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Interleukin 18 receptor accessory protein

IL-18Rbeta, IL18RAP, AcPL, IL-18 receptor beta
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-18, Cytokine Receptor, IFN-gamma, IL-1beta, CAN
Papers on IL-18Rbeta
Polymorphisms of ST2-IL18R1-IL18RAP gene cluster: a new risk for autoimmune thyroid diseases.
Zhang et al., Xi'an, China. In Int J Immunogenet, Feb 2016
Interleukin 33 (IL33) / ST2 pathway and ST2-interlukin18 receptor1-interlukin18 receptor accessory protein (ST2-IL18R1-IL18RAP) gene cluster have been involved in many autoimmune diseases but few report in autoimmune thyroid diseases (AITD).
Age and pro-inflammatory gene polymorphisms influence adjacent segment disc degeneration more than fusion does in patients treated for chronic low back pain.
Brox et al., Oslo, Norway. In Eur Spine J, Jan 2016
RESULTS: Two SNPs from the IL18RAP gene (rs1420106 and rs917997) were each associated with a lower disc space height at the adjacent level (B = -0.34, p = 0.04 and B = -0.35, p = 0.04, respectively) and the MMP-9 gene SNP rs20544 was associated with a greater disc space height (B = 0.35, p = 0.04).
Potential involvement of the interleukin-18 pathway in schizophrenia.
Zhang et al., Taiyuan, China. In J Psychiatr Res, Jan 2016
We compared expression levels of IL18, IL18R1 and IL18RAP in peripheral blood of a cohort of adolescent participants (<18 years), including 14 early-onset SZ patients and 13 healthy controls.
[IL-18 and TNF-α promote the expression of IL-18Rβ in 3T3-L1 adipocytes and RAW264.7 macrophages].
Yu et al., Bengbu, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, Sep 2015
OBJECTIVE: To explore the effects of interleukin 18 (IL-18) and tumor necrosis factor alpha (TNF-α) on the expression of IL-18 receptor beta (IL-18Rβ) in 3T3-L1 adipocytes and RAW264.7 macrophages.
Genome-wide analysis of the genetic regulation of gene expression in human neutrophils.
Rotzschke et al., Singapore, Singapore. In Nat Commun, 2014
In a functional study, we can link the C allele with low expression of the β-chain of IL18-receptor (IL18RAP).
Repositioning of Memantine as a Potential Novel Therapeutic Agent against Meningitic E. coli-Induced Pathogenicities through Disease-Associated Alpha7 Cholinergic Pathway and RNA Sequencing-Based Transcriptome Analysis of Host Inflammatory Responses.
Huang et al., Guangzhou, China. In Plos One, 2014
Differential gene expression analysis of RNA-Seq data from mouse BMEC infected with E. coli K1 showed that several E44-increased inflammatory factors, including IL33, IL18rap, MMP10 and Irs1, were significantly reduced by MEM compared to the infected cells without drug treatment.
Systematic review and meta-analysis of the association between IL18RAP rs917997 and CCR3 rs6441961 polymorphisms with celiac disease risks.
Jing et al., Guangzhou, China. In Expert Rev Gastroenterol Hepatol, 2014
OBJECTIVES: We performed a systematic review and meta-analysis to estimate the polymorphism effects of IL18RAP and CCR3 on celiac disease susceptibility.
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
Tamari et al., Yokohama, Japan. In Nat Genet, 2012
On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P(combined) = 8.36 × 10(-18)), the major histocompatibility complex (MHC) region (P = 8.38 × 10(-20)), OR10A3-NLRP10 (P = 1.54 × 10(-22)), GLB1 (P = 2.77 × 10(-16)), CCDC80 (P = 1.56 × 10(-19)), CARD11 (P = 7.83 × 10(-9)), ZNF365 (P = 5.85 × 10(-20)) and CYP24A1-PFDN4 (P = 1.65 × 10(-8)).
IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants.
Thomas et al., State College, United States. In Pediatr Res, 2012
Data suggest that IL-18RAP and IL-18R1 single-nucleotide polymorphisms identify African-American infants at risk for bronchopulmonary dysplasia.
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Daly et al., Boston, United States. In Nat Genet, 2011
Through follow-up genotyping of 70 rare and low-frequency protein-altering variants in nine independent case-control series (16,054 Crohn's disease cases, 12,153 ulcerative colitis cases and 17,575 healthy controls), we identified four additional independent risk factors in NOD2, two additional protective variants in IL23R, a highly significant association with a protective splice variant in CARD9 (P < 1 × 10(-16), odds ratio ≈ 0.29) and additional associations with coding variants in IL18RAP, CUL2, C1orf106, PTPN22 and MUC19.
Constitutive and LPS-regulated expression of interleukin-18 receptor beta variants in the mouse brain.
Tascedda et al., Reggio nell'Emilia, Italy. In Brain Behav Immun, 2011
Our data highlight the considerable complexity of the IL-18 regulation activity in the mouse brain and further support an important central role for IL-18.
Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.
Carter, Hastings, United Kingdom. In Schizophr Bull, 2009
Genes encoding for proteins related to the innate immune response, including cytokine related (CCR5, CSF2RA, CSF2RB, IL1B, IL1RN, IL2, IL3, IL3RA, IL4, IL10, IL10RA, IL18RAP, lymphotoxin-alpha, tumor necrosis factor alpha [TNF]), human leukocyte antigen (HLA) antigens (HLA-A10, HLA-B, HLA-DRB1), and genes involved in antigen processing (angiotensin-converting enzyme and tripeptidyl peptidase 2) are all concerned with defense against invading pathogens.
Association of IL18RAP and CCR3 with coeliac disease in the Spanish population.
Núñez et al., In J Med Genet, 2009
Investigated the regions 2q12 (IL18RAP) and 3p21 (CCR3)in regards to celiac disease risk in the Spanish population.Two SNPs, rs917997 (2q12) and rs6441961 (3p21), were genotyped; Assoc'n was found w/rs6441961, a non-sign. result was obtained for rs917997.
Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis.
Prakken et al., Utrecht, Netherlands. In Arthritis Rheum, 2009
The mechanism of the impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis involves a defect in IL-18Rbeta phosphorylation.
Shared and distinct genetic variants in type 1 diabetes and celiac disease.
Todd et al., Cambridge, United Kingdom. In N Engl J Med, 2009
RESULTS: Three celiac disease loci--RGS1 on chromosome 1q31, IL18RAP on chromosome 2q12, and TAGAP on chromosome 6q25--were associated with type 1 diabetes (P<1.00x10(-4)).
Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project.
Tregouet et al., Paris, France. In Bmc Med Genet, 2008
Our analysis suggests that the variability of IL18RAP genes is unlikely to contribute to modulate the risk of cardiovascular disease
Newly identified genetic risk variants for celiac disease related to the immune response.
van Heel et al., London, United Kingdom. In Nat Genet, 2008
Variations in IL18RAP is associated with celiac disease
Interleukin-32: a cytokine and inducer of TNFalpha.
Dinarello et al., Denver, United States. In Immunity, 2005
An IL-18 unresponsive cell was converted to a responsive cell by transfection of the IL-18 receptor beta chain, and IL-18-induced microarray revealed high expression of a cytokine-like gene.
Roles of interleukin-18 in tissue destruction and compensatory reactions.
Okamura et al., Nishinomiya, Japan. In J Immunother, 2002
Interleukin-18 is recognized by a heterodimeric receptor, consisting of a ligand-binding alpha-chain (IL-18Ralpha/IL-1Rrp) and an associating beta-chain (IL-18Rbeta/AcPL), which transmits signals through MyD88/IRAK/TRAF-6 molecules.
IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family.
Dinarello, Denver, United States. In J Allergy Clin Immunol, 1999
This IL-18R complex is made up of a binding chain termed IL-18Ralpha, a member of the IL-lR family previously identified as the IL-1R-related protein (IL-1Rrp), and a signaling chain, the IL-18Rbeta, also a member of the IL-1R family.
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