Peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats.
In PLoS ONE, 1997
... used anti-cytokines antibodies against IL-1ß, IL-6, TNFα, IFNγ, and anti-cytokine receptor antibodies against IL-1R1, IL-1R2, IL-6R, TNF-R1, IFN-Rα, IFN-Rß (Santa Cruz Biotechnology, Santa Cruz, CA); guinea ...
Hypersensitivity reactions during treatment with biological agents.
Pisa, Italy. In Clin Exp Rheumatol, 09 Feb 2016
UNASSIGNED: The recent development of biological agents, namely, anti-tumour necrosis factor alpha (TNF-α) agents (infliximab, adalimumab and etanercept), anti- CD20 monoclonal antibody (rituximab) and anti-interleukin 6 receptor (IL-6R) monoclonal antibody (tocilizumab), represents a major breakthrough for the treatment of immune-mediated disorders.
IL-6 trans-signaling promotes KRAS-driven lung carcinogenesis.
Hudson, United States. In Cancer Res, 07 Feb 2016
Mechanistic investigations revealed elevation in the lung of soluble IL-6 receptor (sIL-6R), the key driver of IL-6 trans-signaling, and blocking this mechanism via interventions with an anti-IL-6R antibody or the inhibitor sgp130Fc ameliorated lung cancer pathogenesis.
Strategy for treatment of fibrosis in systemic sclerosis: Present and future.
Tokyo, Japan. In J Dermatol, 31 Jan 2016
immunoglobulins, B-cell depletion, anti-interleukin-6 receptor antibody, autologous hematopoietic stem cell transplantation, rapamycin, pirfenidone and imatinib mesylate are potential candidates for the treatment of SSc, although their efficacy has not been validated.
Metalloproteinases and their natural inhibitors in inflammation and immunity.
Toronto, Canada. In Nat Rev Immunol, 2013
Together with their endogenous inhibitors TIMPs (tissue inhibitor of metalloproteinases), these enzymes regulate signalling downstream of the tumour necrosis factor receptor and the interleukin-6 receptor, as well as that downstream of the epidermal growth factor receptor and Notch, which are all pertinent for inflammatory responses.