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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 4 receptor

IL-4R, IL-4Ralpha, interleukin-4 receptor
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-4, IL-13, TH2, CAN, STAT6
Papers on IL-4R
Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination.
New
Bokarewa et al., Göteborg, Sweden. In Proc Natl Acad Sci U S A, Jan 2016
B cells from Flt3 ligand-deficient mice have impaired IL-4R signaling, with reduced phosphorylation of signal transducer and activator of transcription (Stat) 6, and demonstrate a failure to initiate CSR to IgG1 with low expression of γ1 germ-line transcripts, resulting in impaired IgG1 production.
Targeting IL4/IL4R for the treatment of epithelial cancer metastasis.
Review
New
Fingleton et al., Nashville, United States. In Clin Exp Metastasis, Dec 2015
Interleukin-4 (IL4), a Th2 cytokine, and the IL4/IL4 receptor (IL4R) interaction have well defined roles in the immune system.
Loss of IL-4Rα-mediated PI3K signaling accelerates the progression of IgE/mast cell-mediated reactions.
New
Hogan et al., Cincinnati, United States. In Immun Inflamm Dis, Dec 2015
Clinical and experimental evidence indicate that polymorphisms within the interleukin 4 (IL-4) receptor (IL-4R) chain are sufficient for altered strength of IL-4/IL-13 signaling, leading to an exaggerated allergic inflammatory response and increase susceptibility to allergic phenotypes.
[Correlations of IL-4R gene polymorphism and serum IgE levels with asthma predictive index].
New
Muzhapaer et al., Ürümqi, China. In Zhongguo Dang Dai Er Ke Za Zhi, Dec 2015
OBJECTIVE: To study the correlations of IL-4R gene polymorphism and serum IgE levels with asthma predictive index (API) in children.
Identification, characterization, and targeting of IL-4 receptor by IL-4-Pseudomonas exotoxin in mouse models of anaplastic thyroid cancer.
New
Puri et al., Silver Spring, United States. In Discov Med, Nov 2015
Since interleukin-4 receptor (IL-4R) is overexpressed in human solid cancer, we examined expression of IL-4R in 50 cases of anaplastic thyroid cancer (ATC), 37 well-differentiated papillary cancer (WDPC), 35 well-differentiated follicular cancer of thyroid (WDFC), and 37 normal thyroid specimens by immunohistochemistry (IHC) and in-situ hybridization (ISH) techniques.
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair.
New
Impact
Eming et al., Köln, Germany. In Immunity, Nov 2015
We have demonstrated that, during skin repair in mice, interleukin-4 receptor α (IL-4Rα)-dependent macrophage activation controlled collagen fibril assembly and that this process was important for effective repair while having adverse pro-fibrotic effects.
Enteric nematodes and the path to up-regulation of type 2 cytokines IL-4 and IL-13.
Review
New
Zhao et al., Baltimore, United States. In Cytokine, Sep 2015
Both the immune and functional outcomes depend largely on IL-4/IL-13 signaling through STAT6, with a dominant role for IL-13 working through the type 2 IL-4 receptor (IL-4R).
Personalized Immunomodulatory Therapy for Atopic Dermatitis: An Allergist's View.
Review
New
Nahm, Suwŏn, South Korea. In Ann Dermatol, Aug 2015
In recent clinical studies, monoclonal antibodies including the anti-interleukin-4 receptor antibody and anti-B cell antibody induced significant clinical improvements in patients with AD.
New pathogenic and therapeutic paradigms in atopic dermatitis.
Review
New
Guttman-Yassky et al., New York City, United States. In Cytokine, Jun 2015
An IL-4R antagonist, dupilumab, is the first drug that shows great promise in phase II trials.
APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective.
Review
New
LaDu et al., Chicago, United States. In J Neurochem, May 2015
We present data supporting the hypothesis that impaired apoE4 function modulates Aβ-induced effects on inflammatory receptor signaling, including amplification of detrimental (toll-like receptor 4-p38α) and suppression of beneficial (IL-4R-nuclear receptor) pathways.
Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy.
New
Impact
Chatila et al., Boston, United States. In Immunity, Apr 2015
We show that disease-susceptible (Il4ra(F709)) mice with enhanced interleukin-4 receptor (IL-4R) signaling exhibited STAT6-dependent impaired generation and function of mucosal allergen-specific Treg cells.
Dupilumab in persistent asthma with elevated eosinophil levels.
Impact
Pirozzi et al., Pittsburgh, United States. In N Engl J Med, 2013
We evaluated the efficacy and safety of dupilumab (SAR231893/REGN668), a fully human monoclonal antibody to the alpha subunit of the interleukin-4 receptor, in patients with persistent, moderate-to-severe asthma and elevated eosinophil levels.
Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma.
Impact
Ray et al., Pittsburgh, United States. In Nat Med, 2012
Virus infection induced GATA-3 expression and T helper type 2 (T(H)2) cytokine production in forkhead box P3 (FOXP3)(+) T(reg) cells and compromised the suppressive function of pulmonary T(reg) cells in a manner that was dependent on interleukin-4 receptor α (IL-4Rα) expression in the host.
Allergic airway disease is unaffected by the absence of IL-4Rα-dependent alternatively activated macrophages.
GeneRIF
Brombacher et al., Cape Town, South Africa. In J Allergy Clin Immunol, 2012
LysM(cre)IL-4Ralpha(-/lox) mice and littermate controls also developed similar responses in acute ovalbumin- and house dust mite-induced allergic airway disease
Effects of cytokine and cytokine receptor gene variation on high anti-HB titers: following up on Taiwan's neonatal hepatitis B immunization program.
GeneRIF
Tsai et al., Taiwan. In Clin Chim Acta, 2012
Genetic determinants IL-4 and IL-4R, may contribute to high anti-hepatitis B titers in immune responses to hepatitis B vaccinations.
IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist.
GeneRIF
Bleecker et al., Winston-Salem, United States. In J Allergy Clin Immunol, 2012
Subjects homozygous for the IL4RA rs8832 common G allele randomized to pitrakinra had decreased asthma exacerbations and decreased nocturnal awakenings and activities limited by asthma.
Tumor-induced myeloid-derived suppressor cell function is independent of IFN-γ and IL-4Rα.
GeneRIF
Ostrand-Rosenberg et al., Baltimore, United States. In Eur J Immunol, 2012
neither IFN-gamma nor IL-4R-alpha is a key regulator of Myeloid-derived suppressor cells and targeting these molecules is unlikely to significantly alter MDSC accumulation or function.
Association of interleukin 4 (-590 T/C) and interleukin 4 receptor (Q551R A/G) gene polymorphisms with acne vulgaris.
GeneRIF
Settin et al., Saudi Arabia. In Ann Saudi Med, 2012
This study provides evidence for a significant association of IL-4R (Q551R A/G) genetic polymorphisms with the susceptibility rather than the severity of acne vulgaris
An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection.
Impact
Gause et al., Newark, United States. In Nat Med, 2012
We found that IL-17 initially contributed to inflammation and lung damage, whereas subsequent IL-4 receptor (IL-4R) signaling reduced elevations in IL-17 mRNA levels, enhanced the expression of insulin-like growth factor 1 (IGF-1) and IL-10 and stimulated the development of M2 macrophages, all of which contributed to the rapid resolution of tissue damage.
Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse.
Huh et al., In Cancer Res Treat, 2002
Immunohistochemical studies were performed on implanted tumor nodules (n=8) using antibodies against CD71, EGFR, IGF-IRalpha, CXCR4 and IL-4Ralpha.
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