Micronuclei in Cord Blood Lymphocytes and Associations with Biomarkers of Exposure to Carcinogens and Hormonally Active Factors, Gene Polymorphisms, and Gene Expression: The NewGeneris Cohort.
Genova, Italy. In Environ Health Perspect, 19 Dec 2013
Lower frequencies of MNBN were associated with a 1-unit increase expression of PDCD11, LATS2, TRIM13, CD28, SMC1A, IL7R, and NIPBL genes.
How I treat ALL in Down's syndrome: pathobiology and management.
Tel Aviv-Yafo, Israel. In Blood, 14 Dec 2013
Biologically, these heterogeneous leukemias are characterized by underrepresentation of the common cytogenetic subgroups of childhood ALL and overrepresentation of CRLF2-IL7R-JAK-STAT activating genetic aberrations.
IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia.
Lisbon, Portugal. In Adv Biol Regul, May 2013
However, the two main pathways activated by IL-7, JAK/STAT5 and PI3K/Akt/mTOR, have both been implicated in cancer and there is considerable evidence that IL-7 and its receptor (IL-7R), formed by IL-7Rα (encoded by IL7R) and γc, may partake in T-cell acute lymphoblastic leukemia (T-ALL) development.