Interleukin-22: immunobiology and pathology.
In Annu Rev Immunol, 21 Apr 2015
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs).
Novel therapeutic targets in rheumatoid arthritis.
Nijmegen, Netherlands. In Trends Pharmacol Sci, 27 Mar 2015
Here, we discuss two pathways that are regarded as interesting novel therapeutic targets in the field of rheumatology: the Janus kinase (JAK) pathway and the T helper-17 (Th17) pathway [including interleukin (IL)-17, IL-21, IL-22, and granulocyte-macrophage colony-stimulating factor (GM-CSF)].
Memory T follicular helper CD4 T cells.
Atlanta, United States. In Front Immunol, Dec 2014
This specialized T helper subset provides help to cognate B cells via their expression of CD40 ligand, IL-21, IL-4, and other molecules.
Inflammation versus host defense in obesity.
Houston, United States. In Cell Metab, Dec 2014
(2014) report that immune cells from obese mice have decreased production of IL-22, a cytokine involved in immune responses and inflammation, and reveal therapeutic effects of exogenous IL-22 against obesity-linked metabolic dysfunctions.