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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 17A

IL-17, Interleukin-17, IL-17A
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-6, IL-10, CD4, CAN, IL-23
Papers using IL-17 antibodies
Subchondral trabecular structural changes in the proximal tibia in an ovine model of increased bone turnover
Frey Oliver, In PLoS ONE, 2010
... IL-17 neutralizing antibody and all other antibodies used for FACS studies were purchased from BD Biosciences (Mississauga, ON, CA) ...
CD28 co-stimulation down regulates Th17 development
Witzke Oliver et al., In Arthritis Research & Therapy, 2008
... All antibodies were purchased from Becton Dickinson, Heidelberg, Germany, except for IL-17, which was purchased from eBioscience, San Diego, CA, USA, ...
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
Baumgrass Ria et al., In Frontiers in Immunology, 2006
... staining buffer set (eBioscience) and stained with antibodies against FOXP3-FITC (eBioscience), IL-2-APC (BD), IL-4-PE (BD), IL-17-PE (eBioscience), IFN-γ-Pacific orange (own in-house ...
Distinct gene expression profiles characterize cellular phenotypes of follicle-associated epithelium and M cells.
Alexopoulou Lena, In PLoS ONE, 2004
CD95/Fas (DX2), CR1 (8C12), IL-17 (TC11-18H10.1)
Learning when training data are costly: the effect of class distribution on tree induction
Frey Oliver et al., In Frontiers in Microbiology, 2004
... for 8 min, followed by staining with fluorochrome-conjugated mAbs against CD4, CD154, GM-CSF, TNF-α, RANKL, IL-2, IL-17, and IFN-γ (all from BD, eBiosciences, Biolegend, or Miltenyi Biotech) ...
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Papers on IL-17
Adipose-derived mesenchymal stem cells modulate the immune response in chronic experimental autoimmune encephalomyelitis model.
Abdel Hamid et al., Az Zaqāzīq, Egypt. In Iubmb Life, Feb 2016
ASCs treatment induced a Th2 shift of the immune response and downregulation of IL-17 levels.
miRNA-Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis.
Chakraborty et al., Ch'unch'ŏn, South Korea. In Med Res Rev, Feb 2016
Moreover, we have tried to portray the role of various miRNAs in different cytokines such as TNF-α, IL-1, IL-6, IL-10, IL-17, IL-18, IL-21, and granulocyte macrophage colony-stimulating factor (GMCSF).
Changes of synapses in experimental autoimmune encephalomyelitis by using Fasudil.
Xiao et al., Datong, China. In Wound Repair Regen, Feb 2016
Neurotrophic factor BDNF and GDNF as well as immunomodulatory cytokine IL-10 in spinal cord were elevated in Fasudil-treated mice, while inflammatory cytokine IL-17, IL-1β, IL-6 and TNF-⟨ were obviously inhibited, accompanied by the decrease of inflammatory M1 iNOS and the increase of anti-inflammatory M2 Arg-1, providing a microenvironment that contributes to synaptic protection.
Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via Jak3/Stat3 signaling pathway.
Li et al., Beijing, China. In Int Immunopharmacol, Feb 2016
Administration of astilbin ameliorated IMQ-induced keratinocyte proliferation, infiltration of CD3+ cells to psoriatic lesions and ameliorated elevations in circulating CD4+ and CD8+ T cells and inflammatory cytokines (IL-17A, TNF-α, IL-6, IFN-γ and IL-2).
Could cytokine levels in the peri-implant crevicular fluid be used to distinguish between healthy implants and implants with peri-implantitis? A systematic review.
Feres et al., Guarulhos, Brazil. In J Periodontal Res, Feb 2016
Proinflammatory cytokines [interleukin (IL)-1β, IL-6, IL-12, IL-17 and tumor necrosis factor-α) were the cytokines studied most commonly, followed by anti-inflammatory cytokines (IL-4 and IL-10), osteoclastogenesis-related cytokines (RANKL) and chemokines (IL-8).
A Review of Biologic Therapies Targeting IL-23 and IL-17 for Use in Moderate-to-Severe Plaque Psoriasis.
Menter et al., Dallas, United States. In Dermatol Ther (heidelb), Jan 2016
Although the complex immunological pathway of psoriasis is not yet completely understood, current models emphasize the significant importance of interleukin (IL)-23 and IL-17.
Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation.
Gommerman et al., Toronto, Canada. In Immunity, Jan 2016
Within the CNS, interactions between lymphotoxin αβ (LTαβ) on Th17 cells and LTβR on meningeal radio-resistant cells were necessary for the propagation of de novo interleukin-17 responses, and activated T cells from MS patients expressed elevated levels of LTβR ligands.
The Good, the Bad, or the Pretty: IL-17 Builds Lymphoid Tissues in the Brain.
Becher, Zürich, Switzerland. In Immunity, Jan 2016
In this issue of Immunity, Pikor and colleagues (2015) find that signals from IL-17-producing T helper cells can alter the stromal microenvironment of the inflamed brain to generate a neo-lymphoid organ that drives further inflammation.
Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions.
Kuchroo et al., Basel, Switzerland. In Immunity, Jan 2016
Therapeutic interventions with inhibitors of the different components of the pathway such as interleukin-12 (IL-12), IL-23, IL-17A, and IL-17RA have variably beneficial effects in psoriasis, Crohn's disease, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, non-infectious uveitis, and multiple sclerosis.
Halofuginone Treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.
Keshavjee et al., Toronto, Canada. In J Heart Lung Transplant, Jan 2016
Immunofluorescent staining for IL-17A demonstrated a decreased number and frequency of IL-17A‒positive cells in halofuginone-treated lung grafts on Day 28, as compared with controls.
Overexpression of RORγt Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium.
Hizawa et al., Tsukuba, Japan. In Plos One, Dec 2015
The cytokine expression shifted toward a Th17 phenotype in the lungs of RORγt-overexpressing mice following MAC infection; the levels of IL-6 and IL-17 were significantly higher in the lung of these mice than in WT mice.
Thymosin Beta-4 Suppresses Osteoclastic Differentiation and Inflammatory Responses in Human Periodontal Ligament Cells.
Kim et al., Ch'ŏnan, South Korea. In Plos One, Dec 2015
Tβ4 activation with a Tβ4 peptide attenuated the H2O2-induced production of NO and PGE2 and up-regulated iNOS, COX-2, and osteoclastogenic cytokines (TNF-α, IL-1β, IL-6, IL-8, and IL-17) as well as reversed the effect on RANKL and OPG in PDLCs.
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.
Ashwell et al., Bethesda, United States. In Nat Med, Nov 2015
7), reduced CD4(+) TIL production of TNF-α, IL-17A, IL-10 and secondary cytokines, halted growth of implanted tumors and inhibited progression of spontaneous KRAS-driven adenocarcinoma in mice.
Gut-Busters: IL-17 Ain't Afraid of No IL-23.
Gaffen et al., Pittsburgh, United States. In Immunity, Nov 2015
Interleukin-23 (IL-23) is considered a critical regulator of IL-17 in lymphocytes.
Interleukin-17 Could Promote Breast Cancer Progression at Several Stages of the Disease.
Zhang et al., New Orleans, United States. In Mediators Inflamm, 2014
Here we review current literature on the pathogenic mechanisms driven by IL-17 during breast cancer progression and connect these findings to metastasis.
Brucella abortus-infected macrophages modulate T lymphocytes to promote osteoclastogenesis via IL-17.
Delpino et al., Buenos Aires, Argentina. In Am J Pathol, 2012
Brucella abortus-activated T cells actively secreted the pro-osteoclastogenic cytokines RANKL and IL-17 and osteoclastogenesis depended on IL-17.
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells.
Maloy et al., Oxford, United Kingdom. In J Exp Med, 2012
IL-1beta mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells
CD4+ T cells disarm or delete cytotoxic T lymphocytes under IL-17-polarizing conditions.
Chen et al., Taiwan. In J Immunol, 2012
demonstrate that the presence of CD4(+)CD25(-) T cells, but not the CD4(+)CD25(+) (regulatory T [Treg]) cell population, significantly reduced the elicitation of Tc17 cells, possibly as a result of the induction of apoptotic signals
[Dynamic expressions of IL-17 and IL-23 in mice infected with Schistosoma japonicum].
Liu et al., Wuhan, China. In Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi, 2012
IL-17 and IL-23 may play important roles during the immune process in the very early stage of Schistosoma infection.
IL-17, neutrophil activation and muscle damage following endurance exercise.
Kometani et al., Tokyo, Japan. In Exerc Immunol Rev, 2011
These findings suggest that IL-17 induced by IL-6 and activated by IL-23 or other IL-17 producing-cells and IL-23 might promote neutrophil activation and muscle damage following prolonged endurance exercise.
More papers using IL-17 antibodies
Synthesis of several chemokines but few cytokines by primed uncommitted precursor CD4 T cells suggests that these cells recruit other immune cells without exerting direct effector functions.
Unutmaz Derya, In PLoS ONE, 2003
... Fluor 700 conjugated anti-human IL-2 (MQ1-17H12), FITC conjugated anti-human IL-4 (MP4-25D2), and PerCP-Cy5.5 conjugated anti-human IL-17A (BL168) were purchased from BioLegend (San Diego, CA) ...
Control of Regulatory T Cell Development by the Transcription Factor Foxp3.
Proost Paul, In PLoS ONE, 2002
... staining, liver specimens were incubated with antibodies for CD4 (Shanghai Changdao Biotech, Shanghai, China) and IL-17 (R&D), and imaged with confocal microscopy (Leica TCS SP5II, Wetzlar, Germany).
Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence
López-Larrea Carlos et al., In Age, 2002
... Activation was assessed by intracellular staining with anti-IFN-γ (BD Biosciences), anti-IL-2 and anti-IL-17 (eBioscience).
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Flavell Richard A. et al., In Nature, 2001
... Antibody pairs for ELISA were purchased from R&D Systems (IL-1β), BD Pharmingen (IL-5, IL-6, IL-17 and IFN-γ) or from eBioscience (TNF-α ...
Role of interleukin-8 in tumour growth and metastasis of human melanoma
Jackson Andrew M et al., In Breast Cancer Research : BCR, 1998
... A goat polyclonal anti-human IL-17 antibody and corresponding neutralising peptide were obtained from Santa Cruz Biotechnology (Insight Biotechology, London, UK) ...
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