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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 1 receptor antagonist

IL-1ra, interleukin-1 receptor antagonist, p80, IL-1R
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-1beta, Interleukin-6, IL-10, HAD, CAN
Papers using IL-1ra antibodies
The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions.
Zhang Lin, In PLoS ONE, 2005
... Polyclonal anti-Notch4, anti-OB-R-NH2 antibodies, monoclonal anti-IL-1R tI, nonspecific goat IgG2b, CSL small interference (si)RNA and control siRNA-A were obtained from Santa Cruz Biotechnology, Inc ...
Papers on IL-1ra
T-cell-intrinsic Tif1α/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy.
Wilson et al., London, United Kingdom. In Proc Natl Acad Sci U S A, Feb 2016
Following this prediction, we found that Trim24(-/-) T cells have reduced IL-1 receptor (IL-1R) expression, are refractory to IL-1β-mediated activation in vitro and in vivo, and fail to respond to IL-1β-exacerbated airway allergy.
Activation of NLRP3 inflammasome enhances the proliferation and migration of A549 lung cancer cells.
Xie et al., Nanjing, China. In Oncol Rep, Feb 2016
Moreover, these effects were inhibited by the following treatments: i) downregulating the expression of NLRP3 by short hairpin RNA (shRNA) interference, ii) inhibiting the activation of NLRP3 inflammasome with a caspase-1 inhibitor, iii) blocking the interleukin-1β (IL-1β) and IL-18 signal transduction with IL-1 receptor antagonist (IL-1Ra) and IL-18 binding protein (IL-18BP).
Interleukin-1 and inflammasomes in ALD/AAH and NAFLD/NASH.
Szabo et al., Innsbruck, Austria. In Hepatology, Feb 2016
Indeed, neutralization of IL-1 by IL-1 receptor antagonist (IL-1Ra) has recently been shown to potently prevent liver injury in murine models of ALD.
Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity.
Basile et al., Messina, Italy. In Arch Immunol Ther Exp (warsz), Jan 2016
We have described the role of IL-1, IL-2, IL-6, IL-12, IL-15, IL-18, IL-22, IL-23, TNF-α, IFN-γ as pro-inflammatory cytokines, of IL-1Ra, IL-4, IL-10, TGF-β1 as anti-inflammatory cytokines, and of lipoxin A4 and heat shock proteins as mediators of cytokines.
Exercise and type 2 diabetes: focus on metabolism and inflammation.
Pedersen et al., Copenhagen, Denmark. In Immunol Cell Biol, Jan 2016
Mechanistic studies in humans suggest that moderate acute elevations in IL-6, as provoked by exercise, exert direct anti-inflammatory effects by an inhibition of TNF-α and by stimulating IL-1ra (IL-1 receptor antagonist), thereby limiting IL-1β signaling.
Inflammation as a neurobiological substrate of cognitive impairment in bipolar disorder: Evidence, pathophysiology and treatment implications.
McIntyre et al., Toronto, Canada. In J Affect Disord, Jan 2016
Cognitive dysfunction was associated with elevated levels of pro-inflammatory markers YKL40, IL-6, sCD40L, IL-1Ra, hsCRP and TNF-α.
Establishment of Elevated Serum Levels of IL-10, IL-8 and TNF-β as Potential Peripheral Blood Biomarkers in Tubercular Lymphadenitis: A Prospective Observational Cohort Study.
Bhowmick et al., Delhi, India. In Plos One, Dec 2015
To assess this twelve cytokines (Tumor Necrosis Factor (TNF)-α, Interferon (IFN) -γ, Interleukin (IL)-2, IL-12, IL-18, IL-1β, IL-10, IL-6, IL-4, IL-1Receptor antagonist (IL-1Ra), IL-8 and TNF-β, which have a role in pathogenesis of tuberculosis, were tested as potential peripheral blood biomarkers to aid the diagnosis of TL when routine investigations prove to be of limited value.
Alveolar macrophage inflammatory mediator expression is elevated in the setting of alcohol use disorders.
Burnham et al., Maywood, United States. In Alcohol, Dec 2015
We also observed compensatory increases in the anti-inflammatory cytokine IL-1RA (p < 0.05).
The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.
Stehlik et al., Chicago, United States. In Immunity, Sep 2015
POP1 expression was regulated by TLR and IL-1R signaling, and we propose that POP1 provides a regulatory feedback loop that shuts down excessive inflammatory responses and thereby prevents systemic inflammation.
Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System.
Waisman et al., Mainz, Germany. In Immunity, Aug 2015
Proliferating microglia expressed high amounts of the interleukin-1 receptor (IL-1R), and treatment with an IL-1R antagonist during the repopulation phase impaired microglia proliferation.
Acute Immune-Inflammatory Responses to a Single Bout of Aerobic Exercise in Smokers; The Effect of Smoking History and Status.
Marino et al., Australia. In Front Immunol, 2014
Venous blood was obtained pre- and post- (0 min, 1, and 4 h) exercise to measure circulating leukocytes and inflammatory markers interleukin (IL)-6, IL-1β, IL-1ra, and monocyte chemoattractant protein-1 (MCP-1).
Interleukin-1 Family Cytokines in Liver Diseases.
Hayashi et al., Nishinomiya, Japan. In Mediators Inflamm, 2014
The gene encoding IL-1 was sequenced more than 30 years ago, and many related cytokines, such as IL-18, IL-33, IL-36, IL-37, IL-38, IL-1 receptor antagonist (IL-1Ra), and IL-36Ra, have since been identified.
Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression.
Biswas et al., Singapore, Singapore. In Immunity, 2014
Induction of this protumor phenotype required an interleukin-1 receptor (IL-1R)-dependent mechanism.
Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer.
Alimonti et al., Bellinzona, Switzerland. In Nature, 2014
Mechanistically, we found that Gr-1(+) cells antagonize senescence in a paracrine manner by interfering with the senescence-associated secretory phenotype of the tumour through the secretion of interleukin-1 receptor antagonist (IL-1RA).
Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.
Kabashima et al., Kyoto, Japan. In Nat Immunol, 2014
Treatment with interleukin 1α (IL-1α) induced production of the chemokine CXCL2 by dermal macrophages, and DC clustering was suppressed by blockade of either the receptor for IL-1 (IL-1R) or the receptor for CXCL2 (CXCR2).
Genetic variation within the interleukin-1 gene cluster and ischemic stroke.
Jern et al., Göteborg, Sweden. In Stroke, 2012
This comprehensive study, based on a tagSNP approach and replication, presents support for the role of IL1RN in overall ischemic stroke
Deficient production of IL-1 receptor antagonist and IL-6 coupled to oxidative stress in cryopyrin-associated periodic syndrome monocytes.
Rubartelli et al., Genova, Italy. In Ann Rheum Dis, 2012
The deficient secretion of IL-1Ra and IL-6...explains the severity of the IL-1-related clinical manifestations and the predominant implication of innate immunity in cryopyrin-associated periodic syndromes
TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.
Romier et al., Illkirch-Graffenstaden, France. In J Biol Chem, 2012
TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.
Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice.
Borner et al., Freiburg, Germany. In J Virol, 2012
Lymphocytic choriomeningitis virus is not cleared in IL-1R-deficient mice, and yet the infected mice develop neither splenomegaly nor hepatitis.
Two nuclear localization signals in USP1 mediate nuclear import of the USP1/UAF1 complex.
Rodriguez et al., Leioa, Spain. In Plos One, 2011
USP1 and UAF1 form a complex in the cytoplasm that subsequently translocates to the nucleus through import mediated by USP1 nuclear localization signals.
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