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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 10 receptor, alpha

IL-10R, IL-10R1, IL10RA
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: IL-10, CAN, IL-10R2, HAD, CD4
Papers using IL-10R antibodies
A mouse model of Borrelia meningitis after intradermal injection.
Rotzschke Olaf, In PLoS ONE, 1996
... was obtained from ICN/MP Biomedicals, (Irvine, CA, USA), and the anti-IL-10 receptor (anti-IL-10R) (Clone 1B1.3a) was obtained from BD Biosciences (San Diego, CA, USA) ...
Papers on IL-10R
Posttranscriptional control of NLRP3 inflammasome activation in colonic macrophages.
Kelsall et al., Bethesda, United States. In Mucosal Immunol, Jan 2016
Finally, blocking IL-10R-signaling in vivo enhanced NLRP3 and proIL-1β protein but not mRNA levels in resident cMPs, implicating a role for IL-10 in environmental conditioning of cMPs.
Differential Requirements for IL-17A and IL-22 in Cecal versus Colonic Inflammation Induced by Helicobacter hepaticus.
Kullberg et al., York, United Kingdom. In Am J Pathol, Dec 2015
Cecal, but not colonic, pathology in C57BL/6 mice inoculated with Helicobacter hepaticus plus anti-IL-10 receptor (IL-10R) monoclonal antibody was exacerbated by co-administration of anti-IL-17A monoclonal antibody, suggesting a disease-protective role for IL-17A in the cecum.
Altered neurotrophic factors expression profiles in the nucleus of the solitary tract of spontaneously hypertensive rats.
Waki et al., Tokyo, Japan. In Acta Physiol (oxf), Nov 2015
Gene expressions of corticotropin releasing hormone binding protein (Crhbp), Interleukin-10 receptor alpha (Il10ra), and hypocretin (Hcrt) were downregulated in the NTS of adult SHRs.
IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1.
Nanan et al., Sydney, Australia. In J Immunol, Nov 2015
This process is dependent on IL-10R-mediated STAT3 signaling, as supported by the lack of an IL-10 effect in patients with IL-10R deficiency and dominant-negative STAT3 mutation.
Epigenetic characteristics in inflammatory candidate genes in aggressive periodontitis.
Reichert et al., Halle, Germany. In Hum Immunol, Nov 2015
We assessed CpG methylation in 22 inflammatory candidate genes (ATF2, CCL25, CXCL14, CXCL3, CXCL5, CXCL6, FADD, GATA3, IL10RA, IL12A, IL12B, IL13, IL13RA1, IL15, IL17C, IL17RA, IL4R, IL6R, IL6ST, IL7, INHA, and TYK2) with respect to the occurrence of aggressive periodontitis (AgP).
Vitamin D and 1,25(OH)2D regulation of T cells.
Yang et al., United States. In Nutrients, Apr 2015
Experiments in mice demonstrate that the effectiveness of 1,25(OH)2D requires NKT cells, IL-10, the IL-10R and IL-4.
Early-onset autoimmune disease as a manifestation of primary immunodeficiency.
Coutinho et al., São Paulo, Brazil. In Front Immunol, 2014
Inflammatory bowel disease in infants and children has been associated with IL-10 and IL-10R deficiencies, chronic granulomatous disease, immunedysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (IPEX), autoinflammatory disorders, and others.
Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells.
Coussens et al., Portland, United States. In Cancer Cell, 2014
Infiltrating macrophages were the primary source of IL-10 within tumors, and therapeutic blockade of IL-10 receptor (IL-10R) was equivalent to CSF-1 neutralization in enhancing primary tumor response to paclitaxel and carboplatin.
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.
Snapper et al., Boston, United States. In Immunity, 2014
Intact interleukin-10 receptor (IL-10R) signaling on effector and T regulatory (Treg) cells are each independently required to maintain immune tolerance.
Pathogen manipulation of cIL-10 signaling pathways: opportunities for vaccine development?
Barry et al., Davis, United States. In Curr Top Microbiol Immunol, 2013
Interleukin-10 (IL-10) is a tightly regulated, pleiotropic cytokine that has profound effects on all facets of the immune system, eliciting cell-type-specific responses within cells expressing the IL-10 receptor (IL-10R).
Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.
Snapper et al., Boston, United States. In Adv Immunol, 2013
An association between IL10 and intestinal mucosal homeostasis became clear with the discovery that IL10 and IL10 receptor (IL10R)-deficient mice develop spontaneous intestinal inflammation.
Role of interleukin-10 and interleukin-10 receptor in systemic lupus erythematosus.
Ye et al., Hefei, China. In Clin Rheumatol, 2013
A better understanding of the regulation of IL-10 and its receptors (IL-10R) can likely provide more valuable clues to the pathogenic mechanisms underlying specific forms of SLE, so as to pave the way toward more effective therapeutics.
A regulatory role for IL-10 receptor signaling in development and B cell help of T follicular helper cells in mice.
Shen et al., Shanghai, China. In J Immunol, 2012
IL-10R subunit-alpha signaling plays a key role in the development as well as B-cell help function of T (follicular helper) cells in vitro and in vivo.
Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.
Klein et al., Hannover, Germany. In Gastroenterology, 2012
Of 66 patients with infantile (very early onset) inflammatory bowel disease, 16 had IL-10 or IL-10R deficiency: 3 patients had mutations in IL-10, 5 had mutations in IL-10R1, and 8 had mutations in IL-10R2.
Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma.
Zhang et al., Beijing, China. In Am J Hematol, 2012
The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk.
Inflammation profile of four early onset Crohn patients.
Crovella et al., Trieste, Italy. In Gene, 2012
We found an IL10R variant, which may be associated with a decreased response to the cytokine in one patient.
IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease.
Pearce et al., Saint Louis, United States. In Plos Pathog, 2012
IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease.
Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b.
Pagani et al., Milano, Italy. In Nat Immunol, 2011
One of the signature microRNAs of naive CD4+ T cells, miR-125b, regulated the expression of genes encoding molecules involved in T cell differentiation, including IFNG, IL2RB, IL10RA and PRDM1.
Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection.
Sekaly et al., Montréal, Canada. In Nat Med, 2010
Blocking interactions between PD-1 and programmed death ligand-1 (PD-L1) and between IL-10 and IL-10 receptor (IL-10R) results in viral clearance and improves T cell function in animal models of chronic viral infections.
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
Klein et al., London, United Kingdom. In N Engl J Med, 2009
Mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine.
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