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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

Interleukin 7 receptor

IL-7R, IL-7Ralpha, CD127, interleukin-7 receptor
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CD25, Foxp3, IL-7, CD8
Papers using IL-7R antibodies
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Supplier
Davenport Miles P. et al., In Immunology and cell biology, 2006
... population identified with Thy1.1 (OX-7, Pharmingen), and stained with antibodies for CD62L (MEL-14, eBioscience) or CD127 (A7R34, eBioscience).
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Supplier
Alberola-Ila Jose, In PLoS ONE, 2003
... CD4 (RM4-5, eBioscience, San Diego, CA), CD8α (53-6.7,
Kinetics of Steady-state Differentiation and Mapping of Intrathymic-signaling Environments by Stem Cell Transplantation in Nonirradiated Mice
Supplier
Petrie Howard T. et al., In The Journal of Experimental Medicine, 2002
... Cells were then stained with PE/Texas red–conjugated anti-Ig (Caltag), Alexa 488–conjugated anti–IL-7R (SB-199), PE-conjugated anti–Sca-1 (BD Biosciences), and biotin-conjugated anti–c-kit (ACK-2), ...
Papers on IL-7R
A Treg gene signature is a specific and sensitive biomarker to identify children with new onset type 1 diabetes.
New
Levings et al., Vancouver, Canada. In Diabetes, Feb 2016
The resulting 31-gene panel was validated using the nanoString nCounter platform and then measured in sorted CD4(+)CD25(hi)CD127(lo) Tregs from children with T1D, and age-matched controls.
Human umbilical cord-derived mesenchymal stem cells suppress proliferation of PHA-activated lymphocytes in vitro by inducing CD4(+)CD25(high)CD45RA(+) regulatory T cell production and modulating cytokine secretion.
New
Qu et al., Jinan, China. In Cell Immunol, Feb 2016
In addition, UC-MSCs augmented the expression of CD127(+) and CD45RA(+) but reduced the expression of CD25(+) in PBMCs stimulated by PHA (p<0.05).
Altered microRNA Expression and Immunosuppressive Cytokine Production by Regulatory T Cells of Ulcerative Colitis Patients.
New
Nataj et al., Tehrān, Iran. In Immunol Invest, Jan 2016
We simultaneously investigated the concentration of IL-35, IL-10, TGF-β, and sCD25 in supernatant of cell culture and the expression patterns of several miRNAs in CD4(+)CD25(+) CD127(-/low) FoxP3(+) Tregs of ulcerative colitis (UC) patients.
IL-7 signalling represses Bcl-6 and the TFH gene program.
New
Oestreich et al., Roanoke, United States. In Nat Commun, Dec 2015
Here, we demonstrate that in response to decreased IL-2 signalling, T helper 1 (TH1) cells upregulate Bcl-6 and co-initiate TFH- and TCM-like gene programs, including expression of the cytokine receptors IL-6Rα and IL-7R.
Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.
New
Impact
Walker et al., Durban, South Africa. In Immunity, Oct 2015
HIV-specific CD8(+) T cells secreted little interferon-γ, underwent rapid apoptosis, and failed to upregulate the interleukin-7 receptor, known to be important for T cell survival.
Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.
New
Impact
Sitnicka et al., Lund, Sweden. In Immunity, Sep 2015
Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) population represents a NK lineage-restricted progenitor (NKP) in fetal development, umbilical cord blood, and adult tissues.
Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria.
New
Impact
Spits et al., Amsterdam, Netherlands. In Immunity, Aug 2015
Human group 1 ILCs consist of at least three phenotypically distinct subsets, including NK cells, CD127(+) ILC1, and intraepithelial CD103(+) ILC1.
Immunohistochemistry-based prognostic biomarkers in NSCLC: novel findings on the road to clinical use?
Review
New
Micke et al., Uppsala, Sweden. In Expert Rev Mol Diagn, Apr 2015
Only 26 proteins first described after 2008 (ALDH1A1, ANXA1, BCAR1, CLDN1, EIF4E, EZH2, FOLR1, FOXM1, IL7R, IL12RB2, KIAA1524, CRMP1, LOX, MCM7, MTA1, MTDH, NCOA3, NDRG2, NEDD9, NES, PBK, PPM1D, SIRT1, SLC7A5, SQSTM1 and WNT1) demonstrated a consistent prognostic association in two or more independent patient cohorts, thus qualifying as promising candidates for diagnostic use.
Therapy in RCDII: Rationale for Combination Strategies?
Review
Mulder et al., Amsterdam, Netherlands. In Dig Dis, 2014
The sCD3-CD7+iCD3+ IELs are a heterogeneous lineage-negative cell population, consisting of cells that do or do not express CD127/IL7Rα.
Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation.
Review
Silva-Santos et al., Lisbon, Portugal. In Front Immunol, 2014
Some of the key players are the costimulatory receptors CD27 and CD28, which differentially impact on pro-inflammatory subsets of γδ T-cells; the cytokine receptors IL-2R, IL-7R, and IL-15R, which drive functional differentiation and expansion of γδ T-cells; the NK receptor NKG2D and its contribution to γδ T-cell cytotoxicity; and the inhibitory receptors PD-1 and BTLA that control γδ T-cell homeostasis.
Bromodomain and extraterminal domain inhibitors (BETi) for cancer therapy: chemical modulation of chromatin structure.
Review
Qi, Boston, United States. In Cold Spring Harb Perspect Biol, 2014
In particular, BETi down-regulates the MYC, IL-7R, and E2F transcriptional programs.
Dynamic Control of Long-Range Genomic Interactions at the Immunoglobulin κ Light-Chain Locus.
Review
Stadhouders et al., Oxford, United Kingdom. In Adv Immunol, 2014
Subsequently, the combined activation of pre-B cell antigen receptor signaling pathways and attenuation of IL-7R signaling in small resting pre-B cells dramatically modifies the transcription factor landscape, supporting the induction of monoallelic Igκ gene rearrangements.
Expression and significance of CD4(+)CD25(+)CD127(-) regulatory T cells in peripheral blood of patients with different phenotypes of Guillain-Barré syndrome.
Qian et al., Bengbu, China. In Int J Clin Exp Med, 2014
METHODS: The proportion of CD4(+)CD25(+)CD127(-) regulatory T cells in peripheral blood before immunotherapy for 41 patients with GBS (including 29 classic type and 12 variant type) and 42 normal control patients (healthy volunteers) were evaluated by flow cytometry.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Impact
Mullighan et al., Memphis, United States. In N Engl J Med, 2014
Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common.
The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells.
Impact
Zhu et al., Bethesda, United States. In Immunity, 2014
Similar to CD4(+) T helper (Th) cell subsets, ILC subsets positive for interleukin-7 receptor α (IL-7Rα) produce distinct sets of effector cytokines.
IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.
GeneRIF
Kim et al., Seoul, South Korea. In Rheumatology (oxford), 2012
IL-7Ralphalow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.
Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function.
GeneRIF
Lin et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2012
The durable efficacy and the multipronged tolerogenic mechanisms of IL-7Ralpha antibody therapy suggest a unique disease-modifying approach to T1D.
IL-15 inhibits IL-7Rα expression by memory-phenotype CD8⁺ T cells in the bone marrow.
GeneRIF
Di Rosa et al., Roma, Italy. In Eur J Immunol, 2012
It was shown that the key molecule regulating IL-7 receptor alpha-chain downmodulation was IL-15 but not IL-7, and that the intact IL-7 receptor alpha-chain gene was required, including the promoter.
Increased frequency of IL-7 and IL-15 receptor alpha chain (CD127, CD215) co-expressing CD4(+) T cells in granulomatosis with polyangiitis (Wegener's).
GeneRIF
Lamprecht et al., In Clin Exp Rheumatol, 2012
Letter: report increased frequency of CD127/CD215 co-expressing CD4(+) T cells in Wegener's granulomatosis.
Lack of associations of polymorphisms of IL-7R, IL-13 and IL-15 with NSCLCs in non-smoking Chinese.
GeneRIF
Zhang et al., Hangzhou, China. In Asian Pac J Cancer Prev, 2010
Polymorphisms of IL-7R is not associated with Non-Small-Cell Lung Carcinoma.
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