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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Interleukin 22 receptor, alpha 1

IL-22R1, IL-22R, IL22RA1
The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-21, IL-10, IL-10R2, STAT3, IL-20R1
Papers on IL-22R1
Attenuated Airway Epithelial Cell Interleukin-22R1 Expression in the Infant Nonhuman Primate Lung.
New
Miller et al., Davis, United States. In Am J Respir Cell Mol Biol, Dec 2015
IL-22 and its receptor IL-22R1 are important in host defense and repair of epithelial barriers.
Differential Requirements for IL-17A and IL-22 in Cecal versus Colonic Inflammation Induced by Helicobacter hepaticus.
New
Kullberg et al., York, United Kingdom. In Am J Pathol, Dec 2015
Analysis of transcript levels revealed differential expression of IL-22R, IL-22 binding protein, and IL-23R between cecum and colon, a finding that may help explain why these tissues respond differently after anti-IL-22 treatment.
Exploring the role of interleukin-22 in neurological and autoimmune disorders.
Review
New
Zhang et al., Suzhou, China. In Int Immunopharmacol, Oct 2015
Its biological activity results from its ability to bind to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2.
Neutrophil proteases alter the interleukin-22-receptor-dependent lung antimicrobial defence.
New
Si-Tahar et al., Tours, France. In Eur Respir J, Sep 2015
We hypothesised that neutrophils secrete proteases that may have adverse effects in COPD, by altering the IL-22 receptor (IL-22R)-dependent signalling.Using in vitro and in vivo approaches as well as reverse transcriptase quantitative PCR, flow cytometry and/or Western blotting techniques, we first showed that pathogens such as the influenza virus promote IL-22R expression in human bronchial epithelial cells, whereas Pseudomonas aeruginosa, bacterial lipopolysaccharide or cigarette smoke do not.
Interleukin (IL)-22 receptor 1 is over-expressed in primary Sjogren's syndrome and Sjögren-associated non-Hodgkin lymphomas and is regulated by IL-18.
New
Triolo et al., Palermo, Italy. In Clin Exp Immunol, Aug 2015
Minor salivary glands (MSGs) from patients with pSS and non-specific chronic sialoadenitis (nSCS), parotid glands biopsies from non-Hodgkin lymphomas (NHL) developed in pSS patients, were evaluated for IL-18, IL-22, IL-22 receptor 1 (IL-22R1), IL-22 binding protein (IL-22BP) and signal transducer and activator of transcription-3 (STAT-3) expression.
IL22/IL-22R pathway induces cell survival in human glioblastoma cells.
Lecron et al., Limoges, France. In Plos One, 2014
Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that binds to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2.
Blocking IL-22, a potential treatment strategy for adenomyosis by inhibiting crosstalk between vascular endothelial and endometrial stromal cells.
Li et al., Shanghai, China. In Am J Transl Res, 2014
Here we found that VECs in ectopic lesion from women with adenomyosis highly expressed IL-22 receptors IL-22R1 and IL-10R2.
The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor.
Weathington et al., Washington, D.C., United States. In J Immunol Res, 2014
We recently described processing of mouse lung epithelial IL-22 receptor (IL-22R) by ubiquitination on the intracellular C-terminal.
Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes.
Du Pasquier et al., Lausanne, Switzerland. In J Neuroinflammation, 2014
Identification of the IL-22 receptor subunit, IL-22R1, was performed by immunohistochemistry and immunofluorescence in human brain tissues and human primary astrocytes.
The role of the IL-22/IL-22R1 axis in cancer.
Review
Savan et al., Seattle, United States. In Cytokine Growth Factor Rev, 2014
Thus, the role of the IL-22/IL-22R1 axis in cancer is complex and context-specific.
Interleukin-22: a likely target for treatment of autoimmune diseases.
Review
Zheng et al., Hangzhou, China. In Autoimmun Rev, 2014
IL-22 mediates its effects via the IL-22-IL-22R complex and subsequent Janus kinase-signal transducer and activators of transcription (JAK-STAT) signaling pathway.
Therapeutic opportunities of the IL-22-IL-22R1 system.
Review
Impact
Wolk et al., Berlin, Germany. In Nat Rev Drug Discov, 2014
Data obtained over the past few years indicate that the IL-22-IL-22 receptor subunit 1 (IL-22R1) system has a high potential clinical relevance in psoriasis, ulcerative colitis, graft-versus-host disease, certain infections and tumours, as well as in liver and pancreas damage.
The therapeutic potential of anti-interleukin-20 monoclonal antibody.
Review
Chang et al., Tainan City, Taiwan. In Cell Transplant, 2013
IL-20 acts on multiple cell types by activating on a heterodimer receptor complex of either IL-20R1-IL-20R2 or IL-22R1-IL-20R2.
Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice.
Impact
Haase et al., Köln, Germany. In Immunity, 2013
Therefore, our results expand current views on psoriasis pathogenesis by revealing a new keratinocyte-intrinsic mechanism that links TNFR1, NF-κB, ERK, IL-24, IL-22R1, and STAT3 signaling to disease initiation.
Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22.
Review
Impact
Artis et al., Philadelphia, United States. In Nat Immunol, 2011
Consistent with that, studies of mouse model systems have identified a critical role for signaling by IL-22 through its receptor (IL-22R) in the promotion of antimicrobial immunity, inflammation and tissue repair at barrier surfaces.
A novel role for IL-22R1 as a driver of inflammation.
GeneRIF
Young et al., Frederick, United States. In Blood, 2011
This study documents a previously unknown role of IL-22R1 in inflammation and identifies the involvement of IL-22R1/IL-22 in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation.
GeneRIF
Wang et al., Yangzhou, China. In J Mol Cell Biol, 2010
Tyr251 and Tyr301 of IL-22R1 are required for Shp2 binding and IL-22-induced Erk1/2 activation.
IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression.
GeneRIF
Hashimoto et al., Japan. In Eur J Immunol, 2009
Increased IL-22R expression in epidermal keratinocytes contributes to the pathogenesis of psoriasis through enhancing the coordinated effects of IL-22 and IL-17, inducing the production of the IL-20 subfamily, chemokines, and growth factors.
New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain.
GeneRIF
Renauld et al., Brussels, Belgium. In J Biol Chem, 2009
Data show that deletion of the C-terminal part of IL-22R dramatically decreased its ability to activate STAT3.
Expression pattern of mda-7/IL-24 receptors in liver cancer cell lines.
GeneRIF
Yang et al., Kunming, China. In Hepatobiliary Pancreat Dis Int, 2009
Complete mda-7/IL-24 receptors (IL-22R1/IL-20R2 and IL-20R1/IL-20R2) are seldom expressed in liver cancer cell lines.
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