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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 10 receptor, beta

IL-10R2, CRF2-4, IL10RB, CRFB4, D21S58
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, IL-21, IL-10R, IL-22R1, STAT3
Papers on IL-10R2
PIV-3 blocks antiviral mediators downstream of the IFN-λR by modulating Stat1 phosphorylation.
Sacco et al., Ames, United States. In J Virol, Jan 2016
Type III IFNs signal through a unique heterodimeric receptor, the IFN-λR1/IL-10R2, which is primarily expressed by epithelial cells.
Profile of Inflammation-associated genes during Hepatic Differentiation of Human Pluripotent Stem Cells.
Arumugaswami et al., Los Angeles, United States. In Data Brief, Dec 2015
Furthermore, hepatic phase of cells expressed proinflammatory cytokines IL18 and IL32 as well as cytokine receptors IL18R1, IL1R1, IL1RAP, IL2RG, IL6R, IL6ST and IL10RB.
Pathogen Resistance Mediated by IL-22 Signaling at the Epithelial-Microbiota Interface.
Lawley et al., Cambridge, United Kingdom. In J Mol Biol, Dec 2015
IL-22 stimulates the epithelial cells via the IL-22RA1-IL-10R2 receptor complex inducing changes in the expression of genes involved in the maintenance of epithelial barrier integrity, with a variety of functions in pathogen resistance such as mucus layer modifications and hydration, tight junction fortification and the production of a broad range of bactericidal compounds.
IL-22 capacitates dermal fibroblast responses to TNF in scleroderma.
Chizzolini et al., Genève, Switzerland. In Ann Rheum Dis, Nov 2015
Dermal fibroblasts expressed both IL-22 receptor subunits IL-10RB and IL-22RA, expression of which was enhanced by TNF and reduced by transforming growth factor (TGF)-β.
Exploring the role of interleukin-22 in neurological and autoimmune disorders.
Zhang et al., Suzhou, China. In Int Immunopharmacol, Oct 2015
Its biological activity results from its ability to bind to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2.
Monogenic autoinflammatory diseases: Cytokinopathies.
Masters et al., Australia. In Cytokine, Aug 2015
We propose that this can be extended to cytokines such as IL-36, with mutations in IL-36Ra, and IL-10, with mutations in IL-10RA and IL-10RB, however mutations in sensors or upstream signalling molecules are yet to be described in these instances.
Inherited Inflammatory Response Genes Are Associated with B-Cell Non-Hodgkin's Lymphoma Risk and Survival.
Johnsen et al., Aalborg, Denmark. In Plos One, 2014
RESULTS: We found inherited SNPs in genes critical for inflammatory pathways; TLR9, IL4, TAP2, IL2RA, FCGR2A, TNFA, IL10RB, GALNT12, IL12A and IL1B were significantly associated with disease risk and SELE, IL1RN, TNFA, TAP2, MBL2, IL5, CX3CR1, CHI3L1 and IL12A were, associated with overall survival (OS) in specific diagnostic entities of B-NHL.
Blocking IL-22, a potential treatment strategy for adenomyosis by inhibiting crosstalk between vascular endothelial and endometrial stromal cells.
Li et al., Shanghai, China. In Am J Transl Res, 2014
Here we found that VECs in ectopic lesion from women with adenomyosis highly expressed IL-22 receptors IL-22R1 and IL-10R2.
Baseline blood immunological profiling differentiates between Her2-breast cancer molecular subtypes: implications for immunomediated mechanisms of treatment response.
Berindan-Neagoe et al., Cluj-Napoca / Kolozsvár, Romania. In Onco Targets Ther, 2014
Gene expression analysis revealed a panel of 14 genes to have differential expression between the two groups: several interleukins: IL13, IL16, IL17C and IL17F, IL1A, IL3; interleukin receptors: IL10RB, IL5RA; chemokines: CXCL13 and CCL26; and cytokines: CSF2, IFNA2, OSM, TNSF13.
[Interferons: between structure and function].
Myga-Nowak et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2013
They act on receptors formed by λR1 IFN-and IL-10R2 subunits.
[The function and application of the IL28B gene in HCV infection and treatment].
Xia et al., Kunming, China. In Yi Chuan, 2013
IFN-lambda3 interacts with its acceptor, a heterodimer (IFN-lambdaR1 x IL-10R2), and upregulates the IFN-stimulated gene factors (ISGF).
Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.
Klein et al., Hannover, Germany. In Gastroenterology, 2012
Of 66 patients with infantile (very early onset) inflammatory bowel disease, 16 had IL-10 or IL-10R deficiency: 3 patients had mutations in IL-10, 5 had mutations in IL-10R1, and 8 had mutations in IL-10R2.
Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children.
Kun et al., Tübingen, Germany. In Immunogenetics, 2012
The haplotype -185/-116 of IL10 receptor alpha in combination with the haplotype -754/-750 of IL10 receptor beta contributed towards mild malaria.
Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population.
Chang et al., Seoul, South Korea. In J Korean Med Sci, 2011
It is concluded that there is a strong association between the IL10 and IL10RB SNPs, and BPH in Korean population
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
Klein et al., London, United Kingdom. In N Engl J Med, 2009
Mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine.
Association study of IFNAR2 and IL10RB genes with the susceptibility and interferon response in HBV infection.
Zhang et al., Shanghai, China. In J Viral Hepat, 2009
The association with the susceptibility to HBV infection was only observed for IL10RB K47E when we compared the individuals with persistent HBV infection through nonmaternal transmission to the controls with asymptomatic self-limited HBV infection.
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
Donnelly et al., Newark, United States. In Nat Immunol, 2003
distinct receptor complex that is utilized by all three IFN-lambda proteins for signaling and is composed of two subunits, a receptor designated CRF2-12 (also designated as IFN-lambdaR1) and a second subunit, CRF2-4 (also known as IL-10R2)
Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site.
Walter et al., Birmingham, United States. In Immunity, 2001
This intermediate complex must subsequently recruit the low-affinity IL-10R2 chain before cell signaling can occur.
Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity.
McKenna-Yasek et al., Durham, United States. In N Engl J Med, 1991
obtained 10 centimorgans distal (telomeric) to the DNA marker D21S58.
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