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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Interleukin 20 receptor, alpha

IL-20R1, IL-20R, IL-20Ralpha, IL20RA
The protein encoded by this gene is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). This gene and IL20B are highly expressed in skin. The expression of both genes is found to be upregulated in Psoriasis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, P28, IL-22R1, FISP, IL-19
Papers on IL-20R1
Interleukin-26: An Emerging Player in Host Defense and Inflammation.
New
Lindén et al., Göteborg, Sweden. In J Innate Immun, Aug 2015
It is known that IL-26 binds to the IL-20R1/IL-10R2 receptor complex on certain target cells, where it causes specific intracellular signaling and the secretion of IL-1β, IL-8 and TNF-α.
Molecular characterisation of four class 2 cytokine receptor family members in rainbow trout, Oncorhynchus mykiss.
Secombes et al., Aberdeen, United Kingdom. In Dev Comp Immunol, 2015
To exert their functions they signal through a heterodimeric receptor composed of a subunit with a long intracellular domain (R1 type receptors; IL-10R1, IL-20R1 or IL-22R1) and a subunit with a short intracellular domain (R2 type receptors; IL-10R2 or IL-20R2).
Impact of RGD Peptide Tethering to IL24/mda-7 (Melanoma Differentiation Associated Gene-7) on Apoptosis Induction in Hepatocellular Carcinoma Cells.
Hosseini et al., Shīrāz, Iran. In Asian Pac J Cancer Prev, 2014
Protein modelling analysis revealed that tethering RGD at the end of IL-24/Mda7 disrupt attachment to cognate receptor, IL-20R1/ IL-20R2.
Interleukin-20 promotes airway remodeling in asthma.
Dong et al., Jinan, China. In Inflammation, 2014
To identify the expression of IL-20 and its receptor, IL-20R1/IL-20R2, in the airway epithelium in bronchial tissues, bronchial biopsy specimens were collected from patients and mice with asthma and healthy subjects and stained with specific antibodies.
IL-20 and IL-20R1 antibodies protect against liver fibrosis.
Chang et al., In Hepatology, 2014
In mice with short-term liver injury, anti-IL-20 monoclonal antibody (7E) and anti-IL-20 receptor (IL-20R1) monoclonal antibody (51D) attenuated hepatocyte damage caused by CCl4, TGF-β1, and chemokine production.
Reduction of IL-20 Expression in Rheumatoid Arthritis by Linear Polarized Infrared Light Irradiation.
Abiko et al., Matsudo, Japan. In Laser Ther, 2014
MATERIALS AND METHODS: MH7A was cultured and challenged with IL-1ß, then examined IL-20 and IL-20R mRNA level by DNA microarray.
Decreased interleukin-20 expression in scleroderma skin contributes to cutaneous fibrosis.
Ihn et al., Kumamoto, Japan. In Arthritis Rheumatol, 2014
METHODS: Protein and messenger RNA (mRNA) levels of collagen, Fli-1, IL-20, and IL-20 receptor (IL-20R) were analyzed using polymerase chain reaction (PCR) array, immunoblotting, immunohistochemical staining, enzyme-linked immunosorbent assay, and real-time PCR.
Astrocytes produce IL-19 in response to bacterial challenge and are sensitive to the immunosuppressive effects of this IL-10 family member.
Marriott et al., In Glia, 2014
In the present study, we demonstrate the constitutive and/or inducible expression of IL-19 and its cognate receptor subunits, IL-19Rα and IL-19Rβ (also known as IL-20R1 and IL-20R2, and IL-20RA and IL-20RB), in mouse brain tissue, and by primary murine and human astrocytes.
Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma.
Wirtz et al., Portland, United States. In J Ocul Pharmacol Ther, 2014
PURPOSE: To determine whether interleukin-20 receptors (IL-20R) are expressed in trabecular meshwork cells and the effect of a T104M mutation in IL-20R2 on downstream cellular functions.
Combination of adenoviruses expressing melanoma differentiation-associated gene-7 and chemotherapeutic agents produces enhanced cytotoxicity on esophageal carcinoma.
Tagawa et al., Chiba, Japan. In Cancer Gene Ther, 2014
All the carcinoma cells expressed the melanoma differentiation-associated gene-7/interleukin-24 (MDA-7/IL-24) receptor complexes, IL-20R2 and either IL-20R1 or IL-22R1, and were susceptible to Ad-mda-7, whereas fibroblasts were positive only for IL-20R2 gene and resistant to Ad-mda-7-mediated cytotoxicity.
The therapeutic potential of anti-interleukin-20 monoclonal antibody.
Review
Chang et al., Tainan City, Taiwan. In Cell Transplant, 2013
IL-20 acts on multiple cell types by activating on a heterodimer receptor complex of either IL-20R1-IL-20R2 or IL-22R1-IL-20R2.
Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex.
GeneRIF
Walter et al., Birmingham, United States. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
crystallographic asymmetric unit contains one IL-20-IL-20R1-IL-20R2 complex, corresponding to a solvent content of approximately 54%
Interleukin-26, a highly cationic T-cell cytokine targeting epithelial cells.
Review
Fickenscher et al., Kiel, Germany. In Antiinflamm Antiallergy Agents Med Chem, 2011
IL-26 specifically targets the lL-26-specific heterodimeric receptor complex consisting of IL-20R1 and IL-10R2 which is typically expressed on epithelial cells such as colon carcinoma cells or keratinocytes.
IL-19, IL-20 and IL-24: potential therapeutic targets for autoimmune diseases.
Review
Ye et al., Hefei, China. In Expert Opin Ther Targets, 2011
IL-19, IL-20 and IL-24 are members of the IL-10 family of cytokines, the human IL-19, IL-20 and IL-24 genes are all located on the q32 region of chromosome 1, and the three cytokines also share a common receptor IL-20R1/IL-20R2 heterodimer.
Interleukin-26: an IL-10-related cytokine produced by Th17 cells.
Review
Walter et al., Bethesda, United States. In Cytokine Growth Factor Rev, 2010
It signals through a heterodimeric receptor complex composed of the IL-20R1 and IL-10R2 chains.
Further association analysis of chr 6q22-24 suggests a role of IL-20RA polymorphisms in psoriasis.
GeneRIF
Kõks et al., In J Dermatol Sci, 2010
IL-20RA polymorphisms may have a role in psoriasis
IL-24: physiological and supraphysiological effects on normal and malignant cells.
Review
Kreis et al., Luxembourg, Luxembourg. In Curr Med Chem, 2009
Binding of IL-24 to either of its two heterodimeric receptors IL-20R1/IL-20R2 and IL-22R/IL-20R2 triggers phosphorylation and consequently activation of STAT3 and/or STAT1 in target tissues such as lung, testis, ovary, keratinocytes and skin.
Expression pattern of mda-7/IL-24 receptors in liver cancer cell lines.
GeneRIF
Yang et al., Kunming, China. In Hepatobiliary Pancreat Dis Int, 2009
Complete mda-7/IL-24 receptors (IL-22R1/IL-20R2 and IL-20R1/IL-20R2) are seldom expressed in liver cancer cell lines.
Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition.
GeneRIF
Chang et al., Tainan City, Taiwan. In Genes Immun, 2009
mIL-20R1a functioned as an aggravating factor in promoting calcium deposition in kidney of mice.
Association analysis of IL20RA and IL20RB genes in psoriasis.
GeneRIF
Kõks et al., Tartu, Estonia. In Genes Immun, 2008
The hypotheses that genetic variations of the IL-20-RI influence susceptibility to psoriasis was investigated.
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