Looking beyond the induction of Th2 responses to explain immunomodulation by helminths.
Bethesda, United States. In Parasite Immunol, 13 May 2015
UNASSIGNED: Although helminth infections are characteristically associated with Th2-mediated responses that include the production of the prototypical cytokines IL-4, IL-5, and IL-13 by CD4+ cells, the production of IgE, peripheral blood eosinophilia and mucus production in localized sites, these responses are largely attenuated when helminth infections become less acute.
Immunopathology of chronic rhinosinusitis.
Chicago, United States. In Allergol Int, 30 Apr 2015
Inflammation in eosinophilic NPs is mainly controlled by type 2 cytokines, IL-5 and IL-13, which can be produced from several immune cells including Th2 cells, mast cells and group 2 innate lymphoid cells (ILC2s) that are all elevated in eosinophilic NPs.
Spatial regulation of IL-4 signalling in vivo.
Vancouver, Canada. In Cytokine, 25 Apr 2015
UNASSIGNED: Type 2 immune responses are defined by the cytokines interleukin 4 (IL-4), IL-5 and IL-13 and the cellular and physiological changes that these cytokines induce, including IgE production, eosinophilia, mast cell degranulation, mucus secretion and smooth muscle contraction.
History of interleukin-4.
Bethesda, United States. In Cytokine, 23 Apr 2015
Illustrative is the extended time from the first report of IL-4 in 1982 to the establishment of the efficacy of blocking IL-4 and its congener IL-13 in the treatment of moderate to severe asthma and atopic dermatitis, a period of 31years.
New dog and new tricks: evolving roles for IL-33 in type 2 immunity.
Pittsburgh, United States. In J Leukoc Biol, 23 Apr 2015
IL-33, however, is now being shown to initiate the Th2-polarizing function of DCs, and stimulate the secretion of the type 2-associated cytokines, IL-4, IL-5, and IL-13, from tissue-resident innate-immune cells, especially ILCs and MCs.
Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid.
Rio de Janeiro, Brazil. In Molecules, Dec 2014
In addition, oral administration of curine significantly inhibited eosinophil recruitment and activation, as well as, OVA-induced airway hyper-responsiveness in a mouse model of asthma, through inhibition of the production of IL-13 and eotaxin, and of Ca2+ influx.
GATA-3 function in innate and adaptive immunity.
Rotterdam, Netherlands. In Immunity, Sep 2014
The zinc-finger transcription factor GATA-3 has received much attention as a master regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4), IL-5, and IL-13 expression.