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Interleukin 15

IL-15, Interleukin-15
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Interleukin-2, CAN, CD8, Interleukin-6, IL-7
Papers using IL-15 antibodies
Higher constitutive IL15R alpha expression and lower IL-15 response threshold in coeliac disease patients.
Supplier
Holowka David, In PLoS ONE, 2007
... We used the goat, anti-human IL-15R alpha (R&D Systems, Minneapolis, MN, USA), rabbit anti-human IL-15 (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice
Supplier
Hasenkrug Kim J., In PLoS ONE, 1999
... , IL-15 tg C57BL/6 strain B1 (transgenic for IL-15) ...
Papers on IL-15
The Uterine Immune Profile May Help Women With Repeated Unexplained Embryo Implantation Failure After In Vitro Fertilization.
Review
New
Chaouat et al., Paris, France. In Am J Reprod Immunol, Feb 2016
The endometrial immune profile documented the ratio of IL-15/Fn-14 mRNA as a biomarker of uNK cell activation/maturation (together with the uNK cell count) and the IL-18/TWEAK mRNA ratio as a biomarker of both angiogenesis and the Th1/Th2 balance.
CD8αα TCRαβ Intraepithelial Lymphocytes in the Mouse Gut.
Review
New
Yang et al., Chongqing, China. In Dig Dis Sci, Feb 2016
For instance, epithelial cells and nearby immune cells secrete a number of cytokines, including interleukin-15 (IL-15), IL-7, and transforming growth factor-β, resulting in an assortment of cellular responses, including activation of master transcription factors, cell proliferation, and cytokine secretion.
Recent Progress in the Research of Eosinophilic Esophagitis and Gastroenteritis.
New
Ishihara et al., In Digestion, Feb 2016
Basic knowledge of these diseases has mainly come from studies of EoE and Th2 type allergic reactions, including IL-5, IL-13, and IL-15, thymic stromal protein, and eotaxin 3, which are considered to have important roles.
The level of FoxO1 and IL-15 in skeletal muscle, serum and synovial fluid in people with knee osteoarthritis: a case control study.
New
Levinger et al., Melbourne, Australia. In Osteoporos Int, Feb 2016
We compared the expression of interleukin-15 (IL-15) and Forkhead box protein-O1 (FoxO1) in muscle of patients with knee OA and asymptomatic individuals and examined whether IL-15 was also present in the joint and serum.
Decidual Control of Trophoblast Invasion.
Review
New
Modi et al., Mumbai, India. In Am J Reprod Immunol, Feb 2016
The decidual secretions contain high amounts of pro-invasive factors that include IL-1β, IL-5, IL-6, IL-7, IL-8, IL-9, IL-13, IL-15, Eotaxin CCL11, IP-10 and RANTES, and anti-invasive factors IL-10, IL-12 and VEGF.
T Cell Help Amplifies Innate Signals in CD8(+) DCs for Optimal CD8(+) T Cell Priming.
New
Bedoui et al., Melbourne, Australia. In Cell Rep, Feb 2016
We show that CD8(+) T cell priming upon HSV-1 skin infection depended on DCs receiving stimulation from both IFN-α/β and CD4(+) T cells to provide IL-15.
Homeostasis of IL-15 dependent lymphocyte subsets in the liver.
New
Ramanathan et al., Sherbrooke, Canada. In Cytokine, Feb 2016
UNASSIGNED: IL-15 is a member of the gamma chain family of cytokines (γc - CD132).
Common gamma chain cytokines in combinatorial immune strategies against cancer.
Review
New
Shanker et al., Nashville, United States. In Immunol Lett, Jan 2016
Common γ chain (γC) cytokines, namely IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 are important for the proliferation, differentiation, and survival of lymphocytes that display antitumor activity, thus stimulating considerable interest for the use of cytokines in cancer immunotherapy.
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.
New
Impact
Carbone et al., Melbourne, Australia. In Immunity, Jan 2016
However, whereas extinguishment of Eomes was necessary for CD8(+)CD103(+) Trm cell development, residual T-bet expression maintained cell surface interleukin-15 (IL-15) receptor β-chain (CD122) expression and thus IL-15 responsiveness.
Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity.
Review
New
Basile et al., Messina, Italy. In Arch Immunol Ther Exp (warsz), Jan 2016
We have described the role of IL-1, IL-2, IL-6, IL-12, IL-15, IL-18, IL-22, IL-23, TNF-α, IFN-γ as pro-inflammatory cytokines, of IL-1Ra, IL-4, IL-10, TGF-β1 as anti-inflammatory cytokines, and of lipoxin A4 and heat shock proteins as mediators of cytokines.
IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction.
New
Impact
Abadie et al., Chicago, United States. In Nat Rev Immunol, Dec 2015
In this Opinion article, we discuss the function of tissues as a crucial checkpoint for the regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as a danger molecule that communicates to the immune system that the tissue is under attack and poises it to mediate tissue destruction.
Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.
New
Impact
Nagao et al., Tokyo, Japan. In Nat Med, Nov 2015
Hair follicle expression of IL-15 was required for CD8(+) TRM cells, and IL-7 for CD8(+) and CD4(+) TRM cells, to exert epidermotropism.
Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.
New
Impact
Leonard et al., Bethesda, United States. In Immunity, Jun 2015
Moreover, one variant, H9-RETR, antagonized IL-2 and IL-15 better than blocking antibodies against IL-2Rα or IL-2Rβ.
Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.
New
Impact
Singer et al., Bethesda, United States. In Nat Immunol, May 2015
Upregulation of let-7 miRNAs in developing NKT thymocytes was signaled by IL-15, vitamin D and retinoic acid.
Expression profile and kinetics of cytokines and chemokines in patients with chronic hepatitis C.
Zhu et al., Changchun, China. In Int J Clin Exp Med, 2014
In contrast, IFN-γ, IL-7, and IL-15 were remarkably decreased, especially in HCV genotype 1b infection.
Expression of leukaemia inhibitory factor and interleukin 15 in endometrium of women with recurrent implantation failure after IVF; correlation with the number of endometrial natural killer cells.
GeneRIF
Laird et al., Sheffield, United Kingdom. In Hum Reprod, 2012
there is an altered expression of LIF and IL-15 in the endometrium of women with recurrent implantation failure
The differential production of cytokines by human Langerhans cells and dermal CD14(+) DCs controls CTL priming.
GeneRIF
Klechevsky et al., Dallas, United States. In Blood, 2012
The respective production of IL-15 and IL-10 explains the contrasting effects of Langerhans cells and dermal CD14(+) dendritic cells on CD8(+) T-cell priming.
IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity.
GeneRIF
Metelitsa et al., Houston, United States. In J Clin Invest, 2012
IL-15 protected antigen-activated NKT cells from hypoxia, and transgenic expression of IL-15 in adoptively transferred NKT cells dramatically enhanced their antimetastatic
IL-15 inhibits IL-7Rα expression by memory-phenotype CD8⁺ T cells in the bone marrow.
GeneRIF
Di Rosa et al., Roma, Italy. In Eur J Immunol, 2012
It was shown that the key molecule regulating IL-7 receptor alpha-chain downmodulation was IL-15 but not IL-7, and that the intact IL-7 receptor alpha-chain gene was required, including the promoter.
Oncolytic effects of a novel influenza A virus expressing interleukin-15 from the NS reading frame.
GeneRIF
Cinatl et al., Frankfurt am Main, Germany. In Plos One, 2011
Data show that infection of melanoma cells with delNS1-IL-15 resulted in the production of high levels of biologically active IL-15.
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