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Interleukin 8

IL-8, Interleukin-8, NaF
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-6, IL-10, HAD, CAN, V1a
Papers using IL-8 antibodies
Agents Classified by the IARC Monographs, Volumes 1–102.
Supplier
Fry Rebecca C. et al., In Environmental Health Perspectives, 2009
An OptEIA™ human IL-8 enzyme-linked immunosorbent assay (ELISA) (BD Biosciences, San Jose, CA) was ...
Cystic Fibrosis Airway Epithelial Ca2+i Signaling: the mechanism for the larger agonist-mediated Ca2+i signals in human cystic fibrosis airway epithelia.
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Zhou Wen-Liang, In PLoS ONE, 2004
... IL-6 and IL-8 ELISA kits were obtained from eBioscience (San Diego, CA), and ...
A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
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Moser Bernhard et al., In The Journal of Experimental Medicine, 2002
IL-6 (AS12), IL-8 (AS14), TNF-α (6401.1111),
Natural-killer like cells in the sheep: Functional characterization and regulation by pregnancy-associated proteins
Supplier
Hansen Peter J et al., In BMC Cell Biology, 2001
... was from Anaspec (San Jose, CA) and the ELISA MAX™ Set Deluxe kit for human IL-8 was obtained from BioLegend (San Diego, CA) ...
Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells
Supplier
Shimizu Tadamichi et al., In Mediators of Inflammation, 2001
... (CA); Paeoniflorin was from LKT Laboratories, Inc.; MIF, IL-6, and IL-8 ELISA kits were obtained from R&D Systems (Minneapolis); and the Western blot detection system was obtained from Cell Signaling Technology (Beverly, MA) ...
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Papers on IL-8
H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses.
New
Schelenz et al., London, United Kingdom. In Immunology, 01 Aug 2015
Following recognition, H-ficolin opsonization manifested an increase in IL-8 production from A549 cells which involved activation of the intracellular signalling pathways MEK 1/2, p38 MAPK and JNK.
[Gout - from pathogenesis to treatment - progress in the XXI century].
Review
New
Bogdański et al., Poznań, Poland. In Pol Merkur Lekarski, 22 Jul 2015
New discoveries including the role of inflammasome, inflammatory cytokines ( Il1β, IL-8,TNF-α), but also identification of the URAT -1 transporter or genetic mutation of SLC2A9 has given better understanding of the pathophysiology of gout and enable to use new therapies.
SU-E-I-82: PET Radiopharmaceuticals for Prostate Cancer Imaging: A Review.
New
Rodrigues et al., Bahía de Caráquez, Ecuador. In Med Phys, 30 Jun 2015
Radiopharmaceuticals uptake by glucose metabolism ((18)F-FDG), lipogenesis ((11)C-Choline and (11)C-Acetate), amino acid transport (Anti-(18)F-FACBC), bone matrix ((18)F-NaF), prostatespecific membrane antigen ((68)Ga-PSMA and (89)Zr-J591), CXCR receptors ((89)Ga-Pentixafor), adrenal receptors ((18)F-FDHT) and gastrin release peptide receptor (bombesin analogue).
Association of PCBs and allergies in children.
Review
New
Matsumura et al., Davis, United States. In Pestic Biochem Physiol, May 2015
In conclusion, the mRNA expression levels of IL-8 and IL-22 can be used to detect children who are at particular risk of adverse health events caused by environmental pollutants, especially PCBs.
Humoral factors in ALS patients during disease progression.
New
Garbuzova-Davis et al., Tampa, United States. In J Neuroinflammation, Dec 2014
Cytokine levels (GM-CSF, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, and TNF-α) were determined using the Bio-Rad Bio-Plex® Luminex 200 multiplex assay system.
Role of IL-38 and its related cytokines in inflammation.
Review
New
Li et al., Ningbo, China. In Mediators Inflamm, Dec 2014
IL-38 also inhibits the production of IL-8 induced by IL-36γ, thus inhibiting inflammatory responses.
Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging II: over-expression of neprilysin plays an essential role.
Review
New
Ishida et al., Kasugai, Japan. In Int J Mol Sci, Dec 2014
Direct UVA exposure of human keratinocytes also stimulates the secretion of IL-6, IL-8 and GM-CSF but not of IL-1 and endothelin-1.
Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects.
Review
New
Nieman et al., Brisbane, Australia. In Exerc Immunol Rev, Dec 2014
Exercise stimulates moderate to large increases in the circulating concentrations of interleukin (IL)-6, IL-8, IL- 10, IL-1 receptor antagonist, granulocyte-colony stimulating factor, and smaller increases in tumor necrosis factor-α, monocyte chemotactic protein-1, IL-1β, brain-derived neurotrophic factor, IL-12p35/p40 and IL-15.
Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently.
New
Heuvel et al., Nijmegen, Netherlands. In Cells, Dec 2014
Exposure of ciPTEC to cationic uremic toxins initiated production of the inflammatory cytokines IL-6 (117 ± 3%, p < 0.001), IL-8 (122 ± 3%, p < 0.001), and ET-1 (134 ± 5%, p < 0.001).
Hydroxysafflor yellow A inhibits lipopolysaccharide-induced proliferation and migration of vascular smooth muscle cells via Toll-like receptor-4 pathway.
New
Song et al., Haikou, China. In Int J Clin Exp Med, Dec 2014
In the present study, we showed that HYSA could inhibit LPS-induced VSMCs proliferation and migration, accompanied by the downregulated levels of several key pro-inflammatory cytokines, including TNF-α, IL-6, and IL-8.
Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants.
New
Impact
Hayday et al., London, United Kingdom. In Nat Med, Oct 2014
Here we demonstrate that a major T cell effector function in human newborns is interleukin-8 (CXCL8) production, which has the potential to activate antimicrobial neutrophils and γδ T cells.
γδT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer.
New
Impact
Huang et al., Hangzhou, China. In Immunity, Jun 2014
Activated inf-DCs induced γδT17 cells to secrete IL-8, tumor necrosis factor alpha, and GM-CSF with a concomitant accumulation of immunosuppressive PMN-MDSCs in the tumor.
α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling.
New
Impact
Ma et al., Houston, United States. In Nat Cell Biol, Mar 2014
This stabilization in turn prevents nuclear localization of RelA and p50, leading to decreased expression of TNF-α, IL-8 and RelB.
Biological features of novel avian influenza A (H7N9) virus.
Impact
Shu et al., Beijing, China. In Nature, 2013
In acute serum samples of H7N9-infected patients, increased levels of the chemokines and cytokines IP-10, MIG, MIP-1β, MCP-1, IL-6, IL-8 and IFN-α were detected.
A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells.
Impact
Metcalfe et al., Bethesda, United States. In Immunity, 2013
In addition, gene targeting of t-FcεRIβ attenuated microtubule formation, degranulation, and IL-8 production downstream of Ca2+ signals.
Seminal plasma induces angiogenic chemokine expression in cervical cancer cells and regulates vascular function.
GeneRIF
Katz et al., Cape Town, South Africa. In Biochim Biophys Acta, 2012
Seminal plasma rapidly enhanced the expression of the angiogenic chemokines, interleukin (IL)-8 and growth regulated oncogene alpha (GRO) in HeLa cells.
Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells.
GeneRIF
Akiyama et al., Tokushima, Japan. In Oncol Rep, 2012
The enzymatic activity of thymidine phosphorylase was required for the enhanced expression of IL-8 in human cancer cells.
The lL-8 and IL-13 gene polymorphisms in inflammatory bowel disease and colorectal cancer.
GeneRIF
Majsterek et al., Łódź, Poland. In Dna Cell Biol, 2012
data showed that the IL-8 -251 T/A and IL-13 -1112 C/T polymorphisms might be associated with the inflammatory bowel disease and colorectal cancer occurrence
Role of mechanical stretching and lipopolysaccharide in early apoptosis and IL-8 of alveolar epithelial type II cells A549.
GeneRIF
Zhao et al., Haikou, China. In Asian Pac J Trop Med, 2012
Mechanical stretch can induce early apoptosis and IL-8 secretion. Mechanical stretch and lipopolysaccharide have an additive effect on early apoptosis and IL-8 production in human alveolar type 2 cells.
IL8 and serum soluble TRAIL levels following anti-VEGF monoclonal antibody treatment in patients with metastatic colon cancer.
GeneRIF
Gorczynski et al., Denizli, Turkey. In Clin Lab, 2011
In BevacizumAb therapy, serum IL8 levels were decreased in all patients, and thus, changes in such levels were not correlated with disease outcome.
More papers using IL-8 antibodies
Microarray analysis of eosinophils reveals a number of candidate survival and apoptosis genes
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Kankaanranta Hannu et al., In Journal of Inflammation (London, England), 2000
... (Miltenyi Biotec Ltd., Surrey, UK), human recombinant IL-5, GM-CSF and DuoSet ELISA Development System for IL-8 and MCP-1 (R&D system Europe, Abingdon, UK), May-Grünwald (Merck, Darmstadt, Germany), and Giemsa ...
NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100.
Supplier
Kyprianou Natasha, In PLoS ONE, 2000
... To examine the effect of IL-8 on radiation responses, LNCaP cells were pretreated with IL-8 (BD Biosciences) at concentrations of 0 to ...
Assay for redox-sensitive transcription factor.
Supplier
Hartl Dominik, In PLoS ONE, 1999
... Human IL-6 and IL-8 ELISA kits were from Diaclone (Stamford, CT) and R&D ...
Thrombin and leukocyte recruitment in endotoxemia.
Supplier
Woodman Richard C et al., In BMC Immunology, 1999
... fetal bovine serum (FBS) (Cansera International Inc., Toronto, ON), tumour necrosis factor (TNF) and interleukin-8 (IL-8) (Research Diagnostics Inc.,Flandere,NJ); HTMT dimaleate (6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)-heptanecarboxamide) ...
TNF-α and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAP kinase-dependent pathway
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Pilette Charles et al., In Journal of Biomedicine and Biotechnology, 1999
... After washing, neutrophils were resuspended in RPMI-1640 and activated by 20 ng/ml IL-8 (R&D System, Minneapolis, MN) for 5 min followed by 1 nM formyl-Methionyl-Leucyl-Phenylalanine (fMLP) (Sigma Aldrich, Saint Louis, MO) for ...
Interleukin-1α producing synovial sarcoma with prolonged fever: a case report
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Sugitani Masahiko et al., In Acta Histochemica et Cytochemica, 1997
... Next, we immunohistochemically examined the localization of the proinflammatory cytokine, IL-8 (Abcam Ltd, Cambridge, UK), using ...
A prospective study of maternal and fetal outcome in acute Lassa fever infection during pregnancy
Supplier
Garry Robert F et al., In Virology Journal, 1987
... indicators (Abaxis, Inc.) and serum cytokine levels (Cambridge Biomedical [IL-1b, IL-10], BD Biosciences [IL-2, IL-4, IL-8, IL-12p70], R&D Systems [IL-5, IL-6], Thermo Scientific [TNF-α], BioVendor [TNF-β, IFN-γ]) ...
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