Adaptor and clathrin exchange at the plasma membrane and trans-Golgi network
In Traffic (Copenhagen, Denmark), 2002
... (MBL International, Woburn, MA, USA), mouse monoclonal anti-GFP (ab1218; Abcam, Cambridge, MA, USA), mouse monoclonal anti-IL2 Receptor alpha (Tac) (143–13; Abcam) and mouse monoclonal anti-annexin-II ...
The common γ-chain cytokine receptor: tricks-and-treats for T cells.
Bethesda, United States. In Cell Mol Life Sci, Nov 2015
UNASSIGNED: Originally identified as the third subunit of the high-affinity IL-2 receptor complex, the common γ-chain (γc) also acts as a non-redundant receptor subunit for a series of other cytokines, collectively known as γc family cytokines.
Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut-brain pathways.
Badalona, Spain. In Cns Spectr, Sep 2015
Common IO&NS underpinning between both disorders is evidenced by increased pro-inflammatory cytokine levels, eg, interleukin-1 (IL-1) and tumor necrosis factor-α, IL-6 trans-signalling; Th-1- and Th-17-like responses; neopterin and soluble IL-2 receptor levels; positive acute phase reactants (haptoglobin and C-reactive protein); lowered levels of negative acute phase reactants (albumin, transferrin, zinc) and anti-inflammatory cytokines (IL-10 and transforming growth factor-β); increased O&NS with damage to lipids, proteinsm and DNA; increased production of nitric oxide (NO) and inducible NO synthase; lowered plasma tryptophan but increased TRYCAT levels; autoimmune responses; and increased bacterial translocation.
IL-2: Change Structure … Change Function.
San Francisco, United States. In Immunity, Jun 2015
In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences.
Currently Used Biologic Agents in the Management of Behcet's Syndrome.
İstanbul, Turkey. In Curr Med Chem, 2014
Studies investigating the efficacy of daclizumab, IL2 receptor antibody, and secukinumab, IL17 monoclonal antibody, in the management of BS with eye involvement failed to demonstrate significant clinical improvement and both studies were halted.