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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Interleukin 1, beta

IL-1beta, IL-1, interleukin-1beta, IL-1 alpha
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-6, CAN, HAD, V1a, IL-10
Papers using IL-1beta antibodies
Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells.
Supplier
Ye Juan et al., In Molecular Vision, 2009
... Recombinant human interleukin (IL)-6, IL-1, and tumor necrosis factor-alpha (TNF-α) enzyme-linked immunosorbent assay (ELISA) kits (eBioscience, San Diego, CA) were ...
Plasmodium falciparum-infected erythrocytes decrease the integrity of human blood-brain barrier endothelial cell monolayers
Supplier
Arese Paolo et al., In Malaria Journal, 2006
... I, (N-hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide), a specific inhibitor of MMP-9/MMP-13 activity, were from Merck, Darmstadt, Germany; ELISA kit for IL-1beta assay and 15-HETE were from Cayman, Ann Arbor, MI; anti-D ...
Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP +-affected mesencephalic dopaminergic cells
Supplier
Chan Piu et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... detection ELISA kits, while superoxide Assay Kit-WST and rat IL-1β ELISA kits were obtained from Dojindo (Kyushu, Japan) and IBL (Gunma, Japan), respectively ...
Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
Supplier
Hummler Edith et al., In Nature Communications, 2003
... IL-1α (30 cycles) in transgenic versus wild-type skin ...
Papers on IL-1beta
Treatment of acute gout: a systematic review.
Review
New
Khanna et al., Ann Arbor, United States. In Semin Arthritis Rheum, Aug 2014
We included only randomized controlled trials (RCTs) that included NSAIDs, corticosteroids, colchicine, adrenocorticotropic hormone (ACTH), interleukin-1 (IL-1) inhibitors, topical ice, or herbal supplements.
Targeting inflammation as a therapeutic strategy for drug-resistant epilepsies: an update of new immune-modulating approaches.
Review
New
Falsaperla et al., Catania, Italy. In Hum Vaccin Immunother, Apr 2014
For example, pharmacological blockade of the IL-1beta/IL-1 receptor type 1 axis during epileptogenesis has been demonstrated to provide neuroprotection in temporal lobe epilepsy.
A98: Rescue Treatment by Increased Doses of IL-1 Inhibitors for Macrophage Activation Syndrome in Children With Systemic Juvenile Idiopathic Arthritis.
New
Chasnyk et al., Saint Petersburg, Russia. In Arthritis Rheumatol, Mar 2014
Known interleukin-1 (IL-1) is the key cytokine in pathogenesis of MAS and SJIA, so anti-IL-1 treatment considered as potential effective treatment.
A8: juvenile idiopathic arthritis with dry synovitis: clinical and imaging aspects in a cohort of 10 patients.
New
Wouters et al., Leuven, Belgium. In Arthritis Rheumatol, Mar 2014
Treatments comprised NSAIDs (n = 8/10), corticosteroids (n = 8/10), methotrexate (n = 9/10), anti-TNF (n = 6/10), IL-1 receptor antagonist (n = 1/10) and resulted in some subjective improvement.
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.
New
Impact
Kordula et al., Richmond, United States. In Nat Immunol, Mar 2014
Although interleukin 1 (IL-1) induces expression of the transcription factor IRF1 (interferon-regulatory factor 1), the roles of IRF1 in immune and inflammatory responses and mechanisms of its activation remain elusive.
A160: role of interleukin-1 in abnormal monocyte phenotype in systemic onset juvenile idiopathic arthritis.
New
Mellins et al., Stanford, United States. In Arthritis Rheumatol, Mar 2014
We have observed altered phenotypes in blood monocytes in systemic onset juvenile idiopathic arthritis (sJIA), including a decreased M1 cells, an increased mixed M1/M2 cells, and reduced secretion of IL-1, despite an increased IL-1b response to LPS (PMID 22281427).
A157: Macrophage Activation Syndrome-like Illness Due to an Activating Mutation in NLRC4.
New
Goldbach-Mansky et al., Bethesda, United States. In Arthritis Rheumatol, Mar 2014
The patient's monocytes produced more of a number of inflammatory cytokines in response to stimulation than controls, while monocyte-derived macrophages specifically over-produced IL-1b and IL-18.
Getting nervous about immunity.
Review
New
McCusker et al., Urbana, United States. In Semin Immunol, Mar 2014
Neuroscientists now know that the first formally defined cytokine, IL-1, activates a discrete population of hypothalamic neurons.
Molecular determinants of sterile inflammation.
Review
New
Yanagida et al., Tokyo, Japan. In Curr Opin Immunol, Feb 2014
Tissue resident macrophages recognize the danger signals released from necrotic cells via the pattern recognition receptors and secrete IL-1 that results in acute neutrophilic inflammation.
Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells.
New
Impact
Medzhitov et al., New Haven, United States. In Immunity, Feb 2014
The MyD88 signaling adaptor operates in many cell types downstream of Toll-like receptors (TLRs) and interleukin-1 (IL-1) receptor family members.
Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity.
New
Impact
Umetsu et al., Boston, United States. In Nat Med, Jan 2014
Blockade of IL-1β with an IL-1 receptor antagonist abolished obesity-induced AHR and reduced the number of ILC3 cells.
The interleukin-1 family: back to the future.
Review
New
Impact
Mantovani et al., Rozzano, Italy. In Immunity, Jan 2014
Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation.
Obesity associated hypertension: new insights into mechanism.
Review
New
Kang, Ansan, South Korea. In Electrolyte Blood Press, Dec 2013
Adipose tissue produce and secretes several molecules such as leptin, resistin, adiponectin, and visfatin, as well as cytokines such as TNF-α, IL-6, MCP-1, and IL-1.
Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial.
New
Ghayour-Mobarhan et al., Mashhad, Iran. In Scientificworldjournal, Dec 2013
Serum levels of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFNγ, EGF, MCP-1, and TNF α were measured using a multiplex Biochip Array Technology based method.
Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging.
New
Impact
Dixit et al., Baton Rouge, United States. In Cell Metab, Nov 2013
Notably, IL-1 mediated only Nlrp3 inflammasome-dependent improvement in cognitive function and motor performance in aged mice.
Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population.
GeneRIF
Chowdhury et al., Calcutta, India. In Gene, 2012
identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population
A genetically encoded IL-1β bioluminescence resonance energy transfer sensor to monitor inflammasome activity.
GeneRIF
Pelegrin et al., Manchester, United Kingdom. In J Immunol, 2012
Use of a ratiometric biosensor allows monitoring of IL-1beta processing in real time, as well as a kinetic study of inflammasome activity in individual living macrophages.
IL-1 generated subsequent to radiation-induced tissue injury contributes to the pathogenesis of radiodermatitis.
GeneRIF
Rock et al., Worcester, United States. In Radiat Res, 2012
interleukin-1 (IL-1) pathway plays a significant role in the development of radiodermatitis
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells.
GeneRIF
Maloy et al., Oxford, United Kingdom. In J Exp Med, 2012
IL-1beta signals are required for the development of severe inflammation in both T cell-independent and T cell-mediated colitis
[Interleukin-21: a key cytokine for controlling HIV and other chronic viral infections].
Review
GeneRIF
Ahmad et al., Montréal, Canada. In Med Sci (paris), 2012
IL1 contributes toward mounting efficient antiviral immunity and controlling chronic viral infections, especially HIV-1.
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