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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 34

IL-34, interleukin-34
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008] (from NCBI)
Top mentioned proteins: CsF, M-CSF, FMS, CAN, V1a
Papers using IL-34 antibodies
A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations
Chang Eun-Ju et al., In Arthritis Research & Therapy, 2005
... Rabbit anti-human IL-34 for immunoblotting was from ProSci Incorporated (Poway, CA, USA) ...
Papers on IL-34
miR-28-5p-IL-34-Macrophage Feedback Loop Modulates Hepatocellular Carcinoma Metastasis.
Zhou et al., Shanghai, China. In Hepatology, Feb 2016
Through gene expression profiles and bioinformatics analysis, we identified interleukin-34 (IL-34) as a direct target of miR-28-5p, and the effects of miR-28-5p deficiency on HCC growth and metastasis was dependent on IL-34-mediated tumor-associated macrophage (TAMs) infiltration.
Interleukin-34 Induces Cc-chemokine Ligand 20 in Gut Epithelial Cells.
Monteleone et al., Roma, Italy. In J Crohns Colitis, Jan 2016
In this study, we examined whether intestinal epithelial cells express macrophage colony-stimulating factor receptor 1 [M-CSFR-1], the functional receptor of interleukin-34 [IL-34], a cytokine that is over-produced in IBD and supposed to sustain inflammatory pathways.
Non-redundant roles of keratinocyte-derived IL-34 and neutrophil-derived CSF1 in Langerhans cells renewal in the steady-state and skin inflammation.
Colonna et al., Saint Louis, United States. In Eur J Immunol, Jan 2016
In this study, we investigated the spatio-temporal production of IL-34 and its impact on skin LCs in the developing embryo and adult mice in the steady state and during inflammation using Il34(LacZ) reporter mice and newly generated inducible Il34-knockout mice.
Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study.
Prados et al., India. In Neuro Oncol, Nov 2015
BACKGROUND: The colony stimulating factor 1 receptor (CSF1R) ligands, CSF1 and interleukin-34, and the KIT ligand, stem cell factor, are expressed in glioblastoma (GB).
Transplant tolerance: a new role for IL-34.
Turka et al., In J Clin Invest, Nov 2015
In this issue, Bézie and colleagues identify IL-34 as an important mediator of allograft tolerance in a rat model of heart transplantation.
IL-34 is a Treg-specific cytokine and mediates transplant tolerance.
Guillonneau et al., In J Clin Invest, Nov 2015
Here, we have shown that the cytokine IL-34, the immunoregulatory properties of which have not been previously studied in transplantation or T cell biology, is expressed by rodent CD8+CD45RClo Tregs and human FOXP3+CD45RCloCD8+ and CD4+ Tregs.
Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.
Savvides et al., Gent, Belgium. In Structure, Oct 2015
Human colony-stimulating factor 1 receptor (hCSF-1R) is unique among the hematopoietic receptors because it is activated by two distinct cytokines, CSF-1 and interleukin-34 (IL-34).
[Current Topics on Vitamin D. The role of active forms of vitamin D in regulation of bone remodeling].
Takahashi et al., Matsumoto, Japan. In Clin Calcium, Mar 2015
Recently, IL-34 was discovered as a cytokine functionally overlapping M-CSF.
Cytokine-modulating strategies and newer cytokine targets for arthritis therapy.
Moudgil et al., Baltimore, United States. In Int J Mol Sci, 2014
Furthermore, the relatively newer cytokines such as IL-32, IL-34 and IL-35 are being investigated for their potential role in the pathogenesis and treatment of arthritis.
Targeting IL-34 in chronic inflammation.
Wong et al., San Francisco, United States. In Drug Discov Today, 2014
IL-34 and CSF-1 signal through this common receptor to mediate the biology of mononuclear phagocytic cells.
CSF-1 receptor signaling in myeloid cells.
Chitu et al., New York City, United States. In Cold Spring Harb Perspect Biol, 2014
The CSF-1 receptor (CSF-1R) is activated by the homodimeric growth factors colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34).
[Microglia in neurodegenerative disorders and neuroinflammation].
Suzumura, Nagoya, Japan. In Rinsho Shinkeigaku, 2013
For example, the CX3C chemokine fractalkine, interleukin-34, and fibroblast growth factor-2 are secreted from damaged neurons; these help-me signals induce various microglial activities to rescue neurons, including upregulated phagocytosis of toxicants and damaged debris, and production of antioxidant enzymes and other neurotrophic factors.
Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia.
Becher et al., Zürich, Switzerland. In Immunity, 2013
Here we show that in both mice and humans, interleukin-34 (IL-34), an alternative ligand for Csf-1 receptor, is produced by keratinocytes in the epidermis and by neurons in the brain.
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia.
Colonna et al., Saint Louis, United States. In Nat Immunol, 2012
Here we investigated whether an alternative CSF1R ligand, interleukin 34 (IL-34), is responsible for this discrepancy.
Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients.
Heymann et al., France. In Ann Rheum Dis, 2012
study identifies IL-34 expression in the synovial tissue of patients with arthritis; this cytokine, as a downstream effector of TNFalpha and IL-1beta, may contribute to inflammation and bone erosions in rheumatoid arthritis
Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells.
Stanley et al., United States. In J Leukoc Biol, 2010
The different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues.
Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.
Williams et al., San Francisco, United States. In Science, 2008
Discovered IL-34 and its receptor CSF1 by functional screening of the extracellular proteome.
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