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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Interleukin 5

IL-5, Interleukin-5
The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using IL-5 antibodies
Essential role of nuclear factor B in the induction of eosinophilia in allergic airway inflammation
Kim Sun-Young et al., In Clinical and Molecular Allergy : CMA, 1997
... serum (FBS) was from WelGENE, enzyme immunoassay reagents for cytokine assays, such as IL-4 and IL-5, were from BD Biosciences, the protein assay kit ...
Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial
Luster Andrew D. et al., In The Journal of Experimental Medicine, 1995
... Murine eosinophils were isolated from the spleens of the CD2 promoter IL-5 transgenic mice ( ...
Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma
August Avery et al., In The Journal of Experimental Medicine, 1994
... Jamie and Nancy Lee for the kind gift of IL-5 transgenic mice ...
Papers on IL-5
IL-5-induced migration via ERK1/2-mediated MMP-9 expression by inducing activation of NF-κB in HT1376 cells.
Moon et al., Ch'ŏngju, South Korea. In Oncol Rep, 2012
binding of IL-5 to IL-5Ralpha plays a critical role in MMP-9 expression, which may be involved in the migration of bladder cancer.
IL-5 and IL-17A are critical for the chronic IgE response and differentiation of long-lived antibody-secreting cells in inflamed tissues.
Lima et al., São Paulo, Brazil. In Cytokine, 2012
The hierarchical process of antibody-secreting cells differentiation triggered by venom needs the signal derived from IL-5 and IL-17A.
Structural basis of interleukin-5 dimer recognition by its α receptor.
Yokoyama et al., Yokohama, Japan. In Protein Sci, 2012
The study reports the crystal structure of dimeric IL-5 in complex with the IL5RA extracellular domains.
Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma.
Hendriks et al., Rotterdam, Netherlands. In Eur J Immunol, 2012
It was shown that both type 2 pulmonary innate lymphoid cells and Th2 cells produce large amounts of IL-5 and IL-13 that contribute to allergic airway inflammation.
Higher sensitivity of male CD4+ T cells to suppressive effects of CD8+ T cells on IL-5 production compared to female CD4+ T cells.
Ohno et al., Sendai, Japan. In Int Arch Allergy Immunol, 2011
Sex difference in IL-5 production by splenocytes might be due, at least in part, to the sex difference in the sensitivity of CD4+ T cells to suppression by CD8+ T cells.
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