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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

Interleukin 7 receptor

IL-7R, IL-7Ralpha, CD127, interleukin-7 receptor
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CD25, IL-7, Foxp3, CD8
Papers using IL-7R antibodies
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Supplier
Davenport Miles P. et al., In Immunology and cell biology, 2006
... population identified with Thy1.1 (OX-7, Pharmingen), and stained with antibodies for CD62L (MEL-14, eBioscience) or CD127 (A7R34, eBioscience).
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Supplier
Alberola-Ila Jose, In PLoS ONE, 2003
... CD4 (RM4-5, eBioscience, San Diego, CA), CD8α (53-6.7,
Kinetics of Steady-state Differentiation and Mapping of Intrathymic-signaling Environments by Stem Cell Transplantation in Nonirradiated Mice
Supplier
Petrie Howard T. et al., In The Journal of Experimental Medicine, 2002
... Cells were then stained with PE/Texas red–conjugated anti-Ig (Caltag), Alexa 488–conjugated anti–IL-7R (SB-199), PE-conjugated anti–Sca-1 (BD Biosciences), and biotin-conjugated anti–c-kit (ACK-2), ...
Papers on IL-7R
Bone marrow mesenchymal stem cells suppressing activation of allogeneic cytokine-induced killer/natural killer cells either by direct or indirect interaction.
New
Wei et al., Guangzhou, China. In Cell Biol Int, 09 Jan 2015
MSC can also depress the expression of CD69 on these killer cells, as well as increased the ratio of CD4(+) CD25(+) CD127(low) T regulatory (Treg) cells in the CIK/NK cell culture system.
Comprehensive phenotyping of regulatory T cells after liver transplantation.
New
Wedemeyer et al., Hannover, Germany. In Liver Transpl, 29 Dec 2014
A comprehensive phenotypic analysis was performed using multicolour flow cytometry that included standard Treg markers (CD4(+) , CD25(hi) , CD127(-) and FoxP3(+) ) in addition to HLA-DR, CCR7, CD45RA, CD62L, CD49d, CD39, ICOS and LAP-TGFβ stainings.
A novel intronic splice site deletion of the IL-2 receptor common gamma chain results in expression of a dysfunctional protein and T-cell-positive X-linked Severe combined immunodeficiency.
New
Ziegler et al., Sydney, Australia. In Int J Immunogenet, 28 Dec 2014
Possible explanations are that STAT5-mediated signal transduction may be less relevant to IL7-receptor-mediated T-cell development than are other IL7R-induced intracellular transduction pathways or that a low level of STAT5 phosphorylation, undetectable in the laboratory, may be sufficient to support some T-cell development.
Group 2 innate lymphoid cells (ILC2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia.
New
Harvey et al., Sydney, Australia. In Clin Exp Allergy, 27 Dec 2014
ILC2s were identified as CD45(+) Lin(-) CD127(+) CD4(-) CD8(-) CRTH2(CD294)(+) CD161(+) cells in single cell suspensions through flow cytometry.
Regulatory T-cells in autoimmune diseases: Challenges, controversies and-yet-unanswered questions.
Review
New
Longhi et al., London, United Kingdom. In Autoimmun Rev, 16 Nov 2014
Markers commonly used to define human Tregs in the research setting include high expression of CD25, FOXP3 positivity and low expression/negativity for CD127.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
New
Impact
Mullighan et al., Memphis, United States. In N Engl J Med, Oct 2014
Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common.
The roles of ZFAT in thymocyte differentiation and homeostasis of peripheral naive T-cells.
Review
New
Shirasawa et al., Fukuoka, Japan. In Anticancer Res, Aug 2014
Zfat deficiency in peripheral T-cells results in a reduction in the number of T-cells with decreased expression of the interleukin-7 receptor-α (IL-7Rα) that is critical for T-cell homeostasis.
Association of interleukin 7 receptor gene polymorphism rs6897932 with multiple sclerosis patients in Khuzestan.
New
Mohaghegh et al., Ahvāz, Iran. In Iran J Neurol, Aug 2014
The interleukin 7 receptor (IL7R) gene is a promising candidate for MS, because its involvement in the autoimmunity, regulation of the T-cell homeostasis, proliferation, and anti-apoptotic signaling.
The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells.
New
Impact
Zhu et al., Bethesda, United States. In Immunity, Apr 2014
Similar to CD4(+) T helper (Th) cell subsets, ILC subsets positive for interleukin-7 receptor α (IL-7Rα) produce distinct sets of effector cytokines.
FOXO1 transcription factor: a critical effector of the PI3K-AKT axis in B-cell development.
Review
New
Juszczyński et al., Warsaw, Poland. In Int Rev Immunol, Mar 2014
Several receptors involved in regulating this process, such as IL-7R, pre-B cell receptor (pre-BCR), and BCR, share the ability to trigger the signaling via the phosphoinositide 3-kinase (PI3K)-AKT pathway.
Regulatory T cell proliferative potential is impaired in human autoimmune disease.
New
Impact
Matarese et al., Napoli, Italy. In Nat Med, Jan 2014
Human CD4(+)CD25(high)CD127(-)FoxP3(+) regulatory T (Treg) cells suppress immune responses in vitro and in vivo.
Balancing Proliferation with Igκ Recombination during B-lymphopoiesis.
Review
New
Clark et al., Chicago, United States. In Front Immunol, Dec 2013
Remarkably, the principal downstream proliferative effectors of the IL-7R, STAT5 and cyclin D3, directly repress Igκ accessibility through very divergent yet complementary mechanisms.
Bromodomain and Extraterminal Domain Inhibitors (BETi) for Cancer Therapy: Chemical Modulation of Chromatin Structure.
Review
New
Qi, Boston, United States. In Cold Spring Harb Perspect Biol, Dec 2013
In particular, BETi down-regulates the MYC, IL-7R, and E2F transcriptional programs.
TGF-β cytokine signaling promotes CD8+ T cell development and low-affinity CD4+ T cell homeostasis by regulation of interleukin-7 receptor α expression.
New
Impact
Li et al., New York City, United States. In Immunity, Sep 2013
Interleukin-7 receptor α chain (IL-7Rα) is induced upon T cell positive selection and controls thymic CD8-lineage specification and peripheral naive T cell homeostasis.
GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling.
New
Impact
Wan et al., Chapel Hill, United States. In Nat Immunol, Jul 2013
Although GATA-3-deficient CD8(+) T cells were generated, their peripheral maintenance was impaired, with lower expression of the receptor for interleukin 7 (IL-7R).
IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.
GeneRIF
Kim et al., Seoul, South Korea. In Rheumatology (oxford), 2012
IL-7Ralphalow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.
Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function.
GeneRIF
Lin et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2012
The durable efficacy and the multipronged tolerogenic mechanisms of IL-7Ralpha antibody therapy suggest a unique disease-modifying approach to T1D.
IL-15 inhibits IL-7Rα expression by memory-phenotype CD8⁺ T cells in the bone marrow.
GeneRIF
Di Rosa et al., Roma, Italy. In Eur J Immunol, 2012
It was shown that the key molecule regulating IL-7 receptor alpha-chain downmodulation was IL-15 but not IL-7, and that the intact IL-7 receptor alpha-chain gene was required, including the promoter.
Increased frequency of IL-7 and IL-15 receptor alpha chain (CD127, CD215) co-expressing CD4(+) T cells in granulomatosis with polyangiitis (Wegener's).
GeneRIF
Lamprecht et al., In Clin Exp Rheumatol, 2012
Letter: report increased frequency of CD127/CD215 co-expressing CD4(+) T cells in Wegener's granulomatosis.
Lack of associations of polymorphisms of IL-7R, IL-13 and IL-15 with NSCLCs in non-smoking Chinese.
GeneRIF
Zhang et al., Hangzhou, China. In Asian Pac J Cancer Prev, 2010
Polymorphisms of IL-7R is not associated with Non-Small-Cell Lung Carcinoma.
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