Innate immune cells to the help.
Gent, Belgium. In Immunity, 20 Apr 2014
A study by Halim and Steer (2014) in this issue of Immunity shows that innate lymphoid cells type 2 (ILC2s) are crucial for inducing adaptive T helper 2 immunity by providing interleukin-13.
Biologic targeted therapy in allergic asthma.
Portland, United States. In Ann Allergy Asthma Immunol, 28 Feb 2014
Particular emphasis was placed on articles discussing therapies targeted at IgE, interleukin (IL)-4, IL-4 receptor, IL-5, IL-13, tumor necrosis factor-α, CRTh2, and toll-like receptors 7 and 9.
Epigenetic regulation in allergic diseases and related studies.
Kao-hsiung, Taiwan. In Asia Pac Allergy, Jan 2014
Epigenetic marks (DNA methylation, modifications of histone tails or noncoding RNAs) work with other components of the cellular regulatory machinery to control the levels of expressed genes, and several allergy- and asthma-related genes have been found to be susceptible to epigenetic regulation, including genes important to T-effector pathways (IFN-γ, interleukin [IL] 4, IL-13, IL-17) and T-regulatory pathways (FoxP3).
Autoimmunity as a Double Agent in Tumor Killing and Cancer Promotion.
Miami, United States. In Front Immunol, Dec 2013
This review surveys the tumor-promoting and tumoricidal activities of several prominent cytokines: IFN-γ, TNF-α, TGF-β, IL-17, IL-23, IL-4, and IL-13, produced by three major subsets of T helper cells that interact with innate immune cells.
Regulation of Macrophage Polarization and Wound Healing.
Newark, United States. In Adv Wound Care (new Rochelle), 2012
Recent work has characterized a novel "M2d" phenotype resulting from adenosine-dependent "switching" of M1 Mφs that exhibits a pattern of marker expression that is distinct from canonical IL-4/IL-13-dependent M2a Mφs.