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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 03 Sep 2015.

Interleukin 1, beta

IL-1beta, IL-1, interleukin-1beta, IL-1 alpha
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-6, CAN, V1a, HAD, IL-1ra
Papers using IL-1beta antibodies
Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells.
Supplier
Ye Juan et al., In Molecular Vision, 2009
... Recombinant human interleukin (IL)-6, IL-1, and tumor necrosis factor-alpha (TNF-α) enzyme-linked immunosorbent assay (ELISA) kits (eBioscience, San Diego, CA) were ...
Plasmodium falciparum-infected erythrocytes decrease the integrity of human blood-brain barrier endothelial cell monolayers
Supplier
Arese Paolo et al., In Malaria Journal, 2006
... I, (N-hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide), a specific inhibitor of MMP-9/MMP-13 activity, were from Merck, Darmstadt, Germany; ELISA kit for IL-1beta assay and 15-HETE were from Cayman, Ann Arbor, MI; anti-D ...
Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP +-affected mesencephalic dopaminergic cells
Supplier
Chan Piu et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... detection ELISA kits, while superoxide Assay Kit-WST and rat IL-1β ELISA kits were obtained from Dojindo (Kyushu, Japan) and IBL (Gunma, Japan), respectively ...
Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
Supplier
Hummler Edith et al., In Nature Communications, 2003
... IL-1α (30 cycles) in transgenic versus wild-type skin ...
Papers on IL-1beta
IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance.
Review
New
van Diepen et al., Nijmegen, Netherlands. In Cytokine, 31 Oct 2015
The interleukin-1 (IL-1) family of cytokines and receptors are key mediators of innate inflammatory responses and exhibit both pro- and anti-inflammatory functions.
Interleukin-1α activity in necrotic endothelial cells is controlled by caspase-1 cleavage of interleukin-1 receptor-2; implications for allograft rejection.
New
Clarke et al., Cambridge, United Kingdom. In J Biol Chem, 01 Oct 2015
However, TNFα or IL-1 induce significant levels of active IL-1α in EC necrotic lysates without alteration in protein level.
Acid-dependent interleukin-1 (IL-1) cleavage limits available pro-IL-1β for caspase-1 cleavage.
New
Allan et al., Manchester, United Kingdom. In J Biol Chem, 01 Oct 2015
Interleukin-1 (IL-1) is a driver of inflammation and implicated in many non-communicable diseases.
Novel Toll/IL-1 Receptor Homologous Region Adaptors Act as Negative Regulators in Amphioxus TLR Signaling.
New
Yuan et al., Guangzhou, China. In J Immunol, 01 Oct 2015
UNASSIGNED: Studies have shown that the basal chordate amphioxus possesses an extraordinarily complex TLR system, including 39 TLRs and at least 40 Toll/IL-1R homologous region (TIR) adaptors.
Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β.
New
Czaja et al., United States. In J Hepatol, 29 Sep 2015
Dysregulation of IL-1β was the mechanism of increased liver injury as an IL-1 receptor antagonist prevented injury in knockout mice in concert with decreased neutrophil activation.
Deciphering the crosstalk among IL-1 and IL-10 family cytokines in intestinal immunity.
Review
New
Ouyang et al., San Francisco, United States. In Trends Immunol, 31 Aug 2015
The IL-1 and IL-10 family cytokines are important regulators of intestinal immunity.
Barrier Epithelial Cells and the Control of Type 2 Immunity.
Review
New
Impact
Lambrecht et al., Gent, Belgium. In Immunity, 21 Aug 2015
These ECs mount a prototypical response made up of chemokines, innate cytokines such as interleukin-1 (IL-1), IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), as well as the alarmins uric acid, ATP, HMGB1, and S100 proteins.
Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation.
Review
New
Impact
Locksley et al., San Francisco, United States. In Immunity, Jul 2015
Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described as a potent inducer of allergic type 2 immunity.
Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme.
Review
New
Impact
Beyaert et al., Gent, Belgium. In Immunity, Jul 2015
Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and IL-36, play a pivotal role in the initiation and amplification of immune responses.
Nonsteroidal anti-inflammatory drugs for treatment of acute gout.
New
Impact
Landewé et al., Liège, Belgium. In Jama, Jul 2015
CLINICAL QUESTION: Are nonsteroidal anti-inflammatory drugs (NSAIDs) associated with better outcomes than cyclooxygenase inhibitors, glucocorticoids, IL-1 inhibitors or placebo in the treatment of acute gout?
Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.
New
Impact
Núñez et al., Ann Arbor, United States. In Immunity, May 2015
Furthermore, colonization with P. mirabilis promoted intestinal inflammation upon intestinal injury via the production of hemolysin, which required NLRP3 and IL-1 receptor signaling in vivo.
CROSSTALK BETWEEN VITAMIN B AND IMMUNITY.
Review
New
Conti et al., Cagliari, Italy. In J Biol Regul Homeost Agents, Apr 2015
Deficiency of vitamin B1 may cause beriberi, dysfunction of the nervous system, neuroinflammation, T cell infiltration, chemokine CCL2 activation, over expression of proinflammatory cytokines, such as IL-1, TNF, IL-6, and arachidonic acid products, and induces expression of CD40 by the microglia and CD40L by astrocytes which provoke the death of neurons.
Scanning for Therapeutic Targets within the Cytokine Network of Idiopathic Inflammatory Myopathies.
Review
New
Zschüntzsch et al., Gent, Belgium. In Int J Mol Sci, Dec 2014
This review describes the extensive cytokine network within IIM muscle, characterized by strong expression of Tumor Necrosis Factors (TNFα, LTβ, BAFF), Interferons (IFNα/β/γ), Interleukins (IL-1/6/12/15/18/23) and Chemokines (CXCL9/10/11/13, CCL2/3/4/8/19/21).
The Contribution of Cervicovaginal Infections to the Immunomodulatory Effects of Hormonal Contraception.
New
Mauck et al., Durham, United States. In Mbio, Dec 2014
In no-HC users, T. vaginalis was associated with broadest spectrum of aberrant immunity (higher interleukin 1β [IL-1β], IL-8, macrophage inflammatory protein 3α [MIP-3α], β-defensin 2 [BD2], and IL-1 receptor antigen [IL-1RA]).
In Vivo Silencing of A20 via TLR9-Mediated Targeted SiRNA Delivery Potentiates Antitumor Immune Response.
New
Grabarczyk et al., Greifswald, Germany. In Plos One, Dec 2014
A20 is an ubiquitin-editing enzyme that ensures the transient nature of inflammatory signaling pathways induced by cytokines like TNF-α and IL-1 or pathogens via Toll-like receptor (TLR) pathways.
Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population.
GeneRIF
Chowdhury et al., Calcutta, India. In Gene, 2012
identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population
A genetically encoded IL-1β bioluminescence resonance energy transfer sensor to monitor inflammasome activity.
GeneRIF
Pelegrin et al., Manchester, United Kingdom. In J Immunol, 2012
Use of a ratiometric biosensor allows monitoring of IL-1beta processing in real time, as well as a kinetic study of inflammasome activity in individual living macrophages.
IL-1 generated subsequent to radiation-induced tissue injury contributes to the pathogenesis of radiodermatitis.
GeneRIF
Rock et al., Worcester, United States. In Radiat Res, 2012
interleukin-1 (IL-1) pathway plays a significant role in the development of radiodermatitis
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells.
GeneRIF
Maloy et al., Oxford, United Kingdom. In J Exp Med, 2012
IL-1beta signals are required for the development of severe inflammation in both T cell-independent and T cell-mediated colitis
[Interleukin-21: a key cytokine for controlling HIV and other chronic viral infections].
Review
GeneRIF
Ahmad et al., Montréal, Canada. In Med Sci (paris), 2012
IL1 contributes toward mounting efficient antiviral immunity and controlling chronic viral infections, especially HIV-1.
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