GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Interleukin 25
IL-25, IL-17E, Interleukin-25
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from
NCBI)
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Papers on
IL-25
Lipoxin a4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma.
New
Boston, United States. In Sci Transl Med, 27 Mar 2013
ILC2s generated antigen-independent interleukin-13 (IL-13) in response to the mast cell product prostaglandin D alone and in a synergistic manner with the airway epithelial cytokines IL-25 and IL-33.
IL-25 Downregulates Th1/Th17 Immune Response in an IL-10-Dependent Manner in Inflammatory Bowel Disease.
New
Hamilton, Canada. In Inflamm Bowel Dis, 20 Mar 2013
BACKGROUND:: Interleukin 25 (IL-25) is involved in the initiation of T helper cell (Th)2-mediated immunopathologies.
Nascent Endothelium Initiates Th2 Polarization of Asthma.
New
Cleveland, United States. In J Immunol, 20 Mar 2013
Strikingly, Th2 responses including, IgE production, eosinophil infiltration of the airway, subepithelial fibrosis, mucus metaplasia, and airway-hyperreactivity were also attenuated by VE-cadherin blockade, via mechanisms that blunted endothelial IL-25 and proangiogenic progenitor cell thymic stromal lymphopoietin production.
IL-25 Improves Luminal Innate Immunity and Barrier Function During Parenteral Nutrition.
New
Madison, United States. In Ann Surg, 19 Mar 2013
Because IL-25 stimulates IL-4 and IL-13 release and PN reduces luminal sPLA2 and MUC2, we hypothesized that adding IL-25 to PN would restore these innate immune factors and maintain barrier function.
Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.
New
Toulouse, France. In J Allergy Clin Immunol, 09 Mar 2013
Normal primary human keratinocytes were differentiated in either the absence or presence of IL-4, IL-13, and IL-25.
The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.
New
Impact
Newcastle, Australia. In Nat Med, 28 Feb 2013
siRNA-mediated knockdown of MID1 or pharmacological activation of PP2A using a nonphosphorylatable FTY720 analog in mice exposed to HDM reduces airway hyperreactivity and inflammation, including the expression of interleukin-25 (IL-25), IL-33 and CCL20, IL-5 and IL-13 release, nuclear factor (NF)κB activity, p38 mitogen-activated protein kinase (MAPK) phosphorylation, accumulation of eosinophils, T lymphocytes and myeloid dendritic cells, and the number of mucus-producing cells.
Natural helper cells and TH2-type innate immunity.
Review
New
Tokyo, Japan. In Cornea, Nov 2012
Natural helper (NH) cells are a newly identified innate lymphocyte population, which respond to a combination of interleukin (IL)-2 and IL-25 or IL-33 to produce large amounts of TH2 cytokines, most notably, IL-5 and IL-13.
Regulation of type 2 immunity to helminths by mast cells.
Review
New
Berlin, Germany. In Gut Microbes, Sep 2012
Furthermore, MC degranulation was required for the enhanced expression and production of the tissue-derived cytokines IL-25, IL-33 and TSLP, which are required for the optimal orchestration and priming of type 2 immunity.
Susceptibility and immunity to helminth parasites.
Review
New
Edinburgh, United Kingdom. In Curr Opin Immunol, Aug 2012
Innate cells respond to 'alarmin' cytokines (IL-25, IL-33, TSLP) by producing IL-4, IL-5 and IL-13, and this sets the stage for a more potent subsequent adaptive Th2 response.
Innate type 2 cells and asthma.
Review
New
Dublin, Ireland. In Curr Opin Pharmacol, Aug 2012
However, recent advances have implicated other type 2 cytokines such as IL-25, IL-33 and TSLP in the pathogenesis of allergic conditions.
Regulation of epithelial immunity by IL-17 family cytokines.
Review
New
San Francisco, United States. In Trends Immunol, Jul 2012
Although IL-17A and IL-17F promote antibacterial and antifungal responses, IL-17E is essential for defense against parasitic infections.
Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population.
New
Impact
Cleveland, United States. In Immunity, Jun 2012
Interleukin-25 (IL-25 or IL-17E), a member of the structurally related IL-17 family, functions as an important mediator of T helper 2 cell-type (type 2) responses.
Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology.
New
Impact
Ann Arbor, United States. In Nat Med, May 2012
Interleukin-25 (IL-25) is a cytokine associated with allergy and asthma that functions to promote type 2 immune responses at mucosal epithelial surfaces and serves to protect against helminth parasitic infections in the intestinal tract.
IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation.
GeneRIF
Chiba, Japan. In J Allergy Clin Immunol, 2011
IL-22 attenuates antigen-induced airway inflammation, possibly by inhibiting IL-25 production by lung epithelial cells.
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.
Impact
Amsterdam, Netherlands. In Nat Immunol, 2011
These cells responded in vitro to IL-2 plus IL-25 and IL-33 by producing IL-13.
T cell-derived Act1 is necessary for IL-25-mediated Th2 responses and allergic airway inflammation.
GeneRIF
Cleveland, United States. In J Immunol, 2011
findings indicate that Act1 expression in T cells is required for cellular and humoral Th2-mediated allergic responses and the development of airway hyperresponsiveness, in part, through Act1's function in IL-25-induced development of Th2 T cells
Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses.
GeneRIF
London, United Kingdom. In J Allergy Clin Immunol, 2011
Allergen provocation induces functionally relevant, increased expression of IL-25 and its receptor in the asthmatic bronchial mucosa and dermis of sensitized atopic subjects.
Functional specialization of interleukin-17 family members.
Review
Impact
Tokyo, Japan. In Immunity, 2011
IL-17E (IL-25) is an amplifier of Th2 immune responses.
T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma.
GeneRIF
London, United Kingdom. In Proc Natl Acad Sci U S A, 2011
Findings suggest that IL-25 is elevated in asthma and contributes to angiogenesis.
Critical role of IL-25 in nematode infection-induced alterations in intestinal function.
GeneRIF
Baltimore, United States. In J Immunol, 2011
Epithelial cells, but not immune cells, are the major source of IL-25 in the small intestine. IL-13 is the major downstream T helper (Th) cell type-2 cytokine responsible for IL-25 effects during Nippostrongylus brasiliensis infection.
