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Interleukin 23, alpha subunit p19

IL-23, REG
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-17, Interleukin-6, IL-12, IL-10, IL-21
Papers using IL-23 antibodies
Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients
Supplier
Kotake Shigeru et al., In Arthritis Research & Therapy, 2000
... Goat polyclonal anti-IL-23 antibody was purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Papers on IL-23
Cutting Edge: MicroRNA-223 Regulates Myeloid Dendritic Cell-Driven Th17 Responses in Experimental Autoimmune Encephalomyelitis.
New
Miller et al., Chicago, United States. In J Immunol, Feb 2016
Knockout mDCs have increased PD-L1 and decreased IL-1β, IL-6, and IL-23 expression, as well as a reduced capacity to drive Th17, but not Th1, cell differentiation.
Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review.
New
Maverakis et al., Sacramento, United States. In Clin Rev Allergy Immunol, Feb 2016
Novel therapeutics targeting these mediators (IL-12, IL-23, IL-17, IL-17 receptor, TNF) are effective in treating both the skin and joint manifestations of psoriasis, reaffirming the shared pathophysiology of PsV and PsA.
The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation.
New
Yang et al., Tianjin, China. In Cell Rep, Feb 2016
The expression of these chemokines is associated with regenerating islet-derived (REG) protein-mediated microbiotas.
Resveratrol‑4‑O‑D‑(2'‑galloyl)‑glucopyranoside exerts an anticancer effect on leukemia cells via inducing apoptosis.
New
Guo et al., Shanghai, China. In Mol Med Report, Feb 2016
UNASSIGNED: The aim of the present study was to investigate the anticancer effects of resveratrol‑4‑O‑D-(2'‑galloyl)-glucopyranoside (REG) on leukemia and the mechanism underlying its effects.
TNF-α in a molecularly targeted therapy of psoriasis and psoriatic arthritis.
Review
New
Mazurek et al., Sosnowiec, Poland. In Postgrad Med J, Jan 2016
The current treatment options for psoriasis and psoriatic arthritis include tumour necrosis factor alpha (TNF-α) blockers, interleukin (IL)-12 and IL-23 inhibitors, T cell inhibitors and B cell inhibitors.
Gut inflammation and microbiome in spondyloarthritis.
Review
New
Danda et al., Vellore, India. In Rheumatol Int, Jan 2016
Immunological mechanisms include homing of activated T cells from gut into synovium, excess pro-inflammatory cytokines secretion by immune cells such as IL-23 and genetic variations in immunological genes.
A Review of Biologic Therapies Targeting IL-23 and IL-17 for Use in Moderate-to-Severe Plaque Psoriasis.
Review
New
Menter et al., Dallas, United States. In Dermatol Ther (heidelb), Jan 2016
Drugs targeting IL-23 include BI-655066, briakinumab, guselkumab, tildrakizumab, and ustekinumab.
Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells.
New
Impact
Cua et al., Palo Alto, United States. In Immunity, Jan 2016
UNASSIGNED: Interleukin-23 (IL-23) is a pro-inflammatory cytokine required for the pathogenicity of T helper 17 (Th17) cells but the molecular mechanisms governing this process remain unclear.
Role of interleukin-23 as a biomarker in rheumatoid arthritis patients and its correlation with disease activity.
Review
New
El-Nahrery et al., Cairo, Egypt. In Int Immunopharmacol, Jan 2016
BACKGROUND: IL-23 is a pro-inflammatory cytokine belonging to the IL-12 cytokine family.
Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions.
Review
New
Impact
Kuchroo et al., Basel, Switzerland. In Immunity, Jan 2016
Therapeutic interventions with inhibitors of the different components of the pathway such as interleukin-12 (IL-12), IL-23, IL-17A, and IL-17RA have variably beneficial effects in psoriasis, Crohn's disease, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, non-infectious uveitis, and multiple sclerosis.
Gut-Busters: IL-17 Ain't Afraid of No IL-23.
New
Impact
Gaffen et al., Pittsburgh, United States. In Immunity, Nov 2015
Interleukin-23 (IL-23) is considered a critical regulator of IL-17 in lymphocytes.
Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.
New
Impact
Towne et al., Seattle, United States. In Immunity, Nov 2015
Interleukin-23 (IL-23) and IL-17 are cytokines currently being targeted in clinical trials.
Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability.
New
Impact
Cua et al., Palo Alto, United States. In Immunity, Nov 2015
We have demonstrated that after acute intestinal injury, IL-23R(+) γδ T cells in the colonic lamina propria were the primary producers of early, gut-protective IL-17A, and this production of IL-17A was IL-23 independent, leaving protective IL-17 intact in the absence of IL-23.
The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome.
Review
Pizarro et al., Cleveland, United States. In Front Immunol, 2014
Specific components of the gut microbiome have been implicated in the production of proinflammatory cytokines by innate immune cells, such as IL-6, IL-23, IL-1β, and the subsequent generation and expansion of Th17 cells.
Effect of Bacteriocins and Conditions that Mimic Food and Digestive Tract on Biofilm Formation, In Vitro Invasion of Eukaryotic Cells and Internalin Gene Expression by Listeria monocytogenes.
De Martinis et al., Ribeirão Preto, Brazil. In Probiotics Antimicrob Proteins, 2013
On the other hand, two L. monocytogenes isolates (INCQS 353 and Reg 26c) showed higher invasion rates when cultivated in the presence of NaCl 5 % (P < 0.05).
CCR7 ligands up-regulate IL-23 through PI3-kinase and NF-κ B pathway in dendritic cells.
GeneRIF
Kakiuchi et al., Tokyo, Japan. In J Leukoc Biol, 2012
NF-kappa B plays a major role in the signaling triggered by CCR7 ligands, which results in IL-23p19 subunit mRNA expression.
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells.
Impact
GeneRIF
Cua et al., Palo Alto, United States. In Nat Med, 2012
IL-23 is essential in enthesitis and acts on previously unidentified IL-23 receptor (IL-23R)(+), RAR-related orphan receptor gammat (ROR-gammat)(+)CD3(+)CD4(-)CD8(-), entheseal resident T cells.
IL-27 acts as a priming signal for IL-23 but not IL-12 production on human antigen-presenting cells.
GeneRIF
Wittmann et al., Hannover, Germany. In Exp Dermatol, 2012
IL-27 was found to be the only IL-12 family member that acts on antigen-presenting cells as a priming signal for IL-23.
[Dynamic expressions of IL-17 and IL-23 in mice infected with Schistosoma japonicum].
GeneRIF
Liu et al., Wuhan, China. In Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi, 2012
IL-23 may play an important role during the immune process in the very early stage of Schistosoma infection.
Homeostatic regulation of Salmonella-induced mucosal inflammation and injury by IL-23.
GeneRIF
Smith et al., Seattle, United States. In Plos One, 2011
IL-23 is a homeostatic regulator of IL-12-dependent, IFN-gamma-mediated intestinal inflammation.
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