Complementarity and redundancy of IL-22-producing innate lymphoid cells.
Melbourne, Australia. In Nat Immunol, Feb 2016
Contrary to the prevailing view, we found by conditional deletion of the key ILC3 genes Stat3, Il22, Tbx21 and Mcl1 that NCR(+) ILC3 cells were redundant for the control of mouse colonic infection with Citrobacter rodentium in the presence of T cells.
miRNA-Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis.
Ch'unch'ŏn, South Korea. In Med Res Rev, Feb 2016
Moreover, we have tried to portray the role of various miRNAs in different cytokines such as TNF-α, IL-1, IL-6, IL-10, IL-17, IL-18, IL-21, and granulocyte macrophage colony-stimulating factor (GMCSF).
HIV and Tfh Cells: Circulating New Ideas to Identify and Protect.
Atlanta, United States. In Immunity, Feb 2016
(2016) report that circulating IL-21-producing CD4(+) T cells are phenotypically, transcriptionally, and functionally similar to lymphoid Tfh cells and that such HIV-specific Tfh cells were increased in RV144 trial vaccine recipients.
Subclinical gut inflammation in ankylosing spondylitis.
Palermo, Italy. In Curr Opin Rheumatol, Jan 2016
Furthermore, a growing body of evidence suggests that the gut of AS patients may be actively involved in the pathogenesis of AS through the production of proinflammatory cytokines, such as IL-23p19, and the differentiation of potentially pathogenic innate lymphoid cells producing IL-22 and IL-17.
Common gamma chain cytokines in combinatorial immune strategies against cancer.
Nashville, United States. In Immunol Lett, Jan 2016
Common γ chain (γC) cytokines, namely IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 are important for the proliferation, differentiation, and survival of lymphocytes that display antitumor activity, thus stimulating considerable interest for the use of cytokines in cancer immunotherapy.
Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity.
Messina, Italy. In Arch Immunol Ther Exp (warsz), Jan 2016
We have described the role of IL-1, IL-2, IL-6, IL-12, IL-15, IL-18, IL-22, IL-23, TNF-α, IFN-γ as pro-inflammatory cytokines, of IL-1Ra, IL-4, IL-10, TGF-β1 as anti-inflammatory cytokines, and of lipoxin A4 and heat shock proteins as mediators of cytokines.