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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Oct 2014.

Interleukin 1, beta

IL-1beta, IL-1, interleukin-1beta, IL-1 alpha
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-6, CAN, V1a, HAD, IL-10
Papers using IL-1beta antibodies
Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells.
Supplier
Ye Juan et al., In Molecular Vision, 2009
... Recombinant human interleukin (IL)-6, IL-1, and tumor necrosis factor-alpha (TNF-α) enzyme-linked immunosorbent assay (ELISA) kits (eBioscience, San Diego, CA) were ...
Plasmodium falciparum-infected erythrocytes decrease the integrity of human blood-brain barrier endothelial cell monolayers
Supplier
Arese Paolo et al., In Malaria Journal, 2006
... I, (N-hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide), a specific inhibitor of MMP-9/MMP-13 activity, were from Merck, Darmstadt, Germany; ELISA kit for IL-1beta assay and 15-HETE were from Cayman, Ann Arbor, MI; anti-D ...
Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP +-affected mesencephalic dopaminergic cells
Supplier
Chan Piu et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... detection ELISA kits, while superoxide Assay Kit-WST and rat IL-1β ELISA kits were obtained from Dojindo (Kyushu, Japan) and IBL (Gunma, Japan), respectively ...
Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
Supplier
Hummler Edith et al., In Nature Communications, 2003
... IL-1α (30 cycles) in transgenic versus wild-type skin ...
Papers on IL-1beta
Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.
New
Impact
Kabashima et al., Kyoto, Japan. In Nat Immunol, 30 Nov 2014
Treatment with interleukin 1α (IL-1α) induced production of the chemokine CXCL2 by dermal macrophages, and DC clustering was suppressed by blockade of either the receptor for IL-1 (IL-1R) or the receptor for CXCL2 (CXCR2).
The role of p38 MAPK in acute paraquat-induced lung injury in rats.
New
Qian et al., Nanjing, China. In Inhal Toxicol, 30 Nov 2014
tumor necrosis factor (TNF)-alpha and interleukin-1 beta (IL-1β) concentrations in lung specimens and bronchoalveolar lavage fluid (BALF) were quantified via enzyme-linked immunosorbent assay.
Transvaginal and transrectal natural orifice transluminal endoscopic nephrectomy in a porcine survival model: Comparison with conventional laparoscopic nephrectomy.
New
Kim et al., Seoul, South Korea. In J Endourol, 28 Nov 2014
None of the laboratory parameters, including white blood cell count, TNF-α, IL-1, and IL-6 differed among the groups during the observational period.
Angiotensin II Induces IL-1β-mediated Islet Inflammation and β-cell Dysfunction Independently of Vasoconstrictory Effects.
New
Donath et al., Basel, Switzerland. In Diabetes, 28 Nov 2014
Here we show that exposure of human and mouse islets to angiotensin II induces IL-1-dependent expression of IL-6 and MCP-1, β-cell apoptosis, and impairs mitochondrial function and insulin secretion.
Successful treatment of PASH syndrome with infliximab, cyclosporine and dapsone.
New
Leverkus et al., Heidelberg, Germany. In J Eur Acad Dermatol Venereol, 28 Nov 2014
She had previously been treated unsuccessfully with etanercept, adalimumab, fumaric acid and the IL-1 receptor antagonist (IL-1RA) anakinra without prolonged remission.
Successful Management of Cryopyrin-Associated Periodic Syndrome With Canakinumab in Infancy.
New
Valari et al., Athens, Greece. In Pediatrics, 27 Nov 2014
This report indicates the importance of early diagnosis of NOMID/CINCA syndrome and medication with IL-1 blockers as soon as possible for the improvement of the prognosis of cryopyrin-associated periodic syndrome and of a better patient outcome.
Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production.
New
Impact
Mauri et al., Udine, Italy. In Nat Med, 19 Nov 2014
Mice lacking IL-6 receptor (IL-6R) or IL-1 receptor 1 (IL-1R1) specifically on B cells have a reduced number of IL-10-producing B cells and develop exacerbated arthritis compared to control animals.
Inflammasome activation in response to dead cells and their metabolites.
Review
New
Latz et al., Tokyo, Japan. In Curr Opin Immunol, 01 Nov 2014
Inflammasome activation followed by IL-1alpha release and IL-1beta maturation is crucial for tackling pathological conditions, including infections, whereas inflammasome activation precedes inflammatory pyroptotic cell death.
An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.
New
Impact
Goldbach-Mansky et al., Bethesda, United States. In Nat Genet, 31 Oct 2014
The discovery that dominant gain-of-function mutations in NLRP3 cause the cryopyrin-associated periodic syndromes (CAPS) and trigger spontaneous inflammasome activation and IL-1β oversecretion led to successful treatment with IL-1-blocking agents.
IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy.
Review
New
Girard et al., Toulouse, France. In Curr Opin Immunol, 29 Oct 2014
UNLABELLED: IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epithelial barrier tissues and lymphoid organs, which plays important roles in type-2 innate immunity and human asthma.
Soluble ST2 in heart failure.
Review
New
Mueller et al., Linz, Austria. In Clin Chim Acta, 27 Oct 2014
Among them, soluble ST2 (sST2) a novel biomarker integrating inflammation, fibrosis, and cardiac stress has been included in the 2013 ACCF/AHA guideline for additive risk stratification of patients with acute and chronic HF. sST2 is an interleukin-1 (IL-1) receptor family member, is secreted into the circulation and functions as a "decoy" receptor for IL-33, inhibiting IL-33/ST2 signaling.
Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon.
New
Impact
Cyster et al., San Francisco, United States. In Science, 08 Sep 2014
25-HC acts by antagonizing sterol response element-binding protein (SREBP) processing to reduce Il1b transcription and to broadly repress IL-1-activating inflammasomes.
Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk.
New
Impact
Sher et al., Bethesda, United States. In Nature, Aug 2014
Here we demonstrate that interleukin-1 (IL-1) confers host resistance through the induction of eicosanoids that limit excessive type I interferon (IFN) production and foster bacterial containment.
The role of the blood-brain barrier in the development and treatment of migraine and other pain disorders.
Review
New
Moura-Neto et al., Rio de Janeiro, Brazil. In Front Cell Neurosci, Dec 2013
One possible explanation for these findings is the action of substances typically released at the site of peripheral injuries that could lead to changes in the brain endothelial permeability, including substance P, calcitonin gene-related peptide, and interleukin-1 beta.
Interleukin-1 receptor blockade in perinatal brain injury.
Review
New
Burd et al., Baltimore, United States. In Front Pediatr, Dec 2013
Interleukin-1 (IL-1) is a potent inflammatory cytokine that can be produced by a variety of cell types throughout the body.
Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population.
GeneRIF
Chowdhury et al., Calcutta, India. In Gene, 2012
identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population
A genetically encoded IL-1β bioluminescence resonance energy transfer sensor to monitor inflammasome activity.
GeneRIF
Pelegrin et al., Manchester, United Kingdom. In J Immunol, 2012
Use of a ratiometric biosensor allows monitoring of IL-1beta processing in real time, as well as a kinetic study of inflammasome activity in individual living macrophages.
IL-1 generated subsequent to radiation-induced tissue injury contributes to the pathogenesis of radiodermatitis.
GeneRIF
Rock et al., Worcester, United States. In Radiat Res, 2012
interleukin-1 (IL-1) pathway plays a significant role in the development of radiodermatitis
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells.
GeneRIF
Maloy et al., Oxford, United Kingdom. In J Exp Med, 2012
IL-1beta signals are required for the development of severe inflammation in both T cell-independent and T cell-mediated colitis
[Interleukin-21: a key cytokine for controlling HIV and other chronic viral infections].
Review
GeneRIF
Ahmad et al., Montréal, Canada. In Med Sci (paris), 2012
IL1 contributes toward mounting efficient antiviral immunity and controlling chronic viral infections, especially HIV-1.
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