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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jul 2015.

Interleukin 21

IL-21, IL-22, Interleukin-21, interleukin-22
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: IL-17, CD4, Interleukin-6, CAN, IL-10
Papers using IL-21 antibodies
The biology of human natural killer-cell subsets.
Supplier
Sandberg Johan K., In PLoS ONE, 2000
... IL-7, IL-4, IL-9; 50 ug/mL IL-12, 0.25 mg/mL IL-18 (all from R&D Systems); 100 ug/mL IL-21 (Miltenyi Biotec), 5 ug/mL IL-15 (PeproTech), 100 ...
Modulation of flagellar expression in Escherichia coli by acetyl phosphate and the osmoregulator OmpR.
Supplier
Masucci Maria G., In PLoS ONE, 1994
... Cells were stimulated with human recombinant IL-22 (Cell Signaling Technologies) for the indicated ...
Papers on IL-21
Tc17 cells are a pro-inflammatory, plastic lineage of pathogenic CD8+ T-cells that induce GVHD without anti-leukemic effects.
New
Hill et al., Brisbane, Australia. In Blood, 23 Aug 2015
IL-17A, IL-22, IFNγ, GM-CSF, IL-13).
Direct and immune-mediated cytotoxicity of interleukin-21 contributes to anti-tumor effects in mantle cell lymphoma.
New
Lossos et al., Miami, United States. In Blood, 20 Aug 2015
Interleukin 21 (IL-21), a member of the IL-2 cytokine family, possesses potent anti-tumor activity against a variety of cancers not expressing the IL-21 receptor (IL-21R) through immune activation.
Combination therapy: New hope for alcoholic hepatitis?
New
Shah et al., Bethesda, United States. In Clin Res Hepatol Gastroenterol, 17 Aug 2015
Interleukin-22 (IL-22) is a promising drug for the treatment of AH because of its hepatoprotective and anti-fibrotic functions and relatively few known side effects.
Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.
New
Impact
Diefenbach et al., Mainz, Germany. In Nat Immunol, 31 Jul 2015
Here we identified interleukin 22 (IL-22) produced by innate lymphoid cell group 3 (ILC3) as an amplifier of signaling via interferon-λ (IFN-λ), a synergism needed to curtail the replication of rotavirus, the leading cause of childhood gastroenteritis.
Th22 cells in autoimmunity: a review of current knowledge.
Review
New
Mirshafiey et al., Karaj, Iran. In Eur Ann Allergy Clin Immunol, 31 Jul 2015
This T helper subset, by producing pro-inflammatory cytokines such as IL-22 and tumor necrosis factor-α (TNF-α), is implicated in the pathogenesis of inflammatory and autoimmune disorder.
Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota.
New
Impact
Fu et al., Chicago, United States. In Immunity, May 2015
Utilizing gnotobiotic hosts, we showed that the ID2-dependent early colonization resistance was mediated by interleukin-22 (IL-22) regulation of the microbiota.
Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection.
New
Impact
Ouyang et al., Berlin, Germany. In Immunity, Mar 2015
We show here that attenuated ileitis observed in interleukin-22 (IL-22)-deficient mice was associated with reduced production of Th1-cell-promoting IL-18.
Human RORγt(+)CD34(+) cells are lineage-specified progenitors of group 3 RORγt(+) innate lymphoid cells.
New
Impact
Romagnani et al., Genova, Italy. In Immunity, Jan 2015
Thus, we demonstrate that in humans RORγt(+)CD34(+) cells are lineage-specified progenitors of IL-22(+) ILC3s and propose that tonsils and intestinal LP, which are enriched both in committed precursors and mature ILC3s, might represent preferential sites of ILC3 lineage differentiation.
Interleukin-22: immunobiology and pathology.
New
Impact
van den Brink et al., In Annu Rev Immunol, Dec 2014
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs).
Th22 cells in allergic disease.
Review
New
Eyerich et al., München, Germany. In Allergo J Int, Dec 2014
Th22 cells are terminally differentiated and very specialized T helper cells characterized by the secretion of their signature cytokine IL-22 and lack of IL-4, IL-17 and IFN-γ.
Oropharyngeal Candidiasis in HIV Infection: Analysis of Impaired Mucosal Immune Response to Candida albicans in Mice Expressing the HIV-1 Transgene.
Review
New
Jolicoeur et al., Montréal, Canada. In Pathogens, Dec 2014
Defective IL-17 and IL-22-dependent mucosal responses to C. albicans were found to determine susceptibility to OPC in these transgenic mice.
T Regulatory and T Helper 17 Cells in Primary Sjögren's Syndrome: Facts and Perspectives.
Review
New
Gerli et al., Perugia, Italy. In Mediators Inflamm, Dec 2014
In addition the impact of abnormal proinflammatory cytokine production, such as IL-6, IL-17, IL-22, and IL-23, has also attracted considerable attention.
Revving up Natural Killer Cells and Cytokine-Induced Killer Cells Against Hematological Malignancies.
Review
New
Rutella et al., Doha, Qatar. In Front Immunol, Dec 2014
In this respect, interleukin (IL)-15 and IL-21 are instrumental in driving NK-cell differentiation and maturation, and hold great promise for the design of optimal NK-cell culture protocols.
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family.
New
Vannay et al., Budapest, Hungary. In Mediators Inflamm, Dec 2014
In the present review we provide an overview of the common key mediators of organ fibrosis highlighting the role of interleukin-10 (IL-10) cytokine family members (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26), which recently came into focus as tissue remodeling-related inflammatory cytokines.
New drug targets for alcoholic liver disease.
New
Gao et al., Bethesda, United States. In Hepatol Int, Sep 2014
In this review, we discuss recently identified therapeutic targets that inhibit inflammation, ameliorate hepatocyte death, and promote liver repair in ALD, with a focus on our recent studies on the immunosuppressive drug prednisolone and the hepatoprotective cytokine interleukin-22.
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.
Impact
GeneRIF
van den Brink et al., New York City, United States. In Immunity, 2012
IL-22 as a critical regulator of tissue sensitivity to GVHD and a protective factor for intestinal stem cells during inflammatory intestinal damage.
Preparation and characterization of mouse IL-22 and its four single-amino-acid muteins that act as IL-22 receptor-1 antagonists.
GeneRIF
Gertler et al., Israel. In Protein Eng Des Sel, 2012
Recombinant mouse il-22 (mIL-22) and its variants were expressed in E coli, refolded and purified.The binding of IL-22 and its four muteins to immobilized mIL-22 receptor alpha1 extracellular domain (mIL-22 Ralpha1-ECD) exhibited similar affinity.
NK1.1+ cells and IL-22 regulate vaccine-induced protective immunity against challenge with Mycobacterium tuberculosis.
GeneRIF
Vankayalapati et al., Tyler, United States. In J Immunol, 2012
IL-22, produced by NK1.1-expressing cells, induces optimal protective immunity through enhancing antigen-specific T cell responses after challenge with Mycobacterium tuberculosis.
IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms.
GeneRIF
Rus et al., Baltimore, United States. In J Immunol, 2012
IL-21 promotes autoimmunity in chronic graft-versus-host disease through both CD4+ T cell- and B cell-intrinsic mechanisms.
Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions.
GeneRIF
Gorochov et al., Paris, France. In Ann Rheum Dis, 2012
Systemic sclerosis pathogenesis does not appear to be linked to IL-17-, but rather to IL-22-producing cells with skin-homing potential and a concomitant quantitative Treg defect.
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