Interleukin-34 Induces Cc-chemokine Ligand 20 in Gut Epithelial Cells.
Roma, Italy. In J Crohns Colitis, Jan 2016
In this study, we examined whether intestinal epithelial cells express macrophage colony-stimulating factor receptor 1 [M-CSFR-1], the functional receptor of interleukin-34 [IL-34], a cytokine that is over-produced in IBD and supposed to sustain inflammatory pathways.
Targeting IL-34 in chronic inflammation.
San Francisco, United States. In Drug Discov Today, 2014
IL-34 and CSF-1 signal through this common receptor to mediate the biology of mononuclear phagocytic cells.
CSF-1 receptor signaling in myeloid cells.
New York City, United States. In Cold Spring Harb Perspect Biol, 2014
The CSF-1 receptor (CSF-1R) is activated by the homodimeric growth factors colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34).
[Microglia in neurodegenerative disorders and neuroinflammation].
Nagoya, Japan. In Rinsho Shinkeigaku, 2013
For example, the CX3C chemokine fractalkine, interleukin-34, and fibroblast growth factor-2 are secreted from damaged neurons; these help-me signals induce various microglial activities to rescue neurons, including upregulated phagocytosis of toxicants and damaged debris, and production of antioxidant enzymes and other neurotrophic factors.