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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Interleukin 21

IL-21, IL-22, Interleukin-21, interleukin-22
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: IL-17, CD4, Interleukin-6, CAN, IL-10
Papers using IL-21 antibodies
The biology of human natural killer-cell subsets.
Supplier
Sandberg Johan K., In PLoS ONE, 2000
... IL-7, IL-4, IL-9; 50 ug/mL IL-12, 0.25 mg/mL IL-18 (all from R&D Systems); 100 ug/mL IL-21 (Miltenyi Biotec), 5 ug/mL IL-15 (PeproTech), 100 ...
Modulation of flagellar expression in Escherichia coli by acetyl phosphate and the osmoregulator OmpR.
Supplier
Masucci Maria G., In PLoS ONE, 1994
... Cells were stimulated with human recombinant IL-22 (Cell Signaling Technologies) for the indicated ...
Papers on IL-21
Interleukin-17- and interleukin-22-secreting myelin-specific CD4(+) T cells resistant to corticoids are related with active brain lesions in multiple sclerosis patients.
New
Bento et al., Rio de Janeiro, Brazil. In Immunology, 29 Feb 2016
Although the production of interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor, IL-17 and IL-22 was less sensitive to hydrocortisone inhibition, only IL-17 and IL-22 levels correlated with active brain lesions.
miRNA-Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis.
New
Chakraborty et al., Ch'unch'ŏn, South Korea. In Med Res Rev, 20 Feb 2016
Moreover, we have tried to portray the role of various miRNAs in different cytokines such as TNF-α, IL-1, IL-6, IL-10, IL-17, IL-18, IL-21, and granulocyte macrophage colony-stimulating factor (GMCSF).
HIV and Tfh Cells: Circulating New Ideas to Identify and Protect.
New
Impact
Silvestri et al., Atlanta, United States. In Immunity, 19 Feb 2016
(2016) report that circulating IL-21-producing CD4(+) T cells are phenotypically, transcriptionally, and functionally similar to lymphoid Tfh cells and that such HIV-specific Tfh cells were increased in RV144 trial vaccine recipients.
Vaccine Induction of Lymph Node-Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques.
New
Robert-Guroff et al., Bethesda, United States. In J Immunol, 15 Feb 2016
In this study, we quantified SIV Env-specific IL-21-producing TFH cells for the first time, to our knowledge, in a nonhuman primate vaccine study.
Recombinant lipidated dengue-3 envelope protein domain III stimulates broad immune responses in mice.
New
Chen et al., Taiwan. In Vaccine, 14 Feb 2016
LD3ED III-immunized mice enhance wide ranges of T cell responses as indicated by IFN-γ, IL-17, IL-21 production.
A higher frequency of CD4(+)CXCR5(+) T follicular helper cells in patients with newly diagnosed Henoch-Schönlein purpura nephritis.
New
Jiang et al., Changchun, China. In Int Immunopharmacol, 14 Feb 2016
The numbers of circulating CD4(+)CXCR5(+), CD4(+)CXCR5(+)ICOS(+) and CD4(+)CXCR5(+)PD-1(+) TFH cells, CD86(+)CD19(+), CD38(+)CD19(+) B cells and serum IL-2, IL-4, IL-17A, IL-21 and IFN-γ were significantly higher in HSPN patients (p<0.05)
Expression of cytokine-mRNA in peripheral blood mononuclear cell of human immunodeficiency virus-1 subtype C infected individuals with opportunistic viral infections from India (South).
New
Kannangai et al., Vellore, India. In Indian J Med Microbiol, 31 Jan 2016
The study reported here investigated the level of mRNA expression of different cytokines: Tumour necrosis factor-alpha (TNF-α), interferon (INF)-gamma, interleukin-10 (IL-10) and IL-21 in the peripheral blood mononuclear cell among the antiretroviral therapy naive subtype C HIV-1 infected individuals and normal healthy controls by real time polymerase chain reaction.
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.
New
Impact
Hanash et al., New York City, United States. In Nature, 24 Jan 2016
Using ex vivo organoid cultures, here we show that innate lymphoid cells (ILCs), potent producers of interleukin-22 (IL-22) after intestinal injury, increase the growth of mouse small intestine organoids in an IL-22-dependent fashion.
Halofuginone Treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.
New
Keshavjee et al., Toronto, Canada. In J Heart Lung Transplant, 10 Jan 2016
Halofuginone treatment also decreased IL-17A and IL-22 transcripts at Day 14, transforming growth factor-β1 and matrix metalloproteinase-2 transcripts at Days 14 and 28.
Th-17 regulatory cytokines inhibit corticosteroid induced airway structural cells apoptosis.
New
Al-Muhsen et al., Riyadh, Saudi Arabia. In Respir Res, 31 Dec 2015
Therefore, in this study, we investigated the ability of Th-17 regulatory cytokines, specifically IL-21, IL22 and IL23, to protect structural airway cells against dexamethasone-induced apoptosis.
Mycobacterium tuberculosis-Specific IL-21+IFN-γ+CD4+ T Cells Are Regulated by IL-12.
New
Wu et al., Guangzhou, China. In Plos One, 31 Dec 2015
UNASSIGNED: In the current study of Mycobacterium tuberculosis (MTB)-specific T and B cells, we found that MTB-specific peptides from early secreted antigenic target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10) induced the expression of IL-21 predominantly in CD4+ T cells.
Interleukin-22 Alleviated Palmitate-Induced Endoplasmic Reticulum Stress in INS-1 Cells through Activation of Autophagy.
New
Zhang et al., Guangzhou, China. In Plos One, 31 Dec 2015
Interleukin-22 (IL-22) plays a critical role in preventing β cells from oxidative and ER stress, and autophagy is associated with the survival and function of β cells.
Complementarity and redundancy of IL-22-producing innate lymphoid cells.
New
Impact
Vivier et al., Melbourne, Australia. In Nat Immunol, 30 Dec 2015
Contrary to the prevailing view, we found by conditional deletion of the key ILC3 genes Stat3, Il22, Tbx21 and Mcl1 that NCR(+) ILC3 cells were redundant for the control of mouse colonic infection with Citrobacter rodentium in the presence of T cells.
Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment.
New
Impact
Zhu et al., Bethesda, United States. In Nat Immunol, 23 Dec 2015
Furthermore, GATA-3 was required for IL-22 production in both ILC3 subsets.
An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses.
New
Impact
Littman et al., New York City, United States. In Cell, Nov 2015
We identified an SFB-dependent role of type 3 innate lymphoid cells (ILC3), which secreted IL-22 that induced epithelial SAA production in a Stat3-dependent manner.
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.
Impact
GeneRIF
van den Brink et al., New York City, United States. In Immunity, 2012
IL-22 as a critical regulator of tissue sensitivity to GVHD and a protective factor for intestinal stem cells during inflammatory intestinal damage.
Preparation and characterization of mouse IL-22 and its four single-amino-acid muteins that act as IL-22 receptor-1 antagonists.
GeneRIF
Gertler et al., Israel. In Protein Eng Des Sel, 2012
Recombinant mouse il-22 (mIL-22) and its variants were expressed in E coli, refolded and purified.The binding of IL-22 and its four muteins to immobilized mIL-22 receptor alpha1 extracellular domain (mIL-22 Ralpha1-ECD) exhibited similar affinity.
NK1.1+ cells and IL-22 regulate vaccine-induced protective immunity against challenge with Mycobacterium tuberculosis.
GeneRIF
Vankayalapati et al., Tyler, United States. In J Immunol, 2012
IL-22, produced by NK1.1-expressing cells, induces optimal protective immunity through enhancing antigen-specific T cell responses after challenge with Mycobacterium tuberculosis.
IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms.
GeneRIF
Rus et al., Baltimore, United States. In J Immunol, 2012
IL-21 promotes autoimmunity in chronic graft-versus-host disease through both CD4+ T cell- and B cell-intrinsic mechanisms.
Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions.
GeneRIF
Gorochov et al., Paris, France. In Ann Rheum Dis, 2012
Systemic sclerosis pathogenesis does not appear to be linked to IL-17-, but rather to IL-22-producing cells with skin-homing potential and a concomitant quantitative Treg defect.
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