Pathophysiology of Pruritus in Primary Localised Cutaneous Amyloidosis.
Singapore, Singapore. In Br J Dermatol, Feb 2016
Lesional biopsies were stained for IENF, IL-31 and its receptor's subunits (IL-31RA and OSMRβ), and NGF and its receptor (TrkA), and were compared with age-, gender-, ethnic-, and site-matched normal skin obtained from archival paraffin-embedded specimens.
Philadelphia, United States. In Eur J Pain, Jan 2016
Cutaneous T-cell lymphomas (CTCL), particularly more advanced stages, cause intractable pruritus and recent investigations into the pathophysiology of CTCL-associated itch have implicated cyotokine interleukin-31 as a putative mediator.
Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?
Philadelphia, United States. In Clin Rev Allergy Immunol, Jun 2015
Various receptors (TRPA1, TRPV1, PAR2, gastrin-releasing peptide receptor (GRPR), Mas-related G proteins), secreted molecules (histamine, nerve growth factor (NGF), substance P (SP), proteases), and cytokines/chemokines (thymic stromal lymphopoietin (TSLP), IL-2, IL-4, IL-13, and IL-31) are implicated as mediators of chronic pruritus.