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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Apr 2015.

Interleukin 10

IL-10, Interleukin-10
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: Interleukin-6, IL-4, CAN, HAD, IL-17
Papers using IL-10 antibodies
Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.
Supplier
Dieli Francesco, In PLoS ONE, 2008
... or PE-Cy5-conjugated anti-CD3, CD4, CD8, CD25, F4/80, CD206, IgG2b and IgG2a mAb, IFNγ, IL-12p70, IL-4, IL-10 and TGF-β1 ELISA kits were purchased from eBioscience (San Diego, CA) ...
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia
Supplier
Bian Zhao-Xiang et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... , IL-6, and IL-10 ELISA kits were purchased from eBioscience (San Diego, USA) ...
Multiplexed immunoassays for proteins using magnetic luminescent nanoparticles for internal calibration
Supplier
Preininger Claudia et al., In Sensors (Basel, Switzerland), 2006
... protein, biotinylated anti IL-6 (MQ2-39C3) as well as anti IL-10 (JES3-9D7), recombinant IL-10, biotinylated anti IL-10 (JES3-12G8), anti TNF alpha (MAb1), recombinant TNF alpha and biotinylated TNF alpha (MAbF6C5) were purchased from eBioscience (San Diego, CA, USA) ...
Translocation pathway of the intratracheally instilled ultrafine particles from the lung into the blood circulation in the mouse
Supplier
Lee Moo-Yeol et al., In Safety and Health at Work, 2005
... ELISA kits for interleukin-6 (IL-6), IL-1b, IL-4, IL-10, tumor necrosis factor-α (TNF-α), and interferon-gamma (IFN-γ) were supplied by BD Biosciences (San Diego, CA, USA) ...
4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy.
Supplier
Fallon Padraic G., In PLoS ONE, 2004
... The mAbs against mouse CD3, CD28, IL-4, IL-5, IL-13, TNFα, IL-6, IL-8, IFN-γ and IL-10 ELISA kits were purchased from Biolegend (California, USA) ...
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Papers on IL-10
Ultraviolet-induced alloantigen-specific immunosuppression in transplant immunity.
Review
New
Kato et al., Kyoto, Japan. In World J Transplant, 24 Apr 2015
UV-induced Tregs are also dominantly transferable, with interleukin-10 being important for UV-induced immunosuppression.
Seeking balance: Potentiation and inhibition of multiple sclerosis autoimmune responses by IL-6 and IL-10.
Review
New
Davis et al., Dallas, United States. In Cytokine, 17 Apr 2015
UNASSIGNED: The cytokines IL-6 and IL-10 are produced by cells of the adaptive and innate arms of the immune system and they appear to play key roles in genetically diverse autoimmune diseases such as relapsing remitting multiple sclerosis (MS), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
Psychosocial Telephone Counseling for Survivors of Cervical Cancer: Results of a Randomized Biobehavioral Trial.
New
Impact
Nelson et al., Irvine, United States. In J Clin Oncol, 23 Mar 2015
Participants with decreasing interleukin (IL) -4, IL-5, IL-10, and IL-13 had significantly greater improvement in QOL than those with increasing cytokine levels.
Interleukin-22: Immunobiology and Pathology.
New
Impact
van den Brink et al., Melbourne, Australia. In Annu Rev Immunol, 11 Mar 2015
UNASSIGNED: Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs).
Cytokines for monitoring anti-tuberculous therapy: A systematic review.
Review
New
Curtis et al., Melbourne, Australia. In Tuberculosis (edinb), 02 Mar 2015
TNF-α, IL-2, IL-6, IL-10 and IL-12 were the most extensively investigated cytokines.
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
New
Impact
O'Neill et al., Dublin, Ireland. In Cell Metab, Feb 2015
Finally, activation of PKM2 by TEPP-46 in vivo inhibited LPS and Salmonella typhimurium-induced IL-1β production, while boosting production of IL-10.
Resuscitation with hydroxyethyl starch 130/0.4 attenuates intestinal injury in a rabbit model of sepsis.
New
Shen et al., Wuhu, China. In Indian J Pharmacol, Jan 2015
Arterial and superior mesenteric vein blood samples were collected 4 and 8 h after the CASP procedure for blood gas analysis and measuring tumor necrosis factor-α, interleukin-10, and D-lactate levels.
Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation.
New
Impact
Baba et al., Suita, Japan. In Immunity, Jan 2015
B cells can suppress autoimmunity by secreting interleukin-10 (IL-10).
The incognito journey of a regulatory B cell.
New
Impact
Blair et al., London, United Kingdom. In Immunity, Jan 2015
(2014) report that IL-10(+) plasmablasts restrain autoimmune inflammation and suggest an ontological connection between immature B cells and regulatory plasmablasts.
Human Dendritic Cell DC-SIGN and TLR-2 Mediate Complementary Immune Regulatory Activities in Response to Lactobacillus rhamnosus JB-1.
New
O'Mahony et al., Zürich, Switzerland. In Plos One, Dec 2014
rhamnosus JB-1 adhesion and influenced IL-12 secretion, while TLR-2 influenced IL-10 and IL-12 secretion.
Molecular Genetic Analysis of Orf Virus: A Poxvirus That Has Adapted to Skin.
Review
New
Mercer et al., Dunedin, New Zealand. In Viruses, Dec 2014
Phylogenetic analysis suggests that both viral interleukin-10 and vascular endothelial growth factor genes have been "captured" from their host during the evolution of the parapoxviruses.
Serum levels of proinflammatory cytokines in painful knee osteoarthritis and sensitization.
New
Rizzo Battistella et al., São Paulo, Brazil. In Int J Inflam, Dec 2014
Therefore, the objective of this study was to investigate the seric concentration of pro (IL-6, IL-8, and TNF-α) and anti-inflammatory (IL-10) cytokines in patients with painful knee osteoarthritis and to correlate the levels of these biomarkers with the patients' functional capacity and pressure pain threshold (PPT) values.
[Effect of aluminium hydroxide on innate immunity and immunogenicity of bacterial and synthetic antigens of Streptococcus pneumoniae].
New
In Zh Mikrobiol Epidemiol Immunobiol, Nov 2014
DC produced IL-1β, IL-5, IL-10, IFNγ into the cultivation medium.
[Indexes of local cytokine status in individuals with intestine dysbacteriosis].
New
In Zh Mikrobiol Epidemiol Immunobiol, Nov 2014
MATERIALS AND METHODS: Qualitative and quantitative content of large intestine microbiocenosis was studied; IFNγ, pro-inflammatory (IL-2, IL-6, IL-8, IL-1β) and anti-inflammatory (IL-4, IL-10) content was determined using EIA in coprofiltrates of 139 individuals aged 18 - 60 years.
Mechanisms of immune response regulation in lung cancer.
Review
New
Hoser et al., Warsaw, Poland. In Transl Lung Cancer Res, Feb 2014
The most active are transforming growth factorβ (TGFβ) and IL-10.
Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population.
GeneRIF
Chowdhury et al., Calcutta, India. In Gene, 2012
identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population
IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
GeneRIF
Plevy et al., Chapel Hill, United States. In J Immunol, 2012
These results suggest that histone deacetylation on the Il12b promoter by histone deacetylase 3 mediates homeostatic effects of IL-10 in macrophages.
A protective role for human IL-10-expressing CD4+ T cells in colitis.
GeneRIF
Bream et al., Baltimore, United States. In J Immunol, 2012
CD4-positive T cells represent a protective source of transgenic IL-10 in the mouse colon.
A regulatory role for IL-10 receptor signaling in development and B cell help of T follicular helper cells in mice.
GeneRIF
Shen et al., Shanghai, China. In J Immunol, 2012
Blockade of IL-10 promotes the B-cell help function of activated T helper (Th) cells.
Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation.
GeneRIF
Zhao et al., Beijing, China. In J Immunol, 2012
Mouse embryonic fibroblasts-mesenchymal stem cells secrete IL-10 and control regulatory dendritic cell production by activating SOCS (suppressor of cytokine)3 through the JAK-STAT signaling pathway.
More papers using IL-10 antibodies
Obesity does not alter the pharmacokinetics of drotrecogin alpha (activated) in severe sepsis
Supplier
Schneider Francis et al., In Critical Care, 2004
... For cytokines transcriptional expression (TNF-α, IL-10 and IFN-γ) QuantiTect Primer Assays primers (Qiagen, Courtaboeuf, France) were used ...
Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription
Supplier
Jope Richard S et al., In Journal of Neuroinflammation, 2004
... Mouse IL-1β, TNFα, IL-6, IL-10 and IFNγ were measured with ELISA kits according to the manufacturer's instructions (eBioscience).
A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
Supplier
Moser Bernhard et al., In The Journal of Experimental Medicine, 2002
... OptEIA ELISA kits for the detection of IL-4, IL-10, IFN-γ, TNF-α, and TGF-β in supernatants were obtained from BD Biosciences.
Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production
Supplier
Blanchard Thomas G. et al., In Frontiers in Immunology, 2001
... Mice double deficient in Rag1 and IL-10 were generated by crossing the respective transgenic strains and subsequent progeny ...
Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells
Supplier
Sviland Lisbet et al., In Virchows Archiv, 1998
... IL-10, TNF-α and IFN-γ were detected with antibodies from ImmunoTools, Friesoythe, Germany, TGF-β with antibodies from Santa Cruz Biotechnology, Santa Cruz, CA, USA ...
T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function.
Supplier
Sarkar Devanand, In PLoS ONE, 1998
... IL-2, IFNγ, IL-12, IL-10 and TNFα were quantified with cytokine specific ELISA kits (eBioScience).
Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis
Supplier
Kawai Shinichi et al., In Arthritis Research & Therapy, 1997
... Recombinant human IL-1β, TNF-α, IL-4, IL-6, IL-8, IL-10, and interferon-γ were from BD Biosciences (San Diego, CA) ...
Plasma nitrate concentrations in neutropenic and non-neutropenic patients with suspected septicaemia
Supplier
Burke-Gaffney Anne et al., In Intensive Care Medicine, 1994
... sandwich enzyme-linked immunosorbent assay (ELISA) kits were used to measure IL-6, -8 (Hycult, Uden, Netherlands), IL-10 (BD Biosciences, Erembodegem, Belgium) MIF (R ...
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