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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Nov 2014.

Interleukin 13

IL-13, Interleukin-13
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-4, TH2, IL-5, IL-10, CAN
Papers using IL-13 antibodies
The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis
Supplier
Moser Muriel, In PLoS ONE, 2010
... Human recombinant IL-4 and IL-13 were obtained from Peprotech Inc., Rocky Hill, NJ, USA; LTD4 and rabbit polyclonal anti-human CysLT1 receptor from Cayman Chemical, Ann Arbor, MI, ...
Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation
Supplier
Choe Myeon et al., In Nutrition Research and Practice, 2009
... Jose, CA, USA), anti-IL-4 (mouse monoclonal antibody (Santa Cruz Biotechnology, Santa Cruz, CA, USA), and anti-IL-13 (mouse monoclonal antibody; Santa Cruz Biotechnology).
Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
Supplier
Unutmaz Derya, In PLoS ONE, 2002
... IL-4 and IL-13 specific mAbs were from Biolegend.
The influence of dexamethasone treatment on the lymphoid and stromal composition of the mouse thymus: a flow cytometric and immunohistological analysis
Supplier
McKenzie Andrew N.J. et al., In The Journal of Experimental Medicine, 1985
... Generation of IL-13 Transgenic Mice.
Papers on IL-13
Secretory phospholipases A2 are secreted from ciliated cells and increase mucin and eicosanoid secretion from goblet cells.
New
Rubin et al., In Chest, 27 Dec 2014
We used IL-13 transformed highly enriched goblet cells and differentiated (ciliary cell enriched) human bronchial epithelial (HBE) cell culture to evaluate the relative contribution of ciliated and goblet cells to airway sPLA2 generation and response.
Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes.
New
Melby et al., In Bmc Immunol, 26 Dec 2014
The concomitant expression of IL-4/IL-13 and their downstream target genes, some of which were characteristic of alternative macrophage activation, are likely to contribute to this.
Discrimination between active and latent tuberculosis based on the ratio of antigen-specific to mitogen-induced IP-10 production.
New
Ha et al., Seoul, South Korea. In J Clin Microbiol, 26 Dec 2014
Whole blood samples from 33 active TB patients and 20 individuals with LTBI, and 26 non-TB controls were applied to the commercial IFN-γ release assay QuantiFERON-TB Gold In Tube, and the plasma was analyzed for IL-2, IL-6, IL-8, IL-10, IL-13, TNF-α, IFN-γ, MIG, IP-10, I-TAG, and MCP-1 by using a commercial cytometric bead array.
Galacto-oligosaccharides may directly enhance intestinal barrier function through the modulation of goblet cells.
New
Gaskins et al., In Mol Nutr Food Res, 25 Dec 2014
Addition of the Th2 cytokine IL-13 along with GOS resulted in synergistic induction of RETNLB and CHST5.
Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion.
New
Impact
Gause et al., Newark, United States. In Nat Immunol, 31 Oct 2014
Neutrophils in parasite-infected mice showed a distinct transcriptional profile and promoted alternatively activated M2 macrophage polarization through secretory factors including IL-13.
IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy.
Review
New
Girard et al., Toulouse, France. In Curr Opin Immunol, 29 Oct 2014
Recent studies indicate that IL-33 induces production of large amounts of IL-5 and IL-13 by group 2 innate lymphoid cells (ILC2s), for initiation of allergic inflammation shortly after exposure to allergens or infection with parasites or viruses.
Recent advance in investigation of gene polymorphisms in Japanese patients with aspirin-exacerbated respiratory disease.
Review
New
Mochizuki et al., Annaka, Japan. In Allergol Immunopathol (madr), 12 Oct 2014
Here, we described on our recent genetic investigations on B2ADR, IL-13, IL-17A, CYP2C19, TBXA2R, CRTH2 and HSP70.
MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion.
New
Impact
McKenzie et al., Dublin, Ireland. In Immunity, Sep 2014
Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma.
GATA-3 function in innate and adaptive immunity.
Review
New
Impact
Hendriks et al., Rotterdam, Netherlands. In Immunity, Sep 2014
The zinc-finger transcription factor GATA-3 has received much attention as a master regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4), IL-5, and IL-13 expression.
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
New
Impact
Rothenberg et al., Cincinnati, United States. In Nat Genet, Aug 2014
CAPN14 was specifically expressed in the esophagus, was dynamically upregulated as a function of disease activity and genetic haplotype and after exposure of epithelial cells to interleukin (IL)-13, and was located in an epigenetic hotspot modified by IL-13.
Dupilumab treatment in adults with moderate-to-severe atopic dermatitis.
New
Impact
Radin et al., Bonn, Germany. In N Engl J Med, Aug 2014
BACKGROUND: Dupilumab, a fully human monoclonal antibody that blocks interleukin-4 and interleukin-13, has shown efficacy in patients with asthma and elevated eosinophil levels.
Oral delivery of Brucella spp. recombinant protein U-Omp16 abrogates the IgE-mediated milk allergy.
New
Docena et al., La Plata, Argentina. In Hum Vaccin Immunother, Jul 2014
We found at the mucosal site an inhibition of the gene expression corresponding to IL-13 and Gata-3, with an induction of IFN-γ and T-bet.
Asthma: pathogenesis and novel drugs for treatment.
Review
New
Wechsler et al., Denver, United States. In Bmj, Dec 2013
Several new classes of asthma drugs-including ultra long acting β agonists and modulators of the interleukin 4 (IL-4), IL-5, IL-13, and IL-17 pathways-have been evaluated in randomized controlled trials.
The Differentiation of CD4(+) T-Helper Cell Subsets in the Context of Helminth Parasite Infection.
Review
New
Le Gros et al., Wellington, New Zealand. In Front Immunol, Dec 2013
Originally, type 2 immune responses were defined by the presence and activities of the CD4(+) T-helper 2 subset producing the canonical cytokines IL-4, IL-5, and IL-13.
Evolutionary Roots of Arginase Expression and Regulation.
Review
New
Dzik, Warsaw, Poland. In Front Immunol, Dec 2013
Excretory-secretory products of metazoan parasites are able to induce M2-type of macrophage responses promoting wound healing without participation of Th2 cytokines IL-4/IL-13.
Association of interleukin-13 SNP rs1800925 with allergic rhinitis risk: a meta-analysis based on 1,411 cases and 3169 controls.
GeneRIF
Wang et al., Shanghai, China. In Gene, 2012
combined results based on all studies showed that IL-13 SNP rs1800925 was not associated with increased allergic rhinitis risk
The lL-8 and IL-13 gene polymorphisms in inflammatory bowel disease and colorectal cancer.
GeneRIF
Majsterek et al., Łódź, Poland. In Dna Cell Biol, 2012
data showed that the IL-8 -251 T/A and IL-13 -1112 C/T polymorphisms might be associated with the inflammatory bowel disease and colorectal cancer occurrence
Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children.
GeneRIF
Hong et al., Seoul, South Korea. In J Allergy Clin Immunol, 2012
Children with GA or AA at IL13(12044) are at increased risk for allergic rhinitis when exposed to mold in the home during the first year of life.
Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells.
GeneRIF
Misawa et al., Tokyo, Japan. In Pharmacol Rep, 2011
Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells.
Impact of interleukin-13 and -18 promoter polymorphisms in health care workers with natural rubber latex allergy.
GeneRIF
Raulf-Heimsoth et al., Bochum, Germany. In J Toxicol Environ Health A, 2011
The association between the IL-13 -1055T allele and elevated total IgE levels confirms the role of a genetic background for total IgE regulation
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