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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Nov 2014.

Interleukin 25

IL-25, IL-17E, Interleukin-25
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: TH2, IL-17, IL-13, IL-33, IL-4
Papers on IL-25
Clinical associations between IL-17 family cytokines and periodontitis and potential differential roles for IL-17A and IL-17E in periodontal immunity.
New
Nile et al., Glasgow, United Kingdom. In Inflamm Res, 31 Dec 2014
This study aimed to determine clinical associations between IL-17 family cytokines and periodontitis and to investigate the biological roles of IL-17A and IL-17E using in vitro model systems.
Airway responses towards allergens - from the airway epithelium to T cells.
New
Würtzen et al., Odense, Denmark. In Clin Exp Allergy, 14 Dec 2014
Several epithelial derived cytokines, such as thymic stromal lymphopoietin (TSLP), IL-25 and IL-33 influence tissue-resident dendritic cells (DCs) as well as Th2 effector cells.
Thymic stromal lymphopoietin-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis.
New
Ziegler et al., In J Clin Invest, 03 Dec 2014
Finally, mice lacking the receptor for IL-25 failed to develop acute diarrhea and anaphylaxis, highlighting a role for IL-25 in the initiation of type 2 immunity in the intestine.
A Critical Role for IL-17RB Signaling in HTLV-1 Tax-Induced NF-κB Activation and T-Cell Transformation.
New
Harhaj et al., Kyoto, Japan. In Plos Pathog, 31 Oct 2014
Here, using next-generation RNA sequencing we identified the IL-25 receptor subunit IL-17RB as an aberrantly overexpressed gene in HTLV-1 immortalized T cells.
Innate lymphoid cells and cytokines of the novel subtypes of helper T cells in asthma.
New
Rezaei et al., Eşfahān, Iran. In Asia Pac Allergy, 31 Oct 2014
BACKGROUND: In this study, the expression of interleukin-9 (IL-9), IL-17, IL-22, and IL-25 genes that might be the potential predisposing factors for asthma as well as count of innate lymphoid cells (ILCs) as another source of inflammatory cytokines have been evaluated.
Interleukin-17 in human inflammatory diseases.
Review
New
Shahneh et al., Tehrān, Iran. In Postepy Dermatol Alergol, Aug 2014
Recently discovered related molecules are forming a family of cytokines, the IL-17 family, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F.
Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.
New
Impact
Locksley et al., San Francisco, United States. In Immunity, Apr 2014
We show that inhaled chitin induced expression of three epithelial cytokines, interleukin-25 (IL-25), IL-33, and thymic stromal lymphopoietin (TSLP), which nonredundantly activated resident innate lymphoid type 2 cells (ILC2s) to express IL-5 and IL-13 necessary for accumulation of eosinophils and alternatively activated macrophages (AAMs).
Innate lymphoid cells in asthma: when innate immunity comes in a Th2 flavor.
Review
New
von Mutius et al., Tucson, United States. In Curr Opin Allergy Clin Immunol, Feb 2014
In the past years, however, an innate immune cell type has been discovered in mice that resides in the mucosa and secretes the Th2 cytokines IL-13 and IL-5 in response to IL-33 and IL-25 released by a damaged epithelium.
New insights in the pathogenesis of atopic dermatitis.
Review
New
Ong, Los Angeles, United States. In Pediatr Res, Jan 2014
Recent evidence also suggests the involvement of innate immunity including Toll-like receptors, IL-33, IL-25, and innate lymphoid cells in the pathogenesis of AD.
Brodalumab: an evidence-based review of its potential in the treatment of moderate-to-severe psoriasis.
Review
New
Santos-Silva et al., Portugal. In Core Evid, Dec 2013
Brodalumab is a human monoclonal antibody that targets IL-17 receptor A, blocking the effects of IL-17A, IL-17F, and IL-17E.
Asthma: the importance of dysregulated barrier immunity.
Review
New
Hammad et al., Gent, Belgium. In Eur J Immunol, Dec 2013
Barrier epithelial cells are being ever more implicated in disease pathogenesis than previously thought, as these cells have in recent years been shown to sense exposure to allergens via pattern recognition receptors and to activate conventional and inflammatory-type DCs and other innate immune cells through the secretion of thymic stromal lymphopoietin, granulocyte-macrophage colony stimulating factor, IL-1, IL-33, and IL-25.
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.
New
Impact
Casanova et al., New York City, United States. In Immunity, Nov 2013
The patients' fibroblasts failed to respond to IL-17A and IL-17F, and their T cells to IL-17E.
TH2, allergy and group 2 innate lymphoid cells.
Review
New
Impact
Flavell et al., New Haven, United States. In Nat Immunol, Jun 2013
The initiation of type 2 immune responses by the epithelial cell-derived cytokines IL-25, IL-33 and TSLP has been an area of extensive research in the past decade.
The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.
New
Impact
Mattes et al., Newcastle, Australia. In Nat Med, Feb 2013
siRNA-mediated knockdown of MID1 or pharmacological activation of PP2A using a nonphosphorylatable FTY720 analog in mice exposed to HDM reduces airway hyperreactivity and inflammation, including the expression of interleukin-25 (IL-25), IL-33 and CCL20, IL-5 and IL-13 release, nuclear factor (NF)κB activity, p38 mitogen-activated protein kinase (MAPK) phosphorylation, accumulation of eosinophils, T lymphocytes and myeloid dendritic cells, and the number of mucus-producing cells.
Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population.
Impact
GeneRIF
Li et al., Cleveland, United States. In Immunity, 2012
Th2 cell-inducing cytokine (IL-25) expression were reduced in the intestinal epithelial cells from the infected and IL-25-injected epithelial-specific Act1-deficient mice.
Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology.
Impact
GeneRIF
Lukacs et al., Ann Arbor, United States. In Nat Med, 2012
data establish IL-25 and its receptor IL-17RB as targets for innate and adaptive immune responses in chronic allergic airway disease and identify T2M cells as a new steroid-resistant cell population
The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage.
GeneRIF
Emanuelli et al., Ancona, Italy. In Cytokine, 2012
We observed significant downregulation of IL-25 in women with recurrent miscarriage compared with controls.
IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation.
GeneRIF
Nakajima et al., Chiba, Japan. In J Allergy Clin Immunol, 2011
IL-22 attenuates antigen-induced airway inflammation, possibly by inhibiting IL-25 production by lung epithelial cells.
T cell-derived Act1 is necessary for IL-25-mediated Th2 responses and allergic airway inflammation.
GeneRIF
Li et al., Cleveland, United States. In J Immunol, 2011
findings indicate that Act1 expression in T cells is required for cellular and humoral Th2-mediated allergic responses and the development of airway hyperresponsiveness, in part, through Act1's function in IL-25-induced development of Th2 T cells
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