GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 24 Feb 2014.
Interleukin 21
IL-21, IL-22, Interleukin-21, interleukin-22
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from
NCBI)
Sponsored links
Papers using
IL-21
antibodies
Mesenchymal stem cells inhibit natural killer cell proliferation, cytotoxicity and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2.
Supplier
In PLoS ONE, 2006
... IL-21eBioscience (San Diego USA) ...
IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration.
Supplier
In PLoS ONE, 2005
... Generation of IL-22 transgenic mouse ...
The biology of human natural killer-cell subsets.
Supplier
In PLoS ONE, 2000
... IL-7, IL-4, IL-9; 50 ug/mL IL-12, 0.25 mg/mL IL-18 (all from R&D Systems); 100 ug/mL IL-21 (Miltenyi Biotec), 5 ug/mL IL-15 (PeproTech), 100 ...
Modulation of flagellar expression in Escherichia coli by acetyl phosphate and the osmoregulator OmpR.
Supplier
In PLoS ONE, 1994
Papers on
IL-21
The role of IL-17 in psoriasis.
New
North Chicago, United States. In J Dermatolog Treat, 20 Mar 2014
Th17 derived cytokines (IL-17A, IL-17F, IL-17A/F and IL-22) were elevated in both psoriasis-like murine models and human psoriatic lesional biopsies.
Anti-IL-17 phase II data for psoriasis: A review.
New
Tucson, United States. In J Dermatolog Treat, 20 Mar 2014
UNLABELLED: Abstract Background: Studies investigating the molecular basis of psoriasis have established the central roles of TNFα, interleukin (IL)-12, IL-22 and IL-23 and there is increasing evidence that IL-17 plays a critical role in the complex pathophysiology.
Interleukin-13-Mediated Paneth Cell Degranulation and Antimicrobial Peptide Release.
New
Hannover, Germany. In J Innate Immun, 19 Mar 2014
In contrast, no release of antibacterial activity was noted after treatment with the Toll-like receptor ligands poly(I:C), lipopolysaccharide or CpG, and the cytokines interleukin (IL)-15, IL-22, IL-28 and interferon-γ.
Increased IL-17 and IL-21 producing TCRαβ+CD4-CD8- T cells in Chinese systemic lupus erythematosus patients.
New
China. In Lupus, 19 Mar 2014
IL-17 and IL-21 levels in the blood and in TCRαβ(+)CD4(-)CD8(-) T cells from SLE patients were increased.
Anticytokine Autoantibody-Associated Immunodeficiency.
New
Impact
Bethesda, United States. In Annu Rev Immunol, 05 Mar 2014
Examples include anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria; anti-granulocyte macrophage colony-stimulating factor autoantibodies and cryptococcal meningitis; anti-interleukin (IL)-6 autoantibodies and staphylococcal skin infection; anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies and mucocutaneous candidiasis in the setting of either APECED (autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy syndrome) or thymoma.
The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria.
New
Impact
Irvine, United States. In Immunity, 04 Mar 2014
UNLABELLED: Interleukin-22 (IL-22) is highly induced in response to infections with a variety of pathogens, and its main functions are considered to be tissue repair and host defense at mucosal surfaces.
Current and potential immune therapies and vaccines in the management of psoriasis.
Review
New
Columbus, United States. In Hum Vaccin Immunother, 03 Mar 2014
IL-22 appears to promote keratinocyte dedifferentiation and increased antimicrobial peptide synthesis while TNF-α and IL-17 induce leukocyte localization within the psoriatic plaque.
Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection.
New
Impact
Chicago, United States. In Immunity, 16 Feb 2014
Here we showed that STAT3 deficiency increased morbidity and mortality after Citrobacter rodentium infection with decreased secretion of cytokines including IL-17 and IL-22 associated with the transcription factor RORγt.
Therapeutic opportunities of the IL-22-IL-22R1 system.
New
Impact
Berlin, Germany. In Nat Rev Drug Discov, 31 Jan 2014
Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells, including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate lymphoid cells.
Role of TH17 cytokines in the control of colorectal cancer.
Review
New
Roma, Italy. In Oncoimmunology, Jan 2014
Studies with murine models of CRC have delineated the mechanisms by which TH17 cytokines, notably, interleukin (IL)-17A, IL-17F, IL-21, and IL-22, regulate oncogenesis and tumor progression, paving the way to the development of novel anticancer drugs.
Treg cells: a potential regulator for IL-22 expression?
Review
New
Guangzhou, China. In Int J Clin Exp Pathol, Dec 2013
UNLABELLED: Inteleurkin-22 (IL-22) is a IL-10 family cytokine member and is mainly produced by innate lymphoid cells (ILCs), Th17 cells, and Th22 cells.
Unique Macrophages Different from M1/M2 Macrophages Inhibit T Cell Mitogenesis while Upregulating Th17 Polarization.
New
Izumo, Japan. In Sci Rep, Dec 2013
MIS-MΦs down-regulated T cell production of Th1 and Th2 cytokines but markedly increased production of interleukin (IL)-17A and IL-22 through up-regulation of Th17 cell expansion.
Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4⁺ T cell responses and viral control during chronic infection.
New
Impact
San Diego, United States. In Immunity, Oct 2013
We identified IL-27 as a gp130 cytokine that promoted antiviral CD4⁺ T cell accumulation in vivo and that rapidly induced IL-21 ex vivo.
A Molecular Link Between Interleukin 22 and Intestinal Mucosal Wound Healing.
Review
Beijing, China. In Adv Wound Care (new Rochelle), 2012
BACKGROUND: Interleukin 22 (IL-22) and signal transducer and activator of transcription 3 (STAT3) are two important regulators of inflammation.
IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice.
GeneRIF
Brussels, Belgium. In J Immunol, 2012
IL-22 is required for psoriasis-like lesions in the mouse imiquimod model and is produced by both T cells and innate immune cells.
Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus.
GeneRIF
Birmingham, United States. In Infect Immun, 2012
Collectively, these results indicate that early innate lung defense against Aspergillus fumigatus is mediated by Dectin-1-dependent IL-22 production.
Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner.
Impact
GeneRIF
New York City, United States. In Nat Immunol, 2012
Here we found that cognate iNKT cell help resulted in a B cell differentiation program that was uniquely dependent on iNKT cell-derived interleukin 21 (IL-21).
Natural killer (NK) and NK-like cells at mucosal epithelia: Mediators of anti-microbial defense and maintenance of tissue integrity.
Review
Saint Louis, United States. In Eur J Microbiol Immunol (bp), 2011
A recently identified population of NK-like cells that shares characteristics of both NK cells and lymphoid tissue inducer (LTi) cells promotes innate immune responses in epithelial tissue through the secretion of IL-22.
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells.
Impact
GeneRIF
New Haven, United States. In Immunity, 2011
memory CD8(+) T cell precursor maturation is an active process dependent on IL-10-IL-21-STAT3 signaling.
Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma.
GeneRIF
Wuhan, China. In Asian Pac J Allergy Immunol, 2011
The expression of AhR mRNA in PBMCs and IL-22 protein in plasma of patients with allergic asthma were higher than those in controlled asthma cases.
