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Interleukin 15 receptor, alpha

IL-15Ralpha, sIL-15Ralpha
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: IL-15, Interleukin-2, CD25, CD8, CAN
Papers on IL-15Ralpha
Differential expression of pro-inflammatory cytokines IL-15Ralpha, IL-15, IL-6 and TNFalpha in synovial fluid from rheumatoid arthritis patients.
Guillen Nieto et al., Havana, Cuba. In Bmc Musculoskelet Disord, 2014
Recently we described for the first time, the presence of its specific receptor, IL-15Ralpha, in synovial fluid (SF).
Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum.
Pavlakis et al., Bethesda, United States. In Blood, 2012
IL-15 is produced and secreted only as a heterodimer with IL-15Ralpha.
Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1.
Young et al., New York City, United States. In Blood, 2012
Human Langerhans cells use an IL-15R-alpha/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1.
IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.
Ashkar et al., Hamilton, Canada. In J Immunol, 2012
IL-15 can signal via IL-15Ralpha, JNK, and NF-kappaB to drive RANTES production by myeloid cells.
Increased serum soluble IL-15Rα levels in T-cell large granular lymphocyte leukemia.
Waldmann et al., Bethesda, United States. In Blood, 2012
High serum IL-15R alpha is associated with T-cell large granular lymphocyte leukemia.
Increased frequency of IL-7 and IL-15 receptor alpha chain (CD127, CD215) co-expressing CD4(+) T cells in granulomatosis with polyangiitis (Wegener's).
Lamprecht et al., In Clin Exp Rheumatol, 2012
Letter: report increased frequency of CD127/CD215 co-expressing CD4(+) T cells in Wegener's granulomatosis.
Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes.
Turley et al., Boston, United States. In Proc Natl Acad Sci U S A, 2011
Cytotoxic lymphocytes such as natural killer (NK) and CD8 T cells play important roles in immunosurveillance by killing virally infected or malignant cells.
Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth.
Scheller et al., Kiel, Germany. In Mol Biol Cell, 2010
Because also heterodimeric complexes within the gp130 family may have tumorigenic potential, we seek to generate ligand-independent constitutively active heterodimers for all known gp130-receptor complexes based on IL-15/IL-15R alpha-sushi fusion proteins.
IL-15R alpha-IgG1-Fc enhances IL-2 and IL-15 anti-tumor action through NK and CD8+ T cells proliferation and activation.
Xu et al., Hangzhou, China. In J Mol Cell Biol, 2010
IL-2, IL15 and IL-15Ralpha-IgG1-Fc complexes significantly enhanced NK and CD8(+) T cells proliferation and cytotoxicity.
Trans-presentation: a novel mechanism regulating IL-15 delivery and responses.
Schluns et al., Houston, United States. In Immunol Lett, 2010
As opposed to other cytokines that are secreted, IL-15 primarily exists bound to the high affinity IL-15R alpha.
CD25 appears non essential for human peripheral T(reg) maintenance in vivo.
Taoufik et al., Le Kremlin-Bicêtre, France. In Plos One, 2009
No significant change in the weak or absent expression of IL-7Ralpha and IL-15Ralpha expression on FoxP3+ cells was observed.
Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets.
Ma et al., San Francisco, United States. In Immunity, 2009
IL-15R alpha expression on macrophages but not dendritic cells (DCs) supports the early transition of antigen specific effector CD8(+) T cells to memory cells
Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans.
Ikemizu et al., Kumamoto, Japan. In Nat Immunol, 2007
Whereas IL-2 receptor-alpha (IL-2Ralpha) is expressed together in cis with the beta- and gamma-subunits on T cells and B cells, IL-15Ralpha is expressed in trans on antigen-presenting cells.
The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signaling.
Paus et al., Germany. In Bioessays, 2006
These frontiers in IL-15/IL-15Ralpha research serve as highly instructive examples for key concepts, unsolved problems and therapeutic opportunities in juxtacrine and reverse signaling in general.
Cytokine targeting in psoriasis and psoriatic arthritis: beyond TNFalpha.
MclInnes, Glasgow, United Kingdom. In Ernst Schering Res Found Workshop, 2005
IL-15 is an innate response cytokine that activates leukocyte subsets via binding to its unique IL-15Ralpha and shared beta and gamma chain receptors.
The roles of interleukin-15 receptor alpha: trans-presentation, receptor component, or both?
Lefrançois et al., Houston, United States. In Int J Biochem Cell Biol, 2005
Interleukin-15 receptor alpha (IL-15R alpha) is a high affinity IL-15 binding protein that is crucial for mediating IL-15 functions such as memory CD8 T cell proliferation and NK, NK/T cell, and intestinal intraepithelial lymphocyte development.
IL-15 and IL-15Ralpha in CD4+T cell immunity.
Grooten et al., Gent, Belgium. In Arch Immunol Ther Exp (warsz), 2005
Recently, however, membrane-bound IL-15 was detected in both a membrane-anchored form and an IL-15Ralpha -bound form on monocytes.
IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells.
Tagaya et al., Bethesda, United States. In Immunity, 2002
We report intriguing aspects of the contribution of IL-15Ralpha to IL-15 functions.
The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens.
Tagaya et al., Bethesda, United States. In Annu Rev Immunol, 1998
In T and NK cells the IL-15 receptor includes IL-2/15R beta and gamma c subunits, which are shared with IL-2, and an IL-15-specific receptor subunit, IL-15R alpha.
IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation.
Ma et al., Chicago, United States. In Immunity, 1998
The IL-15 receptor alpha subunit (IL-15Ralpha) mediates high-affinity binding of IL-15, a pleiotropic cytokine implicated in the development of innate immune cells.
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