Elevated TGF-β1/IL-31 Pathway Is Associated with the Disease Severity of Hepatitis B Virus-Related Liver Cirrhosis.
Quanzhou, China. In Viral Immunol, 24 Mar 2015
To investigate the association between TGF-β1/IL-31 and stages of chronic HBV infection, serum TGF-β1, IL-9, IL-10,IL-17, IL-22, IL-23, IL-31, IL-33, and IL-35 were determined among patients with chronic hepatitis B (CHB; n=19), HBV-LC (n=20), and a normal control population (NC; n=18).
Interleukin-22: Immunobiology and Pathology.
Melbourne, Australia. In Annu Rev Immunol, 11 Mar 2015
UNASSIGNED: Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs).
A pathogenetic role for IL-21 in primary Sjögren syndrome.
Seoul, South Korea. In Nat Rev Rheumatol, 13 Feb 2015
IL-21 is receiving attention as a potential key player in the pathogenesis of pSS owing to its pleiotropic effects on the type I interferon signalling pathway, and newly identified roles in generation of follicular and IL-17-producing subtypes of helper T cells, as well as plasma-cell differentiation and B-cell activation.
The 3 major types of innate and adaptive cell-mediated effector immunity.
Florence, Italy. In J Allergy Clin Immunol, 18 Jan 2015
Type 3 immunity is mediated by retinoic acid-related orphan receptor γt(+) ILC3s, TC17 cells, and TH17 cells producing IL-17, IL-22, or both, which activate mononuclear phagocytes but also recruit neutrophils and induce epithelial antimicrobial responses, thus protecting against extracellular bacteria and fungi.
Memory T follicular helper CD4 T cells.
Atlanta, United States. In Front Immunol, Dec 2014
This specialized T helper subset provides help to cognate B cells via their expression of CD40 ligand, IL-21, IL-4, and other molecules.
Inflammation versus host defense in obesity.
Houston, United States. In Cell Metab, Dec 2014
(2014) report that immune cells from obese mice have decreased production of IL-22, a cytokine involved in immune responses and inflammation, and reveal therapeutic effects of exogenous IL-22 against obesity-linked metabolic dysfunctions.