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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 33

IL-33, interleukin-33
IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011] (from NCBI)
Top mentioned proteins: TH2, IL-1beta, IL-13, CAN, IL-5
Papers using IL-33 antibodies
Basophils are essential initiators of a novel type of chronic allergic inflammation.
Unutmaz Derya, In PLoS ONE, 2006
... Rabbit polyclonal anti-mouse IL-33 and recombinant IL-33109–266 were obtained from Axxora.
Papers on IL-33
Controlling the burn and fueling the fire: defining the role for the alarmin interleukin-33 in alloimmunity.
Turnquist et al., Pittsburgh, United States. In Curr Opin Organ Transplant, Feb 2016
PURPOSE OF REVIEW: The purpose of this review is to provide a general update on recent developments in the immunobiology of IL-33 and IL-33-targeted immune cells.
Interleukin 33 is a guardian of barriers and a local alarmin.
Martin et al., Hannover, Germany. In Nat Immunol, Feb 2016
Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing number of target cells and a plethora of biological functions.
ΔNp63 regulates IL-33 and IL-31 signaling in atopic dermatitis.
Romano et al., Buffalo, United States. In Cell Death Differ, Feb 2016
Of particular significance are two p63 target genes, IL-31 and IL-33, both of which are key players in the signaling pathways implicated in AD.
Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit.
Locksley et al., San Francisco, United States. In Nature, Feb 2016
Experiments in mice and humans have demonstrated requirements for the epithelial cytokines IL-33, thymic stromal lymphopoietin (TSLP) and IL-25 in the activation of ILC2s, but the sources and regulation of these signals remain poorly defined.
Substance P, Hemokinin-1, CRH, TNF and IL-6 are increased in serum of patients with Fibromyalgia Syndrome and may serve both as biomarkers and targets for treatment.
Theoharides et al., Logan, United States. In J Pharmacol Exp Ther, Feb 2016
In contrast, serum IL-31 and IL-33 levels were significantly lower (p=0.0001
Elevated levels of Interleukin (IL)-33 induce bone pathology but absence of IL-33 does not negatively impact normal bone homeostasis.
Benschop et al., Indianapolis, United States. In Cytokine, Feb 2016
IL-33 effects are mediated through its receptor, ST2 and IL-1RAcP, and its signaling induces the production of a number of pro-inflammatory mediators, including TNFα, IL-1β, IL-6, and IFN-γ.
Recent advances in understanding the roles of vascular endothelial cells in allergic inflammation.
Matsuda et al., Tokyo, Japan. In Allergol Int, Jan 2016
Additionally, endothelial cells were recently shown to be important functional targets for IL-33-an essential regulator of allergic inflammation.
Drivers of chronic rhinosinusitis: Inflammation versus infection.
Hamilos, Boston, United States. In J Allergy Clin Immunol, Dec 2015
Conversely, certain innate factors, namely IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), are elaborated by sinus epithelial cells in response to microbial stimulation or airway injury and promote local TH2 inflammation.
Measuring serum concentrations of interleukin-33 in atopic dermatitis is associated with potential false positive results.
Hvid et al., Århus, Denmark. In Springerplus, Dec 2015
Interleukin-33 is a relatively newly described cytokine, which holds a promising potential as a biomarker for different diseases including atopic dermatitis.
Oral Probiotic VSL#3 Prevents Autoimmune Diabetes by Modulating Microbiota and Promoting Indoleamine 2,3-Dioxygenase-Enriched Tolerogenic Intestinal Environment.
Falcone et al., Milano, Italy. In J Diabetes Res, Dec 2015
In particular, we show that VSL#3 treatment inhibits IL-1β expression while enhancing release of protolerogenic components of the inflammasome, such as indoleamine 2,3-dioxygenase (IDO) and IL-33.
Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer.
Takenaga et al., Izumo, Japan. In Cell Death Dis, Dec 2015
The proinflammatory interleukin-33 (IL-33) binds to its receptor ST2L on the surface of immune cells and stimulates the production of Th2 cytokines; however, the effects of IL-33 on tumour cells are poorly understood.
Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy.
Wang et al., Cincinnati, United States. In Immunity, Nov 2015
Herein, we have reported the identification of multifunctional IL-9-producing mucosal mast cells (MMC9s) that can secrete prodigious amounts of IL-9 and IL-13 in response to IL-33, and mast cell protease-1 (MCPt-1) in response to antigen and IgE complex crosslinking, respectively.
Innate immunological function of TH2 cells in vivo.
Paul et al., Bethesda, United States. In Nat Immunol, Oct 2015
This innate response is dependent on IL-33 but not T cell antigen receptors (TCRs).
Role of TNF in mast cell neuroinflammation and pain.
Conti et al., Zhengzhou, China. In J Biol Regul Homeost Agents, Oct 2015
Activation of MCs leads to NF-κB and AP1 generation with release of many cytokines including TNF, IL-33 and IL-1.
A Distinct Function of Regulatory T Cells in Tissue Protection.
Rudensky et al., New York City, United States. In Cell, Sep 2015
This tissue repair modality is mobilized in Treg cells in response to inflammatory mediator IL-18 or alarmin IL-33, but not by TCR signaling that is required for suppressor function.
The alarmin IL-33 is a notch target in quiescent endothelial cells.
Haraldsen et al., Oslo, Norway. In Am J Pathol, 2012
Endothelial nuclear IL-33 is induced by Notch and that Dll4 may be the dominant ligand responsible for this signaling in vivo.
Full-length IL-33 promotes inflammation but not Th2 response in vivo in an ST2-independent fashion.
Atamas et al., Baltimore, United States. In J Immunol, 2012
Full-length interleukin (IL)-33 is functionally active in vivo in an IL-1 receptor-like 1 (ST2)-independent fashion, and its effects are partially different from those of mature IL-33.
IL-33 priming regulates multiple steps of the neutrophil-mediated anti-Candida albicans response by modulating TLR and dectin-1 signals.
Kwon et al., Ulsan, South Korea. In J Immunol, 2012
The priming effect of IL-33 occurs during multiple steps of the neutrophil-mediated anti-fungal response: first, rapid induction of neutrophils to the site of the infection, and second, conditioning of neutrophils by IL-33.
Presensitizing with a Toll-like receptor 3 ligand impairs CD8 T-cell effector differentiation and IL-33 responsiveness.
Vella et al., Farmington, United States. In Proc Natl Acad Sci U S A, 2012
nonsensitized effector CD8 T cells responded robustly to IL-33 using a two-signal cytokine mechanism
Nuclear IL-33 is a transcriptional regulator of NF-κB p65 and induces endothelial cell activation.
Kwon et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
data provide the first evidence that IL-33 in the nucleus of endothelial cells participates in inflammatory reactions as a transcriptional regulator of NF-kappaB p65.
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