Role of IL-21 signaling pathway in transplant-related biology.
Hangzhou, China. In Transplant Rev (orlando), Jan 2016
Since pro-inflammatory cytokine IL-21 and its receptor (IL-21R) are closely involved in regulating both innate and adaptive immune responses, it is conceivable that they may play important roles in the field of organ transplantation.
Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy.
Wichita, United States. In Med Sci Monit, Dec 2015
These include mitogens (EGF, Fit-3 ligand, HGF, IGF-1, IL-21R) and chemo-attractants (CTAC, Eotaxin, E-selectin, Lymphotactin, MIP-1, MCP-1, TARC, SDF-1), as well as inflammation and angiogenesis factors (FGF-6, IL-1β, TGF-1).
B-cell memory and primary immune deficiencies: interleukin-21 related defects.
Montréal, Canada. In Curr Opin Allergy Clin Immunol, 2013
PURPOSE OF REVIEW: The purpose of this study is to describe recent advances in our understanding of the role of interleukin-21 (IL-21) in B-cell maturation, and how defects in IL-21 receptor (IL-21R) signalling pathways (IL-21R/γc/JAK3/STAT3) are related to primary immune deficiencies.
Phlegm-dampness constitution: genomics, susceptibility, adjustment and treatment with traditional Chinese medicine.
Beijing, China. In Am J Chin Med, 2012
Genomics studies found four upregulated genes: COPS8, GNPDA1, CD52 and ARPC3; and six downregulated genes: GSPT2, CACNB2, FLJ20584, UXS1, IL21R and TNPO in the phlegm-dampness constitution.