The Immunopathogenesis of Psoriasis.
New York City, United States. In Dermatol Clin, 31 Dec 2014
Most of the psoriatic T cells discretely produce interferon-γ, interleukin (IL)-17, and IL-22.
T cell responses in psoriasis and psoriatic arthritis.
Milano, Italy. In Autoimmun Rev, 28 Dec 2014
In particular, myeloid dendritic cell secretion of IL-23 and IL-12 activates IL-17-producing T cells, Th22 and Th1 cells, leading to the production of inflammatory cytokines such as IL-17, IFN-γ, TNF and IL-22.
Inflammation versus Host Defense in Obesity.
Houston, United States. In Cell Metab, 04 Dec 2014
(2014) report that immune cells from obese mice have decreased production of IL-22, a cytokine involved in immune responses and inflammation, and reveal therapeutic effects of exogenous IL-22 against obesity-linked metabolic dysfunctions.
Genetics of psoriatic arthritis.
St. John's, Canada. In Best Pract Res Clin Rheumatol, Oct 2014
Searching for different types of genetic variants such as small CNVs and/or insertions/deletions has also led to the identification of several genes with a function relative to PsV in particular including DEFB4, LCE3C_LCE3B, and IL-22 gene (exon 1).