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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 13 receptor, alpha 2

IL-13Ralpha2, IL-13 receptor, IL-13 receptor alpha2
The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-13, IL-4, IL-13Ralpha1, IL-4R, STAT6
Papers on IL-13Ralpha2
A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair.
Munitz et al., Tel Aviv-Yafo, Israel. In Mucosal Immunol, Jan 2016
Interleukin (IL)-4 and IL-13 are pro-fibrotic cytokines that share common receptor chains including IL-13 receptor (R) α1 and are key pharmacological targets in fibrotic diseases.
IL-13 receptor α2 is a negative prognostic factor in human lung cancer and stimulates lung cancer growth in mice.
He et al., Guangzhou, China. In Oncotarget, Nov 2015
IL-13 receptor subunit alpha-2 (IL13Rα2) is associated with poor prognosis in some cancers.
Mac-1 Regulates IL-13 Activity in Macrophages by Directly Interacting with IL-13Rα1.
Zhang et al., Baltimore, United States. In J Biol Chem, Sep 2015
In this study, we report the identification of IL-13Rα1, a component of the IL-13 receptor (IL-13R), as a novel ligand of integrin Mac-1, using a co-evolution-based algorithm.
Interleukin-13 interferes with activation-induced t-cell apoptosis by repressing p53 expression.
Yang et al., Zhengzhou, China. In Cell Mol Immunol, Aug 2015
Here we report that CD4(+) T cells expressed IL-13 receptor α2 in the intestine of sensitized mice.
Phase I trial of systemic intravenous infusion of interleukin-13-Pseudomonas exotoxin in patients with metastatic adrenocortical carcinoma.
Kebebew et al., Bethesda, United States. In Cancer Med, Jul 2015
Eligible patients had confirmed IL-13 receptor alpha 2 (IL-13Rα2) expressions in their tumors.
Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma.
Sehmi et al., Hamilton, Canada. In J Allergy Clin Immunol, Jun 2015
This priming effect was inhibited by blocking antibodies to TSLPR and ST2, respectively, and IL-13 receptor α1 in both scenarios.
Targeting IgE production in mice and humans.
Scheerens et al., San Francisco, United States. In Curr Opin Immunol, 2014
Clinical studies using antibodies against IL-13 or the IL-4 and IL-13 receptor subunit IL-4Rα, as well as an antibody against the M1 prime domain of human membrane IgE, indicate that, similar to mice, a proportion of IgE in humans is derived from ongoing IgE immune responses and short-lived plasma cells.
Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium.
Dorscheid et al., In Respir Res, 2014
Experiments with non-asthmatic monolayer cultures indicate IL-13 exert its effect on SP-D through the IL-13 receptor alpha1 and transcription factor STAT6. CONCLUSIONS: SP-D is expressed differently in airways of asthmatics relative to that of non-asthmatics.
Association of IL-13 single nucleotide polymorphisms in Iranian patients to multiple sclerosis.
Babaloo et al., Tabrīz, Iran. In Am J Clin Exp Immunol, 2013
More studies should be done on other IL-13 SNPs, and also polymorphisms of IL-13 receptor and other cytokines to determine the exact role of SNPs in protecting or predisposing of individuals for MS.
[The role of transforming growth factor beta1 R II and interleukin 13 Ralpha2 in schistosomiasis-induced hepatic fibrosis].
Wang et al., In Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi, 2013
This paper reviews the effects of TGF-beta1 type II (TGF-beta1 R II) receptor and IL-13 receptor alpha2 (IL-13 Ralpha2) on hepatic fibrosis.
High expression of IL-13 receptor α2 in colorectal cancer is associated with invasion, liver metastasis, and poor prognosis.
Casal et al., Madrid, Spain. In Cancer Res, 2012
high expression of IL-13Ralpha2 was associated with later stages of disease progression and poor outcome in patients with colorectal cancer
IL-13 receptor-directed cancer vaccines and immunotherapy.
Puri et al., Bethesda, United States. In Immunotherapy, 2012
Many immunotherapy approaches including therapeutic cancer vaccines targeting specific tumor-associated antigens are at various stages of development.
Equilibrium and kinetic analysis of human interleukin-13 and IL-13 receptor alpha-2 complex formation.
Lacy, Radnor, United States. In J Mol Recognit, 2012
IL-13Ralpha2 is a high affinity receptor for IL-13 binding: implications in the understanding of the role of IL-13-R110Q in the disease state.
Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression.
Radstake et al., Nijmegen, Netherlands. In J Rheumatol, 2012
Data showed that polymorphisms in IL4, IL13, and their receptors do not play a role in SSc and do not influence the expression of their corresponding transcript in peripheral blood cells.
A novel combination immunotherapy for cancer by IL-13Rα2-targeted DNA vaccine and immunotoxin in murine tumor models.
Puri et al., Bethesda, United States. In J Immunol, 2011
When combined with IL-13Ralpha2 DNA cancer vaccine, Pseudomonas aeruginosa exotoxin A mediates synergistic antitumor effects on tumor growth and metastasis in established murine breast carcinoma and sarcoma tumor models.
Association of polymorphisms in genes encoding IL-4, IL-13 and their receptors with atopic dermatitis in a Korean population.
Yang et al., Cleveland, United States. In Exp Dermatol, 2011
did not identify any SNPs in the IL-4, IL-4R and IL-13Ralpha2 genes that were associated with atopic dermatitis
Immune modulation for treatment of allergic disease.
Casale et al., Omaha, United States. In Immunol Rev, 2011
Therapies directed against specific effector molecules, such as immunoglobulin E and prostaglandin D2, hold promise in immune modulation of allergic disease, as do targeting the IL-4/IL-13 receptor and augmenting Th1/Th2 balance with Toll-like receptor agonists.
IL-13 and the IL-13 receptor as therapeutic targets for asthma and allergic disease.
Townley et al., Omaha, United States. In Curr Opin Investig Drugs, 2010
Pharmaceutical and biotechnology companies are researching various strategies, based on this approach, aimed at binding IL-13, increasing the level of the IL-13 decoy receptor, IL-13Ralpha2, or blocking the effect of the chemokine receptor CCR5.
IL-13 effector functions.
Wynn, Bethesda, United States. In Annu Rev Immunol, 2002
The mechanisms that regulate IL-13 production and/or function have also been investigated, and IL-4, IL-12, IL-18, IFN-gamma, IL-10, TGF-beta, TNF-alpha, and the IL-4/IL-13 receptor complex play important roles.
Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells.
Strober et al., Bethesda, United States. In Immunity, 2002
Here we show that IL-13 production is a significant pathologic factor in OC since its neutralization by IL-13Ralpha2-Fc administration prevents colitis.
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