IFN-lambda therapy: current status and future perspectives.
United States. In Drug Discov Today, Dec 2015
UNASSIGNED: Interferon-lambda (IFN-λ), the most recently described type III IFN, plays a crucial part by acting on specific cell types, controlling viral infections and establishing robust innate immunity against cancer.
Interferon-λ: Immune Functions at Barrier Surfaces and Beyond.
Saint Louis, United States. In Immunity, Aug 2015
When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs (IFN-α and IFN-β) via the induction of IFN-stimulated genes (ISGs).
Role of Interferon-λ in Allergic Asthma.
Erlangen, Germany. In J Innate Immun, 2014
Asthmatic patients, without a detectable viral infection show an inverse correlation between IL-28 and IL-29 mRNA levels and severity of allergic responses in the airways.
IL-10 function, regulation, and in bacterial keratitis.
Detroit, United States. In J Ocul Pharmacol Ther, 2014
The interleukin (IL)-10 family of cytokines, composed of 9 members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and 3 distantly related members, IL-28A, IL-28B, and IL-29, plays a central role in this regulation.
Regulation and functions of the IL-10 family of cytokines in inflammation and disease.
San Francisco, United States. In Annu Rev Immunol, 2010
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and the more distantly related IL-28A, IL-28B, and IL-29.
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.
Durham, United States. In Nature, 2009
Here we report that a genetic polymorphism near the IL28B gene, encoding interferon-lambda-3 (IFN-lambda-3), is associated with an approximately twofold change in response to treatment, both among patients of European ancestry (P = 1.06 x 10(-25)) and African-Americans (P = 2.06 x 10(-3)).
Interleukin-10 and related cytokines and receptors.
United States. In Annu Rev Immunol, 2003
The Class 2 alpha-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22, IL-24 (Mda-7), and IL-26, interferons (IFN-alpha, -beta, -epsilon, -kappa, -omega, -delta, -tau, and -gamma) and interferon-like molecules (limitin, IL-28A, IL-28B, and IL-29).