Nascent Endothelium Initiates Th2 Polarization of Asthma.
Cleveland, United States. In J Immunol, 20 Mar 2013
Strikingly, Th2 responses including, IgE production, eosinophil infiltration of the airway, subepithelial fibrosis, mucus metaplasia, and airway-hyperreactivity were also attenuated by VE-cadherin blockade, via mechanisms that blunted endothelial IL-25 and proangiogenic progenitor cell thymic stromal lymphopoietin production.
The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.
Newcastle, Australia. In Nat Med, 28 Feb 2013
siRNA-mediated knockdown of MID1 or pharmacological activation of PP2A using a nonphosphorylatable FTY720 analog in mice exposed to HDM reduces airway hyperreactivity and inflammation, including the expression of interleukin-25 (IL-25), IL-33 and CCL20, IL-5 and IL-13 release, nuclear factor (NF)κB activity, p38 mitogen-activated protein kinase (MAPK) phosphorylation, accumulation of eosinophils, T lymphocytes and myeloid dendritic cells, and the number of mucus-producing cells.
Natural helper cells and TH2-type innate immunity.
Tokyo, Japan. In Cornea, Nov 2012
Natural helper (NH) cells are a newly identified innate lymphocyte population, which respond to a combination of interleukin (IL)-2 and IL-25 or IL-33 to produce large amounts of TH2 cytokines, most notably, IL-5 and IL-13.
Regulation of type 2 immunity to helminths by mast cells.
Berlin, Germany. In Gut Microbes, Sep 2012
Furthermore, MC degranulation was required for the enhanced expression and production of the tissue-derived cytokines IL-25, IL-33 and TSLP, which are required for the optimal orchestration and priming of type 2 immunity.
Susceptibility and immunity to helminth parasites.
Edinburgh, United Kingdom. In Curr Opin Immunol, Aug 2012
Innate cells respond to 'alarmin' cytokines (IL-25, IL-33, TSLP) by producing IL-4, IL-5 and IL-13, and this sets the stage for a more potent subsequent adaptive Th2 response.
Innate type 2 cells and asthma.
Dublin, Ireland. In Curr Opin Pharmacol, Aug 2012
However, recent advances have implicated other type 2 cytokines such as IL-25, IL-33 and TSLP in the pathogenesis of allergic conditions.