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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

Interleukin 21

IL-21, IL-22, Interleukin-21, interleukin-22
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: IL-17, CD4, Interleukin-6, CAN, IL-10
Papers using IL-21 antibodies
The biology of human natural killer-cell subsets.
Supplier
Sandberg Johan K., In PLoS ONE, 2000
... IL-7, IL-4, IL-9; 50 ug/mL IL-12, 0.25 mg/mL IL-18 (all from R&D Systems); 100 ug/mL IL-21 (Miltenyi Biotec), 5 ug/mL IL-15 (PeproTech), 100 ...
Modulation of flagellar expression in Escherichia coli by acetyl phosphate and the osmoregulator OmpR.
Supplier
Masucci Maria G., In PLoS ONE, 1994
... Cells were stimulated with human recombinant IL-22 (Cell Signaling Technologies) for the indicated ...
Papers on IL-21
IL-21 Induction of CD4+ T Cell Differentiation into Th17 Cells Contributes to Bleomycin-Induced Fibrosis in Mice.
New
Sun et al., Nanning, China. In Cell Biol Int, 09 Jan 2015
IL-21 is a potent inducer of Th17 differentiation that is produced by activated T cells, and whose relationship with Th17 cells in SSc is unclear.
Interleukin-17 and Interleukin-22 promote tumor progression in human non-melanoma skin cancer.
New
Cavani et al., Roma, Italy. In Eur J Immunol, 09 Jan 2015
UNLABELLED: Interleukin (IL)-17 and IL-22 have been reported to play critical roles in autoimmunity and inflammation but information about their role in cancer is limited.
Inactivation of Notch signaling reverses the Th17/Treg imbalance in cells from patients with immune thrombocytopenia.
New
Ma et al., Jinan, China. In Lab Invest, 08 Jan 2015
Th17 cells and Treg cells were measured by flow cytometry and IL-17, IL-21, and IL-10 secretion by enzyme immunoassay technique.
Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection.
New
Ibrahim et al., Torrance, United States. In Proc Natl Acad Sci U S A, 08 Jan 2015
NDV-3 induced increases in CD3+ T-cell and neutrophil infiltration and IL-17A, IL-22, and host defense peptide expression in local settings of SSSI abscesses.
The Immunopathogenesis of Psoriasis.
Review
New
Krueger et al., New York City, United States. In Dermatol Clin, 31 Dec 2014
Most of the psoriatic T cells discretely produce interferon-γ, interleukin (IL)-17, and IL-22.
IL-22, cell regeneration and autoimmunity.
Review
New
Singh et al., London, Canada. In Cytokine, 29 Dec 2014
UNLABELLED: IL-22 as a cytokine is described with opposing pro-inflammatory and anti-inflammatory functions.
T cell responses in psoriasis and psoriatic arthritis.
Review
New
Reali et al., Milano, Italy. In Autoimmun Rev, 28 Dec 2014
In particular, myeloid dendritic cell secretion of IL-23 and IL-12 activates IL-17-producing T cells, Th22 and Th1 cells, leading to the production of inflammatory cytokines such as IL-17, IFN-γ, TNF and IL-22.
The IL-20 subfamily of cytokines - from host defence to tissue homeostasis.
New
Impact
Ouyang et al., San Francisco, United States. In Nat Rev Immunol, 25 Dec 2014
The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24 and IL-26.
The Chemokine Receptor CXCR6 Controls the Functional Topography of Interleukin-22 Producing Intestinal Innate Lymphoid Cells.
New
Impact
Di Santo et al., Paris, France. In Immunity, 20 Dec 2014
Interleukin-22 (IL-22) plays a critical role in mucosal defense, although the molecular mechanisms that ensure IL-22 tissue distribution remain poorly understood.
Inflammation versus Host Defense in Obesity.
New
Impact
Ballantyne et al., Houston, United States. In Cell Metab, 04 Dec 2014
(2014) report that immune cells from obese mice have decreased production of IL-22, a cytokine involved in immune responses and inflammation, and reveal therapeutic effects of exogenous IL-22 against obesity-linked metabolic dysfunctions.
Role of interleukin-21 in HBV infection: friend or foe?
Review
New
Hou et al., Guangzhou, China. In Cell Mol Immunol, 03 Dec 2014
The roles of IL-21 in modulating immunity to infections are currently being defined.
Deregulation in STAT signaling is important for cutaneous T-cell lymphoma (CTCL) pathogenesis and cancer progression.
New
Duvic et al., Montréal, Canada. In Cell Cycle, 01 Dec 2014
In early stages, IL-2, IL-7 and IL-15 signaling via JAK1 and JAK3 kinases is believed to be responsible for activating STAT5, while in advanced stages development of IL-21 autocrine signaling is thought to be important for STAT3 activation.
The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair.
New
Impact
Chan et al., Worcester, United States. In Immunity, 16 Nov 2014
Ripk3(-/-) mice exhibited an impaired axis of injury-induced IL-1β, IL-23, and IL-22 cytokine cascade, which was partially corrected by adoptive transfer of wild-type DCs, but not Ripk3(-/-) DCs.
Interleukin-22 Regulates the Complement System to Promote Resistance against Pathobionts after Pathogen-Induced Intestinal Damage.
New
Impact
Inohara et al., Ann Arbor, United States. In Immunity, 16 Nov 2014
Here, we report a critical role for interleukin-22 (IL-22) in systemic protection against bacterial pathobionts that translocate into the circulation after infection with the pathogen Clostridium difficile.
Genetics of psoriatic arthritis.
Review
New
Rahman et al., St. John's, Canada. In Best Pract Res Clin Rheumatol, Oct 2014
Searching for different types of genetic variants such as small CNVs and/or insertions/deletions has also led to the identification of several genes with a function relative to PsV in particular including DEFB4, LCE3C_LCE3B, and IL-22 gene (exon 1).
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.
Impact
GeneRIF
van den Brink et al., New York City, United States. In Immunity, 2012
IL-22 as a critical regulator of tissue sensitivity to GVHD and a protective factor for intestinal stem cells during inflammatory intestinal damage.
Preparation and characterization of mouse IL-22 and its four single-amino-acid muteins that act as IL-22 receptor-1 antagonists.
GeneRIF
Gertler et al., Israel. In Protein Eng Des Sel, 2012
Recombinant mouse il-22 (mIL-22) and its variants were expressed in E coli, refolded and purified.The binding of IL-22 and its four muteins to immobilized mIL-22 receptor alpha1 extracellular domain (mIL-22 Ralpha1-ECD) exhibited similar affinity.
NK1.1+ cells and IL-22 regulate vaccine-induced protective immunity against challenge with Mycobacterium tuberculosis.
GeneRIF
Vankayalapati et al., Tyler, United States. In J Immunol, 2012
IL-22, produced by NK1.1-expressing cells, induces optimal protective immunity through enhancing antigen-specific T cell responses after challenge with Mycobacterium tuberculosis.
IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms.
GeneRIF
Rus et al., Baltimore, United States. In J Immunol, 2012
IL-21 promotes autoimmunity in chronic graft-versus-host disease through both CD4+ T cell- and B cell-intrinsic mechanisms.
Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions.
GeneRIF
Gorochov et al., Paris, France. In Ann Rheum Dis, 2012
Systemic sclerosis pathogenesis does not appear to be linked to IL-17-, but rather to IL-22-producing cells with skin-homing potential and a concomitant quantitative Treg defect.
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