Combination therapy: New hope for alcoholic hepatitis?
Bethesda, United States. In Clin Res Hepatol Gastroenterol, 17 Aug 2015
Interleukin-22 (IL-22) is a promising drug for the treatment of AH because of its hepatoprotective and anti-fibrotic functions and relatively few known side effects.
Th22 cells in autoimmunity: a review of current knowledge.
Karaj, Iran. In Eur Ann Allergy Clin Immunol, 31 Jul 2015
This T helper subset, by producing pro-inflammatory cytokines such as IL-22 and tumor necrosis factor-α (TNF-α), is implicated in the pathogenesis of inflammatory and autoimmune disorder.
Interleukin-22: immunobiology and pathology.
In Annu Rev Immunol, Dec 2014
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs).
Th22 cells in allergic disease.
München, Germany. In Allergo J Int, Dec 2014
Th22 cells are terminally differentiated and very specialized T helper cells characterized by the secretion of their signature cytokine IL-22 and lack of IL-4, IL-17 and IFN-γ.
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family.
Budapest, Hungary. In Mediators Inflamm, Dec 2014
In the present review we provide an overview of the common key mediators of organ fibrosis highlighting the role of interleukin-10 (IL-10) cytokine family members (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26), which recently came into focus as tissue remodeling-related inflammatory cytokines.
New drug targets for alcoholic liver disease.
Bethesda, United States. In Hepatol Int, Sep 2014
In this review, we discuss recently identified therapeutic targets that inhibit inflammation, ameliorate hepatocyte death, and promote liver repair in ALD, with a focus on our recent studies on the immunosuppressive drug prednisolone and the hepatoprotective cytokine interleukin-22.