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Interleukin 12A

IL-12, interleukin 12
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: IL-10, Interleukin-6, CAN, IL-4, HAD
Papers using IL-12 antibodies
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
Supplier
Okada Hideho et al., In Journal of Translational Medicine, 2007
... Recombinant murine (rm) IL-12 was purchased from Cell Sciences Technologies ...
Obesity does not alter the pharmacokinetics of drotrecogin alpha (activated) in severe sepsis
Supplier
Schneider Francis et al., In Critical Care, 2004
... Plasma concentrations of IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, TNF-α, IL-10, IFN-γ and IL-12 were measured (CBA Human inflammation kit, BD Biosciences, San José, CA, USA) ...
Bacterial induction of beta interferon in mice is a function of the lipopolysaccharide component.
Supplier
Bereswill Stefan, In PLoS ONE, 1999
... FSL-1 was purchased from EMC microcollections (Tübingen, Germany), recombinant murine IFN-γ and IL-12 from NatuTec (Frankfurt a.M., Germany), murine ...
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
Supplier
Strober Warren et al., In The Journal of Experimental Medicine, 1997
... Murine IL-4, human IL-2, and murine IL-12 were purchased from PeproTech, Life Technologies, and R&D Systems, respectively ...
Papers on IL-12
Tolerogenic Effect of Mouse Fibroblasts on Dendritic Cells.
New
Ghahary et al., Vancouver, Canada. In Immunology, Feb 2016
Fibroblast-primed DCs had significantly reduced IL-12 expression level as compared to that of activated DCs.
Gene therapy approaches against cancer using in vivo and ex vivo gene transfer of interleukin-12.
New
Smerdou et al., Pamplona, Spain. In Immunotherapy, Feb 2016
UNASSIGNED: IL-12 is an immunostimulatory cytokine with strong antitumor properties.
Species-dependent role of type I IFNs and IL-12 in the CTL response induced by humanized CpG complexed with β-glucan.
New
Ishii et al., Ibaraki, Japan. In Eur J Immunol, Feb 2016
By focusing on two DC subsets, plasmacytoid DCs and CD8α(+) DCs, as well as the secreted cytokines, IFN-α and IL-12, we found that K3-SPG strongly activates mouse plasmacytoid DCs to secrete IFN-α and CD8α(+) DCs to secrete IL-12 respectively.
Gastric ghrelin, GOAT, leptin, and leptinR expression as well as peripheral serotonin are dysregulated in humans with obesity.
New
Bischoff et al., Stuttgart, Germany. In Neurogastroenterol Motil, Feb 2016
Interleukin 1 receptor a (IL1Ra), IL-8, IL-12, and monocyte chemoattractant protein 1 (IL1Ra) were increased and IL1Ra correlated negatively with serum leptin.
Could cytokine levels in the peri-implant crevicular fluid be used to distinguish between healthy implants and implants with peri-implantitis? A systematic review.
Review
New
Feres et al., Guarulhos, Brazil. In J Periodontal Res, Feb 2016
Proinflammatory cytokines [interleukin (IL)-1β, IL-6, IL-12, IL-17 and tumor necrosis factor-α) were the cytokines studied most commonly, followed by anti-inflammatory cytokines (IL-4 and IL-10), osteoclastogenesis-related cytokines (RANKL) and chemokines (IL-8).
Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review.
Review
New
Maverakis et al., Sacramento, United States. In Clin Rev Allergy Immunol, Feb 2016
Novel therapeutics targeting these mediators (IL-12, IL-23, IL-17, IL-17 receptor, TNF) are effective in treating both the skin and joint manifestations of psoriasis, reaffirming the shared pathophysiology of PsV and PsA.
Decidual Control of Trophoblast Invasion.
Review
New
Modi et al., Mumbai, India. In Am J Reprod Immunol, Feb 2016
The decidual secretions contain high amounts of pro-invasive factors that include IL-1β, IL-5, IL-6, IL-7, IL-8, IL-9, IL-13, IL-15, Eotaxin CCL11, IP-10 and RANTES, and anti-invasive factors IL-10, IL-12 and VEGF.
In vitro QuantiFERON-TB gold antigen specific interleukin-1beta to diagnose TB among HIV-positive subjects.
New
Raja et al., Chennai, India. In Tuberculosis (edinb), Jan 2016
Apart from IFN-γ, the pro inflammatory cytokines such as Interleukin-1beta (IL-1β), Tumor necrosis factor-alpha (TNF-α), IL-2, IL-6, IL-8 and IL-12 are also play a major role in mycobacterial infections.
Role of interleukin-23 as a biomarker in rheumatoid arthritis patients and its correlation with disease activity.
Review
New
El-Nahrery et al., Cairo, Egypt. In Int Immunopharmacol, Jan 2016
BACKGROUND: IL-23 is a pro-inflammatory cytokine belonging to the IL-12 cytokine family.
Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions.
Review
New
Impact
Kuchroo et al., Basel, Switzerland. In Immunity, Jan 2016
Therapeutic interventions with inhibitors of the different components of the pathway such as interleukin-12 (IL-12), IL-23, IL-17A, and IL-17RA have variably beneficial effects in psoriasis, Crohn's disease, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, non-infectious uveitis, and multiple sclerosis.
Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.
New
Impact
Towne et al., Seattle, United States. In Immunity, Nov 2015
Although inhibition of both of these cytokines is effective for treating psoriasis, IL-12 and IL-23 p40 inhibition attenuates Crohn's disease, whereas IL-17A or IL-17 receptor A (IL-17RA) inhibition exacerbates Crohn's disease.
IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses.
New
Impact
Lu et al., Pittsburgh, United States. In Cancer Cell, Oct 2015
Here we found that IL-36γ stimulated CD8(+) T cells, NK cells, and γδ T cells synergistically with TCR signaling and/or IL-12.
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.
Review
New
Impact
Cua et al., Australia. In Nat Med, Jul 2015
The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell-mediated responses in inflammation for more than a decade after it was first identified.
Genetic variants associated with non-typhoidal Salmonella bacteraemia in African children.
New
Impact
Wellcome Trust Case Control Consortium 2 et al., Kilifi, Kenya. In Lancet, Mar 2015
STAT4 mediates IFNγ release in T cells and natural killer cells in response to interleukin 12 (IL12).
Overview of fundamental study of pazopanib in cancer.
Review
Zhou et al., Tianjin, China. In Thorac Cancer, 2014
In vivo xenograft studies and phase I/II clinical trials revealed a series of plasma cytokine and angiogenic factors, such as interleukin (IL)-6, IL-12, hepatocyte growth factor (HGF), and soluble VEGFR2, which have significant association with clinical curative effect.
Association between single-nucleotide polymorphisms in interleukin-12A and risk of chronic obstructive pulmonary disease.
GeneRIF
Zhang et al., Chengdu, China. In Dna Cell Biol, 2012
IL-12A rs2243115 polymorphism may contribute to genetic susceptibility to COPD in a Chinese population
Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2.
GeneRIF
Li et al., Hangzhou, China. In Febs Lett, 2012
Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2
Effect of IL12A and IL12B polymorphisms on the risk of Chlamydia trachomatis-induced tubal factor infertility and disease severity.
GeneRIF
Surcel et al., Oulu, Finland. In Hum Reprod, 2012
variation in the IL12B gene, but not IL12A, partly explains inter-individual differences in disease susceptibility and severity
Decreased IFN-γ and IL-12 levels in panic disorder.
GeneRIF
Isbir et al., İstanbul, Turkey. In J Psychosom Res, 2012
We found significant differences on the mean values of IL-12 between the panic disorder and control groups
Interleukin-27 and interleukin-12 augment activation of distinct cord blood natural killer cells responses via STAT3 pathways.
GeneRIF
Huang et al., Taiwan. In J Formos Med Assoc, 2012
Interleukin-27 and interleukin-12 augment activation of distinct cord blood natural killer cells responses via STAT3 pathways.
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