Role of IL-4 and Th2 responses in allograft rejection and tolerance.
Sydney, Australia. In Curr Opin Organ Transplant, 2009
In addition to its effects on bone marrow-derived cells, IL-4 affects parenchymal cells by signalling through the type II receptor, which consists of the IL-4R alpha chain (IL-4Ralpha) and the IL-13Ralpha1, which also binds IL-13.
Immune pathways for translating viral infection into chronic airway disease.
Saint Louis, United States. In Adv Immunol, 2008
The interaction between iNKT cells and macrophages depends on contact between the semi-invariant Valpha14Jalpha18-TCR on lung iNKT cells and the oligomorphic MHC-like protein CD1d on macrophages as well as NKT cell production of IL-13 that binds to the IL-13 receptor (IL-13R) on the macrophage.