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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Sep 2015.

Interleukin 25

IL-25, IL-17E, Interleukin-25
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: TH2, IL-17, IL-13, IL-33, IL-4
Papers on IL-25
Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.
New
Yen et al., Taiwan. In Stem Cell Reports, 26 Sep 2015
We found that, along with Th1 responses, hMSCs strongly suppressed Th17 responses and this required both IL-25-also known as IL-17E-as well as programmed death ligand-1 (PD-L1), a potent cell surface ligand for tolerance induction.
The advanced lipoxidation end product precursor malondialdehyde induces IL-17E expression and skews lymphocytes to the Th17 subset.
New
Shanmugam et al., In Cell Mol Biol Lett, 25 Sep 2015
The aim of this study was to examine the molecular mechanisms of MDA-induced IL-17E cytokine expression and its effect on T-cell differentiation.
Distinctive expression pattern of interleukin-17 cytokine family members in colorectal cancer.
New
Bishehsari et al., Helsinki, Finland. In Tumour Biol, 25 Sep 2015
Ten healthy colons and ten CRC mucosa were immunostained for IL-17B, IL-17C, IL-17E, and IL-17F, and their receptors IL-17RA, IL-17RB, and IL-17RC.
Convergence of air pollutant-induced redox-sensitive signals in the dendritic cells contributes to asthma pathogenesis.
Review
New
Buglak et al., East Lansing, United States. In Toxicol Lett, 19 Sep 2015
The epithelial cells can further enhance the DC response to allergen and PM through several immune regulatory cytokines including thymic stromal lymphopoietin (TSLP), IL-33, and IL-25.
Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites.
New
Impact
Lambrecht et al., Gent, Belgium. In Immunity, 18 Sep 2015
Finally, administration of recombinant IL-21 and IL-25 synergistically promoted airway eosinophilia primarily via effects on CD4(+) lymphocytes.
High throughput screening of cytokines, chemokines and matrix metalloproteinases in wound fluid induced by mammary surgery.
New
Zhao et al., Dalian, China. In Oncotarget, 10 Sep 2015
The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1β (IL-1β), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon γ (IFNγ), CD40 ligand (CD40L), tumor necrosis factor α (TNFα), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.
Roles of Epithelial Cell-Derived Type 2-Initiating Cytokines in Experimental Allergic Conjunctivitis.
New
Matsuda et al., Tokyo, Japan. In Invest Ophthalmol Vis Sci, 01 Sep 2015
PURPOSE: To clarify the possible involvement of the type 2-initiating cytokines interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) in the pathophysiology of allergic conjunctivitis, we evaluated ragweed (RW)-induced experimental allergic conjunctivitis (EAC) models by using IL-25 knockout (KO), IL-33 KO, and TSLP receptor (TSLPR) KO mice.
Barrier Epithelial Cells and the Control of Type 2 Immunity.
Review
New
Impact
Lambrecht et al., Gent, Belgium. In Immunity, 21 Aug 2015
These ECs mount a prototypical response made up of chemokines, innate cytokines such as interleukin-1 (IL-1), IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), as well as the alarmins uric acid, ATP, HMGB1, and S100 proteins.
ILC2s and fungal allergy.
Review
New
Kita, Rochester, United States. In Allergol Int, Jul 2015
In mouse models of fungus-induced allergic airway inflammation, IL-33, IL-25, and TSLP are released by airway epithelial cells.
Epithelial cytokines and pulmonary allergic inflammation.
Review
New
Saglani et al., London, United Kingdom. In Curr Opin Immunol, Jun 2015
The triad of epithelial derived cytokines, IL-25, IL-33 and TSLP are important for the initiation and development of pulmonary immune responses to environmental stimuli.
Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation.
New
Impact
Dong et al., Chicago, United States. In Immunity, May 2015
Among them, IL-25 has been shown to be important in allergic inflammation and protection against parasitic infection.
Role of IL-25 in Immunity.
Review
New
Parizad et al., Īlām, Iran. In J Clin Diagn Res, Apr 2015
IL-25 a 2o KDa protein mostly known as IL-17E, encoded by chromosome 14, and containing 117 amino acids.
IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential 'inflammatory' type 2 innate lymphoid cells.
New
Impact
Paul et al., Bethesda, United States. In Nat Immunol, Feb 2015
We report the existence of an inflammatory ILC2 (iILC2) population responsive to interleukin 25 (IL-25) that complemented IL-33-responsive natural ILC2 (nILC2) cells.
IL-17 cytokines in bone healing of diabetic Charcot arthropathy patients: a prospective 2 year follow-up study.
New
Cassuto et al., Göteborg, Sweden. In J Foot Ankle Res, Dec 2014
The aim of this study was to investigate the role of IL-17A, IL-17E and IL-17F in patients presenting with Charcot foot.
Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.
New
Impact
Locksley et al., San Francisco, United States. In Immunity, Apr 2014
We show that inhaled chitin induced expression of three epithelial cytokines, interleukin-25 (IL-25), IL-33, and thymic stromal lymphopoietin (TSLP), which nonredundantly activated resident innate lymphoid type 2 cells (ILC2s) to express IL-5 and IL-13 necessary for accumulation of eosinophils and alternatively activated macrophages (AAMs).
Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population.
Impact
GeneRIF
Li et al., Cleveland, United States. In Immunity, 2012
Th2 cell-inducing cytokine (IL-25) expression were reduced in the intestinal epithelial cells from the infected and IL-25-injected epithelial-specific Act1-deficient mice.
Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology.
Impact
GeneRIF
Lukacs et al., Ann Arbor, United States. In Nat Med, 2012
data establish IL-25 and its receptor IL-17RB as targets for innate and adaptive immune responses in chronic allergic airway disease and identify T2M cells as a new steroid-resistant cell population
The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage.
GeneRIF
Emanuelli et al., Ancona, Italy. In Cytokine, 2012
We observed significant downregulation of IL-25 in women with recurrent miscarriage compared with controls.
IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation.
GeneRIF
Nakajima et al., Chiba, Japan. In J Allergy Clin Immunol, 2011
IL-22 attenuates antigen-induced airway inflammation, possibly by inhibiting IL-25 production by lung epithelial cells.
T cell-derived Act1 is necessary for IL-25-mediated Th2 responses and allergic airway inflammation.
GeneRIF
Li et al., Cleveland, United States. In J Immunol, 2011
findings indicate that Act1 expression in T cells is required for cellular and humoral Th2-mediated allergic responses and the development of airway hyperresponsiveness, in part, through Act1's function in IL-25-induced development of Th2 T cells
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