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Interleukin 10 receptor, alpha

IL-10R, IL-10R1, IL10RA
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009] (from NCBI)
Papers using IL-10R antibodies
A mouse model of Borrelia meningitis after intradermal injection.
Supplier
Rotzschke Olaf, In PLoS ONE, 1996
... was obtained from ICN/MP Biomedicals, (Irvine, CA, USA), and the anti-IL-10 receptor (anti-IL-10R) (Clone 1B1.3a) was obtained from BD Biosciences (San Diego, CA, USA) ...
Papers on IL-10R
A regulatory role for IL-10 receptor signaling in development and B cell help of T follicular helper cells in mice.
GeneRIF
Shen et al., Shanghai, China. In J Immunol, 2012
IL-10R subunit-alpha signaling plays a key role in the development as well as B-cell help function of T (follicular helper) cells in vitro and in vivo.
Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.
GeneRIF
Klein et al., Hannover, Germany. In Gastroenterology, 2012
Of 66 patients with infantile (very early onset) inflammatory bowel disease, 16 had IL-10 or IL-10R deficiency: 3 patients had mutations in IL-10, 5 had mutations in IL-10R1, and 8 had mutations in IL-10R2.
Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma.
GeneRIF
Zhang et al., Beijing, China. In Am J Hematol, 2012
The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk.
Inflammation profile of four early onset Crohn patients.
GeneRIF
Crovella et al., Trieste, Italy. In Gene, 2012
We found an IL10R variant, which may be associated with a decreased response to the cytokine in one patient.
IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease.
GeneRIF
Pearce et al., Saint Louis, United States. In Plos Pathog, 2012
IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease.
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