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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Mar 2015.

Interleukin 21

IL-21, IL-22, Interleukin-21, interleukin-22
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: IL-17, CD4, Interleukin-6, CAN, IL-10
Papers using IL-21 antibodies
The biology of human natural killer-cell subsets.
Supplier
Sandberg Johan K., In PLoS ONE, 2000
... IL-7, IL-4, IL-9; 50 ug/mL IL-12, 0.25 mg/mL IL-18 (all from R&D Systems); 100 ug/mL IL-21 (Miltenyi Biotec), 5 ug/mL IL-15 (PeproTech), 100 ...
Modulation of flagellar expression in Escherichia coli by acetyl phosphate and the osmoregulator OmpR.
Supplier
Masucci Maria G., In PLoS ONE, 1994
... Cells were stimulated with human recombinant IL-22 (Cell Signaling Technologies) for the indicated ...
Papers on IL-21
Altered cytokine levels in pediatric ITP.
New
Olsson et al., Göteborg, Sweden. In Platelets, 25 Apr 2015
Plasma levels of chemokine (C-X3-C motif) ligand 1 (CX3CL1), transforming growth factor β1 (TGF-β1), and interleukin 22 (IL-22) were analyzed in both cohorts using enzyme-linked immunosorbent assays (ELISAs).
Advances in IL-21 biology-enhancing our understanding of human disease.
Review
New
Tangye, Australia. In Curr Opin Immunol, 19 Apr 2015
However, recent discoveries of loss-of function mutations in IL21 or IL21R in humans have unveiled unexpected roles for IL-21 in immune regulation.
Therapeutic and immunomodulatory effects of glucosamine in combination with low-dose cyclosporine A in A murine model of imiquimod-induced psoriasis.
New
Lee et al., South Korea. In Eur J Pharmacol, 18 Apr 2015
We found that combined treatment with Glu (300mg/kg) and low-dose (10 or 20mg/kg) CsA strongly ameliorated the development of psoriasis-like skin lesions and reduced the levels of Th1 cytokine (TNF-α) and Th17 cytokines (IL-17, IL-22, and IL-23) in the serum and dorsal skin.
Peyer's patch innate lymphoid cells regulate commensal bacteria expansion.
New
Kobata et al., Mibu, Japan. In Immunol Lett, 17 Apr 2015
Here we show that Peyer's patch (PP) ILCs robustly produce IL-22 and IFN-γ in the absence of exogenous stimuli.
The biological functions of IL-17 in different clinical expressions of H. pylori-infection.
Review
New
Razavi et al., Tehrān, Iran. In Microb Pathog, 12 Apr 2015
IL-1β, IL-6, tumor necrosis factor (TNF)-α, TGF-β1, IL-17, IL-18, IL-21 and IL-22 have been reported to be involved in H. pylori-induced gastric mucosal inflammation, but the details and relation to different patterns of inflammation remain unclear.
Novel therapeutic targets in rheumatoid arthritis.
Review
New
van den Berg et al., Nijmegen, Netherlands. In Trends Pharmacol Sci, 27 Mar 2015
Here, we discuss two pathways that are regarded as interesting novel therapeutic targets in the field of rheumatology: the Janus kinase (JAK) pathway and the T helper-17 (Th17) pathway [including interleukin (IL)-17, IL-21, IL-22, and granulocyte-macrophage colony-stimulating factor (GM-CSF)].
Recent advances in atopic dermatitis and psoriasis: Genetic background, barrier function, and therapeutic targets.
Review
New
Sugaya et al., Tokyo, Japan. In J Dermatol Sci, 25 Mar 2015
Although clinical pictures of these two diseases are quite different, they share some common pathological backgrounds such as barrier dysfunction and enhanced IL-22 expression.
Interleukin-22 Induces Interleukin-18 Expression from Epithelial Cells during Intestinal Infection.
New
Impact
Ouyang et al., Berlin, Germany. In Immunity, 17 Mar 2015
We show here that attenuated ileitis observed in interleukin-22 (IL-22)-deficient mice was associated with reduced production of Th1-cell-promoting IL-18.
Interleukin-22: Immunobiology and Pathology.
New
Impact
van den Brink et al., Melbourne, Australia. In Annu Rev Immunol, 11 Mar 2015
UNASSIGNED: Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs).
Human RORγt(+)CD34(+) cells are lineage-specified progenitors of group 3 RORγt(+) innate lymphoid cells.
New
Impact
Romagnani et al., Genova, Italy. In Immunity, Jan 2015
Thus, we demonstrate that in humans RORγt(+)CD34(+) cells are lineage-specified progenitors of IL-22(+) ILC3s and propose that tonsils and intestinal LP, which are enriched both in committed precursors and mature ILC3s, might represent preferential sites of ILC3 lineage differentiation.
IL22/IL-22R Pathway Induces Cell Survival in Human Glioblastoma Cells.
New
Lecron et al., Limoges, France. In Plos One, Dec 2014
Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that binds to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2.
Memory T follicular helper CD4 T cells.
Review
New
Ahmed et al., Atlanta, United States. In Front Immunol, Dec 2014
This specialized T helper subset provides help to cognate B cells via their expression of CD40 ligand, IL-21, IL-4, and other molecules.
Activation of Intestinal Epithelial Stat3 Orchestrates Tissue Defense during Gastrointestinal Infection.
New
Becker et al., Erlangen, Germany. In Plos One, Dec 2014
C. rodentium induced transcription of IL-6 and IL-22 in gut samples of mice and was associated with activation of the transcription factor Stat3 in intestinal epithelial cells.
The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells.
New
Impact
Di Santo et al., Paris, France. In Immunity, Dec 2014
Interleukin-22 (IL-22) plays a critical role in mucosal defense, although the molecular mechanisms that ensure IL-22 tissue distribution remain poorly understood.
Inflammation versus host defense in obesity.
New
Impact
Ballantyne et al., Houston, United States. In Cell Metab, Dec 2014
(2014) report that immune cells from obese mice have decreased production of IL-22, a cytokine involved in immune responses and inflammation, and reveal therapeutic effects of exogenous IL-22 against obesity-linked metabolic dysfunctions.
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.
Impact
GeneRIF
van den Brink et al., New York City, United States. In Immunity, 2012
IL-22 as a critical regulator of tissue sensitivity to GVHD and a protective factor for intestinal stem cells during inflammatory intestinal damage.
Preparation and characterization of mouse IL-22 and its four single-amino-acid muteins that act as IL-22 receptor-1 antagonists.
GeneRIF
Gertler et al., Israel. In Protein Eng Des Sel, 2012
Recombinant mouse il-22 (mIL-22) and its variants were expressed in E coli, refolded and purified.The binding of IL-22 and its four muteins to immobilized mIL-22 receptor alpha1 extracellular domain (mIL-22 Ralpha1-ECD) exhibited similar affinity.
NK1.1+ cells and IL-22 regulate vaccine-induced protective immunity against challenge with Mycobacterium tuberculosis.
GeneRIF
Vankayalapati et al., Tyler, United States. In J Immunol, 2012
IL-22, produced by NK1.1-expressing cells, induces optimal protective immunity through enhancing antigen-specific T cell responses after challenge with Mycobacterium tuberculosis.
IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms.
GeneRIF
Rus et al., Baltimore, United States. In J Immunol, 2012
IL-21 promotes autoimmunity in chronic graft-versus-host disease through both CD4+ T cell- and B cell-intrinsic mechanisms.
Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions.
GeneRIF
Gorochov et al., Paris, France. In Ann Rheum Dis, 2012
Systemic sclerosis pathogenesis does not appear to be linked to IL-17-, but rather to IL-22-producing cells with skin-homing potential and a concomitant quantitative Treg defect.
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