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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 13

IL-13, Interleukin-13
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-4, TH2, IL-5, IL-10, CAN
Papers using IL-13 antibodies
The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis
Supplier
Moser Muriel, In PLoS ONE, 2010
... Human recombinant IL-4 and IL-13 were obtained from Peprotech Inc., Rocky Hill, NJ, USA; LTD4 and rabbit polyclonal anti-human CysLT1 receptor from Cayman Chemical, Ann Arbor, MI, ...
Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation
Supplier
Choe Myeon et al., In Nutrition Research and Practice, 2009
... Jose, CA, USA), anti-IL-4 (mouse monoclonal antibody (Santa Cruz Biotechnology, Santa Cruz, CA, USA), and anti-IL-13 (mouse monoclonal antibody; Santa Cruz Biotechnology).
Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
Supplier
Unutmaz Derya, In PLoS ONE, 2002
... IL-4 and IL-13 specific mAbs were from Biolegend.
The influence of dexamethasone treatment on the lymphoid and stromal composition of the mouse thymus: a flow cytometric and immunohistological analysis
Supplier
McKenzie Andrew N.J. et al., In The Journal of Experimental Medicine, 1985
... Generation of IL-13 Transgenic Mice.
Papers on IL-13
The Chronic and Short-Term Effects of Gefinitib on Airway Remodeling and Inflammation in a Mouse Model of Asthma.
New
Li et al., Xi'an, China. In Cell Physiol Biochem, Feb 2016
METHODS: Pathological changes of OVA sensitization of BALB/c mice were measured by H&E and PAS staining; pEGFR, Bcl-2 and Bax expression was measured by western blot; ELISA was used to measure the level of muc5ac, IL-13 and IFN-x03B3;; TUNEL staining was used to detect goblet cell apoptosis.
Effect of yeast-derived products and distillers dried grains with solubles (DDGS) on antibody-mediated immune response and gene expression of pattern recognition receptors and cytokines in broiler chickens immunized with T-cell dependent antigens.
New
Slominski et al., Winnipeg, Canada. In Poult Sci, Feb 2016
On d 35, 5 birds per treatment were euthanized and the tissue samples from the cecal tonsils were collected to assess the gene expression of toll-like receptors TLR2b, TLR4, and TLR21, monocyte mannose receptor (MMR), and cytokines IL-10, IL-13, IL-4, IL-12p35, and IFN-γ.
Analysis of changes in expression of IL-4/IL-13/STAT6 pathway and correlation with the selected clinical parameters in patients with atopic asthma.
New
Brzeziańska-Lasota et al., Łódź, Poland. In Int J Immunopathol Pharmacol, Feb 2016
INTRODUCTION: Asthma is associated with activation of interleukin-4 (IL-4)/interleukin-13 (IL-13)/signal transducer and activator of transcription factor-6(STAT6) inflammatory response via overexpression of all pathway components: IL-4, IL-13, and STAT6.
Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites.
New
Impact
Jay et al., Montpellier, France. In Nature, Feb 2016
Induction of type 2 cytokines, including interleukins (IL) IL-4 and IL-13, induce goblet cell hyperplasia with mucus production, ultimately resulting in worm expulsion.
Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit.
New
Impact
Locksley et al., San Francisco, United States. In Nature, Feb 2016
After helminth infection, tuft-cell-derived IL-25 further activates ILC2s to secrete IL-13, which acts on epithelial crypt progenitors to promote differentiation of tuft and goblet cells, leading to increased frequencies of both.
Recent Progress in the Research of Eosinophilic Esophagitis and Gastroenteritis.
New
Ishihara et al., In Digestion, Feb 2016
Basic knowledge of these diseases has mainly come from studies of EoE and Th2 type allergic reactions, including IL-5, IL-13, and IL-15, thymic stromal protein, and eotaxin 3, which are considered to have important roles.
Decidual Control of Trophoblast Invasion.
Review
New
Modi et al., Mumbai, India. In Am J Reprod Immunol, Feb 2016
The decidual secretions contain high amounts of pro-invasive factors that include IL-1β, IL-5, IL-6, IL-7, IL-8, IL-9, IL-13, IL-15, Eotaxin CCL11, IP-10 and RANTES, and anti-invasive factors IL-10, IL-12 and VEGF.
Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease.
Review
New
Doherty et al., San Diego, United States. In Curr Allergy Asthma Rep, Jan 2016
ILC2s produce Th2 cytokines, IL-4, IL-5, and IL-13, upon activation by epithelial cell-derived cytokines, lipid mediators (cysteinyl leukotrienes and prostaglandin D2), and TNF family member TL1A and promote structural and immune cell responses in the airways after antigen exposure.
Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses.
New
Impact
McKenzie et al., Columbia, United States. In Nat Immunol, Jan 2016
ILC2-derived interleukin 13 (IL-13) is critical for eliciting production of the TH2 cell-attracting chemokine CCL17 by IRF4(+)CD11b(+)CD103(-) dendritic cells (DCs).
Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro.
New
Impact
Ingber et al., Boston, United States. In Nat Methods, Jan 2016
Exposure of the epithelium to interleukin-13 (IL-13) reconstituted the goblet cell hyperplasia, cytokine hypersecretion and decreased ciliary function of asthmatics.
Morin Attenuates Ovalbumin-Induced Airway Inflammation by Modulating Oxidative Stress-Responsive MAPK Signaling.
New
Huang et al., Nanjing, China. In Oxid Med Cell Longev, Dec 2015
Morin administration also significantly suppressed goblet cell hyperplasia and collagen deposition/fibrosis and dose-dependently inhibited the OVA-induced increases in IgE, TNF-α, interleukin- (IL-) 4, IL-13, matrix metalloproteinase-9, and malondialdehyde.
Interleukin-13 as an important cytokine: A review on its roles in some human diseases.
Review
New
Babaloo et al., Tabrīz, Iran. In Acta Microbiol Immunol Hung, Dec 2015
Interleukin-13 (IL-13) as a pleiotropic cytokine acts through the IL-13Ra1/IL-4Ra complex to induce activation responses which contribute to the inflammatory diseases.
Drivers of chronic rhinosinusitis: Inflammation versus infection.
Review
New
Hamilos, Boston, United States. In J Allergy Clin Immunol, Dec 2015
Another feature of epithelial dysregulation in patients with CRS is overproduction of eosinophil-promoting C-C chemokines by sinus epithelium, perhaps driven in part through innate stimuli, as well as TH2 cytokines, such as IL-13.
Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function.
New
Impact
Lloyd et al., London, United Kingdom. In Immunity, Dec 2015
Mice that specifically lacked epithelial cell-derived TGF-β1 displayed a reduction in type 2 innate lymphoid cells (ILCs), resulting in suppression of interleukin-13 and hallmark features of the allergic response including airway hyperreactivity.
Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization.
Review
Bu et al., Shanghai, China. In Int J Endocrinol, 2014
Recently it is found that eosinophils accelerate alternative activation macrophage (AAM) polarization by secreting Th2 type cytokines such as interleukin-4 and interleukin-13, thereby reducing metainflammation in adipose tissue.
Association of interleukin-13 SNP rs1800925 with allergic rhinitis risk: a meta-analysis based on 1,411 cases and 3169 controls.
GeneRIF
Wang et al., Shanghai, China. In Gene, 2012
combined results based on all studies showed that IL-13 SNP rs1800925 was not associated with increased allergic rhinitis risk
The lL-8 and IL-13 gene polymorphisms in inflammatory bowel disease and colorectal cancer.
GeneRIF
Majsterek et al., Łódź, Poland. In Dna Cell Biol, 2012
data showed that the IL-8 -251 T/A and IL-13 -1112 C/T polymorphisms might be associated with the inflammatory bowel disease and colorectal cancer occurrence
Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children.
GeneRIF
Hong et al., Seoul, South Korea. In J Allergy Clin Immunol, 2012
Children with GA or AA at IL13(12044) are at increased risk for allergic rhinitis when exposed to mold in the home during the first year of life.
Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells.
GeneRIF
Misawa et al., Tokyo, Japan. In Pharmacol Rep, 2011
Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells.
Impact of interleukin-13 and -18 promoter polymorphisms in health care workers with natural rubber latex allergy.
GeneRIF
Raulf-Heimsoth et al., Bochum, Germany. In J Toxicol Environ Health A, 2011
The association between the IL-13 -1055T allele and elevated total IgE levels confirms the role of a genetic background for total IgE regulation
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