The role of regulatory T cell (Treg) subsets in gestational diabetes mellitus.
Heidelberg, Germany. In Clin Exp Immunol, 19 Mar 2014
We used six colour flow cytometric analysis to demonstrate that the total CD4(+) CD127(low+/-) CD25(+) FoxP3(+) -Treg pool consists of four different Treg subsets: naïve CD45RA(+) -Tregs, HLA-DR(-) CD45RA(-) memory Tregs (DR(-) Tregs) and the highly differentiated and activated HLA-DR(low+) CD45RA(-) and HLA-DR(high+) CD45RA(-) memory Tregs (DR(low+) - and DR(high+) -Tregs).
Signaling circuits in early B-cell development.
Freiburg, Germany. In Adv Immunol, Dec 2013
In particular, we address the interplay of the interleukin-7 receptor and the pre-B-cell receptor (preBCR) in shaping the survival, proliferation, and differentiation of early B cells.
IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia.
Lisbon, Portugal. In Adv Biol Regul, May 2013
However, the two main pathways activated by IL-7, JAK/STAT5 and PI3K/Akt/mTOR, have both been implicated in cancer and there is considerable evidence that IL-7 and its receptor (IL-7R), formed by IL-7Rα (encoded by IL7R) and γc, may partake in T-cell acute lymphoblastic leukemia (T-ALL) development.
[Analysis of disease-pathway by identifying susceptible genes to primary biliary cirrhosis].
Nagasaki, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2011
Among 21 non-HLA susceptibility loci for PBC identified in GWASs of European descent, 10 loci (CD80, IKZF3, IL7R, NFKB1, STAT4, TNFAIP2, CXCR5, MAP3K7IP1, rs6974491, DENND1B) showed significant associations in the Japanese population.