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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Interleukin 1, beta

IL-1beta, IL-1, interleukin-1beta, IL-1 alpha
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-6, CAN, HAD, IL-10, IL-1ra
Papers using IL-1beta antibodies
Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells.
Supplier
Ye Juan et al., In Molecular Vision, 2009
... Recombinant human interleukin (IL)-6, IL-1, and tumor necrosis factor-alpha (TNF-α) enzyme-linked immunosorbent assay (ELISA) kits (eBioscience, San Diego, CA) were ...
Plasmodium falciparum-infected erythrocytes decrease the integrity of human blood-brain barrier endothelial cell monolayers
Supplier
Arese Paolo et al., In Malaria Journal, 2006
... I, (N-hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide), a specific inhibitor of MMP-9/MMP-13 activity, were from Merck, Darmstadt, Germany; ELISA kit for IL-1beta assay and 15-HETE were from Cayman, Ann Arbor, MI; anti-D ...
Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP +-affected mesencephalic dopaminergic cells
Supplier
Chan Piu et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... detection ELISA kits, while superoxide Assay Kit-WST and rat IL-1β ELISA kits were obtained from Dojindo (Kyushu, Japan) and IBL (Gunma, Japan), respectively ...
Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
Supplier
Hummler Edith et al., In Nature Communications, 2003
... IL-1α (30 cycles) in transgenic versus wild-type skin ...
Papers on IL-1beta
miRNA-Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis.
New
Chakraborty et al., Ch'unch'ŏn, South Korea. In Med Res Rev, 20 Feb 2016
Moreover, we have tried to portray the role of various miRNAs in different cytokines such as TNF-α, IL-1, IL-6, IL-10, IL-17, IL-18, IL-21, and granulocyte macrophage colony-stimulating factor (GMCSF).
Beneficial effects of IL-37 after spinal cord injury in mice.
New
López-Vales et al., Barcelona, Spain. In Proc Natl Acad Sci U S A, 19 Feb 2016
UNASSIGNED: IL-37, a member of the IL-1 family, broadly reduces innate inflammation as well as acquired immunity.
T-cell-intrinsic Tif1α/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy.
New
Wilson et al., London, United Kingdom. In Proc Natl Acad Sci U S A, 19 Feb 2016
Mechanistically, HDM-elicited Trim24(-/-) T cells have reduced expression of many TH2 cytokines and chemokines and were predicted to have compromised IL-1-regulated signaling.
Interleukin 33 is a guardian of barriers and a local alarmin.
New
Impact
Martin et al., Hannover, Germany. In Nat Immunol, 19 Feb 2016
UNASSIGNED: Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing number of target cells and a plethora of biological functions.
Differential activation of innate immune pathways by distinct islet amyloid polypeptide (IAPP) aggregates.
New
Verchere et al., Canada. In J Biol Chem, 19 Feb 2016
TLR2 and its downstream adaptor protein MyD88 were required for IAPP-induced cytokine production by BMDMs, a process that is partially dependent on autoinduction by IL-1.
Activation of NLRP3 inflammasome enhances the proliferation and migration of A549 lung cancer cells.
New
Xie et al., Nanjing, China. In Oncol Rep, 18 Feb 2016
Moreover, these effects were inhibited by the following treatments: i) downregulating the expression of NLRP3 by short hairpin RNA (shRNA) interference, ii) inhibiting the activation of NLRP3 inflammasome with a caspase-1 inhibitor, iii) blocking the interleukin-1β (IL-1β) and IL-18 signal transduction with IL-1 receptor antagonist (IL-1Ra) and IL-18 binding protein (IL-18BP).
Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines.
New
Martin et al., Dublin, Ireland. In Cell Rep, 13 Feb 2016
UNASSIGNED: Recent evidence has strongly implicated the IL-1 family cytokines IL-36α, IL-36β, and IL-36γ as key initiators of skin inflammation.
Secondary amyloidosis in autoinflammatory diseases and the role of inflammation in renal damage.
New
Albertazzi et al., Piacenza, Italy. In World J Nephrol, 06 Feb 2016
Once activated, inflammasome leads to the active form of caspase-1, the enzyme required for the maturation of interleukin-1beta.
Caspase-1 mediated interleukin-18 activation in neutrophils promotes the activity of rheumatoid arthritis in a NLRP3 inflammasome independent manner.
New
Han et al., Jinan, China. In Joint Bone Spine, 05 Feb 2016
Sera levels of interleukin-1 beta (IL-1β) and interleukin-18 (IL-18) were detected by enzyme-linked immunosorbent assay (ELISA).
Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron.
New
Impact
Crowley et al., Durham, United States. In Cell Metab, 16 Jan 2016
We previously discovered elevated levels of the macrophage cytokine IL-1 in the kidney in a murine model of RAS-mediated hypertension.
Interdependence between Interleukin-1 and Tumor Necrosis Factor Regulates TNF-Dependent Control of Mycobacterium tuberculosis Infection.
New
Impact
Shayakhmetov et al., Atlanta, United States. In Immunity, 15 Jan 2016
Furthermore, simultaneous ablation of IL-1RI and TNF-RI signaling on either stroma or hematopoietic cells led to early lethality, indicating non-redundant and synergistic roles of IL-1 and TNF in mediating macrophage-stroma cross-talk that was critical for optimal control of Mtb infection.
Study of oxidative and inflammatory parameters in LDLr-KO mice treated with a hypercholesterolemic diet: Comparison between the use of Campomanesia xanthocarpa and acetylsalicylic acid.
New
Viecili et al., Cruz Alta, Brazil. In Phytomedicine, 12 Jan 2016
RESULTS: The levels of proinflammatory cytokines IL-1, IL-6, TNF-α, and INF-γ were reduced to 19.2 ± 3%, 20.4 + 1.3%, 24.7 ± 1.2%, and 20.8 ± 1.7%, respectively, in the group treated with C. xanthocarpa, when compared to control group.
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.
New
Impact
Campisi et al., Novato, United States. In Cell Metab, 09 Jan 2016
We show here that several manipulations that compromise mitochondrial function in proliferating human cells induce a senescence growth arrest with a modified SASP that lacks the IL-1-dependent inflammatory arm.
A Human Anti-Toll Like Receptor 4 Fab Fragment Inhibits Lipopolysaccharide-Induced Pro-Inflammatory Cytokines Production in Macrophages.
New
Zhu et al., Nanjing, China. In Plos One, 31 Dec 2015
Further, our data demonstrate that hTLR4-Fab01 could specifically bind to TLR4, and its treatment obviously attenuated the proinflammatory effect, characterized by less LPS-induced TNF-α, IL-1, IL-6 and IL-8 production in human macrophages.
Stressed-Out Endoplasmic Reticulum Inflames the Mitochondria.
New
Impact
Argon et al., Philadelphia, United States. In Immunity, Oct 2015
Bacterial infection induces inflammasome activation and release of interleukin-1 (IL-1) cytokines.
Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population.
GeneRIF
Chowdhury et al., Calcutta, India. In Gene, 2012
identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population
A genetically encoded IL-1β bioluminescence resonance energy transfer sensor to monitor inflammasome activity.
GeneRIF
Pelegrin et al., Manchester, United Kingdom. In J Immunol, 2012
Use of a ratiometric biosensor allows monitoring of IL-1beta processing in real time, as well as a kinetic study of inflammasome activity in individual living macrophages.
IL-1 generated subsequent to radiation-induced tissue injury contributes to the pathogenesis of radiodermatitis.
GeneRIF
Rock et al., Worcester, United States. In Radiat Res, 2012
interleukin-1 (IL-1) pathway plays a significant role in the development of radiodermatitis
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells.
GeneRIF
Maloy et al., Oxford, United Kingdom. In J Exp Med, 2012
IL-1beta signals are required for the development of severe inflammation in both T cell-independent and T cell-mediated colitis
[Interleukin-21: a key cytokine for controlling HIV and other chronic viral infections].
GeneRIF
Ahmad et al., Montréal, Canada. In Med Sci (paris), 2012
IL1 contributes toward mounting efficient antiviral immunity and controlling chronic viral infections, especially HIV-1.
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