Therapeutic approaches to asthma-chronic obstructive pulmonary disease overlap syndromes.
London, United Kingdom. In J Allergy Clin Immunol, 30 Sep 2015
Other patients have severe asthma or are asthmatic patients who smoke with features of COPD-induced inflammation and might benefit from treatments targeting neutrophils, including macrolides, CXCR2 antagonists, phosphodiesterase 4 inhibitors, p38 mitogen-activating protein kinase inhibitors, and antibodies against IL-1 and IL-17.
Barrier Epithelial Cells and the Control of Type 2 Immunity.
Gent, Belgium. In Immunity, Aug 2015
These ECs mount a prototypical response made up of chemokines, innate cytokines such as interleukin-1 (IL-1), IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), as well as the alarmins uric acid, ATP, HMGB1, and S100 proteins.