Pathophysiology of Pruritus in Primary Localised Cutaneous Amyloidosis.
Singapore, Singapore. In Br J Dermatol, Feb 2016
Lesional biopsies were stained for IENF, IL-31 and its receptor's subunits (IL-31RA and OSMRβ), and NGF and its receptor (TrkA), and were compared with age-, gender-, ethnic-, and site-matched normal skin obtained from archival paraffin-embedded specimens.
Philadelphia, United States. In Eur J Pain, Jan 2016
Cutaneous T-cell lymphomas (CTCL), particularly more advanced stages, cause intractable pruritus and recent investigations into the pathophysiology of CTCL-associated itch have implicated cyotokine interleukin-31 as a putative mediator.
EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders.
Zürich, Switzerland. In Allergy, Jul 2015
These include agents targeting IgE; T helper 2 (Th2)-type and Th2-promoting cytokines, including interleukin-4 (IL-4), IL-5, IL-9, IL-13, IL-31, and thymic stromal lymphopoietin (TSLP); pro-inflammatory cytokines, such as IL-1β, IL-12, IL-17A, IL-17F, IL-23, and tumor necrosis factor (TNF); chemokine receptor CCR4; and lymphocyte surface and adhesion molecules, including CD2, CD11a, CD20, CD25, CD52, and OX40 ligand.