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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Mar 2015.

Interleukin 7 receptor

IL-7R, IL-7Ralpha, CD127, interleukin-7 receptor
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CD25, Foxp3, IL-7, CD8
Papers using IL-7R antibodies
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Supplier
Davenport Miles P. et al., In Immunology and cell biology, 2006
... population identified with Thy1.1 (OX-7, Pharmingen), and stained with antibodies for CD62L (MEL-14, eBioscience) or CD127 (A7R34, eBioscience).
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Supplier
Alberola-Ila Jose, In PLoS ONE, 2003
... CD4 (RM4-5, eBioscience, San Diego, CA), CD8α (53-6.7,
Kinetics of Steady-state Differentiation and Mapping of Intrathymic-signaling Environments by Stem Cell Transplantation in Nonirradiated Mice
Supplier
Petrie Howard T. et al., In The Journal of Experimental Medicine, 2002
... Cells were then stained with PE/Texas red–conjugated anti-Ig (Caltag), Alexa 488–conjugated anti–IL-7R (SB-199), PE-conjugated anti–Sca-1 (BD Biosciences), and biotin-conjugated anti–c-kit (ACK-2), ...
Papers on IL-7R
Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease.
New
Lord et al., Jerusalem, Israel. In Gut, 24 Mar 2015
METHODS: To define the optimum population for Treg cell therapy in CD, CD4(+)CD25(+)CD127(lo)CD45RA(+) and CD4(+)CD25(+)CD127(lo)CD45RA(-) Treg subsets were isolated from patients' blood and expanded in vitro using a workflow that can be readily transferred to a good manufacturing practice background.
Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia.
New
Sun et al., Houston, United States. In Blood, 23 Mar 2015
This cluster formation was associated with the protection of ALL cells from therapy as leukemic cells switched from BCR-ABL signaling to IL-7R/JAK signaling to survive in the MSC milieu.
Multiple Genetic Variants Associated with Primary Biliary Cirrhosis in a Han Chinese Population.
New
Ma et al., Nanjing, China. In Clin Rev Allergy Immunol, 19 Mar 2015
However, no association was observed for POU2AF1 (rs4938534), IL12A (rs485499 and rs2366408), IL7R (rs6897932), CXCR5 (rs715412), SOCS1 (rs725613), and TNFRSF1A (rs1800693).
Phenotypic Analysis of Immunocompetent Cells in Healthy Human Dental Pulp.
New
Alliot-Licht et al., Nantes, France. In J Endod, 18 Mar 2015
We further identified cells harboring a phenotype compatible with Foxp3/CD25-expressing regulatory T lymphocytes (CD45(+)CD3(+)CD4(+)CD127(low)).
Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation.
Review
New
Silva-Santos et al., Lisbon, Portugal. In Front Immunol, Dec 2014
Some of the key players are the costimulatory receptors CD27 and CD28, which differentially impact on pro-inflammatory subsets of γδ T-cells; the cytokine receptors IL-2R, IL-7R, and IL-15R, which drive functional differentiation and expansion of γδ T-cells; the NK receptor NKG2D and its contribution to γδ T-cell cytotoxicity; and the inhibitory receptors PD-1 and BTLA that control γδ T-cell homeostasis.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
New
Impact
Mullighan et al., Memphis, United States. In N Engl J Med, Oct 2014
Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common.
The roles of ZFAT in thymocyte differentiation and homeostasis of peripheral naive T-cells.
Review
New
Shirasawa et al., Fukuoka, Japan. In Anticancer Res, Aug 2014
Zfat deficiency in peripheral T-cells results in a reduction in the number of T-cells with decreased expression of the interleukin-7 receptor-α (IL-7Rα) that is critical for T-cell homeostasis.
The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells.
New
Impact
Zhu et al., Bethesda, United States. In Immunity, Apr 2014
Similar to CD4(+) T helper (Th) cell subsets, ILC subsets positive for interleukin-7 receptor α (IL-7Rα) produce distinct sets of effector cytokines.
FOXO1 transcription factor: a critical effector of the PI3K-AKT axis in B-cell development.
Review
New
Juszczyński et al., Warsaw, Poland. In Int Rev Immunol, Mar 2014
Several receptors involved in regulating this process, such as IL-7R, pre-B cell receptor (pre-BCR), and BCR, share the ability to trigger the signaling via the phosphoinositide 3-kinase (PI3K)-AKT pathway.
Regulatory T cell proliferative potential is impaired in human autoimmune disease.
Impact
Matarese et al., Napoli, Italy. In Nat Med, 2014
Human CD4(+)CD25(high)CD127(-)FoxP3(+) regulatory T (Treg) cells suppress immune responses in vitro and in vivo.
Patients with posttraumatic stress disorder exhibit an altered phenotype of regulatory T cells.
Sabioncello et al., Zagreb, Croatia. In Allergy Asthma Clin Immunol, 2013
METHODS: We analyzed peripheral blood mononuclear cells (PBMCs) of patients with PTSD (N = 21) (mean age = 45.9) and age-matched healthy controls (N = 23) (mean age = 45.7) to determine the proportion of Tregs and their phenotype according to the expression of CD127 and HLA-DR markers which describe the differentiation stages of Tregs.
Interleukin-7 and type 1 diabetes.
Review
Bonifacio et al., Milano, Italy. In Curr Diab Rep, 2013
In this article, we discuss recent evidence of the role of IL-7 mediated T-cell proliferation in the pathogenesis of Type 1 diabetes and the rationale for including immunomodulatory molecules targeting the IL-7/IL-7R axis in immunotherapeutic strategies to control beta-cell autoimmunity.
Balancing Proliferation with Igκ Recombination during B-lymphopoiesis.
Review
Clark et al., Chicago, United States. In Front Immunol, 2013
Remarkably, the principal downstream proliferative effectors of the IL-7R, STAT5 and cyclin D3, directly repress Igκ accessibility through very divergent yet complementary mechanisms.
TGF-β cytokine signaling promotes CD8+ T cell development and low-affinity CD4+ T cell homeostasis by regulation of interleukin-7 receptor α expression.
Impact
Li et al., New York City, United States. In Immunity, 2013
Interleukin-7 receptor α chain (IL-7Rα) is induced upon T cell positive selection and controls thymic CD8-lineage specification and peripheral naive T cell homeostasis.
GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling.
Impact
Wan et al., Chapel Hill, United States. In Nat Immunol, 2013
Although GATA-3-deficient CD8(+) T cells were generated, their peripheral maintenance was impaired, with lower expression of the receptor for interleukin 7 (IL-7R).
IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.
GeneRIF
Kim et al., Seoul, South Korea. In Rheumatology (oxford), 2012
IL-7Ralphalow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.
Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function.
GeneRIF
Lin et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2012
The durable efficacy and the multipronged tolerogenic mechanisms of IL-7Ralpha antibody therapy suggest a unique disease-modifying approach to T1D.
IL-15 inhibits IL-7Rα expression by memory-phenotype CD8⁺ T cells in the bone marrow.
GeneRIF
Di Rosa et al., Roma, Italy. In Eur J Immunol, 2012
It was shown that the key molecule regulating IL-7 receptor alpha-chain downmodulation was IL-15 but not IL-7, and that the intact IL-7 receptor alpha-chain gene was required, including the promoter.
Increased frequency of IL-7 and IL-15 receptor alpha chain (CD127, CD215) co-expressing CD4(+) T cells in granulomatosis with polyangiitis (Wegener's).
GeneRIF
Lamprecht et al., In Clin Exp Rheumatol, 2012
Letter: report increased frequency of CD127/CD215 co-expressing CD4(+) T cells in Wegener's granulomatosis.
Lack of associations of polymorphisms of IL-7R, IL-13 and IL-15 with NSCLCs in non-smoking Chinese.
GeneRIF
Zhang et al., Hangzhou, China. In Asian Pac J Cancer Prev, 2010
Polymorphisms of IL-7R is not associated with Non-Small-Cell Lung Carcinoma.
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