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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

Interleukin 10

IL-10, Interleukin-10
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: Interleukin-6, IL-4, CAN, HAD, IL-17
Papers using IL-10 antibodies
Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.
Supplier
Dieli Francesco, In PLoS ONE, 2008
... or PE-Cy5-conjugated anti-CD3, CD4, CD8, CD25, F4/80, CD206, IgG2b and IgG2a mAb, IFNγ, IL-12p70, IL-4, IL-10 and TGF-β1 ELISA kits were purchased from eBioscience (San Diego, CA) ...
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia
Supplier
Bian Zhao-Xiang et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... , IL-6, and IL-10 ELISA kits were purchased from eBioscience (San Diego, USA) ...
Multiplexed immunoassays for proteins using magnetic luminescent nanoparticles for internal calibration
Supplier
Preininger Claudia et al., In Sensors (Basel, Switzerland), 2006
... protein, biotinylated anti IL-6 (MQ2-39C3) as well as anti IL-10 (JES3-9D7), recombinant IL-10, biotinylated anti IL-10 (JES3-12G8), anti TNF alpha (MAb1), recombinant TNF alpha and biotinylated TNF alpha (MAbF6C5) were purchased from eBioscience (San Diego, CA, USA) ...
Translocation pathway of the intratracheally instilled ultrafine particles from the lung into the blood circulation in the mouse
Supplier
Lee Moo-Yeol et al., In Safety and Health at Work, 2005
... ELISA kits for interleukin-6 (IL-6), IL-1b, IL-4, IL-10, tumor necrosis factor-α (TNF-α), and interferon-gamma (IFN-γ) were supplied by BD Biosciences (San Diego, CA, USA) ...
4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy.
Supplier
Fallon Padraic G., In PLoS ONE, 2004
... The mAbs against mouse CD3, CD28, IL-4, IL-5, IL-13, TNFα, IL-6, IL-8, IFN-γ and IL-10 ELISA kits were purchased from Biolegend (California, USA) ...
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Papers on IL-10
The Geriatric Cytokine Response to Trauma: Time To Consider a New Threshold.
New
Heffernan et al., Providence, United States. In Surg Infect (larchmt), 10 Jan 2015
Blood was drawn within 36 h of presentation to measure circulating cytokines including interleukin (IL)-6 (pg/mL), IL-10 (pg/mL), and tumor necrosis factor (TNF)-α (pg/mL) levels.
Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer.
New
Pouniotis et al., Buraydah, Saudi Arabia. In World J Clin Oncol, 10 Jan 2015
Th1 and Th2 cytokines [interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12 (p70), tumor necrosis factor (TNF)-α, TNF-β, and interferon-γ] analysis revealed no significant difference between patients with NSCLC and non-cancer controls.
Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
New
Cao et al., Jinan, China. In Cancer Res, 09 Jan 2015
M2 macrophages were particularly potent when induced by IL-4, IL-10 and TGF-β.
Clostridium difficile infection aggravates colitis in interleukin 10-deficient mice.
New
Kim et al., Seoul, South Korea. In World J Gastroenterol, 07 Jan 2015
difficile) infection in an interleukin 10-deficient (IL-10(-/-)) mouse model of inflammatory bowel disease.
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue.
New
Impact
Brenner et al., Boston, United States. In Nat Immunol, 01 Jan 2015
Here we found that iNKT cells in adipose tissue had a unique transcriptional program and produced interleukin 2 (IL-2) and IL-10.
The IL-20 subfamily of cytokines - from host defence to tissue homeostasis.
New
Impact
Ouyang et al., San Francisco, United States. In Nat Rev Immunol, 25 Dec 2014
These cytokines are all members of the larger IL-10 family, but have been grouped together to form the IL-20 subfamily based on their usage of common receptor subunits and similarities in their target-cell profiles and biological functions.
Macrophage IL-10 Blocks CD8(+) T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells.
New
Impact
Coussens et al., Portland, United States. In Cancer Cell, 10 Dec 2014
Infiltrating macrophages were the primary source of IL-10 within tumors, and therapeutic blockade of IL-10 receptor (IL-10R) was equivalent to CSF-1 neutralization in enhancing primary tumor response to paclitaxel and carboplatin.
Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation.
New
Impact
Baba et al., Suita, Japan. In Immunity, 04 Dec 2014
UNLABELLED: B cells can suppress autoimmunity by secreting interleukin-10 (IL-10).
The therapeutic potential of interleukin-10 in neuroimmune diseases.
Review
New
Watkins et al., Boulder, United States. In Neuropharmacology, 04 Dec 2014
Critically, many neuroimmune diseases also involve insufficient signaling/bioavailability of interleukin-10 (IL-10).
Immune and inflammatory role of hydroxyethyl starch 130/0.4 and fluid gelatin in patients undergoing coronary surgery.
Review
New
Civi et al., Manisa, Turkey. In Cytokine, 04 Dec 2014
OBJECTIVES: Compare the effects on inflammatory (TNF-α, IL-6, IL-8 and IL-10) and immunologic (CD3(+), CD4(+), CD8(+), CD11b(+), CD16(+)/56(+) T cells and total lymphocyte concentration) variables of hydroxyethyl starch 130/0.4,
Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production.
New
Impact
Mauri et al., Udine, Italy. In Nat Med, 30 Nov 2014
Regulatory B cells (Breg cells) differentiate in response to inflammation and subsequently restrain excessive immune responses via the release of interleukin-10 (IL-10).
Perspectives on host adaptation in response to Mycobacterium tuberculosis: Modulation of inflammation.
Review
New
Kaufmann et al., Berlin, Germany. In Semin Immunol, 25 Nov 2014
Most of the host components involved in TB inflammation, including cytokines (interferons, interleukin (IL)-1, IL-10, tumour necrosis factor) and cells (neutrophils, macrophages, regulatory T cells, type 1 helper lymphocytes, pneumocytes), exhibit dual features: they foster or repress local inflammatory events.
Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and Autoimmunity.
Review
New
Birge et al., Newark, United States. In Front Immunol, Dec 2013
PS-dependent efferocytosis is associated with the production of anti-inflammatory factors such as IL-10 and TGF-β that function, in part, to maintain tolerance to auto-antigens.
Eosinophilic granulomatosis with polyangiitis: an overview.
Review
New
Buzio et al., Parma, Italy. In Front Immunol, Dec 2013
EGPA pathogenesis is not well known: HLA-DRB1*04 and *07, HLA-DRB4 and IL10.2 haplotype of the IL-10 promoter gene are the most studied genetic determinants.
Over-expression of TLR4-CD14, pro-inflammatory cytokines, metabolic markers and NEFAs in obese non-diabetic Mexicans.
New
Fafutis-Morris et al., Guadalajara, Mexico. In J Inflamm (lond), Dec 2013
As for cytokine concentration, non- diabetic obese individuals vs the normal weight/thin, the numbers were: IL-1β = 2.0 vs 2.5 pg/ml (p = NS), IL-6 = 36 vs 28 pg/ml (p = 0.030), IL-8 = 27 vs 27 pg/ml (p = NS), IL-10 = 8.4 vs 6.8 pg/ml (p = NS), TNF-α =31 vs 15 pg/ml (p = 0.000) respectively.
Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population.
GeneRIF
Chowdhury et al., Calcutta, India. In Gene, 2012
identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population
IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
GeneRIF
Plevy et al., Chapel Hill, United States. In J Immunol, 2012
These results suggest that histone deacetylation on the Il12b promoter by histone deacetylase 3 mediates homeostatic effects of IL-10 in macrophages.
A protective role for human IL-10-expressing CD4+ T cells in colitis.
GeneRIF
Bream et al., Baltimore, United States. In J Immunol, 2012
CD4-positive T cells represent a protective source of transgenic IL-10 in the mouse colon.
A regulatory role for IL-10 receptor signaling in development and B cell help of T follicular helper cells in mice.
GeneRIF
Shen et al., Shanghai, China. In J Immunol, 2012
Blockade of IL-10 promotes the B-cell help function of activated T helper (Th) cells.
Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation.
GeneRIF
Zhao et al., Beijing, China. In J Immunol, 2012
Mouse embryonic fibroblasts-mesenchymal stem cells secrete IL-10 and control regulatory dendritic cell production by activating SOCS (suppressor of cytokine)3 through the JAK-STAT signaling pathway.
More papers using IL-10 antibodies
Obesity does not alter the pharmacokinetics of drotrecogin alpha (activated) in severe sepsis
Supplier
Schneider Francis et al., In Critical Care, 2004
... For cytokines transcriptional expression (TNF-α, IL-10 and IFN-γ) QuantiTect Primer Assays primers (Qiagen, Courtaboeuf, France) were used ...
Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription
Supplier
Jope Richard S et al., In Journal of Neuroinflammation, 2004
... Mouse IL-1β, TNFα, IL-6, IL-10 and IFNγ were measured with ELISA kits according to the manufacturer's instructions (eBioscience).
A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
Supplier
Moser Bernhard et al., In The Journal of Experimental Medicine, 2002
... OptEIA ELISA kits for the detection of IL-4, IL-10, IFN-γ, TNF-α, and TGF-β in supernatants were obtained from BD Biosciences.
Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production
Supplier
Blanchard Thomas G. et al., In Frontiers in Immunology, 2001
... Mice double deficient in Rag1 and IL-10 were generated by crossing the respective transgenic strains and subsequent progeny ...
Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells
Supplier
Sviland Lisbet et al., In Virchows Archiv, 1998
... IL-10, TNF-α and IFN-γ were detected with antibodies from ImmunoTools, Friesoythe, Germany, TGF-β with antibodies from Santa Cruz Biotechnology, Santa Cruz, CA, USA ...
T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function.
Supplier
Sarkar Devanand, In PLoS ONE, 1998
... IL-2, IFNγ, IL-12, IL-10 and TNFα were quantified with cytokine specific ELISA kits (eBioScience).
Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis
Supplier
Kawai Shinichi et al., In Arthritis Research & Therapy, 1997
... Recombinant human IL-1β, TNF-α, IL-4, IL-6, IL-8, IL-10, and interferon-γ were from BD Biosciences (San Diego, CA) ...
Plasma nitrate concentrations in neutropenic and non-neutropenic patients with suspected septicaemia
Supplier
Burke-Gaffney Anne et al., In Intensive Care Medicine, 1994
... sandwich enzyme-linked immunosorbent assay (ELISA) kits were used to measure IL-6, -8 (Hycult, Uden, Netherlands), IL-10 (BD Biosciences, Erembodegem, Belgium) MIF (R ...
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