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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2014.

Interleukin 7 receptor

IL-7R, IL-7Ralpha, CD127, interleukin-7 receptor
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CD25, IL-7, Foxp3, CD8
Papers using IL-7R antibodies
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Supplier
Davenport Miles P. et al., In Immunology and cell biology, 2006
... population identified with Thy1.1 (OX-7, Pharmingen), and stained with antibodies for CD62L (MEL-14, eBioscience) or CD127 (A7R34, eBioscience).
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Supplier
Alberola-Ila Jose, In PLoS ONE, 2003
... CD4 (RM4-5, eBioscience, San Diego, CA), CD8α (53-6.7,
Kinetics of Steady-state Differentiation and Mapping of Intrathymic-signaling Environments by Stem Cell Transplantation in Nonirradiated Mice
Supplier
Petrie Howard T. et al., In The Journal of Experimental Medicine, 2002
... Cells were then stained with PE/Texas red–conjugated anti-Ig (Caltag), Alexa 488–conjugated anti–IL-7R (SB-199), PE-conjugated anti–Sca-1 (BD Biosciences), and biotin-conjugated anti–c-kit (ACK-2), ...
Papers on IL-7R
O-018 genome-wide association identifies multiple collagenous colitis susceptibility Loci.
New
Jean-Frédéric et al., Rochester, United States. In Inflamm Bowel Dis, 31 Dec 2014
These genes map on chromosomes 5 (IL7R), 6 (PTPRK), 9 (TNFSF15), 17 (IKZF, ORMDL3), and 17 (ATP6VOA1, STAT3).
O-020 IL-10 Dependent Changes in Chromatin Accessibility Drive Altered Transcriptional Responses to the Enteric Microbiota in Lamina Propria Macrophages.
New
Shehzad et al., Los Angeles, United States. In Inflamm Bowel Dis, 31 Dec 2014
We identified and characterized one key accessible region upstream of Il7r/IL7R that was functionally conserved in these specimens and overlapped a previously uncharacterized sequence variant (rs185659576).
Early-onset Evans syndrome, immunodeficiency and premature immunosenescence associated with tripeptidyl-peptidase II deficiency.
New
Ehl et al., Jerusalem, Israel. In Blood, 20 Dec 2014
Similar to cells from naïve, uninfected TPPII deficient mice, patient cells showed increased MHC I expression and most CD8+ T-cells had a senescent CCR7-CD127-CD28-CD57+ phenotype with poor proliferative responses and enhanced staurosporine-induced apoptosis.
Interleukin 7 Upregulates CD95 on CD4+ T Cells by Affecting mRNA Alternative Splicing: Priming for a Synergistic Effect on HIV-1 Reservoir Maintenance.
New
Zhang et al., Xinhui, China. In J Biol Chem, 19 Dec 2014
As a result, co-stimulation through IL-7/IL-7R and FasL/CD95 signal pathways augments IL-7-mediated survival and expansion of HIV-1-latently-infected memory CD4+ T lymphocytes.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
New
Impact
Mullighan et al., Memphis, United States. In N Engl J Med, 11 Oct 2014
Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common.
The roles of ZFAT in thymocyte differentiation and homeostasis of peripheral naive T-cells.
Review
New
Shirasawa et al., Fukuoka, Japan. In Anticancer Res, Aug 2014
Zfat deficiency in peripheral T-cells results in a reduction in the number of T-cells with decreased expression of the interleukin-7 receptor-α (IL-7Rα) that is critical for T-cell homeostasis.
The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells.
New
Impact
Zhu et al., Bethesda, United States. In Immunity, Apr 2014
Similar to CD4(+) T helper (Th) cell subsets, ILC subsets positive for interleukin-7 receptor α (IL-7Rα) produce distinct sets of effector cytokines.
FOXO1 transcription factor: a critical effector of the PI3K-AKT axis in B-cell development.
Review
New
Juszczyński et al., Warsaw, Poland. In Int Rev Immunol, Mar 2014
Several receptors involved in regulating this process, such as IL-7R, pre-B cell receptor (pre-BCR), and BCR, share the ability to trigger the signaling via the phosphoinositide 3-kinase (PI3K)-AKT pathway.
How I treat ALL in Down's syndrome: pathobiology and management.
Review
New
Whitlock et al., Tel Aviv-Yafo, Israel. In Blood, Feb 2014
Biologically, these heterogeneous leukemias are characterized by under-representation of the common cytogenetic subgroups of childhood ALL and overrepresentation of CRLF2-IL7R-JAK-STAT activating genetic aberrations.
Regulatory T cell proliferative potential is impaired in human autoimmune disease.
New
Impact
Matarese et al., Napoli, Italy. In Nat Med, Jan 2014
Human CD4(+)CD25(high)CD127(-)FoxP3(+) regulatory T (Treg) cells suppress immune responses in vitro and in vivo.
Viro-immunological characterization of naïve patients with high cerebrospinal fluid (CSF) HIV RNA.
New
Carla et al., Milano, Italy. In J Int Aids Soc, Dec 2013
Plasma HIV-RNA and peripheral T-cell immune-phenotypes (CD38/CD45RA/CD45R0/CD127 on CD4/CD8) were also assessed (flow cytometry).
Balancing Proliferation with Igκ Recombination during B-lymphopoiesis.
Review
New
Clark et al., Chicago, United States. In Front Immunol, Dec 2013
Remarkably, the principal downstream proliferative effectors of the IL-7R, STAT5 and cyclin D3, directly repress Igκ accessibility through very divergent yet complementary mechanisms.
Signaling circuits in early B-cell development.
Review
New
Nielsen et al., Freiburg, Germany. In Adv Immunol, Dec 2013
In particular, we address the interplay of the interleukin-7 receptor and the pre-B-cell receptor (preBCR) in shaping the survival, proliferation, and differentiation of early B cells.
TGF-β cytokine signaling promotes CD8+ T cell development and low-affinity CD4+ T cell homeostasis by regulation of interleukin-7 receptor α expression.
New
Impact
Li et al., New York City, United States. In Immunity, Sep 2013
Interleukin-7 receptor α chain (IL-7Rα) is induced upon T cell positive selection and controls thymic CD8-lineage specification and peripheral naive T cell homeostasis.
GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling.
New
Impact
Wan et al., Chapel Hill, United States. In Nat Immunol, Jul 2013
Although GATA-3-deficient CD8(+) T cells were generated, their peripheral maintenance was impaired, with lower expression of the receptor for interleukin 7 (IL-7R).
IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.
GeneRIF
Kim et al., Seoul, South Korea. In Rheumatology (oxford), 2012
IL-7Ralphalow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.
Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function.
GeneRIF
Lin et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2012
The durable efficacy and the multipronged tolerogenic mechanisms of IL-7Ralpha antibody therapy suggest a unique disease-modifying approach to T1D.
IL-15 inhibits IL-7Rα expression by memory-phenotype CD8⁺ T cells in the bone marrow.
GeneRIF
Di Rosa et al., Roma, Italy. In Eur J Immunol, 2012
It was shown that the key molecule regulating IL-7 receptor alpha-chain downmodulation was IL-15 but not IL-7, and that the intact IL-7 receptor alpha-chain gene was required, including the promoter.
Increased frequency of IL-7 and IL-15 receptor alpha chain (CD127, CD215) co-expressing CD4(+) T cells in granulomatosis with polyangiitis (Wegener's).
GeneRIF
Lamprecht et al., In Clin Exp Rheumatol, 2012
Letter: report increased frequency of CD127/CD215 co-expressing CD4(+) T cells in Wegener's granulomatosis.
Lack of associations of polymorphisms of IL-7R, IL-13 and IL-15 with NSCLCs in non-smoking Chinese.
GeneRIF
Zhang et al., Hangzhou, China. In Asian Pac J Cancer Prev, 2010
Polymorphisms of IL-7R is not associated with Non-Small-Cell Lung Carcinoma.
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