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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Interleukin 2 receptor, beta

IL-2 receptor
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-2, CD25, CAN, HAD, CD4
Papers using IL-2 receptor antibodies
Adaptor and clathrin exchange at the plasma membrane and trans-Golgi network
Supplier
Puertollano Rosa et al., In Traffic (Copenhagen, Denmark), 2002
... (MBL International, Woburn, MA, USA), mouse monoclonal anti-GFP (ab1218; Abcam, Cambridge, MA, USA), mouse monoclonal anti-IL2 Receptor alpha (Tac) (143–13; Abcam) and mouse monoclonal anti-annexin-II ...
Papers on IL-2 receptor
Prepartum feeding level and body condition score affect immunological performance in grazing dairy cows during the transition period.
New
Heiser et al., Brisbane, Australia. In J Dairy Sci, Feb 2016
The numbers of T helper lymphocytes (CD4+), cytotoxic T lymphocytes (CD8+), natural killer cells (CD335+), and γδ T lymphocytes (WC1+) as well as their activation status [IL-2 receptor (CD25)+ cells] were highly variable between animals, but there was no evident effect of BCS, feeding level, or time.
New Molecular and Cellular Mechanisms of Tolerance: Tolerogenic Actions of IL-2.
Review
New
Piaggio et al., Paris, France. In Methods Mol Biol, Dec 2015
Treg cells are exquisitely sensitive to IL-2 due to their constitutive expression of the high affinity IL-2 receptor (IL-2R) and the new paradigm suggests that low-doses of IL-2 could selectively boost Treg cells in vivo.
Immune Alterations in Patients with Anti-Interferon-γ Autoantibodies.
New
Kasinrerk et al., Chiang Mai, Thailand. In Plos One, Dec 2015
Upon TCR activation, T cell proliferation and IL-2 receptor of the patients remained intact.
Macrophage activation syndrome complicating adult onset Still's disease: A single center case series and comparison with literature.
New
Yao et al., Lexington, United States. In Semin Arthritis Rheum, Dec 2015
While the 2 cohorts were similar clinically, in the CCF cohort, more patients had renal insufficiency (p < 0.001), higher soluble IL-2 receptor level (p = 0.01), and lower ESR (p = 0.02) as compared with the literature cohort.
Polyclonal and monoclonal antibodies in renal transplant: an update.
Review
New
Kaplan et al., Kansas City, United States. In Curr Opin Nephrol Hypertens, Nov 2015
The risk of acute rejection was higher in IL-2 receptor blockers mainly in the first year, but graft survivals were similar in both groups long term.
The common γ-chain cytokine receptor: tricks-and-treats for T cells.
Review
New
Park et al., Bethesda, United States. In Cell Mol Life Sci, Nov 2015
UNASSIGNED: Originally identified as the third subunit of the high-affinity IL-2 receptor complex, the common γ-chain (γc) also acts as a non-redundant receptor subunit for a series of other cytokines, collectively known as γc family cytokines.
Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut-brain pathways.
Review
New
Maes et al., Badalona, Spain. In Cns Spectr, Sep 2015
Common IO&NS underpinning between both disorders is evidenced by increased pro-inflammatory cytokine levels, eg, interleukin-1 (IL-1) and tumor necrosis factor-α, IL-6 trans-signalling; Th-1- and Th-17-like responses; neopterin and soluble IL-2 receptor levels; positive acute phase reactants (haptoglobin and C-reactive protein); lowered levels of negative acute phase reactants (albumin, transferrin, zinc) and anti-inflammatory cytokines (IL-10 and transforming growth factor-β); increased O&NS with damage to lipids, proteinsm and DNA; increased production of nitric oxide (NO) and inducible NO synthase; lowered plasma tryptophan but increased TRYCAT levels; autoimmune responses; and increased bacterial translocation.
Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory Diseases.
Review
New
Grisham et al., Salt Lake City, United States. In Inflamm Bowel Dis, Jul 2015
The discovery that targeted mutation of the IL-2 receptor common gamma chain in lymphopenic mice allows for the long-term engraftment of functional human immune cells has advanced greatly our ability to humanize the mouse immune system.
IL-2: Change Structure … Change Function.
New
Impact
Trotta et al., San Francisco, United States. In Immunity, Jun 2015
In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences.
Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study.
Waldron-Lynch et al., Cambridge, United Kingdom. In Bmj Open, 2014
Genetic analyses indicate that alterations of the interleukin-2 (IL-2) pathway mediating immune activation and tolerance predispose to T1D, specifically the polymorphic expression of the IL-2 receptor-α chain (CD25) on T lymphocytes.
Opportunistic Infections in Patients with HTLV-1 Infection.
Imashuku et al., Uji, Japan. In Case Report Hematol, 2014
High levels of serum soluble IL-2 receptor (sIL-2R; 4,304 U/mL) and an increased percentage of CD4+CD25+ T cells (75.5%) in peripheral blood were also detected.
The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2.
Impact
Bishop et al., United States. In Nat Immunol, 2014
TRAF3 dampened interleukin 2 (IL-2) signaling by facilitating recruitment of the tyrosine phosphatase TCPTP to the IL-2 receptor complex, which resulted in dephosphorylation of the signaling molecules Jak1 and Jak3 and negative regulation of signaling via Jak and the transcription factor STAT5.
Downmodulation of tumor suppressor p53 by T cell receptor signaling is critical for antigen-specific CD4(+) T cell responses.
Impact
Hodes et al., Bethesda, United States. In Immunity, 2014
In the absence of T cell receptor (TCR) signal, IL-2 induced sustained increase in p53 protein, which prevented proliferative responses despite strong signaling through the IL-2 receptor.
Regulatory T cell proliferative potential is impaired in human autoimmune disease.
Impact
Matarese et al., Napoli, Italy. In Nat Med, 2014
Here we report that proliferation of Treg cells after TCR stimulation is impaired in subjects with relapsing-remitting multiple sclerosis (RRMS) because of altered interleukin-2 (IL-2) secretion and IL-2 receptor (IL-2R)-signal transducer and activator of transcription 5 (STAT5) signaling.
Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial.
Impact
Ricordi et al., Fuzhou, China. In Jama, 2012
Fifty-three patients received standard-dose and 52 patients received low-dose CNIs (80% of standard); 51 patients in the control group received anti-IL-2 receptor antibody plus standard-dose CNIs.
Soluble cytokine receptors (sIL-2Rα, sIL-2Rβ) induce subunit-specific behavioral responses and accumulate in the cerebral cortex and basal forebrain.
GeneRIF
Siegel et al., Newark, United States. In Plos One, 2011
sIL-2Ralpha and sIL-2Rbeta induce marked subunit- and soluble cytokine receptor-specific behavioral disturbances
The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development.
GeneRIF
Malek et al., Miami, United States. In J Immunol, 2011
This study directly examines proximal signaling by transgenic IL-2 and IL-15 and CD8-positive T cell primary and memory responses as a consequence of varied CD122-dependent signaling.
Placenta-specific expression of the interleukin-2 (IL-2) receptor β subunit from an endogenous retroviral promoter.
GeneRIF
Mager et al., Vancouver, Canada. In J Biol Chem, 2011
LTR of the THE1D retroelement family has been domesticated as an alternative promoter of human IL2RB, the gene encoding the beta subunit of the IL-2 receptor.
Impact of IL2 and IL2RB genetic polymorphisms in kidney transplantation.
GeneRIF
Kim et al., Pusan, South Korea. In Transplant Proc, 2011
Genetic variants of IL2RB may be associated with the development of acute rejection episodes and may help predict risk in kidney transplantation patients.
Genetic variation at 5 new autosomal short tandem repeat markers (D10S1248, D22S1045, D2S441, D1S1656, D12S391) in a population-based sample from Maghreb region.
GeneRIF
Verzeletti et al., Brescia, Italy. In Croat Med J, 2011
The researchers found evidence that there were significant differences between the D22S1045 locus in the Maghreb population and other populations.
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