Interleukin-22 inhibits bleomycin-induced pulmonary fibrosis.
Shanghai, China. In Mediators Inflamm, Dec 2012
Although dysregulation of interleukin- (IL-) 22 is involved in various pulmonary pathophysiological processes, the role of IL-22 in fibrotic lung diseases is still unclear and needs to be further addressed.
Immunity to infection in IL-17-deficient mice and humans.
New York City, United States. In Eur J Immunol, Sep 2012
In humans, the study of patients with various primary immunodeficiencies, including autosomal dominant hyper-IgE syndrome caused by dominant-negative STAT3 mutations and autosomal recessive autoimmune polyendocrinopathy syndrome type 1 caused by null mutations in AIRE, has suggested that IL-17A, IL-17F and/or IL-22 are essential for mucocutaneous immunity to Candida albicans.
IL-17-producing γδ T cells and innate lymphoid cells.
Dublin, Ireland. In Eur J Immunol, Sep 2012
γδ T cells also play a pathological role in certain autoimmune diseases, where they provide an early source of IL-17 and IL-21, which initiate responses mediated by conventional IL-17-secreting CD4(+) T cells (Th17 cells).
A role for Th17 cells in the regulation of tertiary lymphoid follicles.
San Francisco, United States. In Eur J Immunol, Sep 2012
Here, we compare and contrast LTi and Th17 cells, and review recent evidence that Th17 cells and Th17 cytokines, such as IL-17 and IL-22, contribute to the development of ectopic lymphoid structures in chronic-ally inflamed tissue.
Invariant NKT cells: regulation and function during viral infection.
Winnipeg, Canada. In Plos Pathog, 2011
In vitro studies of influenza infection have revealed novel effector functions of iNKT cells including IL-22 production and modulation of myeloid-derived suppressor cells, but ex vivo characterization of human iNKT cells during influenza infection are lacking.
Immunoregulation by naturally occurring and disease-associated autoantibodies : binding to cytokines and their role in regulation of T-cell responses.
Copenhagen, Denmark. In Adv Exp Med Biol, 2011
Both naturally occurring and disease-associated autoantibodies against a variety of cytokines have been reported, including NAbs against interleukin (IL)-1α, IL-6, IL-8, IL-10, granulocyte-macrophage colony-stimulating factor, interferon (IFN)-α, IFN-β, IFN-γ, macrophage chemotactic protein-1 and IL-21.