Small interfering RNA against CD86 during allergen challenge blocks experimental allergic asthma.
In Respir Res, 27 Nov 2014
CD86 siRNA treatment ameliorated OVA-induced airway eosinophilia, airway hyperresponsiveness, and the elevations of OVA-specific IgE in the sera and IL-5, IL-13, and CCL17 in the bronchoalveolar lavage fluid, but not the goblet cell hyperplasia.ConclusionThese results suggest that local administration of CD86 siRNA during the effector phase ameliorates lines of asthma phenotypes.
GATA-3 function in innate and adaptive immunity.
Rotterdam, Netherlands. In Immunity, 21 Sep 2014
The zinc-finger transcription factor GATA-3 has received much attention as a master regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4), IL-5, and IL-13 expression.
Cytokines in acute chikungunya.
Pune, India. In Plos One, Dec 2013
Interferons (IFN)-α, -β and -γ, Interferon Gamma-Induced Protein-10 (CXCL-10/IP-10), Tumor Necrosis Factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-13 (IL-13), Monocyte Chemoattractant Protein-1 (MCP-1), Interleukin-4 (IL-4) and Interleukin-10 (IL-10) performed by ELISA.
Dupilumab: a novel treatment for asthma.
Salerno, Italy. In J Asthma Allergy, Dec 2013
In particular, given the key role played by interleukin (IL)-4 and IL-13 in the pathophysiology of the most typical aspects of asthma, such as chronic airway inflammation, tissue remodeling, and bronchial hyperresponsiveness, these pleiotropic cytokines are now considered as suitable therapeutic targets.