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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 4

IL-4, Interleukin-4
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, Interleukin-6, TH2, CAN, IL-13
Papers using IL-4 antibodies
Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis.
Supplier
Ryffel Bernhard, In PLoS ONE, 2009
... Anti-IL-4 antibody (11B11) was purchased from BioLegend Inc., and anti-IFN-γ antibody ...
Prolonged culture of mast cells with high-glucose medium enhances the Fc epsilon RI-mediated degranulation response and leukotriene C4 production.
Supplier
Fessler Michael B., In PLoS ONE, 2009
... IL-4 ELISA kits were purchased from Biolegend (Cambridge BioScience Ltd, UK) ...
Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation
Supplier
Choe Myeon et al., In Nutrition Research and Practice, 2009
... kit (eBioscience, San Diego, CA, USA), ECL chemiluminescence kit (BD Biosciences, San Jose, CA, USA), anti-IL-4 (mouse monoclonal antibody (Santa Cruz Biotechnology, Santa Cruz, CA, USA), ...
A protective function for interleukin 17A in T cell-mediated intestinal inflammation.
Supplier
Mossman Karen L., In PLoS ONE, 2008
... Murine IFNα and IFNβ proteins were from PBL Biomedical Laboratories (Piscataway, NJ); Anti-CD3, anti-CD28, anti-IFNγ, anti-IL-4, were from BD Biosciences (San Diego, CA) ...
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
Supplier
Okada Hideho et al., In Journal of Translational Medicine, 2007
... Purified mAbs against CD3 (UCHT1) and CD28 (CD28.2) and IL-4 (MP4-25D2) were purchased from Biolegend.
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Papers on IL-4
Effect of yeast-derived products and distillers dried grains with solubles (DDGS) on antibody-mediated immune response and gene expression of pattern recognition receptors and cytokines in broiler chickens immunized with T-cell dependent antigens.
New
Slominski et al., Winnipeg, Canada. In Poult Sci, Feb 2016
On d 35, 5 birds per treatment were euthanized and the tissue samples from the cecal tonsils were collected to assess the gene expression of toll-like receptors TLR2b, TLR4, and TLR21, monocyte mannose receptor (MMR), and cytokines IL-10, IL-13, IL-4, IL-12p35, and IFN-γ.
Analysis of changes in expression of IL-4/IL-13/STAT6 pathway and correlation with the selected clinical parameters in patients with atopic asthma.
New
Brzeziańska-Lasota et al., Łódź, Poland. In Int J Immunopathol Pharmacol, Feb 2016
INTRODUCTION: Asthma is associated with activation of interleukin-4 (IL-4)/interleukin-13 (IL-13)/signal transducer and activator of transcription factor-6(STAT6) inflammatory response via overexpression of all pathway components: IL-4, IL-13, and STAT6.
ANNALS EXPRESS: Cytokine profiles in overweight and obese subjects and normal weight individuals matched for age and gender.
New
Ghayour-Mobarhan et al., Mashhad, Iran. In Ann Clin Biochem, Feb 2016
The concentrations of serum interleukin-1α, -1β, -2, -4, -6, -8 and -10 (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, and IL-10), were measured in all subjects, together with serum vascular endothelial growth factor (VEGF), interferon γ (IFN-γ), epidermal growth factor (EGF), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α).
Could cytokine levels in the peri-implant crevicular fluid be used to distinguish between healthy implants and implants with peri-implantitis? A systematic review.
Review
New
Feres et al., Guarulhos, Brazil. In J Periodontal Res, Feb 2016
Proinflammatory cytokines [interleukin (IL)-1β, IL-6, IL-12, IL-17 and tumor necrosis factor-α) were the cytokines studied most commonly, followed by anti-inflammatory cytokines (IL-4 and IL-10), osteoclastogenesis-related cytokines (RANKL) and chemokines (IL-8).
Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites.
New
Impact
Jay et al., Montpellier, France. In Nature, Feb 2016
Induction of type 2 cytokines, including interleukins (IL) IL-4 and IL-13, induce goblet cell hyperplasia with mucus production, ultimately resulting in worm expulsion.
Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial.
New
Impact
Ardeleanu et al., Lübeck, Germany. In Lancet, Feb 2016
Our findings show that IL-4 and IL-13 are key drivers of atopic dermatitis.
Targeting key proximal drivers of type 2 inflammation in disease.
Review
New
Impact
Yancopoulos et al., New York City, United States. In Nat Rev Drug Discov, Jan 2016
Rather than reducing inflammation with broad-acting immunosuppressants or narrowly targeting downstream products of the TH2 pathway, such as immunoglobulin E (IgE), efforts to target the key proximal type 2 cytokines - interleukin-4 (IL-4), IL-5 and IL-13 - represent a promising strategy to achieve therapeutic benefit across multiple diseases.
Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease.
Review
New
Doherty et al., San Diego, United States. In Curr Allergy Asthma Rep, Jan 2016
ILC2s produce Th2 cytokines, IL-4, IL-5, and IL-13, upon activation by epithelial cell-derived cytokines, lipid mediators (cysteinyl leukotrienes and prostaglandin D2), and TNF family member TL1A and promote structural and immune cell responses in the airways after antigen exposure.
Interleukin-13 as an important cytokine: A review on its roles in some human diseases.
Review
New
Babaloo et al., Tabrīz, Iran. In Acta Microbiol Immunol Hung, Dec 2015
Animal models such as in IL-13 deficient mice and transgenic animals also have been confirmed the critical role of this cytokine in the immune responses, mostly by IL-13 neutralization and IL-13/IL-4 dual neutralization strategies.
A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance.
Review
New
Ptak et al., Kraków, Poland. In Ann N Y Acad Sci, Dec 2015
sB-1a cells resemble memory B2 cells, as they are stimulated within 1 h of immunization and depend on T helper cytokines-uniquely IL-4 from hepatic iNKT cells-for activation and rapid migration from the peritoneal cavity to the spleen to secrete IgM antibody (Ab) and Ab-derived free light chains (FLCs) by only 1 day after immunization.
Establishment of Elevated Serum Levels of IL-10, IL-8 and TNF-β as Potential Peripheral Blood Biomarkers in Tubercular Lymphadenitis: A Prospective Observational Cohort Study.
New
Bhowmick et al., Delhi, India. In Plos One, Dec 2015
To assess this twelve cytokines (Tumor Necrosis Factor (TNF)-α, Interferon (IFN) -γ, Interleukin (IL)-2, IL-12, IL-18, IL-1β, IL-10, IL-6, IL-4, IL-1Receptor antagonist (IL-1Ra), IL-8 and TNF-β, which have a role in pathogenesis of tuberculosis, were tested as potential peripheral blood biomarkers to aid the diagnosis of TL when routine investigations prove to be of limited value.
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair.
New
Impact
Eming et al., Köln, Germany. In Immunity, Nov 2015
We have demonstrated that, during skin repair in mice, interleukin-4 receptor α (IL-4Rα)-dependent macrophage activation controlled collagen fibril assembly and that this process was important for effective repair while having adverse pro-fibrotic effects.
Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy.
New
Impact
Wang et al., Cincinnati, United States. In Immunity, Nov 2015
Repeated intragastric antigen challenge induced MMC9 development that required T cells, IL-4, and STAT6 transcription factor, but not IL-9 signals.
Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization.
Review
Bu et al., Shanghai, China. In Int J Endocrinol, 2014
Recently it is found that eosinophils accelerate alternative activation macrophage (AAM) polarization by secreting Th2 type cytokines such as interleukin-4 and interleukin-13, thereby reducing metainflammation in adipose tissue.
Tyrosine phosphorylation of c-Maf enhances the expression of IL-4 gene.
GeneRIF
Miaw et al., Taipei, Taiwan. In J Immunol, 2012
this study sheds new light on the role of posttranslational modification of c-Maf in IL-4 production and Th cell-mediated autoimmune diseases.
Interleukin-4 rs2243250 polymorphism is associated with asthma among Caucasians and related to atopic asthma.
GeneRIF
Liu et al., Beijing, China. In Cytokine, 2012
This meta-analysis suggests that T allele at position -589 of the IL-4 gene promoter region is a low-penetrant risk factor for asthma development especially for Caucasians and atopic type.
Dendritic cell-specific transcript: dendritic cell marker and regulator of TLR-induced cytokine production.
GeneRIF
Adema et al., Nijmegen, Netherlands. In J Immunol, 2012
IL-4 is the dominant factor that induces dendritic cell (DC)-SCRIPT mRNA expression in monocyte-derived DCs.
Association of interleukin 4 (-590 T/C) and interleukin 4 receptor (Q551R A/G) gene polymorphisms with acne vulgaris.
GeneRIF
Settin et al., Saudi Arabia. In Ann Saudi Med, 2012
Acne patients compared to controls showed no significant difference in the frequencies of IL-4 polymorphic genotypes, yet had a highly significant difference in IL-4R genotypes
Interleukin-4 polymorphisms and response to combination therapy in Egyptian chronic hepatitis C patients.
GeneRIF
Nafee et al., Az Zaqāzīq, Egypt. In Cell Immunol, 2012
IL4-590 T/T and -33 T/T genotypes were associated with resistance to the therapy (p<0.001, p=0.001 respectively)
Effect of Lactobacillus casei on the Production of Pro-Inflammatory Markers in Streptozotocin-Induced Diabetic Rats.
Mutalib et al., Kuala Selangor, Malaysia. In Probiotics Antimicrob Proteins, 2011
casei Shirota) on the blood glucose, C-reactive protein (CRP), Interleukin-6 (IL-6), Interleukin-4 (IL-4), and body weight among STZ-induced diabetic rats.
More papers using IL-4 antibodies
A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification
Supplier
Watts Colin et al., In The EMBO Journal, 2001
... monocytes in GMCSF (800 U/ml; Leucomax, Sandoz) and IL-4 (1000 U/ml; BD Biosciences) essentially as described by ...
Overexpression of IL-4 alters the homeostasis in the skin
Supplier
Chan Lawrence S. et al., In Immunology and cell biology, 2001
... Four to 12 weeks old IL-4 epidermal transgenic mice (IL-4 Tg) were ...
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
Supplier
Butcher Eugene C. et al., In The Journal of Experimental Medicine, 1998
CD45RA (HI100); CD45RO (UCHL1); CD57 (NK-1); CD69 (CH/4; Caltag); CD134 (ACT35); IL-2 (MQ1-17H12); IL-4 (3010.211;
IL-4–induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease
Supplier
Reininger Luc et al., In The Journal of Experimental Medicine, 1995
... The 129/Sv IL-4 transgenic mutant strain (pEP-IL-4), which ...
Effect of treatment with interferon-γ alone in Indian visceral leishmaniasis
Supplier
Coffman Robert L. et al., In The Journal of Experimental Medicine, 1994
... IL-4 transgenic 129/Sv/PEP mice ( ...
Tumor Rejection by Modulation of Tumor Stromal Fibroblasts
Supplier
Blankenstein Thomas et al., In The Journal of Experimental Medicine, 1985
... J558-IL-4 cells secrete 6.3 ng/ml IL-4 as determined by ELISA (BD Biosciences).
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