Gut inflammation and microbiome in spondyloarthritis.
Vellore, India. In Rheumatol Int, Jan 2016
Immunological mechanisms include homing of activated T cells from gut into synovium, excess pro-inflammatory cytokines secretion by immune cells such as IL-23 and genetic variations in immunological genes.
Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions.
Basel, Switzerland. In Immunity, Jan 2016
Therapeutic interventions with inhibitors of the different components of the pathway such as interleukin-12 (IL-12), IL-23, IL-17A, and IL-17RA have variably beneficial effects in psoriasis, Crohn's disease, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, non-infectious uveitis, and multiple sclerosis.