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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 16 Apr 2015.

Interleukin 13

IL-13, Interleukin-13
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-4, TH2, IL-5, IL-10, CAN
Papers using IL-13 antibodies
The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis
Supplier
Moser Muriel, In PLoS ONE, 2010
... Human recombinant IL-4 and IL-13 were obtained from Peprotech Inc., Rocky Hill, NJ, USA; LTD4 and rabbit polyclonal anti-human CysLT1 receptor from Cayman Chemical, Ann Arbor, MI, ...
Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation
Supplier
Choe Myeon et al., In Nutrition Research and Practice, 2009
... Jose, CA, USA), anti-IL-4 (mouse monoclonal antibody (Santa Cruz Biotechnology, Santa Cruz, CA, USA), and anti-IL-13 (mouse monoclonal antibody; Santa Cruz Biotechnology).
Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
Supplier
Unutmaz Derya, In PLoS ONE, 2002
... IL-4 and IL-13 specific mAbs were from Biolegend.
The influence of dexamethasone treatment on the lymphoid and stromal composition of the mouse thymus: a flow cytometric and immunohistological analysis
Supplier
McKenzie Andrew N.J. et al., In The Journal of Experimental Medicine, 1985
... Generation of IL-13 Transgenic Mice.
Papers on IL-13
Phenotypic, Functional and Plasticity Features of Classical and Alternatively Activated Human Macrophages.
New
Fantino et al., Brisbane, Australia. In Am J Respir Cell Mol Biol, 14 May 2015
Human peripheral blood monocytes were differentiated into macrophages (M0) and then polarized to M1 and M2 phenotypes using LPS/IFN-g and IL-4/IL-13, respectively.
Blocking high fat diet-induced obesity, insulin resistance and fatty liver by overexpression of Il-13 gene in mice.
New
Liu et al., Athens, United States. In Int J Obes (lond), 14 May 2015
OBJECTIVES: The objective of this study is to assess the activity of anti-inflammatory cytokine IL-13 in blocking high-fat diet-induced obesity and obesity-associated insulin resistance and liver steatosis.
Looking beyond the induction of Th2 responses to explain immunomodulation by helminths.
New
Nutman, Bethesda, United States. In Parasite Immunol, 13 May 2015
UNASSIGNED: Although helminth infections are characteristically associated with Th2-mediated responses that include the production of the prototypical cytokines IL-4, IL-5, and IL-13 by CD4+ cells, the production of IgE, peripheral blood eosinophilia and mucus production in localized sites, these responses are largely attenuated when helminth infections become less acute.
Amelioration of allergic airway inflammation in mice by regulatory IL-35 through dampening inflammatory dendritic cells.
New
Lam et al., Hong Kong, Hong Kong. In Allergy, 13 May 2015
This was reflected by the significantly reduced concentration of asthma-related Th2 cytokines IL-5 and IL-13, as well as eosinophil counts in bronchoalveolar lavage fluid (all p<0.05).
Psychosocial telephone counseling for survivors of cervical cancer: results of a randomized biobehavioral trial.
New
Impact
Nelson et al., Irvine, United States. In J Clin Oncol, 01 May 2015
Participants with decreasing interleukin (IL) -4, IL-5, IL-10, and IL-13 had significantly greater improvement in QOL than those with increasing cytokine levels.
Immunopathology of chronic rhinosinusitis.
Review
New
Kato, Chicago, United States. In Allergol Int, 30 Apr 2015
Inflammation in eosinophilic NPs is mainly controlled by type 2 cytokines, IL-5 and IL-13, which can be produced from several immune cells including Th2 cells, mast cells and group 2 innate lymphoid cells (ILC2s) that are all elevated in eosinophilic NPs.
Spatial regulation of IL-4 signalling in vivo.
Review
New
Perona-Wright et al., Vancouver, Canada. In Cytokine, 25 Apr 2015
UNASSIGNED: Type 2 immune responses are defined by the cytokines interleukin 4 (IL-4), IL-5 and IL-13 and the cellular and physiological changes that these cytokines induce, including IgE production, eosinophilia, mast cell degranulation, mucus secretion and smooth muscle contraction.
History of interleukin-4.
Review
New
Paul, Bethesda, United States. In Cytokine, 23 Apr 2015
Illustrative is the extended time from the first report of IL-4 in 1982 to the establishment of the efficacy of blocking IL-4 and its congener IL-13 in the treatment of moderate to severe asthma and atopic dermatitis, a period of 31years.
New dog and new tricks: evolving roles for IL-33 in type 2 immunity.
Review
New
Turnquist et al., Pittsburgh, United States. In J Leukoc Biol, 23 Apr 2015
IL-33, however, is now being shown to initiate the Th2-polarizing function of DCs, and stimulate the secretion of the type 2-associated cytokines, IL-4, IL-5, and IL-13, from tissue-resident innate-immune cells, especially ILCs and MCs.
ICOS:ICOS-Ligand Interaction Is Required for Type 2 Innate Lymphoid Cell Function, Homeostasis, and Induction of Airway Hyperreactivity.
New
Impact
Akbari et al., Los Angeles, United States. In Immunity, 17 Apr 2015
Type 2 innate lymphoid cells (ILC2s) are a newly identified subset of immune cells that, along with Th2 cells, contribute to the pathogenesis of asthma by producing copious amounts of IL-5 and IL-13, which cause eosinophilia and airway hyperreactivity (AHR), a cardinal feature of asthma.
Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid.
Review
New
Bozza et al., Rio de Janeiro, Brazil. In Molecules, Dec 2014
In addition, oral administration of curine significantly inhibited eosinophil recruitment and activation, as well as, OVA-induced airway hyper-responsiveness in a mouse model of asthma, through inhibition of the production of IL-13 and eotaxin, and of Ca2+ influx.
LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARγ ligand synthesis.
New
Coste et al., Toulouse, France. In Nat Commun, Dec 2014
Here we report that LRH-1 is expressed in macrophages and induced by the Th2 cytokine IL-13 via a mechanism involving STAT6.
Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion.
New
Impact
Gause et al., Newark, United States. In Nat Immunol, Oct 2014
Neutrophils in parasite-infected mice showed a distinct transcriptional profile and promoted alternatively activated M2 macrophage polarization through secretory factors including IL-13.
MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion.
New
Impact
McKenzie et al., Dublin, Ireland. In Immunity, Sep 2014
Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma.
GATA-3 function in innate and adaptive immunity.
Review
New
Impact
Hendriks et al., Rotterdam, Netherlands. In Immunity, Sep 2014
The zinc-finger transcription factor GATA-3 has received much attention as a master regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4), IL-5, and IL-13 expression.
Association of interleukin-13 SNP rs1800925 with allergic rhinitis risk: a meta-analysis based on 1,411 cases and 3169 controls.
GeneRIF
Wang et al., Shanghai, China. In Gene, 2012
combined results based on all studies showed that IL-13 SNP rs1800925 was not associated with increased allergic rhinitis risk
The lL-8 and IL-13 gene polymorphisms in inflammatory bowel disease and colorectal cancer.
GeneRIF
Majsterek et al., Łódź, Poland. In Dna Cell Biol, 2012
data showed that the IL-8 -251 T/A and IL-13 -1112 C/T polymorphisms might be associated with the inflammatory bowel disease and colorectal cancer occurrence
Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children.
GeneRIF
Hong et al., Seoul, South Korea. In J Allergy Clin Immunol, 2012
Children with GA or AA at IL13(12044) are at increased risk for allergic rhinitis when exposed to mold in the home during the first year of life.
Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells.
GeneRIF
Misawa et al., Tokyo, Japan. In Pharmacol Rep, 2011
Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells.
Impact of interleukin-13 and -18 promoter polymorphisms in health care workers with natural rubber latex allergy.
GeneRIF
Raulf-Heimsoth et al., Bochum, Germany. In J Toxicol Environ Health A, 2011
The association between the IL-13 -1055T allele and elevated total IgE levels confirms the role of a genetic background for total IgE regulation
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