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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Aug 2015.

Interleukin 8

IL-8, Interleukin-8, NaF
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-6, IL-10, HAD, CAN, V1a
Papers using IL-8 antibodies
Agents Classified by the IARC Monographs, Volumes 1–102.
Supplier
Fry Rebecca C. et al., In Environmental Health Perspectives, 2009
An OptEIA™ human IL-8 enzyme-linked immunosorbent assay (ELISA) (BD Biosciences, San Jose, CA) was ...
Cystic Fibrosis Airway Epithelial Ca2+i Signaling: the mechanism for the larger agonist-mediated Ca2+i signals in human cystic fibrosis airway epithelia.
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Zhou Wen-Liang, In PLoS ONE, 2004
... IL-6 and IL-8 ELISA kits were obtained from eBioscience (San Diego, CA), and ...
A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
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Moser Bernhard et al., In The Journal of Experimental Medicine, 2002
IL-6 (AS12), IL-8 (AS14), TNF-α (6401.1111),
Natural-killer like cells in the sheep: Functional characterization and regulation by pregnancy-associated proteins
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Hansen Peter J et al., In BMC Cell Biology, 2001
... was from Anaspec (San Jose, CA) and the ELISA MAX™ Set Deluxe kit for human IL-8 was obtained from BioLegend (San Diego, CA) ...
Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells
Supplier
Shimizu Tadamichi et al., In Mediators of Inflammation, 2001
... (CA); Paeoniflorin was from LKT Laboratories, Inc.; MIF, IL-6, and IL-8 ELISA kits were obtained from R&D Systems (Minneapolis); and the Western blot detection system was obtained from Cell Signaling Technology (Beverly, MA) ...
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Papers on IL-8
Selenoproteins and heat shock proteins play important roles in immunosuppression in the bursa of Fabricius of chickens with selenium deficiency.
New
Li et al., Harbin, China. In Cell Stress Chaperones, 31 Aug 2015
The expression levels of IL-2, IL-6, IL-8, IL-10, IL-17, IL-1β, IFN-α, IFN-β, and IFN-γ were significantly lower (P < 0.05) and TNF-α was significantly higher (P < 0.05) in the L group compared with the control group.
Pioglitazone inhibits the secretion of proinflammatory cytokines and chemokines in astrocytes stimulated with lipopolysaccharide.
New
Li et al., In Int J Clin Pharmacol Ther, 31 Aug 2015
Treatment of astrocytes with LPS significantly increased the levels of pro-inflammatory factors nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-8, but decreased the level of anti-inflammatory factors IL-4 and IL-10 (p < 0.05) compared to untreated control astrocytes.
Effects of home-based bench step exercise on inflammatory cytokines and lipid profiles in elderly Japanese females: A randomized controlled trial.
New
Ohta et al., Saga, Japan. In Arch Gerontol Geriatr, 18 Aug 2015
At baseline and 12 weeks, circulating levels of nine inflammatory cytokines (high-molecular-weight adiponectin, interleukin-4 [IL-4], IL-5, IL-6, IL-8, IL-15, tumor necrosis factor-α [TNF-α], TNF-β and interferon-γ [IFN-γ]) and serum lipids including high-density lipoprotein cholesterol (HDL-C) were measured.
[Gout - from pathogenesis to treatment - progress in the XXI century].
Review
New
Bogdański et al., Poznań, Poland. In Pol Merkur Lekarski, Jun 2015
New discoveries including the role of inflammasome, inflammatory cytokines ( Il1β, IL-8,TNF-α), but also identification of the URAT -1 transporter or genetic mutation of SLC2A9 has given better understanding of the pathophysiology of gout and enable to use new therapies.
Association of PCBs and allergies in children.
Review
New
Matsumura et al., Davis, United States. In Pestic Biochem Physiol, May 2015
In conclusion, the mRNA expression levels of IL-8 and IL-22 can be used to detect children who are at particular risk of adverse health events caused by environmental pollutants, especially PCBs.
Transcription of Interleukin-8: How Altered Regulation Can Affect Cystic Fibrosis Lung Disease.
Review
New
Greene et al., Dublin, Ireland. In Biomolecules, Dec 2014
Interleukin-8 (IL-8) is a neutrophil chemokine that is encoded on the CXCL8 gene.
Role of IL-38 and its related cytokines in inflammation.
Review
New
Li et al., Ningbo, China. In Mediators Inflamm, Dec 2014
IL-38 also inhibits the production of IL-8 induced by IL-36γ, thus inhibiting inflammatory responses.
Thyroid dysfunction: an autoimmune aspect.
Review
New
Tabassum et al., Riyadh, Saudi Arabia. In Int J Clin Exp Med, Dec 2014
Various cytokines IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-14, TNF-α and IFN-γ are found in thyroid follicular cells which enhance inflammatory response with nitric oxide (NO) and prostaglandins.
HCV NS5A Up-Regulates COX-2 Expression via IL-8-Mediated Activation of the ERK/JNK MAPK Pathway.
New
Lee et al., Kao-hsiung, Taiwan. In Plos One, Dec 2014
In this study, we found that cyclooxygenase-2 (COX-2) and interleukin-8 (IL-8) were significantly induced by HCV infection and HCV NS5A expression, and induction of COX-2 correlated with HCV-induced IL-8 production.
The Transcription Factor ZNF395 Is Required for the Maximal Hypoxic Induction of Proinflammatory Cytokines in U87-MG Cells.
New
Steger et al., Köln, Germany. In Mediators Inflamm, Dec 2014
By gene expression analysis, RT-PCR and ELISA, we demonstrated that the siRNA-mediated suppression of ZNF395 impairs the hypoxic induction of IL-1β, IL-6, IL-8, and LIF in U87-MG cells.
Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants.
New
Impact
Hayday et al., London, United Kingdom. In Nat Med, Oct 2014
Here we demonstrate that a major T cell effector function in human newborns is interleukin-8 (CXCL8) production, which has the potential to activate antimicrobial neutrophils and γδ T cells.
γδT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer.
New
Impact
Huang et al., Hangzhou, China. In Immunity, Jun 2014
Activated inf-DCs induced γδT17 cells to secrete IL-8, tumor necrosis factor alpha, and GM-CSF with a concomitant accumulation of immunosuppressive PMN-MDSCs in the tumor.
α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling.
New
Impact
Ma et al., Houston, United States. In Nat Cell Biol, Mar 2014
This stabilization in turn prevents nuclear localization of RelA and p50, leading to decreased expression of TNF-α, IL-8 and RelB.
Biological features of novel avian influenza A (H7N9) virus.
Impact
Shu et al., Beijing, China. In Nature, 2013
In acute serum samples of H7N9-infected patients, increased levels of the chemokines and cytokines IP-10, MIG, MIP-1β, MCP-1, IL-6, IL-8 and IFN-α were detected.
A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells.
Impact
Metcalfe et al., Bethesda, United States. In Immunity, 2013
In addition, gene targeting of t-FcεRIβ attenuated microtubule formation, degranulation, and IL-8 production downstream of Ca2+ signals.
Seminal plasma induces angiogenic chemokine expression in cervical cancer cells and regulates vascular function.
GeneRIF
Katz et al., Cape Town, South Africa. In Biochim Biophys Acta, 2012
Seminal plasma rapidly enhanced the expression of the angiogenic chemokines, interleukin (IL)-8 and growth regulated oncogene alpha (GRO) in HeLa cells.
Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells.
GeneRIF
Akiyama et al., Tokushima, Japan. In Oncol Rep, 2012
The enzymatic activity of thymidine phosphorylase was required for the enhanced expression of IL-8 in human cancer cells.
The lL-8 and IL-13 gene polymorphisms in inflammatory bowel disease and colorectal cancer.
GeneRIF
Majsterek et al., Łódź, Poland. In Dna Cell Biol, 2012
data showed that the IL-8 -251 T/A and IL-13 -1112 C/T polymorphisms might be associated with the inflammatory bowel disease and colorectal cancer occurrence
Role of mechanical stretching and lipopolysaccharide in early apoptosis and IL-8 of alveolar epithelial type II cells A549.
GeneRIF
Zhao et al., Haikou, China. In Asian Pac J Trop Med, 2012
Mechanical stretch can induce early apoptosis and IL-8 secretion. Mechanical stretch and lipopolysaccharide have an additive effect on early apoptosis and IL-8 production in human alveolar type 2 cells.
IL8 and serum soluble TRAIL levels following anti-VEGF monoclonal antibody treatment in patients with metastatic colon cancer.
GeneRIF
Gorczynski et al., Denizli, Turkey. In Clin Lab, 2011
In BevacizumAb therapy, serum IL8 levels were decreased in all patients, and thus, changes in such levels were not correlated with disease outcome.
More papers using IL-8 antibodies
Microarray analysis of eosinophils reveals a number of candidate survival and apoptosis genes
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Kankaanranta Hannu et al., In Journal of Inflammation (London, England), 2000
... (Miltenyi Biotec Ltd., Surrey, UK), human recombinant IL-5, GM-CSF and DuoSet ELISA Development System for IL-8 and MCP-1 (R&D system Europe, Abingdon, UK), May-Grünwald (Merck, Darmstadt, Germany), and Giemsa ...
NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100.
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Kyprianou Natasha, In PLoS ONE, 2000
... To examine the effect of IL-8 on radiation responses, LNCaP cells were pretreated with IL-8 (BD Biosciences) at concentrations of 0 to ...
Assay for redox-sensitive transcription factor.
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Hartl Dominik, In PLoS ONE, 1999
... Human IL-6 and IL-8 ELISA kits were from Diaclone (Stamford, CT) and R&D ...
Thrombin and leukocyte recruitment in endotoxemia.
Supplier
Woodman Richard C et al., In BMC Immunology, 1999
... fetal bovine serum (FBS) (Cansera International Inc., Toronto, ON), tumour necrosis factor (TNF) and interleukin-8 (IL-8) (Research Diagnostics Inc.,Flandere,NJ); HTMT dimaleate (6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)-heptanecarboxamide) ...
TNF-α and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAP kinase-dependent pathway
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Pilette Charles et al., In Journal of Biomedicine and Biotechnology, 1999
... After washing, neutrophils were resuspended in RPMI-1640 and activated by 20 ng/ml IL-8 (R&D System, Minneapolis, MN) for 5 min followed by 1 nM formyl-Methionyl-Leucyl-Phenylalanine (fMLP) (Sigma Aldrich, Saint Louis, MO) for ...
Interleukin-1α producing synovial sarcoma with prolonged fever: a case report
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Sugitani Masahiko et al., In Acta Histochemica et Cytochemica, 1997
... Next, we immunohistochemically examined the localization of the proinflammatory cytokine, IL-8 (Abcam Ltd, Cambridge, UK), using ...
A prospective study of maternal and fetal outcome in acute Lassa fever infection during pregnancy
Supplier
Garry Robert F et al., In Virology Journal, 1987
... indicators (Abaxis, Inc.) and serum cytokine levels (Cambridge Biomedical [IL-1b, IL-10], BD Biosciences [IL-2, IL-4, IL-8, IL-12p70], R&D Systems [IL-5, IL-6], Thermo Scientific [TNF-α], BioVendor [TNF-β, IFN-γ]) ...
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