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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 31

IL-31, Interleukin-31
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: TH2, Interleukin-6, IL-4, IL-13, Itch
Papers on IL-31
IL-31-induced pruritus in dogs: a novel experimental model to evaluate anti-pruritic effects of canine therapeutics.
McCall et al., Kalamazoo, United States. In Vet Dermatol, Feb 2016
IL-31 is a cytokine found in the serum of some dogs with AD and can induce pruritic behaviours in laboratory beagle dogs.
ΔNp63 regulates IL-33 and IL-31 signaling in atopic dermatitis.
Romano et al., Buffalo, United States. In Cell Death Differ, Feb 2016
Of particular significance are two p63 target genes, IL-31 and IL-33, both of which are key players in the signaling pathways implicated in AD.
The association of interleukin-31 polymorphisms with interleukin-31 serum levels and risk of systemic lupus erythematosus.
Wei et al., China. In Rheumatol Int, Feb 2016
UNASSIGNED: Interleukin-31 (IL-31) is the most recently discovered member of the gp130/IL-6 cytokine family which is produced mainly by activated Th2 cells.
Substance P, Hemokinin-1, CRH, TNF and IL-6 are increased in serum of patients with Fibromyalgia Syndrome and may serve both as biomarkers and targets for treatment.
Theoharides et al., Logan, United States. In J Pharmacol Exp Ther, Feb 2016
In contrast, serum IL-31 and IL-33 levels were significantly lower (p=0.0001
Pathophysiology of Pruritus in Primary Localised Cutaneous Amyloidosis.
Yosipovitch et al., Singapore, Singapore. In Br J Dermatol, Feb 2016
Lesional biopsies were stained for IENF, IL-31 and its receptor's subunits (IL-31RA and OSMRβ), and NGF and its receptor (TrkA), and were compared with age-, gender-, ethnic-, and site-matched normal skin obtained from archival paraffin-embedded specimens.
Medium-dose ultraviolet A1 phototherapy improves SCORAD index and increases mRNA expression of interleukin-4 without direct effect on human β defensin-1, interleukin-10, and interleukin-31.
Wozniacka et al., Łódź, Poland. In Int J Dermatol, Feb 2016
The aim of the study was to investigate whether mRNA expression of human β defensin-1 (hβD-1) correlates with that of interleukin (IL)-4, IL-10, and IL-31 in skin lesions in AD before and after UVA1 phototherapy, to determine whether UVA1 decreases the expression of the aforementioned mediators, and to confirm whether changes in mRNA expression correspond with the clinical efficacy of UVA1.
Malignancy-associated pruritus.
Yosipovitch et al., Philadelphia, United States. In Eur J Pain, Jan 2016
Cutaneous T-cell lymphomas (CTCL), particularly more advanced stages, cause intractable pruritus and recent investigations into the pathophysiology of CTCL-associated itch have implicated cyotokine interleukin-31 as a putative mediator.
Possible Antipruritic Mechanism of Cyclosporine A in Atopic Dermatitis.
Takamori et al., In Acta Derm Venereol, Jan 2016
Intraperitoneal injection of cyclosporine A dose-dependently inhibited increased itch-related receptor gene expression, such as interleukin-31 receptor A and neurokinin-1 receptor, in the dorsal root ganglion of atopic dermatitis model mice.
Itching sensation in psoriatic patients and its relation to body mass index and IL-17 and IL-31 concentrations.
Jenerowicz et al., Poznań, Poland. In Postepy Dermatol Alergol, Dec 2015
Moreover, serum levels of interleukin 17 (IL-17) and IL-31 were analyzed in relation to Psoriasis Activity and Severity Index, BMI and severity of pruritus.
Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology.
Hermanns, Würzburg, Germany. In Cytokine Growth Factor Rev, Oct 2015
Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ).
Emerging drugs for the treatment of pruritus.
Raap et al., Münster, Germany. In Expert Opin Emerg Drugs, Sep 2015
Targets identified are, for example, receptors for substance P, IL-31 and nerve growth factor.
EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders.
Spertini et al., Zürich, Switzerland. In Allergy, Jul 2015
These include agents targeting IgE; T helper 2 (Th2)-type and Th2-promoting cytokines, including interleukin-4 (IL-4), IL-5, IL-9, IL-13, IL-31, and thymic stromal lymphopoietin (TSLP); pro-inflammatory cytokines, such as IL-1β, IL-12, IL-17A, IL-17F, IL-23, and tumor necrosis factor (TNF); chemokine receptor CCR4; and lymphocyte surface and adhesion molecules, including CD2, CD11a, CD20, CD25, CD52, and OX40 ligand.
Increased levels of interleukin 31 (IL-31) in osteoporosis.
Gangemi et al., L'Aquila, Italy. In Bmc Immunol, 2014
Until now, involvement of the Th2 cytokine interleukin-31 (IL-31) in osteoporosis hadn't yet been studied.
Role of cytokines and chemokines in itch.
Steinhoff et al., Dublin, Ireland. In Handb Exp Pharmacol, 2014
For some cytokines such as IL-31 and TSLP, the evidence for this role is strong in rodents.
Dendritic cells activated by IFN-γ/STAT1 express IL-31 receptor and release proinflammatory mediators upon IL-31 treatment.
Duschl et al., Salzburg, Austria. In J Immunol, 2012
IL-31-specific activation of dendritic cells may be part of a positive feedback loop driving the progression of inflammatory skin diseases.
Increased frequencies of IL-31-producing T cells are found in chronic atopic dermatitis skin.
Middelkamp-Hup et al., Amsterdam, Netherlands. In Exp Dermatol, 2012
T cells in chronic atopic dermatitis (AD) skin produce IL-31 and AD lesions contain increased levels of these IL-31-producing T cells.
IL-31 significantly correlates with disease activity and Th2 cytokine levels in children with atopic dermatitis.
Fölster-Holst et al., Hannover, Germany. In Pediatr Allergy Immunol, 2012
IL-31 serum levels correlate with the SCORAD score, sleeplessness, and Th2 cytokines including IL-4 and IL-13, in sixty children with the extrinsic type of atopic dermatitis.
IL-31 regulates differentiation and filaggrin expression in human organotypic skin models.
Baron et al., Aachen, Germany. In J Allergy Clin Immunol, 2012
This study suggests that IL-31 is an important regulator of keratinocyte differentiation and demonstrates a link between the presence of IL-31 in skin, as found in patients with atopic dermatitis, and filaggrin expression
Distinct SPINK5 and IL-31 polymorphisms are associated with atopic eczema and non-atopic hand dermatitis in Taiwanese nursing population.
Chen et al., Kao-hsiung, Taiwan. In Exp Dermatol, 2011
Distinct SPINK5 and IL-31 gene variants (SNPs) were associated with the development of atopic eczema and non-atopic hand dermatitis in Taiwanese nurses.
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice.
Gross et al., Seattle, United States. In Nat Immunol, 2004
IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases
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