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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Interleukin 25

IL-25, IL-17E, Interleukin-25
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: TH2, IL-17, IL-13, IL-4, IL-33
Papers on IL-25
Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation.
New
Sukkar et al., Sydney, Australia. In J Allergy Clin Immunol, Aug 2014
Significantly, HMGB1 release occurred downstream of TLR4-induced IL-1α, and upstream of IL-25 and IL-33 production.
IL-25 promotes Th2 immunity responses in airway inflammation of asthmatic mice via activation of dendritic cells.
New
Liang et al., Jinan, China. In Inflammation, Aug 2014
Recent studies indicated that interleukin (IL)-25, a member of the IL-17 cytokine family, had been implicated in inducing Th2 cell-dependent inflammation in airway epithelium and IL-25-deficient mice exhibit impaired Th2 immunity responses; however, how these cytokines influence innate immune responses remains poorly understood.
P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps.
New
Han et al., Boston, United States. In Int Forum Allergy Rhinol, Jun 2014
Lipopolysaccharide (LPS)-stimulated cytokine secretion of interleukin 6 (IL-6), IL-8, IL-25, and granulocyte macrophage colony stimulating factor (GM-CSF) were quantified by ELISA and compared to secretion following P-gp inhibition.
Direct comparison of the dynamics of IL-25- and 'allergen'-induced airways inflammation, remodelling and hypersensitivity in a murine asthma model.
New
Ying et al., Beijing, China. In Clin Exp Allergy, May 2014
BACKGROUND: Interleukin-25 has been implicated in the pathogenesis of asthma from studies on human asthmatics and in murine asthma models.
Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.
New
Impact
Locksley et al., San Francisco, United States. In Immunity, Apr 2014
We show that inhaled chitin induced expression of three epithelial cytokines, interleukin-25 (IL-25), IL-33, and thymic stromal lymphopoietin (TSLP), which nonredundantly activated resident innate lymphoid type 2 cells (ILC2s) to express IL-5 and IL-13 necessary for accumulation of eosinophils and alternatively activated macrophages (AAMs).
Asthma: the importance of dysregulated barrier immunity.
Review
New
Hammad et al., Gent, Belgium. In Eur J Immunol, Dec 2013
Barrier epithelial cells are being ever more implicated in disease pathogenesis than previously thought, as these cells have in recent years been shown to sense exposure to allergens via pattern recognition receptors and to activate conventional and inflammatory-type DCs and other innate immune cells through the secretion of thymic stromal lymphopoietin, granulocyte-macrophage colony stimulating factor, IL-1, IL-33, and IL-25.
Acanthamoeba protease activity promotes allergic airway inflammation via protease-activated receptor 2.
New
Yu et al., Yangsan, South Korea. In Plos One, Dec 2013
ES proteins had strong protease activity and activated the expression of several chemokine genes (CCL11, CCL17, CCL22, TSLP, and IL-25) in mouse lung epithelial cells.
Group 2 innate lymphoid cells in lung inflammation.
Review
New
Hendriks et al., Rotterdam, Netherlands. In Immunology, Nov 2013
These ILC2 are activated by epithelial cell-derived cytokines, including IL-25 and IL-33, which have been implicated in the initiation of asthma.
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.
New
Impact
Casanova et al., New York City, United States. In Immunity, Nov 2013
The patients' fibroblasts failed to respond to IL-17A and IL-17F, and their T cells to IL-17E.
TH2, allergy and group 2 innate lymphoid cells.
Review
New
Impact
Flavell et al., New Haven, United States. In Nat Immunol, Jun 2013
The initiation of type 2 immune responses by the epithelial cell-derived cytokines IL-25, IL-33 and TSLP has been an area of extensive research in the past decade.
Cytokine targets in airway inflammation.
Review
New
Lambrecht et al., Gent, Belgium. In Curr Opin Pharmacol, Jun 2013
Emerging Th2 cytokines such as thymic stromal lymphopoietin, GM-CSF, IL-1, IL-33, IL-25 mediate the crosstalk between epithelial cells, DCs, and ILCs.
Interleukin-4 and interleukin-13 cause barrier dysfunction in human airway epithelial cells.
New
Georas et al., Rochester, United States. In Tissue Barriers, May 2013
The basolateral or apical surfaces of airway epithelia were exposed to human interleukin-4 (IL-4), IL-13, IL-25, IL-33, thymic stromal lymphopoietin (TSLP) alone or in combination at various concentrations and time points.
Th2-type innate immune responses mediated by natural helper cells.
Review
New
Moro et al., Tokyo, Japan. In Ann N Y Acad Sci, Apr 2013
Natural helper (NH) cells are a newly identified innate lymphocyte population that responds to a combination of interleukin (IL)-2 and either IL-25 or IL-33 to produce large amounts of T helper cell type 2 (Th2) cytokines.
The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.
New
Impact
Mattes et al., Newcastle, Australia. In Nat Med, Feb 2013
siRNA-mediated knockdown of MID1 or pharmacological activation of PP2A using a nonphosphorylatable FTY720 analog in mice exposed to HDM reduces airway hyperreactivity and inflammation, including the expression of interleukin-25 (IL-25), IL-33 and CCL20, IL-5 and IL-13 release, nuclear factor (NF)κB activity, p38 mitogen-activated protein kinase (MAPK) phosphorylation, accumulation of eosinophils, T lymphocytes and myeloid dendritic cells, and the number of mucus-producing cells.
Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population.
Impact
GeneRIF
Li et al., Cleveland, United States. In Immunity, 2012
Th2 cell-inducing cytokine (IL-25) expression were reduced in the intestinal epithelial cells from the infected and IL-25-injected epithelial-specific Act1-deficient mice.
Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology.
Impact
GeneRIF
Lukacs et al., Ann Arbor, United States. In Nat Med, 2012
data establish IL-25 and its receptor IL-17RB as targets for innate and adaptive immune responses in chronic allergic airway disease and identify T2M cells as a new steroid-resistant cell population
The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage.
GeneRIF
Emanuelli et al., Ancona, Italy. In Cytokine, 2012
We observed significant downregulation of IL-25 in women with recurrent miscarriage compared with controls.
IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation.
GeneRIF
Nakajima et al., Chiba, Japan. In J Allergy Clin Immunol, 2011
IL-22 attenuates antigen-induced airway inflammation, possibly by inhibiting IL-25 production by lung epithelial cells.
T cell-derived Act1 is necessary for IL-25-mediated Th2 responses and allergic airway inflammation.
GeneRIF
Li et al., Cleveland, United States. In J Immunol, 2011
findings indicate that Act1 expression in T cells is required for cellular and humoral Th2-mediated allergic responses and the development of airway hyperresponsiveness, in part, through Act1's function in IL-25-induced development of Th2 T cells
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