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Interleukin 28A

IL-28A, IFN-lambda2, interleukin-28A, interleukin-28
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-29, IL-10, CAN, IL-21, HAD
Papers on IL-28A
Regulation of tissue infiltration by neutrophils: role of integrin α3β1 and other factors.
New
Chavakis et al., Philadelphia, United States. In Curr Opin Hematol, Jan 2016
Furthermore, several endogenous inhibitory mechanisms of leukocyte recruitment have been identified, including the secreted molecules Del-1, PTX3, and GDF-15, which block distinct steps of the leukocyte adhesion cascade, as well as novel regulatory signaling pathways, involving the protein kinase AKT1 and IFN-λ2/IL-28A.
Glucocorticoid receptors, brain-derived neurotrophic factor, serotonin and dopamine neurotransmission are associated with interferon-induced depression.
New
Martín-Santos et al., Barcelona, Spain. In Int J Neuropsychopharmacol, Jan 2016
We genotyped several functional polymorphisms of interleukin-28 (IL28B), indoleamine 2,3-dioxygenase (IDO-1), serotonin receptor-1A (HTR1A), catechol-O-methyl transferase (COMT), glucocorticoid receptors (GCR1 and GCR2), brain-derived neurotrophic factor (BDNF) and FK506 binding protein 5 (FKBP5) genes.
Expression of Early Growth Response Gene-2 and Regulated Cytokines Correlates with Recovery from Guillain-Barré Syndrome.
New
de la Fuente et al., Toledo, Spain. In J Immunol, Jan 2016
The results provided evidence for the implication of EGR2 in GBS and suggested a role for EGR2 in the regulation of IL-17, IL-22, IL-28A, and TNF-β cytokines in GBS patients.
Enhanced Anti-Tumor (Anti-Proliferation) Activity of Recombinant Human Interleukin-29 (IL-29) Mutants Using Site-Directed Mutagenesis Method.
New
Wu et al., Wuxi, China. In Appl Biochem Biotechnol, Nov 2015
Interferon (IFN)-λ, also known as IL-28A, IL-28B, or IL-29, is a new type III IFN, which shares many functional characteristics with type I IFN (α/β).
Interferon-λ: Immune Functions at Barrier Surfaces and Beyond.
Review
New
Impact
Diamond et al., Saint Louis, United States. In Immunity, Aug 2015
When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs (IFN-α and IFN-β) via the induction of IFN-stimulated genes (ISGs).
[Impact of interleukin-10 and interleukin-28 gene polymorphisms on the development and course of lupus nephritis].
Mukhin et al., In Ter Arkh, 2014
AIM: To assess the relationship of the carriage of IL-10-1080 G/A and IL-28 rs8099917 C/T polymorphisms to the course of lupus nephritis (LN).
Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese.
Wei et al., Kunming, China. In Genet Mol Res, 2014
The aim of this study was to determine the relationship between polymorphisms in the IL-28B and IL-28R genes and lower urinary tract symptoms (LUTS) in Chinese patients.
IL-10 function, regulation, and in bacterial keratitis.
Review
McClellan et al., Detroit, United States. In J Ocul Pharmacol Ther, 2014
The interleukin (IL)-10 family of cytokines, composed of 9 members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and 3 distantly related members, IL-28A, IL-28B, and IL-29, plays a central role in this regulation.
[Significance of allelic variants of interleukin-28B gene in chronic hepatitis C].
Review
Krasnova et al., In Ter Arkh, 2012
Major attention is paid to the discussion of the value of the allelic variants of IL-28B during standard double and current triple antiviral therapy for chronic hepatitis C. Furthermore, the paper covers the biological role of interferon-lambda, a product of IL-28A, B, and IL-29 gene expression, other associations of the allelic variants of the IL-28B gene with different clinical signs, as well as the possibilities of practical use of this genetic marker in chronic hepatitis C today and futures prospects.
Novel type III interferons produce anti-tumor effects through multiple functions.
Review
Tagawa et al., Chiba, Japan. In Front Biosci, 2012
They include IFN-lambda1, IFN-lambda2 and IFN-lambda3, which are also named as interleukin (IL)-29, IL-28A and IL-28B, respectively.
Interferons lambda, new cytokines with antiviral activity.
Review
Kabát et al., Bratislava, Slovakia. In Acta Virol, 2012
This family consists of three structurally related IFN-λ subtypes called IFN-λ1 (IL-29), IFN-λ2 (IL-28A), and IFN-λ3 (IL-28B).
Sequence analysis of the IL28A/IL28B inverted gene duplication that contains polymorphisms associated with treatment response in hepatitis C patients.
GeneRIF
Johnston et al., United States. In Plos One, 2011
This study aimed to 1) examine DNA sequences in IL28B surrounding each of the reported associated single nucleotide polymorphisms and the corresponding regions in IL28A.
IL-29/IL-28A suppress HSV-1 infection of human NT2-N neurons.
GeneRIF
Ho et al., Philadelphia, United States. In J Neurovirol, 2011
IL-29/IL-28A suppress herpes simplex virus type 1 (HSV-1) infection of human NT2-N neurons.
Interferon-lambda serum levels in hepatitis C.
GeneRIF
Spengler et al., Bonn, Germany. In J Hepatol, 2011
In general IL-29 serum levels exceeded IL-28A/B at least twofold, with IL-29 and IL-28A/B levels being significantly higher in carriers of the rs12979860 C allele than in TT homozygous individuals in hepatitis C
Regulation and functions of the IL-10 family of cytokines in inflammation and disease.
Review
Impact
Hymowitz et al., San Francisco, United States. In Annu Rev Immunol, 2010
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and the more distantly related IL-28A, IL-28B, and IL-29.
Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection.
GeneRIF
McCarthy et al., Durham, United States. In Hepatology, 2010
Chronic hepatitis C patients with the rs12979860 CC responder genotype may have a lower endogenous IFN response to the virus.
Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus.
GeneRIF
Brand et al., München, Germany. In Plos One, 2009
In contrast to IL-29, IL-28A is a potent gene repressor in patients with hepatitis C
Interleukin-10 and related cytokines and receptors.
Review
Impact
Fisher et al., United States. In Annu Rev Immunol, 2003
The Class 2 alpha-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22, IL-24 (Mda-7), and IL-26, interferons (IFN-alpha, -beta, -epsilon, -kappa, -omega, -delta, -tau, and -gamma) and interferon-like molecules (limitin, IL-28A, IL-28B, and IL-29).
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
Impact
GeneRIF
Donnelly et al., Newark, United States. In Nat Immunol, 2003
closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3
IL-28, IL-29 and their class II cytokine receptor IL-28R.
Impact
GeneRIF
Klucher et al., Seattle, United States. In Nat Immunol, 2003
identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family
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