Angiopoietins 1& 2 in sputum supernatant of optimally treated asthmatics: The effect of smoking.
Athens, Greece. In Eur J Clin Invest, 17 Dec 2014
All subjects underwent lung function tests, bronchial hyperresponsiveness assessment and sputum induction for cell count identification and measurement of Ang-1, Ang-2, VEGF, TGF-β1, MMP-2, IL-13, ECP, and IL-8 in supernatants.
GATA-3 function in innate and adaptive immunity.
Rotterdam, Netherlands. In Immunity, Sep 2014
The zinc-finger transcription factor GATA-3 has received much attention as a master regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4), IL-5, and IL-13 expression.
Dupilumab: a novel treatment for asthma.
Salerno, Italy. In J Asthma Allergy, Dec 2013
In particular, given the key role played by interleukin (IL)-4 and IL-13 in the pathophysiology of the most typical aspects of asthma, such as chronic airway inflammation, tissue remodeling, and bronchial hyperresponsiveness, these pleiotropic cytokines are now considered as suitable therapeutic targets.