Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness.
Chicago, United States. In Nature, 01 Nov 2014
Here we show that systemic exposure to Toll-like receptor (TLR) ligands causes rapid α(1,2)-fucosylation of small intestine epithelial cells (IECs) in mice, which requires the sensing of TLR agonists, as well as the production of interleukin (IL)-23 by dendritic cells, activation of innate lymphoid cells and expression of fucosyltransferase 2 (Fut2) by IL-22-stimulated IECs.
[Th17 cells and aplastic anemia].
Taiyuan, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 30 Sep 2014
During the past few years, a novel family of CD4(+)T cell lineage was detected and named as Th17 cells because of its unique ability expressing IL-17, which also can produce IL-17A, IL-17F, IL-21, IL-22 and IL-26.
[Construction and In Vitro Study of Eukaryotic Expression Vector Carrying GITRL and IL-21 Gene].
Lanzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 30 Sep 2014
The aim of this study was to construct the eukaryotic expression vector carrying glucocorticoid-induced tumor necrosis factor receptor ligand (GITRL) and interleukin-21 (IL-21) gene for transfection into chronic myeloid leukemia (CML) dervied dendritic cell (DC), so as to provide an effective platform for exploring the function of target gene in CML.
Targeting Th17 cells in autoimmune diseases.
Cambridge, United States. In Trends Pharmacol Sci, 14 Sep 2014
Given that Th17 cells express IL-17 together with many other proinflammatory cytokines [IL-17F, IL-22, IL-26, and granulocyte-macrophage colony-stimulating factor (GM-CSF)], targeting the Th17 cell lineage may be superior to blocking a single effector cytokine.
Interleukin-17 in human inflammatory diseases.
Tehrān, Iran. In Postepy Dermatol Alergol, Aug 2014
Human Th17 pro-inflammatory cells are currently defined as cells that produce IL-17A and F, tumor necrosis factor (TNF)-α, IL-6, IL-21, IL-22 and IL-23.