Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections.
London, United Kingdom. In J Interferon Cytokine Res, 25 Mar 2015
The underlying mechanisms by which type I IFNs promote susceptibility or severity include direct tissue damage by apoptosis induction or suppression of proliferation in tissue cells, immunopathology due to excessive inflammation, and cell death induced by TRAIL- and Fas-expressing immune cells, as well as immunosuppression through IL-10, IL-27, PD-L1, IL-1Ra, and other regulatory molecules that antagonize the induction or action of IL-1, IL-12, IL-17, IFN-γ, KC, and other effectors of the immune response.
Soluble ST2-Analytical Considerations.
Linz, Austria. In Am J Cardiol, 23 Feb 2015
UNASSIGNED: Suppression of tumorigenicity 2 (ST2, also known as interleukin [IL]-1 receptor-like-1) is an IL-1 receptor family member with transmembrane (ST2L) and soluble isoforms (sST2).
Interleukin-1 and acute brain injury.
Salford, United Kingdom. In Front Cell Neurosci, Dec 2014
Research over the last 20 years or so reveals that IL-1 is an important mediator of neuronal injury and blocking the actions of IL-1 is beneficial in a number of experimental models of brain damage.
Tailored therapy for severe asthma.
Reggio nell'Emilia, Italy. In Multidiscip Respir Med, Dec 2014
Other interesting drugs have as a target TNF-α or its soluble receptor (infliximab, golimumab and etanercept) or IL-1 (canakinumab), a cytokine with an important systemic proinflammatory action.