 2013
In placenta and fetal membranes, all treatments significantly reduced LPS-stimulated release and gene expression of pro-inflammatory cytokines IL-6 and IL-8; placenta decreased cyclooxygenase (COX-2) mRNA expression, subsequent release of prostaglandins PGE2 and PGF2α; and expression and activity of matrix degrading enzyme matrix metalloproteinase (MMP)-9.
Induction of chicken cytokine responses in vivo and in vitro by lipooligosaccharide of Campylobacter jejuni HS:10.
New
Guelph, Canada. In Vet Microbiol, 16 Mar 2013
Chickens were injected with purified LOS, and expression of interleukin (IL)-1β (pro-inflammatory cytokine), IL-8 (pro-inflammatory chemokine), interferon (IFN)γ (Th1-like cytokine), IL-10 (immune regulatory/anti-inflammatory cytokine) and IL-13 (Th2-like cytokine) was evaluated in spleen using quantitative RT-PCR, up to 24h post-injection.
JAK2/STAT5 inhibition circumvents resistance to PI3K/mTOR blockade: a rationale for cotargeting these pathways in metastatic breast cancer.
New
Impact
Basel, Switzerland. In Cancer Cell, Jan 2013
Mechanistically, PI3K/mTOR inhibition increased IRS1-dependent activation of JAK2/STAT5 and secretion of IL-8 in several cell lines and primary breast tumors.
Chemokine to the rescue: interleukin-8 mediates resistance to PI3K-pathway-targeted therapy in breast cancer.
New
Impact
San Diego, United States. In Cancer Cell, Jan 2013
In this issue of Cancer Cell, Britschgi and coworkers show that certain tumors acquire resistance to PI3K-mTOR inhibitors through activation of a JAK2-dependent pathway, leading to interleukin-8 secretion.
Inflammation in atrial fibrillation.
Review
New
Birmingham, United Kingdom. In J Am Coll Cardiol, Jan 2013
Various inflammatory markers (C-reactive protein, tumor necrosis factor-α, interleukin-2, interleukin-6, and interleukin-8) have been associated with AF.
The Role of IL-6, 8, and 10, sTNFr, CRP, and Pancreatic Elastase in the Prediction of Systemic Complications in Patients with Acute Pancreatitis.
New
Rijeka, Croatia. In Gastroenterol Res Pract, Dec 2012
Our study confirmed that IL-6, IL-8, IL-10, and sTNFr measured on admission, and CRP and pancreatic elastase measured on third day of admission represent valuable prognostic factors of severity and systemic complications of AP.
Structure of the chemokine receptor CXCR1 in phospholipid bilayers.
New
Impact
San Diego, United States. In Nature, Dec 2012
CXCR1 is one of two high-affinity receptors for the CXC chemokine interleukin-8 (IL-8), a major mediator of immune and inflammatory responses implicated in many disorders, including tumour growth.
Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses.
New
Impact
Beijing, China. In Cell, Oct 2012
Rab1 inactivation by EspG severely blocks host secretory pathway, resulting in inhibited interleukin-8 secretion from infected cells.
Nutrition and cancer prevention.
Review
New
Pescara, Italy. In Int J Immunopathol Pharmacol, Jul 2012
Many cytokines, such as IL-1, IL-6, IL-8, IL-32, IL-33 and MCP-1, are biomarkers for cancer and chronic diseases along with transcription factors NFκB and AP-1; these last two factors are important bioactive substances on the molecular mechanism of the control of genes which in turn affect cellular metabolism.
Interleukin-9 and mast cells.
Review
New
In J Biol Regul Homeost Agents, Jul 2012
These cells express proinflammatory cytokines such as IL-1, IL-6, IL-8 and tumor necrosis factor which are necessary for innate immunity.
Healthy effects exerted by prebiotics, probiotics, and symbiotics with special reference to their impact on the immune system.
Review
New
Bari, Italy. In Int J Vitam Nutr Res, Jun 2012
In particular, administration of a symbiotic to free-living elderly was able to potentiate the release of interleukin-8, thus increasing neutrophils in the host, perhaps explaining the reduced frequency of winter infections in the elderly.
Polyclonal immunoglobulin free light chain levels predict survival in myeloid neoplasms.
New
Impact
Rochester, United States. In J Clin Oncol, May 2012
In patients with PMF who were studied by cytokine profiling, the prognostic value of an increased FLC level was independent of that from circulating interleukin-2 receptor (IL-2R) or IL-8 levels.
Up-regulation of chemokine C-C ligand 2 (CCL2) and C-X-C chemokine 8 (CXCL8) expression by monocytes in chronic idiopathic urticaria.
GeneRIF
São Paulo, Brazil. In Clin Exp Immunol, 2012
Chronic urticaria patients had high serum CXCL8. SEA stimulation upregulated CXCL8 mRNA in their monocytes. PHA lymphocyte activation released more CXCL8 in these patients.
Interactions of interleukin-8 with the human chemokine receptor CXCR1 in phospholipid bilayers by NMR spectroscopy.
GeneRIF
San Diego, United States. In J Mol Biol, 2011
combination of solution NMR and solid-state NMR studies of IL-8 in the presence of various constructs of CXCR1 enables us to propose a model for the multistep binding process
Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells.
GeneRIF
Taipei, Taiwan. In Biochem Biophys Res Commun, 2011
these data suggest that IL-8 and IL-32 play a role in regulating the cancer stem cell -like properties that promote tumorigenesis of colorectal cancer cells in both autocrine and paracrine manners.
Effects of nicotine on an in vitro reconstituted model oral mucosa in terms of cytokine production.
Karāchi, Pakistan. In J Ayub Med Coll Abbottabad, 2011
TNF-alpha increased release of pro-inflammatory cytokines, IL-6, IL-8, and also GM-CSF from the model mucosa after 24 hours, but had no effect on the release of IL-1alpha, IL-6, IL-8, and GM-CSF after 5 minutes and 24 hours respectively.
Suppression of IL-8 production from airway cells by tiotropium bromide in vitro.
GeneRIF
Tokyo, Japan. In Int J Chron Obstruct Pulmon Dis, 2010
Tiotropium bromide exerts the inhibitory effect on neutrophilic inflammation through the suppression of IL-8 production from epithelial cells and lung fibroblasts.
Tumor-derived CCL-2 and CXCL-8 as possible prognostic markers of breast cancer: correlation with estrogen and progestrone receptor phenotyping.
GeneRIF
Alexandria, Egypt. In Egypt J Immunol, 2008
possible prognostic marker of breast cancer; correlation with estrogen and progestrone receptor phenotyping
[Biochemical markers in assessment of severity and prognosis of acute pancreatitis].
More papers using
IL-8
antibodies
Review
Zagreb, Croatia. In Lijec Vjesn, 2008
These parameters include trypsinogen activation peptide (TAP), C-reactive protein (CRP, tripsinogen-2, procalcitonin, phospholipase-A2 (PLA2), carboxypeptidase activation peptide (CAPAP) and interleukin-6 and 8 (IL-6, IL-8).
NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100.
Supplier
In PLoS ONE, 2000
... To examine the effect of IL-8 on radiation responses, LNCaP cells were pretreated with IL-8 (BD Biosciences) at concentrations of 0 to ...
Microarray analysis of eosinophils reveals a number of candidate survival and apoptosis genes
Supplier
In Journal of Inflammation (London, England), 2000
... (Miltenyi Biotec Ltd., Surrey, UK), human recombinant IL-5, GM-CSF and DuoSet ELISA Development System for IL-8 and MCP-1 (R&D system Europe, Abingdon, UK), May-Grünwald (Merck, Darmstadt, Germany), and Giemsa ...
Assay for redox-sensitive transcription factor.
Supplier
In PLoS ONE, 1999
... Human IL-6 and IL-8 ELISA kits were from Diaclone (Stamford, CT) and R&D ...
TNF-α and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAP kinase-dependent pathway
Supplier
In Journal of Biomedicine and Biotechnology, 1999
... After washing, neutrophils were resuspended in RPMI-1640 and activated by 20 ng/ml IL-8 (R&D System, Minneapolis, MN) for 5 min followed by 1 nM formyl-Methionyl-Leucyl-Phenylalanine (fMLP) (Sigma Aldrich, Saint Louis, MO) for ...
Thrombin and leukocyte recruitment in endotoxemia.
Supplier
In BMC Immunology, 1999
... fetal bovine serum (FBS) (Cansera International Inc., Toronto, ON), tumour necrosis factor (TNF) and interleukin-8 (IL-8) (Research Diagnostics Inc.,Flandere,NJ); HTMT dimaleate (6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)-heptanecarboxamide) ...
Interleukin-1α producing synovial sarcoma with prolonged fever: a case report
Supplier
In Acta Histochemica et Cytochemica, 1997
... Next, we immunohistochemically examined the localization of the proinflammatory cytokine, IL-8 (Abcam Ltd, Cambridge, UK), using ...
A prospective study of maternal and fetal outcome in acute Lassa fever infection during pregnancy
Supplier
In Virology Journal, 1987
... indicators (Abaxis, Inc.) and serum cytokine levels (Cambridge Biomedical [IL-1b, IL-10], BD Biosciences [IL-2, IL-4, IL-8, IL-12p70], R&D Systems [IL-5, IL-6], Thermo Scientific [TNF-α], BioVendor [TNF-β, IFN-γ]) ...
