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Interleukin 26

IL-26, AK155, interleukin-26
This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: IL-21, IL-10, P28, IL-19, FISP
Papers on IL-26
Targeting Th17 Effector Cytokines for the Treatment of Autoimmune Diseases.
Yang et al., Cambridge, United States. In Arch Immunol Ther Exp (warsz), Dec 2015
The pathogenic function of Th17 cells results from their production of Th17 effector cytokines, namely IL-17 (or IL-17A), IL-17F, IL-22 and IL-26.
Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency.
Cunningham-Rundles et al., New York City, United States. In J Allergy Clin Immunol, Dec 2015
ILCs contained detectable amounts of the transcription factors inhibitor of DNA binding 2, T-box transcription factor, and RORγt and increased mRNA transcripts for IL-23 receptor (IL-23R) and IL-26, demonstrating inflammatory potential.
Identification of interleukin-26 in the dromedary camel (Camelus dromedarius): Evidence of alternative splicing and isolation of novel splice variants.
Rasool et al., Al `Ayn, United Arab Emirates. In Mol Immunol, Oct 2015
Interleukin-26 (IL-26) is a member of the IL-10 family of cytokines.
Association analysis of class II cytokine and receptor genes in vitiligo patients.
Kingo et al., Tartu, Estonia. In Hum Immunol, Oct 2015
The strongest involved SNPs rs12301088 (near IL26 gene), that was associated with familial vitiligo and existence of halo nevi, and rs2257167 (IFNAR1 gene), that was associated with female vitiligo.
T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.
Gilliet et al., Houston, United States. In Nat Immunol, Sep 2015
We found that interleukin 26 (IL-26), a human T(H)17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation.
Interleukin-26: An Emerging Player in Host Defense and Inflammation.
Lindén et al., Göteborg, Sweden. In J Innate Immun, Aug 2015
However, more recent findings indicate IL-26 production in natural killer (NK) cells, macrophages and fibroblast-like cells as well.
Cytokine crowdsourcing: multicellular production of TH17-associated cytokines.
O'Connor et al., Albany, United States. In J Leukoc Biol, Mar 2015
IL-17A is often present in a composite milieu that includes cytokines produced by TH17 cells (i.e., IL-17F, IL-21, IL-22, and IL-26) or associated with other T cell lineages (e.g., IFN-γ).
Association between the Interaction of Key Genes Involved in Effector T-Cell Pathways and Susceptibility to Developallergic Rhinitis: A Population-Based Case-Control Association Study.
Zhang et al., Beijing, China. In Plos One, 2014
RESULTS: Simple SNP-phenotype association analysis using logistic regression showed SNP rs8193036 in IL17A gene, rs2569254 in IL-12 and rs1898413 in RORα weresignificantlyassociatedwith AR.Simple SNP-phenotype association analysis with genetic models demonstrated thatrs2569254 in IL-12, rs1031508 in STAT4, and rs3741809 in IL-26 were likely to be recessive, rs8193036 in IL17A allelic, rs897200in STAT4 genotypic, and rs1898413 in RORα dominant.
The IL-20 subfamily of cytokines--from host defence to tissue homeostasis.
Ouyang et al., San Francisco, United States. In Nat Rev Immunol, 2014
The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24 and IL-26.
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family.
Vannay et al., Budapest, Hungary. In Mediators Inflamm, 2014
In the present review we provide an overview of the common key mediators of organ fibrosis highlighting the role of interleukin-10 (IL-10) cytokine family members (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26), which recently came into focus as tissue remodeling-related inflammatory cytokines.
Targeting Th17 cells in autoimmune diseases.
Yamagata et al., Cambridge, United States. In Trends Pharmacol Sci, 2014
Given that Th17 cells express IL-17 together with many other proinflammatory cytokines [IL-17F, IL-22, IL-26, and granulocyte-macrophage colony-stimulating factor (GM-CSF)], targeting the Th17 cell lineage may be superior to blocking a single effector cytokine.
IL-10 function, regulation, and in bacterial keratitis.
McClellan et al., Detroit, United States. In J Ocul Pharmacol Ther, 2014
The interleukin (IL)-10 family of cytokines, composed of 9 members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and 3 distantly related members, IL-28A, IL-28B, and IL-29, plays a central role in this regulation.
Regulation and functions of the IL-10 family of cytokines in inflammation and disease.
Hymowitz et al., San Francisco, United States. In Annu Rev Immunol, 2010
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and the more distantly related IL-28A, IL-28B, and IL-29.
CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus.
Wilson et al., Seattle, United States. In Immunity, 2009
Here we identify a cryptic upstream orchestrator of interferon-gamma (IFNG) transcription, which is embedded within the human IL26 gene, compromised of a single CCCTC-binding factor (CTCF) binding site and retained in all mammals, even surviving near-complete evolutionary deletion of the equivalent gene encoding IL-26 in rodents.
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity.
Colonna et al., Saint Louis, United States. In Nature, 2009
Here we report the characterization of a human NK cell subset located in mucosa-associated lymphoid tissues, such as tonsils and Peyer's patches, which is hard-wired to secrete interleukin (IL)-22, IL-26 and leukaemia inhibitory factor.
An unexpected discovery of two interferon gamma-like genes along with interleukin (IL)-22 and -26 from teleost: IL-22 and -26 genes have been described for the first time outside mammals.
Savan et al., Miyazaki, Japan. In Mol Immunol, 2006
Expression analysis of IL-22, IL-26 and two IFN-gamma genes suggests an active role of these genes in immune responses in fish.
The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains.
Fickenscher et al., Cambridge, United Kingdom. In J Biol Chem, 2004
sensitivity to recombinant interleukin-26(IL-26) of various cell lines strictly correlated with the expression of IL-20 receptor 1 and blocking antibodies against either IL-10 receptor 2 or IL-20 receptor 1 inhibited IL-26-dependent signal transduction
Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2.
Kotenko et al., Bethesda, United States. In J Immunol, 2004
The active receptor complex for IL-26 is a heterodimer composed of two receptor proteins: IL-20 receptor 1 and IL-10 receptor 2. Signaling through the IL-26 receptor results in activation of STAT1 and STAT3.
Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis.
Rooney et al., Belfast, United Kingdom. In Arthritis Rheum, 2003
common polymorphisms in the IFNgamma/IL-26 gene region may contribute to sex bias in susceptibility to rheumatoid arthritis, by distorting the propensity of female carriers versus male carriers to contract this disease.
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