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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Interleukin 25

IL-25, IL-17E, Interleukin-25
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: TH2, IL-17, IL-13, IL-33, IL-4
Papers on IL-25
Allergen-encoded signals that control allergic responses.
Corry et al., Houston, United States. In Curr Opin Allergy Clin Immunol, 29 Feb 2016
RECENT FINDINGS: The last few years have seen crucial advances in how innate immune cells such as innate lymphoid cells group 2 and airway epithelial cells and related molecular pathways through organismal proteinases and innate immune cytokines, such as thymic stromal lymphopoietin, IL-25, and IL-33 contribute to allergy and asthma.
Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit.
Locksley et al., San Francisco, United States. In Nature, 14 Feb 2016
Experiments in mice and humans have demonstrated requirements for the epithelial cytokines IL-33, thymic stromal lymphopoietin (TSLP) and IL-25 in the activation of ILC2s, but the sources and regulation of these signals remain poorly defined.
Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites.
Jay et al., Montpellier, France. In Nature, 14 Feb 2016
Moreover, tuft cells secrete IL-25, thereby regulating type 2 immune responses.
Intralymphatic treatment of flagellin-ovalbumin mixture reduced allergic inflammation in murine model of allergic rhinitis.
Mo et al., Ch'ŏnan, South Korea. In Allergy, 11 Feb 2016
Moreover, the expression of innate cytokines such as IL-25 and IL-33 in nasal epithelial cells were reduced and the expression of chemokines such as CCL24 (eotaxin-2), CXCL1 and CXCL2 was decreased in the nasal mucosa, suggesting the underlying mechanism for intralymphatic administration of the OVA-FlaB mixture.
Characterization of six IL-17 family genes in miiuy croaker and evolution analysis of vertebrate IL-17 family.
Xu et al., Zhoushan, China. In Fish Shellfish Immunol, 22 Jan 2016
Six member of IL-17 family cytokines (IL-17A-F) were found in mammals.In fish, all IL-17 family genes except IL-17B and IL-17E have been isolated and identified.
Interleukin (IL)-25: Pleiotropic roles in asthma.
Sun et al., Beijing, China. In Respirology, 14 Jan 2016
UNASSIGNED: IL-25, also named IL-17E, is a distinct member of the IL-17 cytokine family, which can promote and augment T helper type 2 (Th2) responses locally or systemically.
IL-25/IL-33-responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa.
Till et al., London, United Kingdom. In J Allergy Clin Immunol, 09 Jan 2016
Type 2 innate lymphoid cells from polyps produce IL-5 and IL-13 in response to IL-25 and IL-33, although the relevance of this axis to local mucosal T-cell responses is unknown.
Interleukin 25 Receptor Expression on Airway Dendritic Cells After Allergen Challenge in Asthmatic Subjects.
O'Byrne et al., Hamilton, Canada. In Am J Respir Crit Care Med, 01 Jan 2016
RATIONALE: Interleukin (IL)-25 is an epithelial-derived cytokine, whose effects are mediated by the IL-25 receptor (IL-17RB), and which has been implicated in the pathogenesis of allergic disease and airway viral responses.
IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma.
Gauvreau et al., Hamilton, Canada. In Respir Res, 31 Dec 2015
BACKGROUND: The alarmin cytokines IL-25 and IL-33 are key promoters of type 2 inflammation.
Interleukin-25 initiates Th2 differentiation of human CD4(+) T cells and influences expression of its own receptor.
Cameron et al., Edmonton, Canada. In Immun Inflamm Dis, 31 Dec 2015
Human CRTh2(+) Th2 cells express IL-25 receptor (IL-25R) and IL-25 has been shown to potentiate production of Th2 cytokines.
Drivers of chronic rhinosinusitis: Inflammation versus infection.
Hamilos, Boston, United States. In J Allergy Clin Immunol, 31 Dec 2015
Conversely, certain innate factors, namely IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), are elaborated by sinus epithelial cells in response to microbial stimulation or airway injury and promote local TH2 inflammation.
Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice.
Bendelac et al., Beltsville, United States. In J Allergy Clin Immunol, Nov 2015
METHODS: PLZF(-/-) mice, wild-type littermates, or mixed bone marrow chimeras were treated with the protease allergen papain or the cytokines IL-25 and IL-33 or infected with the helminth Nippostrongylus brasiliensis to induce innate type 2 allergic responses.
Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites.
Lambrecht et al., Gent, Belgium. In Immunity, Sep 2015
Finally, administration of recombinant IL-21 and IL-25 synergistically promoted airway eosinophilia primarily via effects on CD4(+) lymphocytes.
Barrier Epithelial Cells and the Control of Type 2 Immunity.
Lambrecht et al., Gent, Belgium. In Immunity, Aug 2015
These ECs mount a prototypical response made up of chemokines, innate cytokines such as interleukin-1 (IL-1), IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), as well as the alarmins uric acid, ATP, HMGB1, and S100 proteins.
Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation.
Dong et al., Chicago, United States. In Immunity, May 2015
Among them, IL-25 has been shown to be important in allergic inflammation and protection against parasitic infection.
Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population.
Li et al., Cleveland, United States. In Immunity, 2012
Th2 cell-inducing cytokine (IL-25) expression were reduced in the intestinal epithelial cells from the infected and IL-25-injected epithelial-specific Act1-deficient mice.
Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology.
Lukacs et al., Ann Arbor, United States. In Nat Med, 2012
data establish IL-25 and its receptor IL-17RB as targets for innate and adaptive immune responses in chronic allergic airway disease and identify T2M cells as a new steroid-resistant cell population
The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage.
Emanuelli et al., Ancona, Italy. In Cytokine, 2012
We observed significant downregulation of IL-25 in women with recurrent miscarriage compared with controls.
IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation.
Nakajima et al., Chiba, Japan. In J Allergy Clin Immunol, 2011
IL-22 attenuates antigen-induced airway inflammation, possibly by inhibiting IL-25 production by lung epithelial cells.
T cell-derived Act1 is necessary for IL-25-mediated Th2 responses and allergic airway inflammation.
Li et al., Cleveland, United States. In J Immunol, 2011
findings indicate that Act1 expression in T cells is required for cellular and humoral Th2-mediated allergic responses and the development of airway hyperresponsiveness, in part, through Act1's function in IL-25-induced development of Th2 T cells
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