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Interleukin 18 binding protein

IL-18BP, interleukin-18 binding protein, IL-18BPa
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: IL-18, IFN-gamma, IL-1beta, CAN, HAD
Papers using IL-18BP antibodies
Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with Munc 13-4 polymorphisms
Supplier
Kaplanski Gilles et al., In Frontiers in Immunology, 2007
... injections of 10 μg per mouse of recombinant human IL-18BP (a generous gift from Merck Serono, Geneva, Switzerland), starting ...
Papers on IL-18BP
Serum levels of interleukin-18-binding protein isoform a: Clinical association with inflammation and pulmonary hypertension in systemic sclerosis.
New
Sato et al., Tokyo, Japan. In J Dermatol, Feb 2016
To address this issue, we herein determined serum levels of IL-18-binding protein isoform a (IL-18BPa), a soluble decoy receptor for IL-18, by enzyme-linked immunosorbent assay in 57 SSc patients and 20 healthy controls and evaluated their clinical correlation.
Activation of NLRP3 inflammasome enhances the proliferation and migration of A549 lung cancer cells.
New
Xie et al., Nanjing, China. In Oncol Rep, Feb 2016
Moreover, these effects were inhibited by the following treatments: i) downregulating the expression of NLRP3 by short hairpin RNA (shRNA) interference, ii) inhibiting the activation of NLRP3 inflammasome with a caspase-1 inhibitor, iii) blocking the interleukin-1β (IL-1β) and IL-18 signal transduction with IL-1 receptor antagonist (IL-1Ra) and IL-18 binding protein (IL-18BP).
Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine.
New
Mika et al., Spain. In Mol Cell Neurosci, Feb 2016
We have studied the changes in the mRNA and protein levels (qRT-PCR and Western blot analysis, respectively) of IL-18, IL-18-binding protein (IL-18BP) and the IL-18 receptor (IL-18R) over time in rats following chronic constriction injury (CCI) of the sciatic nerve.
IL-27 induces the expression of IDO and PD-L1 in human cancer cells.
New
Ferrini et al., Genova, Italy. In Oncotarget, Jan 2016
We reported that IL-27 induces the expression of the IL-18 inhibitor IL-18BP, in human Epithelial Ovarian Cancer (EOC) cells, thus potentially limiting the immune response.
The protective role of interleukin-18 binding protein in a murine model of cardiac ischemia/reperfusion injury.
New
Lv et al., Hangzhou, China. In Transpl Int, Dec 2015
Recent study indicated that neutralization of IL-18 with anti-IL-18 antibody or IL-18-binding protein (IL-18BP) ameliorates IR-induced myocardial injury.
Interleukin-18 modulation in autism spectrum disorders.
New
Ricci et al., Latina, Italy. In J Neuroinflammation, Dec 2015
IL-18 binding protein (IL-18BP) was evaluated in Reeler and wild-type mice plasma as well as in their brains (sections and homogenates).
Increased IL18 mRNA levels in peripheral artery disease and its association with triglyceride and LDL cholesterol levels: a pilot study.
New
Arslan et al., Samsun, Turkey. In Heart Vessels, Nov 2015
IL18 activity is balanced by high-affinity naturally occurring IL18-binding protein (IL18BP).
Evaluation and validation of biomarkers in granulomatosis with polyangiitis and microscopic polyangiitis.
New
Rudnicki et al., Innsbruck, Austria. In Nephrol Dial Transplant, Oct 2015
RESULTS: The review indicated abundant expression of sC5bC9, C3a, C5a and monocyte chemotactic protein (MCP)-1 in urine, whereas granulocyte macrophage colony-stimulating factor, C-reactive protein (CRP), soluble fms-like tyrosine kinase-1, interleukin-17A (IL-17A), C5a, hyaluronan, C3a and interleukin-18 binding protein (IL-18BP) were identified to be highly diverse in active and inactive disease in blood samples.
Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP.
Review
New
Ferrini et al., Genova, Italy. In J Leukoc Biol, Apr 2015
The natural inhibitor IL-18BP , whose production is enhanced by IFN-γ and IL-27, further regulates IL-18 activity in the extracellular environment.
Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women.
Kain et al., Toronto, Canada. In Plos One, 2014
FINDINGS: In both the training and test cohorts plasma levels of IL-18BP, sICAM-1, sEndoglin and CHI3L1 were elevated and Leptin was lower at enrollment in women who subsequently experienced sPTB.
Interleukin-18, more than a Th1 cytokine.
Review
Dinarello et al., Israel. In Semin Immunol, 2014
The activity of IL-18 is balanced by the presence of a high-affinity, naturally occurring IL-18 binding protein (IL-18BP).
Negative regulatory receptors of the IL-1 family.
Review
Mantovani et al., Rozzano, Italy. In Semin Immunol, 2014
In this review, the negative regulation mediated by decoy receptors are presented and include IL-1R2 and IL-IL-18BP as well as atypical receptors, which include TIR8/SIGIRR, IL-1RAcPb, TIGIRR-1 and IL-1RAPL.
The interleukin-1 family: back to the future.
Review
Impact
Mantovani et al., Rozzano, Italy. In Immunity, 2014
Members of the IL-1 Receptor (IL-1R) family include six receptor chains forming four signaling receptor complexes, two decoy receptors (IL-1R2, IL-18BP), and two negative regulators (TIR8 or SIGIRR, IL-1RAcPb).
Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure.
Review
Toldo et al., Richmond, United States. In Mol Med, 2013
Recombinant human IL-18BP (r-hIL-18BP) has been investigated in animal studies and in phase I/II clinical trials for psoriasis and rheumatoid arthritis.
High circulating levels of interleukin-18 binding protein indicate the severity of glomerular involvement in systemic lupus erythematosus.
GeneRIF
Soma et al., Tokyo, Japan. In Mod Rheumatol, 2012
High IL-18 BP levels indicate the severity of existing glomerular injury in systemic lupus erythematosus.
Serum interleukin-18 binding protein increases with behavior different from IL-18 in patients with diabetic nephropathy.
GeneRIF
Soma et al., Tokyo, Japan. In Diabetes Res Clin Pract, 2011
In T2DM patients, 18 BP began to increase after IL-18 increased and reached a threshold, in which case kidney dysfunction would have developed.
[Role of IL-18/IL-18BP balance in spleen of patients with primary immune thrombocytopenia].
GeneRIF
Hou et al., Jinan, China. In Zhonghua Yi Xue Za Zhi, 2011
IL-18/IL-18BP imbalance plays an important role in pathogenesis of primary immune thrombocytopenia.
Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus.
GeneRIF
Boraschi et al., Pisa, Italy. In Eur Cytokine Netw, 2010
increased levels of both IL-18 and its natural inhibitor IL-18BP, characterise SLE
Imbalance of interleukin-18 and interleukin-18 binding protein in children with Henoch-Schönlein purpura.
GeneRIF
Zhang et al., Jinan, China. In J Int Med Res, 2010
The balance between interleukin-18 (IL-18) and its endogenous antagonist, IL-18 binding protein (IL-18BP), was evaluated in children with Henoch-Schonlein purpura.
Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.
Impact
Rubinstein et al., Israel. In Immunity, 1999
An interleukin-18 binding protein (IL-18BP) was purified from urine by chromatography on IL-18 beads, sequenced, cloned, and expressed in COS7 cells.
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