The role of IL-17 in psoriasis.
North Chicago, United States. In J Dermatolog Treat, 20 Mar 2014
Th17 derived cytokines (IL-17A, IL-17F, IL-17A/F and IL-22) were elevated in both psoriasis-like murine models and human psoriatic lesional biopsies.
Anti-IL-17 phase II data for psoriasis: A review.
Tucson, United States. In J Dermatolog Treat, 20 Mar 2014
UNLABELLED: Abstract Background: Studies investigating the molecular basis of psoriasis have established the central roles of TNFα, interleukin (IL)-12, IL-22 and IL-23 and there is increasing evidence that IL-17 plays a critical role in the complex pathophysiology.
Anticytokine Autoantibody-Associated Immunodeficiency.
Bethesda, United States. In Annu Rev Immunol, 05 Mar 2014
Examples include anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria; anti-granulocyte macrophage colony-stimulating factor autoantibodies and cryptococcal meningitis; anti-interleukin (IL)-6 autoantibodies and staphylococcal skin infection; anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies and mucocutaneous candidiasis in the setting of either APECED (autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy syndrome) or thymoma.
Therapeutic opportunities of the IL-22-IL-22R1 system.
Berlin, Germany. In Nat Rev Drug Discov, 31 Jan 2014
Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells, including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate lymphoid cells.
Role of TH17 cytokines in the control of colorectal cancer.
Roma, Italy. In Oncoimmunology, Jan 2014
Studies with murine models of CRC have delineated the mechanisms by which TH17 cytokines, notably, interleukin (IL)-17A, IL-17F, IL-21, and IL-22, regulate oncogenesis and tumor progression, paving the way to the development of novel anticancer drugs.