GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Interleukin 1, beta
IL-1beta, IL-1, interleukin-1beta, IL-1 alpha
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers using
IL-1beta
antibodies
Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells.
Supplier
In Molecular Vision, 2009
... Recombinant human interleukin (IL)-6, IL-1, and tumor necrosis factor-alpha (TNF-α) enzyme-linked immunosorbent assay (ELISA) kits (eBioscience, San Diego, CA) were ...
Plasmodium falciparum-infected erythrocytes decrease the integrity of human blood-brain barrier endothelial cell monolayers
Supplier
In Malaria Journal, 2006
... I, (N-hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide), a specific inhibitor of MMP-9/MMP-13 activity, were from Merck, Darmstadt, Germany; ELISA kit for IL-1beta assay and 15-HETE were from Cayman, Ann Arbor, MI; anti-D ...
Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
Supplier
In Nature Communications, 2003
... IL-1α (30 cycles) in transgenic versus wild-type skin ...
Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP +-affected mesencephalic dopaminergic cells
Supplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... detection ELISA kits, while superoxide Assay Kit-WST and rat IL-1β ELISA kits were obtained from Dojindo (Kyushu, Japan) and IBL (Gunma, Japan), respectively ...
Papers on
IL-1beta
The Interleukin-1 Gene Cluster Polymorphisms Are Associated with Takayasu's Arteritis in Mexican Patients.
New
Mexico City, Mexico. In J Interferon Cytokine Res, 08 Apr 2013
The interleukin (IL) 1β and IL-1 receptor antagonist have been playing an important role as regulators of inflammation.
Spinal Cord Injury Level and the Circulating Cytokine Response to Strenuous Exercise.
New
Loughborough, United Kingdom. In Med Sci Sports Exerc, 07 Apr 2013
Blood samples were taken pre-exercise, post-exercise and 30 min post-exercise (post30) and analysed for concentrations of IL-6, IL-10, IL-1 receptor-antagonist (IL-1ra), tumor necrosis factor-alpha (TNF-α), epinephrine and cortisol.
The interleukin-1β system in the corpora lutea of pigs during early pregnancy and the estrous cycle.
New
Olsztyn, Poland. In J Reprod Immunol, 05 Apr 2013
Expression of mRNAs encoding interleukin-1β (IL-1β), IL-1β receptor I (IL-1RI), IL-1 receptor accessory protein (IL-1RAcP) and IL-1 receptor antagonist (IL-1Ra), as well as synthesis of IL-1β and IL-1RI proteins, were examined in the corpus luteum (CL) during critical stages of CL activity on days 10-16 of pregnancy and 2-16 of the estrous cycle.
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8(+) T cell responses to influenza A virus.
New
Impact
New Haven, United States. In Nat Immunol, 31 Mar 2013
DCs activated by IL-1 in trans were both required and sufficient for the generation of virus-specific CD8(+) T cell immunity.
Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation.
New
Impact
Cambridge, United Kingdom. In Immunity, 21 Mar 2013
Most cell types examined expressed a cytosolic IL-1 receptor 2 (IL-1R2) whose binding to pro-IL-1α inhibited its cytokine activity.
Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β.
New
Impact
Worcester, United States. In Nat Immunol, Jan 2013
Interleukin 1 (IL-1) is an important mediator of innate immunity but can also promote inflammatory tissue damage.
Comprehensive evaluation of 11 cytokines in premature infants with surgical necrotizing enterocolitis.
New
Vienna, Austria. In Plos One, Dec 2012
IL-1 beta and TNF-alpha showed no statistically different levels.
The anti-inflammatory effects of acupuncture and their relevance to allergic rhinitis: a narrative review and proposed model.
New
Gold Coast, Australia. In Evid Based Complement Alternat Med, Dec 2012
Other reported anti-inflammatory effects of acupuncture include an antihistamine action and downregulation of proinflammatory cytokines (such as TNF- , IL-1 , IL-6, and IL-10), proinflammatory neuropeptides (such as SP, CGRP, and VIP), and neurotrophins (such as NGF and BDNF) which can enhance and prolong inflammatory response.
Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance.
New
Impact
Cleveland, United States. In Immunity, Dec 2012
Interleukin-1 (IL-1)-induced activation of the mTOR kinase pathway has major influences on Th17 cell survival, proliferation, and effector function.
IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice.
Review
New
Worcester, United States. In J Clin Invest, Nov 2012
IL-1β, type I IL-1 receptor (IL-1R1), and IL-1 receptor antagonist (IL-1Ra) are all important regulators of the IL-1 signaling complex, which plays a role in inflammation.
[Nosology of inflammatory diseases: lessons learned from the auto-inflammatory syndromes--a focus on skin manifestations].
Review
New
Strasbourg, France. In Harefuah, Oct 2012
The understanding of the underlying pathogenic mechanisms of these disorders, and especially the fact that they are mediated by IL-1 secretion by stimulated monocytes/macrophages, facilitated significant progress in patient management.
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases.
Review
New
Impact
Aurora, United States. In Nat Rev Drug Discov, Aug 2012
Interleukin-1 (IL-1) is a highly active pro-inflammatory cytokine that lowers pain thresholds and damages tissues.
Nutrition and cancer prevention.
Review
New
Pescara, Italy. In Int J Immunopathol Pharmacol, Jul 2012
Many cytokines, such as IL-1, IL-6, IL-8, IL-32, IL-33 and MCP-1, are biomarkers for cancer and chronic diseases along with transcription factors NFκB and AP-1; these last two factors are important bioactive substances on the molecular mechanism of the control of genes which in turn affect cellular metabolism.
Interleukin-9 and mast cells.
Review
New
In J Biol Regul Homeost Agents, Jul 2012
These cells express proinflammatory cytokines such as IL-1, IL-6, IL-8 and tumor necrosis factor which are necessary for innate immunity.
Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1β in osteoarthritic osteoblasts.
New
GeneRIF
Valencia, Spain. In Biochem Pharmacol, Mar 2012
The inhibition of nuclear factor-kappaB activation induced by IL-1beta in osteoarthritis (OA) osteoblasts may contribute to some of the heme oxygenase-1 effects.
Differential effects of systemic interleukin-1β on gene expression in brainstem noradrenergic nuclei.
New
GeneRIF
East Lansing, United States. In Life Sci, Feb 2012
Systemic administration of rat recombinant IL-1beta causes significant changes in the expression of tyrosine hydroxylase and several chemokines in brain stem noradrenergic nuclei, thereby mediating its neuroendocrine effects.
Mitogen-activated protein kinase-dependent interleukin-1α intracrine signaling is modulated by YopP during Yersinia enterocolitica infection.
GeneRIF
San Antonio, United States. In Infect Immun, 2012
These data suggest that Yersinia enterocolitica YopP inhibits intracellular pre-IL-1alpha signaling and subsequent proinflammatory responses through inhibition of MAP kinase pathways.
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
GeneRIF
Irvine, United States. In J Immunol, 2012
Inhibition of IL-1beta signaling provides disease-modifying benefits in an Alzheimer's disease (AD) transgenic mouse model; the IL-1 signaling cascade may be a key mechanism for AD.
Genetic variability in the IL1RN gene and the balance between interleukin (IL)-1 receptor agonist and IL-1β in idiopathic pulmonary fibrosis.
GeneRIF
Nieuwegein, Netherlands. In Clin Exp Immunol, 2011
study showed that variation in the IL1RN associates with susceptibility to idiopathic pulmonary fibrosis (IPF); the subsequent imbalance between IL-1beta and IL-1Ra might have a significant pathogenetic effect in IPF patients
Roles of dopamine and inflammation-related molecules in behavioral alterations caused by repeated stress.
Review
Kyoto, Japan. In J Pharmacol Sci, 2011
IL-1 signaling is critical not only for emotional changes but also for microglial activation induced by repeated stress.
