gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 5

IL-5, Interleukin-5
The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-13, IL-4, TH2, IL-10, IgE
Papers using IL-5 antibodies
Essential role of nuclear factor B in the induction of eosinophilia in allergic airway inflammation
Supplier
Kim Sun-Young et al., In Clinical and Molecular Allergy : CMA, 1997
... serum (FBS) was from WelGENE, enzyme immunoassay reagents for cytokine assays, such as IL-4 and IL-5, were from BD Biosciences, the protein assay kit ...
Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial
Supplier
Luster Andrew D. et al., In The Journal of Experimental Medicine, 1995
... Murine eosinophils were isolated from the spleens of the CD2 promoter IL-5 transgenic mice ( ...
Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma
Supplier
August Avery et al., In The Journal of Experimental Medicine, 1994
... Jamie and Nancy Lee for the kind gift of IL-5 transgenic mice ...
Papers on IL-5
Recent Progress in the Research of Eosinophilic Esophagitis and Gastroenteritis.
New
Ishihara et al., In Digestion, Feb 2016
Basic knowledge of these diseases has mainly come from studies of EoE and Th2 type allergic reactions, including IL-5, IL-13, and IL-15, thymic stromal protein, and eotaxin 3, which are considered to have important roles.
Decidual Control of Trophoblast Invasion.
Review
New
Modi et al., Mumbai, India. In Am J Reprod Immunol, Feb 2016
The decidual secretions contain high amounts of pro-invasive factors that include IL-1β, IL-5, IL-6, IL-7, IL-8, IL-9, IL-13, IL-15, Eotaxin CCL11, IP-10 and RANTES, and anti-invasive factors IL-10, IL-12 and VEGF.
meso-Dihydroguaiaretic acid attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma.
New
Son et al., Taejŏn, South Korea. In Int Immunopharmacol, Feb 2016
Intragastric administration of MDGA significantly lowered the productions of interleukin (IL)-4, IL-5, IL-13, tumor necrosis-α (TNF-α), eotaxin, monocyte chemoattractant protein-1 (MCP-1), vascular cell adhesion molecule-1 (VCAM-1), and immunoglobulin (Ig)E in bronchoalveolar lavage fluid (BALF), plasma, or lung tissues.
Long-term azithromycin ameliorates not only airway inflammation but also remodeling in a murine model of chronic asthma.
New
Kim et al., Seoul, South Korea. In Pulm Pharmacol Ther, Feb 2016
The concentrations of IL-5 and IL-13 in the OVA/LPS group decreased significantly after azithromycin administration.
Reductions in eosinophil biomarkers by benralizumab in patients with asthma.
New
Ranade et al., Gaithersburg, United States. In Respir Med, Feb 2016
Blood eosinophils, IL-5, eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), eotaxin/chemokine (C-C motif) 11 (CCL11), eotaxin-2/CCL24, tumor necrosis factor (TNF), and interferon-γ (IFN-γ) were measured at baseline and post-treatment.
Mixture of Alum - Naloxone and Alum - Naltrexone as a novel adjuvant elicits immune responses for Toxoplasma gondii lysate Antigen in BALB /c mice.
New
Tappeh et al., Sārī, Iran. In Exp Parasitol, Feb 2016
The DTH and cellular immune responses showed that in mice immunized with the TLA vaccine combined with the Alum-NLT mixture, the efficacy improved by increasing the production of Interleukin-5(IL-5) and Interferon gamma.
Targeting key proximal drivers of type 2 inflammation in disease.
Review
New
Impact
Yancopoulos et al., New York City, United States. In Nat Rev Drug Discov, Jan 2016
Rather than reducing inflammation with broad-acting immunosuppressants or narrowly targeting downstream products of the TH2 pathway, such as immunoglobulin E (IgE), efforts to target the key proximal type 2 cytokines - interleukin-4 (IL-4), IL-5 and IL-13 - represent a promising strategy to achieve therapeutic benefit across multiple diseases.
Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease.
Review
New
Doherty et al., San Diego, United States. In Curr Allergy Asthma Rep, Jan 2016
ILC2s produce Th2 cytokines, IL-4, IL-5, and IL-13, upon activation by epithelial cell-derived cytokines, lipid mediators (cysteinyl leukotrienes and prostaglandin D2), and TNF family member TL1A and promote structural and immune cell responses in the airways after antigen exposure.
Mepolizumab in the treatment of severe eosinophilic asthma.
Review
New
Chetta et al., Parma, Italy. In Immunotherapy, Jan 2016
IL-5 is crucial in the pathogenesis and evolution of eosinophilic asthma.
Targeting the interleukin pathway in the treatment of asthma.
Review
New
Impact
Chung, London, United Kingdom. In Lancet, Oct 2015
Studies examining cytokine blockers such as anti-interleukin-5, anti-interleukin-4Rα, and anti-interleukin-13 monoclonal antibodies in patients with severe asthma with recurrent exacerbations and high blood eosinophil counts despite use of inhaled corticosteroids have reported improved outcomes in terms of exacerbations, asthma control, and forced expiratory volume in 1 s.
Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis.
New
Impact
Powrie et al., Oxford, United Kingdom. In Immunity, Aug 2015
IL-5 blockade or eosinophil depletion ameliorated colitis, implicating eosinophils in disease pathogenesis.
Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme.
New
Impact
Renz et al., Marburg an der Lahn, Germany. In N Engl J Med, Jun 2015
Inhibition of the late asthmatic response by SB010 was associated with attenuation of allergen-induced sputum eosinophilia and with lower levels of tryptase in sputum and lower plasma levels of interleukin-5.
Type 2 cytokines: mechanisms and therapeutic strategies.
Review
New
Impact
Wynn, Bethesda, United States. In Nat Rev Immunol, May 2015
Type 2 immune responses are defined by the cytokines interleukin-4 (IL-4), IL-5, IL-9 and IL-13, which can either be host protective or have pathogenic activity.
The importance of the granulocyte-colony stimulating factor in oncology.
Review
Oprean et al., Cluj-Napoca / Kolozsvár, Romania. In Clujul Med, 2014
Granulocyte-colony stimulating factor (G-CSF) is a glycoprotein, the second CSF, sharing some common effects with granulocyte macrophage-colony stimulating factor (GM-CSF), interleukin-3 (IL-3) and interleukin-5 (IL-5).
The past, present, and future of monoclonal antibodies to IL-5 and eosinophilic asthma: a review.
Review
Kennedy et al., Little Rock, United States. In J Asthma Allergy, 2014
As the development of eosinophilic inflammation is categorically dependent on the biological activity of Interleukin (IL)-5, IL-5 antagonism became an obvious target for therapy in this phenotype.
IL-5-induced migration via ERK1/2-mediated MMP-9 expression by inducing activation of NF-κB in HT1376 cells.
GeneRIF
Moon et al., Ch'ŏngju, South Korea. In Oncol Rep, 2012
binding of IL-5 to IL-5Ralpha plays a critical role in MMP-9 expression, which may be involved in the migration of bladder cancer.
IL-5 and IL-17A are critical for the chronic IgE response and differentiation of long-lived antibody-secreting cells in inflamed tissues.
GeneRIF
Lima et al., São Paulo, Brazil. In Cytokine, 2012
The hierarchical process of antibody-secreting cells differentiation triggered by venom needs the signal derived from IL-5 and IL-17A.
Structural basis of interleukin-5 dimer recognition by its α receptor.
GeneRIF
Yokoyama et al., Yokohama, Japan. In Protein Sci, 2012
The study reports the crystal structure of dimeric IL-5 in complex with the IL5RA extracellular domains.
Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma.
GeneRIF
Hendriks et al., Rotterdam, Netherlands. In Eur J Immunol, 2012
It was shown that both type 2 pulmonary innate lymphoid cells and Th2 cells produce large amounts of IL-5 and IL-13 that contribute to allergic airway inflammation.
Higher sensitivity of male CD4+ T cells to suppressive effects of CD8+ T cells on IL-5 production compared to female CD4+ T cells.
GeneRIF
Ohno et al., Sendai, Japan. In Int Arch Allergy Immunol, 2011
Sex difference in IL-5 production by splenocytes might be due, at least in part, to the sex difference in the sensitivity of CD4+ T cells to suppression by CD8+ T cells.
share on facebooktweetadd +1mail to friends