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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Interleukin 10

IL-10, Interleukin-10
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: Interleukin-6, CAN, HAD, IL-4, CD4
Papers using IL-10 antibodies
Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.
Supplier
Dieli Francesco, In PLoS ONE, 2008
... or PE-Cy5-conjugated anti-CD3, CD4, CD8, CD25, F4/80, CD206, IgG2b and IgG2a mAb, IFNγ, IL-12p70, IL-4, IL-10 and TGF-β1 ELISA kits were purchased from eBioscience (San Diego, CA) ...
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia
Supplier
Bian Zhao-Xiang et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... , IL-6, and IL-10 ELISA kits were purchased from eBioscience (San Diego, USA) ...
Multiplexed immunoassays for proteins using magnetic luminescent nanoparticles for internal calibration
Supplier
Preininger Claudia et al., In Sensors (Basel, Switzerland), 2006
... protein, biotinylated anti IL-6 (MQ2-39C3) as well as anti IL-10 (JES3-9D7), recombinant IL-10, biotinylated anti IL-10 (JES3-12G8), anti TNF alpha (MAb1), recombinant TNF alpha and biotinylated TNF alpha (MAbF6C5) were purchased from eBioscience (San Diego, CA, USA) ...
Translocation pathway of the intratracheally instilled ultrafine particles from the lung into the blood circulation in the mouse
Supplier
Lee Moo-Yeol et al., In Safety and Health at Work, 2005
... ELISA kits for interleukin-6 (IL-6), IL-1b, IL-4, IL-10, tumor necrosis factor-α (TNF-α), and interferon-gamma (IFN-γ) were supplied by BD Biosciences (San Diego, CA, USA) ...
4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy.
Supplier
Fallon Padraic G., In PLoS ONE, 2004
... The mAbs against mouse CD3, CD28, IL-4, IL-5, IL-13, TNFα, IL-6, IL-8, IFN-γ and IL-10 ELISA kits were purchased from Biolegend (California, USA) ...
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Papers on IL-10
Role of interleukin-6 in differentiating interleukin-11 induced Fever and early bacterial infection.
New
Tang et al., Hangzhou, China. In Indian J Pediatr, 30 Sep 2014
OBJECTIVE: To evaluate the role of Th1/Th2 cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ) in differentiating interleukin 11 induced fever with C-reactive protein elevation from early bacterial infection.
The role of regulatory T-cells in glioma immunology.
Review
New
Yang et al., Los Angeles, United States. In Clin Neurol Neurosurg, Apr 2014
While the exact mechanisms by which regulatory T-cells function require further elucidation, various cytokines such as interleukin-10 (IL-10) and transforming growth factor-β (TFG-β) have been implicated in these processes and are currently under investigation.
Whole blood assay and visceral leishmaniasis: Challenges and promises.
Review
New
Sundar et al., Benares, India. In Immunobiology, Apr 2014
Employing whole blood assay (WBA), we recently reported that whole blood cells of active VL patients maintain the capacity to secrete significant levels of antigen driven IFN-γ and IL-10.
IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.
New
Impact
Fillatreau et al., Berlin, Germany. In Nature, Apr 2014
Their inhibitory function has been associated primarily with interleukin 10 (IL-10) because B-cell-derived IL-10 can protect against autoimmune disease and increase susceptibility to pathogens.
A113: TCR-independent Activation of T-cells Through CD31 Triggering as an Etiology of Cytokine Production in Juvenile Idiopathic Arthritis.
New
Vallejo et al., Pittsburgh, United States. In Arthritis Rheumatol, Mar 2014
RESULTS: The overall cytokine signature of JIA characterized by the dominance of IL-6, IL-10 and TNFα.
Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens.
Review
New
Akdis et al., Zürich, Switzerland. In J Allergy Clin Immunol, Mar 2014
Recently, inducible IL-10-secreting Breg cells were also demonstrated to contribute to allergen tolerance through suppression of effector T cells and selective induction of IgG4 isotype antibodies.
A17: A Prospective Study Comparing Infectious Risks, Disease Activity, and Cytokine Alterations in Children with Juvenile Idiopathic Arthritis Treated with and without Tumor Necrosis Factor-alpha Inhibitors.
New
Toussi et al., New York City, United States. In Arthritis Rheumatol, Mar 2014
TNF-α, interleukin (IL)-1β, IL-6, IL-8, IL-10, and IL-17 cytokine levels were collected at pre-specified time points.
A173: Cerebrospinal Fluid Cytokines Correlate With Innate Immune Cells in Neonatal Onset Multisystem Inflammatory Disease (NOMID) Patients in Clinical Remission Treated With Anakinra.
New
Goldbach-Mansky et al., Bethesda, United States. In Arthritis Rheumatol, Mar 2014
Cytokines levels (IL-1β, IL-6, IL-10, IP-10, IL-12 (p70) and (p40), IFN-γ, TNF-α, and IL-18) were correlated to CSF WBC, protein, albumin quotient (AQ), and opening pressure at baseline, post-treatment, and clinical remission.
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.
New
Impact
Ganapathy et al., Augusta, United States. In Immunity, Feb 2014
Here we showed that Gpr109a signaling promoted anti-inflammatory properties in colonic macrophages and dendritic cells and enabled them to induce differentiation of Treg cells and IL-10-producing T cells.
FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells.
New
Impact
Sa et al., Calcutta, India. In Immunity, Jan 2014
We identified an interleukin-10 (IL-10)-producing FoxP3(+) T regulatory cell population that contributes to IL-10-dependent type 2 cytokine bias in breast-cancer patients.
Sibling donor and recipient immune modulation with atorvastatin for the prophylaxis of acute graft-versus-host disease.
New
Impact
Craig et al., Morgantown, United States. In J Clin Oncol, Jan 2014
Compared with baseline, atorvastatin administration in sibling donors was associated with a trend toward increased mean plasma interleukin-10 concentrations (5.6 v 7.1 pg/mL; P = .06).
The role of decay accelerating factor in environmentally induced and idiopathic systemic autoimmune disease.
Review
New
Pollard et al., Durham, United States. In Autoimmune Dis, Dec 2013
These observations are used to develop a hypothetical model to explain how DAF expression may impact T cell differentiation via interaction with CD97 leading to T regulatory cells, increased production of IL-10, and immune tolerance.
Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial.
New
Ghayour-Mobarhan et al., Mashhad, Iran. In Scientificworldjournal, Dec 2013
Serum levels of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFNγ, EGF, MCP-1, and TNF α were measured using a multiplex Biochip Array Technology based method.
Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation.
New
Impact
Nagai et al., Tokyo, Japan. In Cell Metab, Nov 2013
We identified Breg cells that produce interleukin-10 constitutively within adipose tissue.
The paradox of IL-10-mediated modulation in cervical cancer.
Review
New
Li et al., Tangshan, China. In Biomed Rep, May 2013
UNLABELLED: Interleukin-10 (IL-10) has opposing effects as an anti-inflammatory (potentially cancer-promoting) and antiangiogenic (potentially cancer-inhibiting) agent.
Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population.
GeneRIF
Chowdhury et al., Calcutta, India. In Gene, 2012
identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population
IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
GeneRIF
Plevy et al., Chapel Hill, United States. In J Immunol, 2012
These results suggest that histone deacetylation on the Il12b promoter by histone deacetylase 3 mediates homeostatic effects of IL-10 in macrophages.
A protective role for human IL-10-expressing CD4+ T cells in colitis.
GeneRIF
Bream et al., Baltimore, United States. In J Immunol, 2012
CD4-positive T cells represent a protective source of transgenic IL-10 in the mouse colon.
A regulatory role for IL-10 receptor signaling in development and B cell help of T follicular helper cells in mice.
GeneRIF
Shen et al., Shanghai, China. In J Immunol, 2012
Blockade of IL-10 promotes the B-cell help function of activated T helper (Th) cells.
Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation.
GeneRIF
Zhao et al., Beijing, China. In J Immunol, 2012
Mouse embryonic fibroblasts-mesenchymal stem cells secrete IL-10 and control regulatory dendritic cell production by activating SOCS (suppressor of cytokine)3 through the JAK-STAT signaling pathway.
More papers using IL-10 antibodies
Obesity does not alter the pharmacokinetics of drotrecogin alpha (activated) in severe sepsis
Supplier
Schneider Francis et al., In Critical Care, 2004
... For cytokines transcriptional expression (TNF-α, IL-10 and IFN-γ) QuantiTect Primer Assays primers (Qiagen, Courtaboeuf, France) were used ...
Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription
Supplier
Jope Richard S et al., In Journal of Neuroinflammation, 2004
... Mouse IL-1β, TNFα, IL-6, IL-10 and IFNγ were measured with ELISA kits according to the manufacturer's instructions (eBioscience).
A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
Supplier
Moser Bernhard et al., In The Journal of Experimental Medicine, 2002
... OptEIA ELISA kits for the detection of IL-4, IL-10, IFN-γ, TNF-α, and TGF-β in supernatants were obtained from BD Biosciences.
Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production
Supplier
Blanchard Thomas G. et al., In Frontiers in Immunology, 2001
... Mice double deficient in Rag1 and IL-10 were generated by crossing the respective transgenic strains and subsequent progeny ...
Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells
Supplier
Sviland Lisbet et al., In Virchows Archiv, 1998
... IL-10, TNF-α and IFN-γ were detected with antibodies from ImmunoTools, Friesoythe, Germany, TGF-β with antibodies from Santa Cruz Biotechnology, Santa Cruz, CA, USA ...
T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function.
Supplier
Sarkar Devanand, In PLoS ONE, 1998
... IL-2, IFNγ, IL-12, IL-10 and TNFα were quantified with cytokine specific ELISA kits (eBioScience).
Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis
Supplier
Kawai Shinichi et al., In Arthritis Research & Therapy, 1997
... Recombinant human IL-1β, TNF-α, IL-4, IL-6, IL-8, IL-10, and interferon-γ were from BD Biosciences (San Diego, CA) ...
Plasma nitrate concentrations in neutropenic and non-neutropenic patients with suspected septicaemia
Supplier
Burke-Gaffney Anne et al., In Intensive Care Medicine, 1994
... sandwich enzyme-linked immunosorbent assay (ELISA) kits were used to measure IL-6, -8 (Hycult, Uden, Netherlands), IL-10 (BD Biosciences, Erembodegem, Belgium) MIF (R ...
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