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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 26 Jul 2015.

Interleukin 7 receptor

IL-7R, IL-7Ralpha, CD127, interleukin-7 receptor
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CD25, Foxp3, IL-7, CD8
Papers using IL-7R antibodies
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Supplier
Davenport Miles P. et al., In Immunology and cell biology, 2006
... population identified with Thy1.1 (OX-7, Pharmingen), and stained with antibodies for CD62L (MEL-14, eBioscience) or CD127 (A7R34, eBioscience).
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Supplier
Alberola-Ila Jose, In PLoS ONE, 2003
... CD4 (RM4-5, eBioscience, San Diego, CA), CD8α (53-6.7,
Kinetics of Steady-state Differentiation and Mapping of Intrathymic-signaling Environments by Stem Cell Transplantation in Nonirradiated Mice
Supplier
Petrie Howard T. et al., In The Journal of Experimental Medicine, 2002
... Cells were then stained with PE/Texas red–conjugated anti-Ig (Caltag), Alexa 488–conjugated anti–IL-7R (SB-199), PE-conjugated anti–Sca-1 (BD Biosciences), and biotin-conjugated anti–c-kit (ACK-2), ...
Papers on IL-7R
Targeted sequencing identifies association between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia.
New
Cools et al., Leuven, Belgium. In Haematologica, 23 Aug 2015
We identified the IL7R-JAK pathway to be mutated in 27.7% of cases, with JAK3 mutations being the most frequent event in this group.
Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria.
New
Impact
Spits et al., Amsterdam, Netherlands. In Immunity, 21 Aug 2015
Human group 1 ILCs consist of at least three phenotypically distinct subsets, including NK cells, CD127(+) ILC1, and intraepithelial CD103(+) ILC1.
STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus.
New
Ikuta et al., Kyoto, Japan. In J Immunol, 20 Aug 2015
UNASSIGNED: The transcription factor STAT5, which is activated by IL-7R, controls chromatin accessibility and rearrangements of the TCRγ locus.
Elevated IFN-alpha/beta levels in a streptozotocin-induced type I diabetic mouse model promote oxidative stress and mediate depletion of spleen-homing CD8+ T cells by apoptosis through impaired CCL21/CCR7 axis and IL-7/CD127 signaling.
New
Mohamed et al., Riyadh, Saudi Arabia. In Cell Signal, 17 Aug 2015
UNASSIGNED: Type 1 diabetes mellitus (T1D) is associated with increased type 1 interferon (IFN) levels and subsequent severe defects in lymphocyte function, which increase susceptibility to infections.
T-regulatory cell phenotypes in peripheral blood and bronchoalveolar lavage from non-asthmatic and asthmatic subjects.
New
O'Byrne et al., Hamilton, Canada. In Clin Exp Allergy, 14 Aug 2015
Three nTreg phenotypes were defined: nTreg1 (CD4(+) CD25(+) Foxp3(+) ), nTreg2 (CD4(+) CD25(+) CD127(low) Foxp3(+) ), and nTreg3 (CD4(+) CD25(high) Foxp3(+) ).
Mycobacterium tuberculosis-specific and MHC class I-restricted CD8+ T-cells exhibit a stem cell precursor-like phenotype in patients with active pulmonary tuberculosis.
Review
New
Maeurer et al., Stockholm, Sweden. In Int J Infect Dis, Mar 2015
MTB-specific T-cell function was defined by intracellular cytokine production (interleukin (IL)-2, interferon gamma, tumour necrosis factor alpha, and IL-17) and by multimer-guided (HLA-A*02:01 and HLA-A*24:02) analysis of epitope-specific CD8+ T-cells, along with phenotypic markers (CD45RA and CCR7), CD107a, a marker for degranulation, and CD127 co-staining for T-cell differentiation and homing.
Regulatory T-cells in autoimmune diseases: challenges, controversies and--yet--unanswered questions.
Review
New
Longhi et al., London, United Kingdom. In Autoimmun Rev, Feb 2015
Markers commonly used to define human Tregs in the research setting include high expression of CD25, FOXP3 positivity and low expression/negativity for CD127.
Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation.
Review
New
Silva-Santos et al., Lisbon, Portugal. In Front Immunol, Dec 2014
Some of the key players are the costimulatory receptors CD27 and CD28, which differentially impact on pro-inflammatory subsets of γδ T-cells; the cytokine receptors IL-2R, IL-7R, and IL-15R, which drive functional differentiation and expansion of γδ T-cells; the NK receptor NKG2D and its contribution to γδ T-cell cytotoxicity; and the inhibitory receptors PD-1 and BTLA that control γδ T-cell homeostasis.
JAK kinase inhibitors for the treatment of acute lymphoblastic leukemia.
New
Cools et al., Leuven, Belgium. In J Hematol Oncol, Dec 2014
UNASSIGNED: Recent studies of acute lymphoblastic leukemia have identified activating mutations in components of the interleukin-7 receptor complex (IL7R, JAK1, and JAK3).
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
New
Impact
Mullighan et al., Memphis, United States. In N Engl J Med, Oct 2014
Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common.
Exploiting differential expression of the IL-7 receptor on memory T cells to modulate immune responses.
Review
New
Seddiki et al., Australia. In Cytokine Growth Factor Rev, Aug 2014
Importantly, CD4 Tregs express greatly reduced levels of IL-7R compared to conventional CD4 T cells, presenting an opportunity to selectively target the latter cells with either more IL-7 to boost responses, or to block IL-7 signalling to limit responses.
The roles of ZFAT in thymocyte differentiation and homeostasis of peripheral naive T-cells.
Review
New
Shirasawa et al., Fukuoka, Japan. In Anticancer Res, Aug 2014
Zfat deficiency in peripheral T-cells results in a reduction in the number of T-cells with decreased expression of the interleukin-7 receptor-α (IL-7Rα) that is critical for T-cell homeostasis.
The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells.
New
Impact
Zhu et al., Bethesda, United States. In Immunity, Apr 2014
Similar to CD4(+) T helper (Th) cell subsets, ILC subsets positive for interleukin-7 receptor α (IL-7Rα) produce distinct sets of effector cytokines.
Regulatory T cell proliferative potential is impaired in human autoimmune disease.
Impact
Matarese et al., Napoli, Italy. In Nat Med, 2014
Human CD4(+)CD25(high)CD127(-)FoxP3(+) regulatory T (Treg) cells suppress immune responses in vitro and in vivo.
TGF-β cytokine signaling promotes CD8+ T cell development and low-affinity CD4+ T cell homeostasis by regulation of interleukin-7 receptor α expression.
Impact
Li et al., New York City, United States. In Immunity, 2013
Interleukin-7 receptor α chain (IL-7Rα) is induced upon T cell positive selection and controls thymic CD8-lineage specification and peripheral naive T cell homeostasis.
IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.
GeneRIF
Kim et al., Seoul, South Korea. In Rheumatology (oxford), 2012
IL-7Ralphalow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.
Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function.
GeneRIF
Lin et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2012
The durable efficacy and the multipronged tolerogenic mechanisms of IL-7Ralpha antibody therapy suggest a unique disease-modifying approach to T1D.
IL-15 inhibits IL-7Rα expression by memory-phenotype CD8⁺ T cells in the bone marrow.
GeneRIF
Di Rosa et al., Roma, Italy. In Eur J Immunol, 2012
It was shown that the key molecule regulating IL-7 receptor alpha-chain downmodulation was IL-15 but not IL-7, and that the intact IL-7 receptor alpha-chain gene was required, including the promoter.
Increased frequency of IL-7 and IL-15 receptor alpha chain (CD127, CD215) co-expressing CD4(+) T cells in granulomatosis with polyangiitis (Wegener's).
GeneRIF
Lamprecht et al., In Clin Exp Rheumatol, 2012
Letter: report increased frequency of CD127/CD215 co-expressing CD4(+) T cells in Wegener's granulomatosis.
Lack of associations of polymorphisms of IL-7R, IL-13 and IL-15 with NSCLCs in non-smoking Chinese.
GeneRIF
Zhang et al., Hangzhou, China. In Asian Pac J Cancer Prev, 2010
Polymorphisms of IL-7R is not associated with Non-Small-Cell Lung Carcinoma.
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