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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Interleukin 13

IL-13, Interleukin-13
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-4, TH2, IL-5, IL-10, CAN
Papers using IL-13 antibodies
The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis
Supplier
Moser Muriel, In PLoS ONE, 2010
... Human recombinant IL-4 and IL-13 were obtained from Peprotech Inc., Rocky Hill, NJ, USA; LTD4 and rabbit polyclonal anti-human CysLT1 receptor from Cayman Chemical, Ann Arbor, MI, ...
Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation
Supplier
Choe Myeon et al., In Nutrition Research and Practice, 2009
... Jose, CA, USA), anti-IL-4 (mouse monoclonal antibody (Santa Cruz Biotechnology, Santa Cruz, CA, USA), and anti-IL-13 (mouse monoclonal antibody; Santa Cruz Biotechnology).
Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
Supplier
Unutmaz Derya, In PLoS ONE, 2002
... IL-4 and IL-13 specific mAbs were from Biolegend.
The influence of dexamethasone treatment on the lymphoid and stromal composition of the mouse thymus: a flow cytometric and immunohistological analysis
Supplier
McKenzie Andrew N.J. et al., In The Journal of Experimental Medicine, 1985
... Generation of IL-13 Transgenic Mice.
Papers on IL-13
Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation.
New
Druey et al., Bethesda, United States. In J Allergy Clin Immunol, Aug 2014
Unexpectedly, induced IL-13 and IL-33 levels were much lower in challenged lungs from Rgs5(-/-) mice relative to those seen in wild-type mice.
Inhibitory effect of galangin on atopic dermatitis-like skin lesions.
New
Kim et al., Taegu, South Korea. In Food Chem Toxicol, Jun 2014
Galangin suppressed DFE/DNCB-induced expression of interleukin (IL)-4, IL-5, IL-13, IL-31, IL-32, and interferon (IFN)-γ in the ear tissue.
Innate immune cells to the help.
New
Impact
Hammad et al., Gent, Belgium. In Immunity, Apr 2014
A study by Halim and Steer (2014) in this issue of Immunity shows that innate lymphoid cells type 2 (ILC2s) are crucial for inducing adaptive T helper 2 immunity by providing interleukin-13.
Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation.
New
Impact
Takei et al., Vancouver, Canada. In Immunity, Apr 2014
Whereas interleukin-4 (IL-4) was dispensable for papain-induced Th2 cell differentiation, ILC2-derived IL-13 was critical as it promoted migration of activated lung dendritic cells into the draining lymph node where they primed naive T cells to differentiate into Th2 cells.
Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.
New
Impact
Locksley et al., San Francisco, United States. In Immunity, Apr 2014
We show that inhaled chitin induced expression of three epithelial cytokines, interleukin-25 (IL-25), IL-33, and thymic stromal lymphopoietin (TSLP), which nonredundantly activated resident innate lymphoid type 2 cells (ILC2s) to express IL-5 and IL-13 necessary for accumulation of eosinophils and alternatively activated macrophages (AAMs).
Biologic targeted therapy in allergic asthma.
Review
New
Montanaro et al., Portland, United States. In Ann Allergy Asthma Immunol, Feb 2014
Particular emphasis was placed on articles discussing therapies targeted at IgE, interleukin (IL)-4, IL-4 receptor, IL-5, IL-13, tumor necrosis factor-α, CRTh2, and toll-like receptors 7 and 9.
Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity.
New
Impact
Belkaid et al., Bethesda, United States. In Science, Feb 2014
However, vitamin A deprivation paradoxically resulted in dramatic expansion of interleukin-13 (IL-13)-producing ILC2s and resistance to nematode infection in mice, which revealed that ILCs are primary sensors of dietary stress.
Epigenetic regulation in allergic diseases and related studies.
Review
New
Hung et al., Kao-hsiung, Taiwan. In Asia Pac Allergy, Jan 2014
Epigenetic marks (DNA methylation, modifications of histone tails or noncoding RNAs) work with other components of the cellular regulatory machinery to control the levels of expressed genes, and several allergy- and asthma-related genes have been found to be susceptible to epigenetic regulation, including genes important to T-effector pathways (IFN-γ, interleukin [IL] 4, IL-13, IL-17) and T-regulatory pathways (FoxP3).
Chemotactic chemokines are important in the pathogenesis of irritable bowel syndrome.
New
Dupont et al., Houston, United States. In Plos One, Dec 2013
Anti-inflammatory cytokines (IL-10, IL-4, and IL-13) were variable except IL-10, which was significantly higher in the healthy volunteers than the IBS patients.
Autoimmunity as a double agent in tumor killing and cancer promotion.
Review
New
Chen et al., Miami, United States. In Front Immunol, Dec 2013
This review surveys the tumor-promoting and tumoricidal activities of several prominent cytokines: IFN-γ, TNF-α, TGF-β, IL-17, IL-23, IL-4, and IL-13, produced by three major subsets of T helper cells that interact with innate immune cells.
Importance of Both Innate Immunity and Acquired Immunity for Rapid Expulsion of S. venezuelensis.
Review
New
Nakanishi et al., Nishinomiya, Japan. In Front Immunol, Dec 2013
IL-33 from ATII cells induces ILC2 proliferation and at the same time activates them to produce IL-5 and IL-13, which in combination induce lung eosinophilic inflammation, aiding to expel infected worms in the lungs.
Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1.
New
Impact
Singh et al., San Francisco, United States. In Nat Immunol, Dec 2013
Loss of Gfi1 in activated ILC2 cells resulted in impaired expression of the transcription factor GATA-3 and a dysregulated genome-wide effector state characterized by coexpression of IL-13 and IL-17.
Allergic airway inflammation by nasal inoculation of particulate matter (PM2.5) in NC/Nga mice.
New
Fujikura et al., Okayama, Japan. In Plos One, Dec 2013
The synergistic effect of Sup and Pre was observed in terms of increases in AHR, BALF cells, the mRNA expression of IL-13, eotaxin1 and IL-1β, and the IL-1β concentration in BALF.
Parasite densities modulate susceptibility of mice to cerebral malaria during co-infection with Schistosoma japonicum and Plasmodium berghei.
New
Cao et al., Shenyang, China. In Malar J, Dec 2013
Interferon-gamma (IFN-γ), interleukin (IL)-4, IL-5, IL-13, IL-10, and TGF-β levels were determined in splenocyte supernatants using enzyme-linked immunosorbent assay (ELISA).
Association of interleukin-13 SNP rs1800925 with allergic rhinitis risk: a meta-analysis based on 1,411 cases and 3169 controls.
GeneRIF
Wang et al., Shanghai, China. In Gene, 2012
combined results based on all studies showed that IL-13 SNP rs1800925 was not associated with increased allergic rhinitis risk
The lL-8 and IL-13 gene polymorphisms in inflammatory bowel disease and colorectal cancer.
GeneRIF
Majsterek et al., Łódź, Poland. In Dna Cell Biol, 2012
data showed that the IL-8 -251 T/A and IL-13 -1112 C/T polymorphisms might be associated with the inflammatory bowel disease and colorectal cancer occurrence
Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children.
GeneRIF
Hong et al., Seoul, South Korea. In J Allergy Clin Immunol, 2012
Children with GA or AA at IL13(12044) are at increased risk for allergic rhinitis when exposed to mold in the home during the first year of life.
Regulation of Macrophage Polarization and Wound Healing.
Review
Leibovich et al., Newark, United States. In Adv Wound Care (new Rochelle), 2012
Recent work has characterized a novel "M2d" phenotype resulting from adenosine-dependent "switching" of M1 Mφs that exhibits a pattern of marker expression that is distinct from canonical IL-4/IL-13-dependent M2a Mφs.
Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells.
GeneRIF
Misawa et al., Tokyo, Japan. In Pharmacol Rep, 2011
Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells.
Impact of interleukin-13 and -18 promoter polymorphisms in health care workers with natural rubber latex allergy.
GeneRIF
Raulf-Heimsoth et al., Bochum, Germany. In J Toxicol Environ Health A, 2011
The association between the IL-13 -1055T allele and elevated total IgE levels confirms the role of a genetic background for total IgE regulation
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