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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Aug 2015.

Interleukin 13

IL-13, Interleukin-13
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-4, TH2, IL-5, IL-10, CAN
Papers using IL-13 antibodies
The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis
Supplier
Moser Muriel, In PLoS ONE, 2010
... Human recombinant IL-4 and IL-13 were obtained from Peprotech Inc., Rocky Hill, NJ, USA; LTD4 and rabbit polyclonal anti-human CysLT1 receptor from Cayman Chemical, Ann Arbor, MI, ...
Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation
Supplier
Choe Myeon et al., In Nutrition Research and Practice, 2009
... Jose, CA, USA), anti-IL-4 (mouse monoclonal antibody (Santa Cruz Biotechnology, Santa Cruz, CA, USA), and anti-IL-13 (mouse monoclonal antibody; Santa Cruz Biotechnology).
Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
Supplier
Unutmaz Derya, In PLoS ONE, 2002
... IL-4 and IL-13 specific mAbs were from Biolegend.
The influence of dexamethasone treatment on the lymphoid and stromal composition of the mouse thymus: a flow cytometric and immunohistological analysis
Supplier
McKenzie Andrew N.J. et al., In The Journal of Experimental Medicine, 1985
... Generation of IL-13 Transgenic Mice.
Papers on IL-13
Enteric nematodes and the path to up-regulation of type 2 cytokines IL-4 and IL-13.
Review
New
Zhao et al., Baltimore, United States. In Cytokine, 30 Sep 2015
Protective immunity against enteric parasitic nematodes is dependent on IL-4, IL-13 activation of their exclusive transcription factor STAT6.
PLD1 activation mediates Amb a 1-induced Th2-associated cytokine expression via the JNK/ATF-2 pathway in BEAS-2B cells.
New
Han et al., Seoul, South Korea. In Cell Immunol, 14 Sep 2015
UNASSIGNED: The purpose of this study was to identify the role of phospholipase D1 (PLD1) in Amb a 1-induced IL-5 and IL-13 expression.
Group 2 innate lymphoid cells and asthma.
Review
New
Asano et al., Tokyo, Japan. In Allergol Int, 31 Jul 2015
Group 2 innate lymphoid cells (ILC2s) are recently identified cell populations that produce type 2 cytokines such as IL-5 and IL-13 in response to epithelial cell-derived cytokines.
Complex host genetic susceptibility to Staphylococcus aureus infections.
Review
New
Schrodi et al., Marshfield, United States. In Trends Microbiol, 22 Jul 2015
Mouse models show variable susceptibility to S. aureus infections across mouse strains and disease models with roles for signaling pathways involving Toll-like receptors (TLR-1, TLR-2, and TLR-6), interleukins (IL-4, IL-6, IL-10, and IL-13), chemokines [CXC ligand (CXCL)-1 and CXCL-2], and T helper (Th)1/Th2 responses.
Type 2 cytokines: mechanisms and therapeutic strategies.
Review
New
Impact
Wynn, Bethesda, United States. In Nat Rev Immunol, May 2015
Type 2 immune responses are defined by the cytokines interleukin-4 (IL-4), IL-5, IL-9 and IL-13, which can either be host protective or have pathogenic activity.
Psychosocial telephone counseling for survivors of cervical cancer: results of a randomized biobehavioral trial.
New
Impact
Nelson et al., Irvine, United States. In J Clin Oncol, May 2015
Participants with decreasing interleukin (IL) -4, IL-5, IL-10, and IL-13 had significantly greater improvement in QOL than those with increasing cytokine levels.
ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.
New
Impact
Akbari et al., Los Angeles, United States. In Immunity, Apr 2015
Type 2 innate lymphoid cells (ILC2s) are a newly identified subset of immune cells that, along with Th2 cells, contribute to the pathogenesis of asthma by producing copious amounts of IL-5 and IL-13, which cause eosinophilia and airway hyperreactivity (AHR), a cardinal feature of asthma.
Profile of lebrikizumab and its potential in the treatment of asthma.
New
Rogers et al., San Antonio, United States. In J Asthma Allergy, Dec 2014
Periostin, an extracellular protein, has been used as a surrogate marker of IL-13 activity and has been linked to airway remodeling by inducing subepithelial fibrosis.
Thyroid dysfunction: an autoimmune aspect.
Review
New
Tabassum et al., Riyadh, Saudi Arabia. In Int J Clin Exp Med, Dec 2014
Various cytokines IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-14, TNF-α and IFN-γ are found in thyroid follicular cells which enhance inflammatory response with nitric oxide (NO) and prostaglandins.
Effects of environment on human cytokine responses during childhood in the tropics: role of urban versus rural residence.
New
Barreto et al., Quito, Ecuador. In World Allergy Organiz J, Dec 2014
Peripheral blood leukocytes (PBLs) in whole blood were stimulated with superantigen, parasite antigens and aeroallergens and IFN-γ, IL-5, IL-10, IL-13, and IL-17 were measured in supernatants.
A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease.
New
Yoshino et al., Okayama, Japan. In Sci Rep, Dec 2014
Ocular IgG4-RD and IgG4-associated MZL exhibited significantly higher expression ratios of interleukin (IL)-4/β-actin, IL-10/β-actin, IL-13/β-actin, transforming growth factor (TGF) β1/β-actin, and FOXP3/β-actin than did IgG4-negative MZL (p < 0.05).
Protective effect of the ω-3 polyunsaturated fatty acids on the schistosomiasis liver fibrosis in mice.
New
Xiao et al., Hengyang, China. In Int J Clin Exp Med, Dec 2014
The serum level of IL-13 and TNF-α were lower than that of model group and praziquantel treated group.
Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion.
New
Impact
Gause et al., Newark, United States. In Nat Immunol, Oct 2014
Neutrophils in parasite-infected mice showed a distinct transcriptional profile and promoted alternatively activated M2 macrophage polarization through secretory factors including IL-13.
GATA-3 function in innate and adaptive immunity.
Review
New
Impact
Hendriks et al., Rotterdam, Netherlands. In Immunity, Sep 2014
The zinc-finger transcription factor GATA-3 has received much attention as a master regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4), IL-5, and IL-13 expression.
Bronchial asthma: is personalized therapy on the horizon?
Review
Taube, Leiden, Netherlands. In Allergo J Int, 2013
In addition to already used anti-IgE, novel monoclonal antibodies such as anti-IL-5 and anti-IL-13 are becoming available.
Association of interleukin-13 SNP rs1800925 with allergic rhinitis risk: a meta-analysis based on 1,411 cases and 3169 controls.
GeneRIF
Wang et al., Shanghai, China. In Gene, 2012
combined results based on all studies showed that IL-13 SNP rs1800925 was not associated with increased allergic rhinitis risk
The lL-8 and IL-13 gene polymorphisms in inflammatory bowel disease and colorectal cancer.
GeneRIF
Majsterek et al., Łódź, Poland. In Dna Cell Biol, 2012
data showed that the IL-8 -251 T/A and IL-13 -1112 C/T polymorphisms might be associated with the inflammatory bowel disease and colorectal cancer occurrence
Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children.
GeneRIF
Hong et al., Seoul, South Korea. In J Allergy Clin Immunol, 2012
Children with GA or AA at IL13(12044) are at increased risk for allergic rhinitis when exposed to mold in the home during the first year of life.
Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells.
GeneRIF
Misawa et al., Tokyo, Japan. In Pharmacol Rep, 2011
Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells.
Impact of interleukin-13 and -18 promoter polymorphisms in health care workers with natural rubber latex allergy.
GeneRIF
Raulf-Heimsoth et al., Bochum, Germany. In J Toxicol Environ Health A, 2011
The association between the IL-13 -1055T allele and elevated total IgE levels confirms the role of a genetic background for total IgE regulation
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