Comprehensive phenotyping of regulatory T cells after liver transplantation.
Hannover, Germany. In Liver Transpl, 29 Dec 2014
A comprehensive phenotypic analysis was performed using multicolour flow cytometry that included standard Treg markers (CD4(+) , CD25(hi) , CD127(-) and FoxP3(+) ) in addition to HLA-DR, CCR7, CD45RA, CD62L, CD49d, CD39, ICOS and LAP-TGFβ stainings.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Memphis, United States. In N Engl J Med, Oct 2014
Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common.