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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Interleukin 7 receptor

IL-7R, IL-7Ralpha, CD127, interleukin-7 receptor
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CD25, Foxp3, IL-7, CD8
Papers using IL-7R antibodies
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Supplier
Davenport Miles P. et al., In Immunology and cell biology, 2006
... population identified with Thy1.1 (OX-7, Pharmingen), and stained with antibodies for CD62L (MEL-14, eBioscience) or CD127 (A7R34, eBioscience).
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Supplier
Alberola-Ila Jose, In PLoS ONE, 2003
... CD4 (RM4-5, eBioscience, San Diego, CA), CD8α (53-6.7,
Kinetics of Steady-state Differentiation and Mapping of Intrathymic-signaling Environments by Stem Cell Transplantation in Nonirradiated Mice
Supplier
Petrie Howard T. et al., In The Journal of Experimental Medicine, 2002
... Cells were then stained with PE/Texas red–conjugated anti-Ig (Caltag), Alexa 488–conjugated anti–IL-7R (SB-199), PE-conjugated anti–Sca-1 (BD Biosciences), and biotin-conjugated anti–c-kit (ACK-2), ...
Papers on IL-7R
Enhanced pretreatment CD25 expression on peripheral blood CD4+ T cell predicts shortened survival in acute myeloid leukemia patients receiving induction chemotherapy.
New
Moniuszko et al., Białystok, Poland. In Pharmacol Rep, 29 Feb 2016
METHODS: The mean fluorescence intensity (MFI) of CD25 expression and frequencies of peripheral blood CD4+ T cells with varying levels of CD25 and CD127 expression were assessed by flow cytometry in all studied individuals.
A Treg gene signature is a specific and sensitive biomarker to identify children with new onset type 1 diabetes.
New
Levings et al., Vancouver, Canada. In Diabetes, 19 Feb 2016
The resulting 31-gene panel was validated using the nanoString nCounter platform and then measured in sorted CD4(+)CD25(hi)CD127(lo) Tregs from children with T1D, and age-matched controls.
Human umbilical cord-derived mesenchymal stem cells suppress proliferation of PHA-activated lymphocytes in vitro by inducing CD4(+)CD25(high)CD45RA(+) regulatory T cell production and modulating cytokine secretion.
New
Qu et al., Jinan, China. In Cell Immunol, 05 Feb 2016
In addition, UC-MSCs augmented the expression of CD127(+) and CD45RA(+) but reduced the expression of CD25(+) in PBMCs stimulated by PHA (p<0.05).
Retrogenic ICOS Expression Increases Differentiation of KLRG-1hiCD127loCD8+ T Cells during Listeria Infection and Diminishes Recall Responses.
New
Ford et al., Atlanta, United States. In J Immunol, 04 Feb 2016
Our results reveal that these ICOS signals critically impacted cell fate decisions of Ag-specific CD8(+) T cells, resulting in increased frequencies of KLRG-1(hi)CD127(lo) cells, altered BLIMP-1, T-bet, and eomesodermin expression, and increased cytolytic capacity as compared with empty vector controls.
Altered microRNA Expression and Immunosuppressive Cytokine Production by Regulatory T Cells of Ulcerative Colitis Patients.
New
Nataj et al., Tehrān, Iran. In Immunol Invest, 31 Jan 2016
We simultaneously investigated the concentration of IL-35, IL-10, TGF-β, and sCD25 in supernatant of cell culture and the expression patterns of several miRNAs in CD4(+)CD25(+) CD127(-/low) FoxP3(+) Tregs of ulcerative colitis (UC) patients.
Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients.
New
Thomson et al., Madison, United States. In Am J Transplant, 23 Jan 2016
Very few studies, however, have addressed the therapeutic potential of adoptively-transferred, CD4(+) CD25(+) CD127(-) Foxp3(+) (Treg) in clinically-relevant large animal models.
Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum.
New
Grewal et al., Drammen, Norway. In Sci Rep, 31 Dec 2015
We identified 12 biomarkers consistently associated with either clinical groups "upstream" towards culture-positive TB on the TB disease spectrum (CD14, FCGR1A, FPR1, MMP9, RAB24, SEC14L1, and TIMP2) or "downstream" towards a decreased likelihood of TB disease (BLR1, CD3E, CD8A, IL7R, and TGFBR2), suggesting a correlation with MTB-related pathology and high relevance to a future POC test for pediatric TB.
IL-7 signalling represses Bcl-6 and the TFH gene program.
New
Oestreich et al., Roanoke, United States. In Nat Commun, 31 Dec 2015
Here, we demonstrate that in response to decreased IL-2 signalling, T helper 1 (TH1) cells upregulate Bcl-6 and co-initiate TFH- and TCM-like gene programs, including expression of the cytokine receptors IL-6Rα and IL-7R.
Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.
New
Impact
Walker et al., Durban, South Africa. In Immunity, Oct 2015
HIV-specific CD8(+) T cells secreted little interferon-γ, underwent rapid apoptosis, and failed to upregulate the interleukin-7 receptor, known to be important for T cell survival.
Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.
New
Impact
Sitnicka et al., Lund, Sweden. In Immunity, Sep 2015
Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) population represents a NK lineage-restricted progenitor (NKP) in fetal development, umbilical cord blood, and adult tissues.
Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria.
New
Impact
Spits et al., Amsterdam, Netherlands. In Immunity, Aug 2015
Human group 1 ILCs consist of at least three phenotypically distinct subsets, including NK cells, CD127(+) ILC1, and intraepithelial CD103(+) ILC1.
Association of interleukin 7 receptor (rs1494555 and rs6897932) gene polymorphisms with asthma in a north Indian population.
Jindal et al., Chandīgarh, India. In Allergy Rhinol (providence), 2015
BACKGROUND: Interleukin 7R (IL-7R), a cytokine receptor gene, plays an important role in the development of innate and adaptive inflammatory response in asthma etiology.
Expression and significance of CD4(+)CD25(+)CD127(-) regulatory T cells in peripheral blood of patients with different phenotypes of Guillain-Barré syndrome.
Qian et al., Bengbu, China. In Int J Clin Exp Med, 2014
METHODS: The proportion of CD4(+)CD25(+)CD127(-) regulatory T cells in peripheral blood before immunotherapy for 41 patients with GBS (including 29 classic type and 12 variant type) and 42 normal control patients (healthy volunteers) were evaluated by flow cytometry.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Impact
Mullighan et al., Memphis, United States. In N Engl J Med, 2014
Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common.
The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells.
Impact
Zhu et al., Bethesda, United States. In Immunity, 2014
Similar to CD4(+) T helper (Th) cell subsets, ILC subsets positive for interleukin-7 receptor α (IL-7Rα) produce distinct sets of effector cytokines.
IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.
GeneRIF
Kim et al., Seoul, South Korea. In Rheumatology (oxford), 2012
IL-7Ralphalow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.
Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function.
GeneRIF
Lin et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2012
The durable efficacy and the multipronged tolerogenic mechanisms of IL-7Ralpha antibody therapy suggest a unique disease-modifying approach to T1D.
IL-15 inhibits IL-7Rα expression by memory-phenotype CD8⁺ T cells in the bone marrow.
GeneRIF
Di Rosa et al., Roma, Italy. In Eur J Immunol, 2012
It was shown that the key molecule regulating IL-7 receptor alpha-chain downmodulation was IL-15 but not IL-7, and that the intact IL-7 receptor alpha-chain gene was required, including the promoter.
Increased frequency of IL-7 and IL-15 receptor alpha chain (CD127, CD215) co-expressing CD4(+) T cells in granulomatosis with polyangiitis (Wegener's).
GeneRIF
Lamprecht et al., In Clin Exp Rheumatol, 2012
Letter: report increased frequency of CD127/CD215 co-expressing CD4(+) T cells in Wegener's granulomatosis.
Lack of associations of polymorphisms of IL-7R, IL-13 and IL-15 with NSCLCs in non-smoking Chinese.
GeneRIF
Zhang et al., Hangzhou, China. In Asian Pac J Cancer Prev, 2010
Polymorphisms of IL-7R is not associated with Non-Small-Cell Lung Carcinoma.
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