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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Jun 2015.

Interleukin 25

IL-25, IL-17E, Interleukin-25
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: TH2, IL-17, IL-13, IL-33, IL-4
Papers on IL-25
ILC2s and fungal allergy.
Review
New
Kita, Rochester, United States. In Allergol Int, 31 Jul 2015
In mouse models of fungus-induced allergic airway inflammation, IL-33, IL-25, and TSLP are released by airway epithelial cells.
Immunomodulatory effect of tonsil-derived mesenchymal stem cells in mouse model of allergic rhinitis.
New
Mo et al., In Am J Rhinol Allergy, 16 Jul 2015
In addition, innate cytokine (IL-25 and IL-33) expression and eotaxin messenger RNA expression was inhibited in the nasal mucosa, which is suggestive of the mechanism of reduced allergic inflammation.
Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps.
New
Liu et al., Wuhan, China. In Allergy, 10 Jul 2015
BACKGROUND: Thymic stromal lymphopoietin (TSLP), IL-25, and IL-33 system contribute to the initiation and development of Th2 responses.
Triclosan induces thymic stromal lymphopoietin in skin promoting Th2 allergic responses.
New
Anderson et al., Morgantown, United States. In Toxicol Sci, 05 Jul 2015
Exposure to triclosan increased the expression of TSLP, IL-1β and TNF-α in the skin with concomitant decreases in IL-25, IL-33 and IL-1α.
Convergence of air pollutant-induced redox-sensitive signals in the dendritic cells contributes to asthma pathogenesis.
Review
New
Buglak et al., East Lansing, United States. In Toxicol Lett, 27 Jun 2015
The epithelial cells can further enhance the DC response to allergen and PM through several immune regulatory cytokines including thymic stromal lymphopoietin (TSLP), IL-33, and IL-25.
Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation.
New
Impact
Dong et al., Chicago, United States. In Immunity, 21 May 2015
Among them, IL-25 has been shown to be important in allergic inflammation and protection against parasitic infection.
Role of IL-25 in Immunity.
Review
New
Parizad et al., Īlām, Iran. In J Clin Diagn Res, Apr 2015
IL-25 a 2o KDa protein mostly known as IL-17E, encoded by chromosome 14, and containing 117 amino acids.
[Effects of acupuncture stimulation of different acupoint groups on sleeping latency, serum and hippocampal TNF-α and IL-25 contents in rats with gastric mucosal injury].
New
Ma et al., In Zhen Ci Yan Jiu, Apr 2015
The contents of tumor necrosis factor-alpha (TNF-α) and interleukin-25(IL-25) in the serum and hippocampal tissues were detected by ELISA.
Epithelial cytokines and pulmonary allergic inflammation.
Review
New
Saglani et al., London, United Kingdom. In Curr Opin Immunol, Mar 2015
UNASSIGNED: The triad of epithelial derived cytokines, IL-25, IL-33 and TSLP are important for the initiation and development of pulmonary immune responses to environmental stimuli.
IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential 'inflammatory' type 2 innate lymphoid cells.
New
Impact
Paul et al., Bethesda, United States. In Nat Immunol, Feb 2015
We report the existence of an inflammatory ILC2 (iILC2) population responsive to interleukin 25 (IL-25) that complemented IL-33-responsive natural ILC2 (nILC2) cells.
Group 2 Innate Lymphoid Cells in Health and Disease.
Review
New
Artis et al., New York City, United States. In Cold Spring Harb Perspect Biol, Feb 2015
The epithelial cell-derived cytokines IL-25, IL-33, and TSLP regulate the activation and effector functions of ILC2s, and recent studies suggest that their responsiveness to these cytokines and other factors may depend on their tissue environment.
Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study.
New
Liu et al., Wuhan, China. In Bmc Immunol, Dec 2014
RESULTS: We found that both clarithromycin and dexamethasone up-regulated the production of anti-inflammatory mediators (Clara cell 10-kDa protein and interleukin (IL)-10), whereas down-regulated the production of Th2 response and eosinophilia promoting molecules (thymic stromal lymphopoietin, IL-25, IL-33, CD80, CD86, OX40 ligand, programmed cell death ligand 1, CCL17, CCL22, CCL11, CCL5, IL-5, IL-13, and eosinophilic cationic protein) and Th1 response and neutrophilia promoting molecules (CXCL8, CXCL5, CXCL10, CXCL9, interferon-γ, and IL-12), from sinonasal mucosa from distinct phenotypic CRS.
Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.
New
Impact
Locksley et al., San Francisco, United States. In Immunity, Apr 2014
We show that inhaled chitin induced expression of three epithelial cytokines, interleukin-25 (IL-25), IL-33, and thymic stromal lymphopoietin (TSLP), which nonredundantly activated resident innate lymphoid type 2 cells (ILC2s) to express IL-5 and IL-13 necessary for accumulation of eosinophils and alternatively activated macrophages (AAMs).
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.
Impact
Casanova et al., New York City, United States. In Immunity, 2013
The patients' fibroblasts failed to respond to IL-17A and IL-17F, and their T cells to IL-17E.
TH2, allergy and group 2 innate lymphoid cells.
Review
Impact
Flavell et al., New Haven, United States. In Nat Immunol, 2013
The initiation of type 2 immune responses by the epithelial cell-derived cytokines IL-25, IL-33 and TSLP has been an area of extensive research in the past decade.
Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population.
Impact
GeneRIF
Li et al., Cleveland, United States. In Immunity, 2012
Th2 cell-inducing cytokine (IL-25) expression were reduced in the intestinal epithelial cells from the infected and IL-25-injected epithelial-specific Act1-deficient mice.
Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology.
Impact
GeneRIF
Lukacs et al., Ann Arbor, United States. In Nat Med, 2012
data establish IL-25 and its receptor IL-17RB as targets for innate and adaptive immune responses in chronic allergic airway disease and identify T2M cells as a new steroid-resistant cell population
The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage.
GeneRIF
Emanuelli et al., Ancona, Italy. In Cytokine, 2012
We observed significant downregulation of IL-25 in women with recurrent miscarriage compared with controls.
IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation.
GeneRIF
Nakajima et al., Chiba, Japan. In J Allergy Clin Immunol, 2011
IL-22 attenuates antigen-induced airway inflammation, possibly by inhibiting IL-25 production by lung epithelial cells.
T cell-derived Act1 is necessary for IL-25-mediated Th2 responses and allergic airway inflammation.
GeneRIF
Li et al., Cleveland, United States. In J Immunol, 2011
findings indicate that Act1 expression in T cells is required for cellular and humoral Th2-mediated allergic responses and the development of airway hyperresponsiveness, in part, through Act1's function in IL-25-induced development of Th2 T cells
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