GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Interleukin 7 receptor
IL-7R, IL-7Ralpha, CD127, interleukin-7 receptor
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Papers using
IL-7R
antibodies
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Supplier
In Immunology and cell biology, 2006
... population identified with Thy1.1 (OX-7, Pharmingen), and stained with antibodies for CD62L (MEL-14, eBioscience) or CD127 (A7R34, eBioscience).
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Supplier
In PLoS ONE, 2003
... CD4 (RM4-5, eBioscience, San Diego, CA), CD8α (53-6.7,
Kinetics of Steady-state Differentiation and Mapping of Intrathymic-signaling Environments by Stem Cell Transplantation in Nonirradiated Mice
Supplier
In The Journal of Experimental Medicine, 2002
... Cells were then stained with PE/Texas red–conjugated anti-Ig (Caltag), Alexa 488–conjugated anti–IL-7R (SB-199), PE-conjugated anti–Sca-1 (BD Biosciences), and biotin-conjugated anti–c-kit (ACK-2), ...
Papers on
IL-7R
Polymorphisms in the interleukin-7 receptor α gene and mortality in untreated HIV-infected individuals.
New
Århus, Denmark. In Aids, 04 Apr 2013
OBJECTIVES:: Recently, polymorphisms in the gene encoding the Interleukin-7 receptor α (IL7RA) have been shown to influence the CD4 cell count in HIV-infected individuals.
Impact of culture medium on CD4+ CD25highCD127lo/neg Treg expansion for the purpose of clinical application.
New
Chicago, United States. In Int Immunopharmacol, 02 Apr 2013
We compared Treg fold of expansion and their phenotypical characteristics including expression of FoxP3, CD25, CD127, CD62L and CD45RA in three commercially available culture media (RPMI 1640 (Cellgro; Manassas VA, USA), SCGM (Cellgenix; Freiburg, Germany), and X-VIVO 20 (Lonza; Walkersville, MD, USA)) with addition of human serum (HS, 10%) or fetal bovine serum (FBS, 10%).
Concentration and activity of the soluble form of the Interleukin-7 Receptor alpha in type I diabetes identifies an interplay between hyperglycemia and immune function.
New
Milano, Italy. In Diabetes, 01 Apr 2013
Soluble IL-7 receptor alpha (sCD127) is implicated in the pathogenesis of autoimmune diseases.
Association between peripheral T-Lymphocyte activation and impaired bone mineral density in HIV-infected patients.
New
In J Transl Med, 28 Mar 2013
CD4+/CD8+ phenotype (CD38/HLA-DR, CD127, CD28/CD57), and circulating IL-7, TNF-alpha, RANKL, OPG were measured.
IL-7 Licenses Activation of Human Liver Intrasinusoidal Mucosal-Associated Invariant T Cells.
New
Singapore, Singapore. In J Immunol, 27 Mar 2013
MAIT cells also expressed high levels of IL-7R, and we showed that IL-7, a cytokine produced by hepatocytes during inflammation, regulated TCR-mediated activation of MAIT cells, licensing them to dramatically increase Th1 cytokines and IL-17A production.
Clinical impact of immune microenvironment in stage I lung adenocarcinoma: tumor interleukin-12 receptor β2 (IL-12Rβ2), IL-7R, and stromal FoxP3/CD3 ratio are independent predictors of recurrence.
New
Impact
New York City, United States. In J Clin Oncol, 01 Mar 2013
whereas high expression of tumor IL-7R was associated with worse outcome (5-year RFP, 76% for high v 86% for low expression; P = .001).
The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.
New
Impact
Amsterdam, Netherlands. In Immunity, Nov 2012
Ectopic expression of GATA3 in Lin(-)CD127(+)CRTH2(-) cells resulted in induction of CRTH2 and the capacity to produce high amounts of type 2 cytokines in response to TSLP plus IL-33.
The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.
New
Impact
London, United Kingdom. In Immunity, Nov 2012
Crucially, T-bet also suppressed the expression of IL-7R, a key molecule involved in controlling intestinal ILC homeostasis.
T regulatory cell separation for clinical application.
Review
New
Perugia, Italy. In Transfus Apher Sci, Oct 2012
CD127(+) cells were 12.5%±8.2.
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.
New
Impact
Memphis, United States. In Cancer Cell, Sep 2012
We performed transcriptome and whole genome sequencing on 15 cases of Ph-like ALL and identified rearrangements involving ABL1, JAK2, PDGFRB, CRLF2, and EPOR, activating mutations of IL7R and FLT3, and deletion of SH2B3, which encodes the JAK2-negative regulator LNK.
IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis.
Review
New
Los Angeles, United States. In Semin Immunol, Jun 2012
It is becoming increasingly clear that multiple mechanisms exist to regulate expression of IL-7R at the transcriptional and post-translational levels.
The human IL-7 receptor gene: deletions, polymorphisms and mutations.
Review
New
Milano, Italy. In Semin Immunol, Jun 2012
Deletion of IL-7Ra in humans has, for some time, been known to cause severe combined immunodeficiency.
Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation.
Review
New
Irvine, United States. In Semin Immunopathol, May 2012
A central role for T cells in MS is supported by mouse models, association of the major histocompatibility complex region, and association of critical T cell growth regulator genes such as interleukin-2 receptor (IL-2RA) and interleukin-7 receptor (IL-7RA).
Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation.
New
Impact
Vancouver, Canada. In Immunity, Apr 2012
LNH (Lin(-)Sca-1(+)c-kit(+/lo)CD25(+)CD127(+)) cells, when stimulated by IL-33 plus IL-2, IL-7, or thymic stroma lymphopoietin (TSLP), produced large amounts of IL-5 and IL-13.
Notch1 and IL-7 receptor signalling in early T-cell development and leukaemia.
Review
Madrid, Spain. In Curr Top Microbiol Immunol, 2011
In addition to Notch1 signals, survival and proliferation signals provided by the IL-7 receptor (IL-7R) are also required during thymopoiesis.
The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.
GeneRIF
Durham, United States. In J Immunol, 2011
Though dispensable for autophagy induction, transgenic Vps34 is a critical regulator of naive T cell homeostasis, modulating interleukin (IL)-7 receptor alpha trafficking, signaling, and recycling.
Advanced flowcytometric analysis of regulatory T cells: CD127 downregulation early post stem cell transplantation and altered Treg/CD3(+)CD4(+)-ratio in severe GvHD or relapse.
GeneRIF
Frankfurt am Main, Germany. In J Immunol Methods, 2011
Results show a downregulation of CD127 expression on T cells including Tregs in patients early post-SCT.
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.
Impact
GeneRIF
Campinas, Brazil. In Nat Genet, 2011
IL7R mutational activation is involved in human T-cell leukemogenesis.
Comparative approach to define increased regulatory T cells in different cancer subtypes by combined assessment of CD127 and FOXP3.
GeneRIF
Bonn, Germany. In Clin Dev Immunol, 2010
Our data strongly support superiority of combined CD127 and FOXP3 analysis in comparison to CD25 and FOXP3 assessment for further quantification of T(reg) cells in malignant diseases.
HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression.
GeneRIF
Ottawa, Canada. In Retrovirology, 2010
HIV infection of thymocytes did not affect CD127 expression on either total thymocytes or on single positive CD4 or single positive CD8 subsets.
