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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 16 Apr 2015.

Interleukin 1, beta

IL-1beta, IL-1, interleukin-1beta, IL-1 alpha
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-6, CAN, V1a, HAD, IL-10
Papers using IL-1beta antibodies
Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells.
Supplier
Ye Juan et al., In Molecular Vision, 2009
... Recombinant human interleukin (IL)-6, IL-1, and tumor necrosis factor-alpha (TNF-α) enzyme-linked immunosorbent assay (ELISA) kits (eBioscience, San Diego, CA) were ...
Plasmodium falciparum-infected erythrocytes decrease the integrity of human blood-brain barrier endothelial cell monolayers
Supplier
Arese Paolo et al., In Malaria Journal, 2006
... I, (N-hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide), a specific inhibitor of MMP-9/MMP-13 activity, were from Merck, Darmstadt, Germany; ELISA kit for IL-1beta assay and 15-HETE were from Cayman, Ann Arbor, MI; anti-D ...
Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP +-affected mesencephalic dopaminergic cells
Supplier
Chan Piu et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... detection ELISA kits, while superoxide Assay Kit-WST and rat IL-1β ELISA kits were obtained from Dojindo (Kyushu, Japan) and IBL (Gunma, Japan), respectively ...
Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
Supplier
Hummler Edith et al., In Nature Communications, 2003
... IL-1α (30 cycles) in transgenic versus wild-type skin ...
Papers on IL-1beta
Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain.
New
Vogel et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 13 May 2015
UNASSIGNED: Toll-like receptor (TLR) signaling is initiated by dimerization of intracellular Toll/IL-1 receptor resistance (TIR) domains.
Use of ibuprofen to assess inflammatory biomarkers in induced sputum: Implications for clinical trials in cystic fibrosis.
New
Ramsey et al., Cleveland, United States. In J Cyst Fibros, 10 May 2015
METHODS: We conducted a 28-day, open-label, randomized, controlled trial among 72 clinically stable CF subjects (FEV1≥40% predicted) randomized to HDI or routine care that assessed IL-6, IL-8, TNF-α, IL-1-β, free neutrophil elastase, and white cell counts with differentials change from baseline in induced sputum.
Interleukin-1α activation and localization in lipopolysaccharide-stimulated human monocytes and macrophages.
New
Birkelund et al., Aalborg, Denmark. In J Immunol Methods, 10 May 2015
BACKGROUND: Interleukin-1α (IL-1α) is a proinflammatory cytokine belonging to the IL-1 family.
Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.
New
Impact
Núñez et al., Ann Arbor, United States. In Immunity, 03 May 2015
Furthermore, colonization with P. mirabilis promoted intestinal inflammation upon intestinal injury via the production of hemolysin, which required NLRP3 and IL-1 receptor signaling in vivo.
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.
New
Impact
Nold et al., Melbourne, Australia. In Nat Immunol, 30 Apr 2015
Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan members of the IL-1 ligand family and IL-1 receptor family, respectively.
Immunopathology of chronic rhinosinusitis.
Review
New
Kato, Chicago, United States. In Allergol Int, 30 Apr 2015
Epithelial derived cytokines, TSLP, IL-33 and IL-1 can directly and indirectly control type 2 cytokine production from these cells in eosinophilic NPs.
Pathways involved in interleukin-1β-mediated murine cardiomyocyte apoptosis.
New
Bu et al., In Tex Heart Inst J, 30 Apr 2015
Accumulating evidence suggests that interleukin-1 (IL-1) signaling plays an essential role in the pathogenesis of heart failure by inducing cardiomyocyte apoptosis, but the mechanisms of this process are poorly defined.
Interleukin-33 and Behçet disease: Another cytokine among others.
Review
New
Hamzaoui et al., Tunisia. In Hum Immunol, 24 Apr 2015
IL-33 is member of the IL-1 superfamily of cytokines that is expressed by epithelial cells, endothelial cells, inflammatory cells and central nervous tissue.
Monogenic autoinflammatory diseases: Cytokinopathies.
Review
New
Masters et al., Australia. In Cytokine, 23 Apr 2015
Cytokine antagonism is profoundly effective in a subset of these conditions, particularly those associated with increased interleukin-1 (IL-1) activity, the inflammasomopathies.
Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling.
New
Impact
Goldbach-Mansky et al., Bethesda, United States. In Annu Rev Immunol, 21 Apr 2015
Studying such patients has revealed genetic defects that have helped unravel key innate immune pathways, including excessive IL-1 signaling, constitutive NF-κB activation, and, more recently, chronic type I IFN signaling.
Inflammasome-Independent Regulation of IL-1-Family Cytokines.
New
Impact
Joosten et al., In Annu Rev Immunol, 21 Apr 2015
Cytokines of the interleukin-1 (IL-1) family induce inflammation and regulate T lymphocyte responses while also displaying homeostatic and metabolic activities.
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
New
Impact
Weaver et al., Birmingham, United States. In Nat Immunol, 31 Mar 2015
Here we found that IL-1 was needed to fully override RA-mediated expression of the transcription factor Foxp3 and induce protective TH17 cell responses.
Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors.
New
Zhu et al., Wuxi, China. In Genet Mol Res, Dec 2014
In conclusion, Tanshinone IIA may inhibit the release of inflammatory cytokines, such as, IL-1 β, IL-6 α, TNF-α.
Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging II: Over-Expression of Neprilysin Plays an Essential Role.
Review
New
Ishida et al., Kasugai, Japan. In Int J Mol Sci, Dec 2014
Direct UVA exposure of human keratinocytes also stimulates the secretion of IL-6, IL-8 and GM-CSF but not of IL-1 and endothelin-1.
Role of IL-38 and Its Related Cytokines in Inflammation.
Review
New
Li et al., Ningbo, China. In Mediators Inflamm, Dec 2014
UNASSIGNED: Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family.
Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population.
GeneRIF
Chowdhury et al., Calcutta, India. In Gene, 2012
identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population
A genetically encoded IL-1β bioluminescence resonance energy transfer sensor to monitor inflammasome activity.
GeneRIF
Pelegrin et al., Manchester, United Kingdom. In J Immunol, 2012
Use of a ratiometric biosensor allows monitoring of IL-1beta processing in real time, as well as a kinetic study of inflammasome activity in individual living macrophages.
IL-1 generated subsequent to radiation-induced tissue injury contributes to the pathogenesis of radiodermatitis.
GeneRIF
Rock et al., Worcester, United States. In Radiat Res, 2012
interleukin-1 (IL-1) pathway plays a significant role in the development of radiodermatitis
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells.
GeneRIF
Maloy et al., Oxford, United Kingdom. In J Exp Med, 2012
IL-1beta signals are required for the development of severe inflammation in both T cell-independent and T cell-mediated colitis
[Interleukin-21: a key cytokine for controlling HIV and other chronic viral infections].
Review
GeneRIF
Ahmad et al., Montréal, Canada. In Med Sci (paris), 2012
IL1 contributes toward mounting efficient antiviral immunity and controlling chronic viral infections, especially HIV-1.
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