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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 4

IL-4, Interleukin-4
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, Interleukin-6, TH2, CAN, IL-13
Papers using IL-4 antibodies
Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis.
Ryffel Bernhard, In PLoS ONE, 2009
... Anti-IL-4 antibody (11B11) was purchased from BioLegend Inc., and anti-IFN-γ antibody ...
Prolonged culture of mast cells with high-glucose medium enhances the Fc epsilon RI-mediated degranulation response and leukotriene C4 production.
Fessler Michael B., In PLoS ONE, 2009
... IL-4 ELISA kits were purchased from Biolegend (Cambridge BioScience Ltd, UK) ...
Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation
Choe Myeon et al., In Nutrition Research and Practice, 2009
... kit (eBioscience, San Diego, CA, USA), ECL chemiluminescence kit (BD Biosciences, San Jose, CA, USA), anti-IL-4 (mouse monoclonal antibody (Santa Cruz Biotechnology, Santa Cruz, CA, USA), ...
A protective function for interleukin 17A in T cell-mediated intestinal inflammation.
Mossman Karen L., In PLoS ONE, 2008
... Murine IFNα and IFNβ proteins were from PBL Biomedical Laboratories (Piscataway, NJ); Anti-CD3, anti-CD28, anti-IFNγ, anti-IL-4, were from BD Biosciences (San Diego, CA) ...
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
Okada Hideho et al., In Journal of Translational Medicine, 2007
... Purified mAbs against CD3 (UCHT1) and CD28 (CD28.2) and IL-4 (MP4-25D2) were purchased from Biolegend.
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Papers on IL-4
Effect of yeast-derived products and distillers dried grains with solubles (DDGS) on antibody-mediated immune response and gene expression of pattern recognition receptors and cytokines in broiler chickens immunized with T-cell dependent antigens.
Slominski et al., Winnipeg, Canada. In Poult Sci, Feb 2016
On d 35, 5 birds per treatment were euthanized and the tissue samples from the cecal tonsils were collected to assess the gene expression of toll-like receptors TLR2b, TLR4, and TLR21, monocyte mannose receptor (MMR), and cytokines IL-10, IL-13, IL-4, IL-12p35, and IFN-γ.
Analysis of changes in expression of IL-4/IL-13/STAT6 pathway and correlation with the selected clinical parameters in patients with atopic asthma.
Brzeziańska-Lasota et al., Łódź, Poland. In Int J Immunopathol Pharmacol, Feb 2016
INTRODUCTION: Asthma is associated with activation of interleukin-4 (IL-4)/interleukin-13 (IL-13)/signal transducer and activator of transcription factor-6(STAT6) inflammatory response via overexpression of all pathway components: IL-4, IL-13, and STAT6.
ANNALS EXPRESS: Cytokine profiles in overweight and obese subjects and normal weight individuals matched for age and gender.
Ghayour-Mobarhan et al., Mashhad, Iran. In Ann Clin Biochem, Feb 2016
The concentrations of serum interleukin-1α, -1β, -2, -4, -6, -8 and -10 (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, and IL-10), were measured in all subjects, together with serum vascular endothelial growth factor (VEGF), interferon γ (IFN-γ), epidermal growth factor (EGF), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α).
Could cytokine levels in the peri-implant crevicular fluid be used to distinguish between healthy implants and implants with peri-implantitis? A systematic review.
Feres et al., Guarulhos, Brazil. In J Periodontal Res, Feb 2016
Proinflammatory cytokines [interleukin (IL)-1β, IL-6, IL-12, IL-17 and tumor necrosis factor-α) were the cytokines studied most commonly, followed by anti-inflammatory cytokines (IL-4 and IL-10), osteoclastogenesis-related cytokines (RANKL) and chemokines (IL-8).
Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites.
Jay et al., Montpellier, France. In Nature, Feb 2016
Induction of type 2 cytokines, including interleukins (IL) IL-4 and IL-13, induce goblet cell hyperplasia with mucus production, ultimately resulting in worm expulsion.
Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial.
Ardeleanu et al., Lübeck, Germany. In Lancet, Feb 2016
Our findings show that IL-4 and IL-13 are key drivers of atopic dermatitis.
Targeting key proximal drivers of type 2 inflammation in disease.
Yancopoulos et al., New York City, United States. In Nat Rev Drug Discov, Jan 2016
Rather than reducing inflammation with broad-acting immunosuppressants or narrowly targeting downstream products of the TH2 pathway, such as immunoglobulin E (IgE), efforts to target the key proximal type 2 cytokines - interleukin-4 (IL-4), IL-5 and IL-13 - represent a promising strategy to achieve therapeutic benefit across multiple diseases.
Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease.
Doherty et al., San Diego, United States. In Curr Allergy Asthma Rep, Jan 2016
ILC2s produce Th2 cytokines, IL-4, IL-5, and IL-13, upon activation by epithelial cell-derived cytokines, lipid mediators (cysteinyl leukotrienes and prostaglandin D2), and TNF family member TL1A and promote structural and immune cell responses in the airways after antigen exposure.
Interleukin-13 as an important cytokine: A review on its roles in some human diseases.
Babaloo et al., Tabrīz, Iran. In Acta Microbiol Immunol Hung, Dec 2015
Animal models such as in IL-13 deficient mice and transgenic animals also have been confirmed the critical role of this cytokine in the immune responses, mostly by IL-13 neutralization and IL-13/IL-4 dual neutralization strategies.
A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance.
Ptak et al., Kraków, Poland. In Ann N Y Acad Sci, Dec 2015
sB-1a cells resemble memory B2 cells, as they are stimulated within 1 h of immunization and depend on T helper cytokines-uniquely IL-4 from hepatic iNKT cells-for activation and rapid migration from the peritoneal cavity to the spleen to secrete IgM antibody (Ab) and Ab-derived free light chains (FLCs) by only 1 day after immunization.
Establishment of Elevated Serum Levels of IL-10, IL-8 and TNF-β as Potential Peripheral Blood Biomarkers in Tubercular Lymphadenitis: A Prospective Observational Cohort Study.
Bhowmick et al., Delhi, India. In Plos One, Dec 2015
To assess this twelve cytokines (Tumor Necrosis Factor (TNF)-α, Interferon (IFN) -γ, Interleukin (IL)-2, IL-12, IL-18, IL-1β, IL-10, IL-6, IL-4, IL-1Receptor antagonist (IL-1Ra), IL-8 and TNF-β, which have a role in pathogenesis of tuberculosis, were tested as potential peripheral blood biomarkers to aid the diagnosis of TL when routine investigations prove to be of limited value.
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair.
Eming et al., Köln, Germany. In Immunity, Nov 2015
We have demonstrated that, during skin repair in mice, interleukin-4 receptor α (IL-4Rα)-dependent macrophage activation controlled collagen fibril assembly and that this process was important for effective repair while having adverse pro-fibrotic effects.
Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy.
Wang et al., Cincinnati, United States. In Immunity, Nov 2015
Repeated intragastric antigen challenge induced MMC9 development that required T cells, IL-4, and STAT6 transcription factor, but not IL-9 signals.
Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization.
Bu et al., Shanghai, China. In Int J Endocrinol, 2014
Recently it is found that eosinophils accelerate alternative activation macrophage (AAM) polarization by secreting Th2 type cytokines such as interleukin-4 and interleukin-13, thereby reducing metainflammation in adipose tissue.
Tyrosine phosphorylation of c-Maf enhances the expression of IL-4 gene.
Miaw et al., Taipei, Taiwan. In J Immunol, 2012
this study sheds new light on the role of posttranslational modification of c-Maf in IL-4 production and Th cell-mediated autoimmune diseases.
Interleukin-4 rs2243250 polymorphism is associated with asthma among Caucasians and related to atopic asthma.
Liu et al., Beijing, China. In Cytokine, 2012
This meta-analysis suggests that T allele at position -589 of the IL-4 gene promoter region is a low-penetrant risk factor for asthma development especially for Caucasians and atopic type.
Dendritic cell-specific transcript: dendritic cell marker and regulator of TLR-induced cytokine production.
Adema et al., Nijmegen, Netherlands. In J Immunol, 2012
IL-4 is the dominant factor that induces dendritic cell (DC)-SCRIPT mRNA expression in monocyte-derived DCs.
Association of interleukin 4 (-590 T/C) and interleukin 4 receptor (Q551R A/G) gene polymorphisms with acne vulgaris.
Settin et al., Saudi Arabia. In Ann Saudi Med, 2012
Acne patients compared to controls showed no significant difference in the frequencies of IL-4 polymorphic genotypes, yet had a highly significant difference in IL-4R genotypes
Interleukin-4 polymorphisms and response to combination therapy in Egyptian chronic hepatitis C patients.
Nafee et al., Az Zaqāzīq, Egypt. In Cell Immunol, 2012
IL4-590 T/T and -33 T/T genotypes were associated with resistance to the therapy (p<0.001, p=0.001 respectively)
Effect of Lactobacillus casei on the Production of Pro-Inflammatory Markers in Streptozotocin-Induced Diabetic Rats.
Mutalib et al., Kuala Selangor, Malaysia. In Probiotics Antimicrob Proteins, 2011
casei Shirota) on the blood glucose, C-reactive protein (CRP), Interleukin-6 (IL-6), Interleukin-4 (IL-4), and body weight among STZ-induced diabetic rats.
More papers using IL-4 antibodies
A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification
Watts Colin et al., In The EMBO Journal, 2001
... monocytes in GMCSF (800 U/ml; Leucomax, Sandoz) and IL-4 (1000 U/ml; BD Biosciences) essentially as described by ...
Overexpression of IL-4 alters the homeostasis in the skin
Chan Lawrence S. et al., In Immunology and cell biology, 2001
... Four to 12 weeks old IL-4 epidermal transgenic mice (IL-4 Tg) were ...
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
Butcher Eugene C. et al., In The Journal of Experimental Medicine, 1998
CD45RA (HI100); CD45RO (UCHL1); CD57 (NK-1); CD69 (CH/4; Caltag); CD134 (ACT35); IL-2 (MQ1-17H12); IL-4 (3010.211;
IL-4–induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease
Reininger Luc et al., In The Journal of Experimental Medicine, 1995
... The 129/Sv IL-4 transgenic mutant strain (pEP-IL-4), which ...
Effect of treatment with interferon-γ alone in Indian visceral leishmaniasis
Coffman Robert L. et al., In The Journal of Experimental Medicine, 1994
... IL-4 transgenic 129/Sv/PEP mice ( ...
Tumor Rejection by Modulation of Tumor Stromal Fibroblasts
Blankenstein Thomas et al., In The Journal of Experimental Medicine, 1985
... J558-IL-4 cells secrete 6.3 ng/ml IL-4 as determined by ELISA (BD Biosciences).
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