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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Interleukin 17 receptor C

IL-17RC, interleukin-17 receptor-like protein, IL-17RL
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: IL-17, mL-1, V1a, CAN, Interleukin-6
Papers on IL-17RC
Antibody blockade of IL-17 family cytokines in immunity to acute murine oral mucosal candidiasis.
New
Gaffen et al., Pittsburgh, United States. In J Leukoc Biol, Feb 2016
IL-17A, IL-17F, and IL-17AF bind the IL-17RA-IL-17RC heterodimeric complex and deliver qualitatively similar signals through the adaptor Act1.
Interleukin-17A promotes the growth of human germinal center derived non-Hodgkin B cell lymphoma.
New
Pistoia et al., Genova, Italy. In Oncoimmunology, Oct 2015
UNASSIGNED: Interleukin (IL)-17A belongs to IL-17 superfamily and binds the heterodimeric IL-17 receptor (R)(IL-17RA/IL-17RC). IL-17A promotes germinal center (GC) formation in mouse models of autoimmune or infectious diseases, but the role of IL-17A/IL-17AR complex in human neoplastic GC is unknown.
Distinctive expression pattern of interleukin-17 cytokine family members in colorectal cancer.
New
Bishehsari et al., Helsinki, Finland. In Tumour Biol, Sep 2015
Ten healthy colons and ten CRC mucosa were immunostained for IL-17B, IL-17C, IL-17E, and IL-17F, and their receptors IL-17RA, IL-17RB, and IL-17RC.
Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis.
New
Puel et al., Paris, France. In J Exp Med, Jun 2015
We report three patients from unrelated kindreds, aged 8, 12, and 37 yr with isolated CMC, who display AR IL-17RC deficiency.
[Effects of IL-17F/IL-17RC on the expression of caveolae-1 in rat pulmonary microvascular endothelial cells].
New
You et al., Hefei, China. In Zhonghua Yi Xue Za Zhi, May 2015
OBJECTIVE: To explore the expression of caveolin-1 (Cav-1) induced by interleukin-17F/IL-17 receptor C (IL-17F/IL-17RC) in rat pulmonary microvascular endothelial cells (PMVECs).
Signaling through IL-17C/IL-17RE is dispensable for immunity to systemic, oral and cutaneous candidiasis.
Gaffen et al., Pittsburgh, United States. In Plos One, 2014
The cytokine IL-17 (IL-17A) and its receptor subunits, IL-17RA and IL-17RC, are required for protection to most forms of candidiasis.
Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.
Richards et al., In Respir Res, 2014
OSM elevated steady state mRNA levels of IL-4Rα, OSMRβ and gp130, but not IL-17RA or IL-17RC.
An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling.
Review
Santibanez et al., Belgrade, Serbia. In Protein Pept Lett, 2014
IL-17RA is widely expressed, and forms a complex with IL-17RC.
Targeting IL-17 and IL-23 in Immune Mediated Renal Disease.
Kitching et al., Australia. In Curr Med Chem, 2014
Th17 cells are a subset of Th cells, characterized by the production of the inflammatory cytokines interleukin (IL)-17A (IL-17A) and IL-17F, which bind to a receptor complex comprised of IL-17RA and IL-17RC subunits.
The plot thickens while the scope broadens: a holistic view on IL-17 in psoriasis and other inflammatory disorders.
Review
Schön, Göttingen, Germany. In Exp Dermatol, 2014
Several monoclonal antibodies targeting IL-17A (secukinumab, ixekizumab) or its IL-17RC/RA receptor (brodalumab) are currently in late stages of clinical development, where they have shown impressive efficacy.
Interleukin-17 in human inflammatory diseases.
Review
Shahneh et al., Tehrān, Iran. In Postepy Dermatol Alergol, 2014
The associated receptors for the IL-17 family identified are IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE.
Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.
Impact
Pearlman et al., Cleveland, United States. In Nat Immunol, 2014
IL-6 and IL-23 induced expression of the receptors IL-17RC and dectin-2 on neutrophils, and IL-17RC expression was augmented by activation of dectin-2.
Potential involvement of IL-17F in asthma.
Review
Hizawa et al., Tsukuba, Japan. In J Immunol Res, 2013
The receptor for IL-17F is the heterodimeric complex of IL-17RA and IL-17RC, and IL-17F activates many signaling pathways.
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.
Impact
Sheppard et al., San Francisco, United States. In Nat Med, 2012
Interleukin-17A (IL-17A), but not IL-17F or IL-22, enhanced contractile force generation of airway smooth muscle through an IL-17 receptor A (IL-17RA)-IL-17RC, nuclear factor κ light-chain enhancer of activated B cells (NF-κB)-ras homolog gene family, member A (RhoA)-Rho-associated coiled-coil containing protein kinase 2 (ROCK2) signaling cascade.
Association study of IL-17RC, CHL1, DSCAM and CNTNAP2 genes polymorphisms with adolescent idiopathic scoliosis susceptibility in a Chinese Han population.
GeneRIF
Qiu et al., Nanjing, China. In Stud Health Technol Inform, 2011
Overall, our study found a significant association of IL-17RC gene polymorphisms with AIS in a Chinese Han population, indicating IL-17RC gene may be as a susceptibility gene for AIS.
The IL-17 pathway as a major therapeutic target in autoimmune diseases.
Review
Ouyang et al., Saint Louis, United States. In Ann N Y Acad Sci, 2011
IL-17A and IL-17F signal through IL-17RA and IL-17RC heterodimeric receptors that are mainly expressed on tissue epithelial cells and fibroblasts.
IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.
GeneRIF
Gaffen et al., Buffalo, United States. In J Immunol, 2010
Data show that signaling in IL-17RC(-/-) fibroblasts required the SEF/IL-17R signaling domain (SEFIR).
IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis.
GeneRIF
Ouyang et al., San Francisco, United States. In J Immunol, 2010
IL-17RC is essential for mediating the functions of IL-17A, IL-17F, and IL-17A/F both in vitro and in vivo and directly participates in the pathogenesis of central nervous system inflammation.
IL-17 contributes to angiogenesis in rheumatoid arthritis.
GeneRIF
Shahrara et al., Chicago, United States. In J Immunol, 2010
IL-17 and its receptor IL-17RC are involved in rheumatoid arthritis synovial fluid-mediated chemotaxis in human lung microvascular endothelial cell culture.
The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex.
GeneRIF
Carreno et al., Cambridge, United States. In J Immunol, 2008
Interleukin-17F is inhibited by the IL-17RC receptor, a combination of soluble IL-17RA/IL-17RC receptors is required for inhibition of the IL-17F/IL-17A activity.
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