GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Interleukin 10
IL-10, Interleukin-10
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011] (from
NCBI)
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Papers using
IL-10
antibodies
Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.
Supplier
In PLoS ONE, 2008
... or PE-Cy5-conjugated anti-CD3, CD4, CD8, CD25, F4/80, CD206, IgG2b and IgG2a mAb, IFNγ, IL-12p70, IL-4, IL-10 and TGF-β1 ELISA kits were purchased from eBioscience (San Diego, CA) ...
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia
Supplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... , IL-6, and IL-10 ELISA kits were purchased from eBioscience (San Diego, USA) ...
Multiplexed immunoassays for proteins using magnetic luminescent nanoparticles for internal calibration
Supplier
In Sensors (Basel, Switzerland), 2006
... protein, biotinylated anti IL-6 (MQ2-39C3) as well as anti IL-10 (JES3-9D7), recombinant IL-10, biotinylated anti IL-10 (JES3-12G8), anti TNF alpha (MAb1), recombinant TNF alpha and biotinylated TNF alpha (MAbF6C5) were purchased from eBioscience (San Diego, CA, USA) ...
Translocation pathway of the intratracheally instilled ultrafine particles from the lung into the blood circulation in the mouse
Supplier
In Safety and Health at Work, 2005
... ELISA kits for interleukin-6 (IL-6), IL-1b, IL-4, IL-10, tumor necrosis factor-α (TNF-α), and interferon-gamma (IFN-γ) were supplied by BD Biosciences (San Diego, CA, USA) ...
4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy.
more suppliersSupplier
In PLoS ONE, 2004
... The mAbs against mouse CD3, CD28, IL-4, IL-5, IL-13, TNFα, IL-6, IL-8, IFN-γ and IL-10 ELISA kits were purchased from Biolegend (California, USA) ...
Papers on
IL-10
Amelioration of Cholesterol Induced Atherosclerosis by Normalizing Gene Expression, Cholesterol Profile and Antioxidant Enzymes by Vigna unguiculata.
New
Thiruvananthapuram, India. In Plant Foods Hum Nutr, 10 Apr 2013
Supplementation of EAVU normalized cholesterol profile, generation of reactive oxygen species (ROS), lipid peroxidation products like thiobarbituric acid reactive substance (TBARS), antioxidant system and important genes of cardiovascular diseases like interleukin-10 (IL 10), paraoxanase-1 (PON I), interleukin-6 (IL 6), and cyclooxygenase-2 (Cox 2) to near normal level as compared with normal diet.
Are IL-10+ regulatory Th17 cells implicated in the sustained response to glucocorticoid treatment in patients with giant cell arteritis? Comment on the paper of Espigol-Frigole et al.
New
Dijon, France. In Ann Rheum Dis, 08 Apr 2013
Spinal Cord Injury Level and the Circulating Cytokine Response to Strenuous Exercise.
New
Loughborough, United Kingdom. In Med Sci Sports Exerc, 07 Apr 2013
Blood samples were taken pre-exercise, post-exercise and 30 min post-exercise (post30) and analysed for concentrations of IL-6, IL-10, IL-1 receptor-antagonist (IL-1ra), tumor necrosis factor-alpha (TNF-α), epinephrine and cortisol.
Type I Interferon Suppresses Type II Interferon-Triggered Human Anti-Mycobacterial Responses.
New
Impact
Los Angeles, United States. In Science, 28 Mar 2013
In contrast, IFN-β and its downstream genes, including interleukin 10 (IL-10), were induced in monocytes by M. leprae in vitro, and preferentially expressed in disseminated and progressive lepromatous lesions.
Mast cell interleukin-10 drives localized tolerance in chronic bladder infection.
New
Impact
Durham, United States. In Immunity, 21 Mar 2013
This involves localized production of interleukin-10 and results in suppressed humoral and cell-mediated responses and bacterial persistence.
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.
New
Impact
Cleveland, United States. In Nat Immunol, 28 Feb 2013
The absence of signaling via C3aR and C5aR resulted in lower expression of costimulatory molecules and interleukin 6 (IL-6) and more production of IL-10.
Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation.
New
Impact
Charlottesville, United States. In Nature, 24 Feb 2013
Administration of exogenous IL-10 'rescued' the airway inflammation phenotype in Rac1-deficient mice, with decreased IL-33.
Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation.
New
Impact
Boston, United States. In Immunity, 24 Feb 2013
Surprisingly, antigen cross-presentation by resident CX3CR1(+) DCs induced differentiation of precursor cells into CD8(+) T cells that expressed interleukin-10 (IL-10), IL-13, and IL-9 and could migrate into adjacent compartments.
The anti-inflammatory effects of acupuncture and their relevance to allergic rhinitis: a narrative review and proposed model.
New
Gold Coast, Australia. In Evid Based Complement Alternat Med, Dec 2012
Other reported anti-inflammatory effects of acupuncture include an antihistamine action and downregulation of proinflammatory cytokines (such as TNF- , IL-1 , IL-6, and IL-10), proinflammatory neuropeptides (such as SP, CGRP, and VIP), and neurotrophins (such as NGF and BDNF) which can enhance and prolong inflammatory response.
The Role of IL-6, 8, and 10, sTNFr, CRP, and Pancreatic Elastase in the Prediction of Systemic Complications in Patients with Acute Pancreatitis.
New
Rijeka, Croatia. In Gastroenterol Res Pract, Dec 2012
Our study confirmed that IL-6, IL-8, IL-10, and sTNFr measured on admission, and CRP and pancreatic elastase measured on third day of admission represent valuable prognostic factors of severity and systemic complications of AP.
Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke.
Review
New
Tokyo, Japan. In J Neurochem, Nov 2012
Various cytokines from helper T cells and γδT cells function as neurotoxic (IL-23/IL-17, IFN-γ) or neuroprotective (IL-10, IL-4) mediators.
From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines.
Review
New
Impact
Dallas, United States. In Nat Immunol, Oct 2012
Interleukin 2 (IL-2), IL-10 and transforming growth factor-β (TGF-β) are well characterized, whereas IL-27, IL-35 and IL-37 represent newcomers to the spectrum of anti-inflammatory cytokines.
[Role of shedding in the activity of immunocompetent cells with reagin protection mechanism].
Review
New
In Fiziol Cheloveka, Jul 2012
Abscission of cells CD23 and increase of concentration sCD23 occurs at excessive increase in maintenance IgE and anti-inflammatory ofcytokine IL-10.
Adenosine augments IL-10 production by microglial cells through an A2B adenosine receptor-mediated process.
GeneRIF
Newark, United States. In J Immunol, 2012
adenosine augmented IL-10 production by stimulating p38 MAPK. Collectively, our results establish that A(2B)ARs augment IL-10 production by activated murine microglia.
Myeloid cell IL-10 production in response to leishmania involves inactivation of glycogen synthase kinase-3β downstream of phosphatidylinositol-3 kinase.
GeneRIF
Vancouver, Canada. In J Immunol, 2012
Thus, GSK-3beta negatively regulates myeloid cell IL-10 production in response to leishmania.
IL-10 elicits IFNγ-dependent tumor immune surveillance.
Impact
GeneRIF
Palo Alto, United States. In Cancer Cell, 2012
interleukin-10 elicits interferon-gamma-dependent tumor immune surveillance
Association of interleukin 10 promoter polymorphism at -819 T>C with aspirin-induced urticaria in a Korean population.
GeneRIF
In Ann Allergy Asthma Immunol, 2011
Data showed a statistically significant association of interleukin 10 promoter polymorphism at -819 T>C with aspirin-induced urticaria.
Vitreous diagnosis in neoplastic diseases.
Review
Madrid, Spain. In Mediators Inflamm, 2011
The most usefulness for vitreous diagnosis would be the masquerade syndromes, and the best exponent in this group is the primary vitreoretinal lymphoma (PVRL), in which cytology and an IL-10/IL-6 ratio more than 1 is fundamental for the diagnosis.
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells.
Impact
GeneRIF
New Haven, United States. In Immunity, 2011
memory CD8(+) T cell precursor maturation is an active process dependent on IL-10-IL-21-STAT3 signaling.
[Biochemical markers in assessment of severity and prognosis of acute pancreatitis].
More papers using
IL-10
antibodies
Review
Zagreb, Croatia. In Lijec Vjesn, 2008
Although these markers are still not incorporated in routine clinical practice, IL-6, IL-10, procalcitonin and trypsinogen activation peptide seem to have a good chance to be used as a new biochemical markers in assessment of severity and prognosis of acute pancreatitis.
Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription
Supplier
In Journal of Neuroinflammation, 2004
... Mouse IL-1β, TNFα, IL-6, IL-10 and IFNγ were measured with ELISA kits according to the manufacturer's instructions (eBioscience).
Obesity does not alter the pharmacokinetics of drotrecogin alpha (activated) in severe sepsis
Supplier
In Critical Care, 2004
... For cytokines transcriptional expression (TNF-α, IL-10 and IFN-γ) QuantiTect Primer Assays primers (Qiagen, Courtaboeuf, France) were used ...
A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
Supplier
In The Journal of Experimental Medicine, 2002
... OptEIA ELISA kits for the detection of IL-4, IL-10, IFN-γ, TNF-α, and TGF-β in supernatants were obtained from BD Biosciences.
Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production
Supplier
In Frontiers in Immunology, 2001
... Mice double deficient in Rag1 and IL-10 were generated by crossing the respective transgenic strains and subsequent progeny ...
Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells
Supplier
In Virchows Archiv, 1998
... IL-10, TNF-α and IFN-γ were detected with antibodies from ImmunoTools, Friesoythe, Germany, TGF-β with antibodies from Santa Cruz Biotechnology, Santa Cruz, CA, USA ...
T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function.
Supplier
In PLoS ONE, 1998
... IL-2, IFNγ, IL-12, IL-10 and TNFα were quantified with cytokine specific ELISA kits (eBioScience).
Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis
Supplier
In Arthritis Research & Therapy, 1997
... Recombinant human IL-1β, TNF-α, IL-4, IL-6, IL-8, IL-10, and interferon-γ were from BD Biosciences (San Diego, CA) ...
Plasma nitrate concentrations in neutropenic and non-neutropenic patients with suspected septicaemia
Supplier
In Intensive Care Medicine, 1994
... sandwich enzyme-linked immunosorbent assay (ELISA) kits were used to measure IL-6, -8 (Hycult, Uden, Netherlands), IL-10 (BD Biosciences, Erembodegem, Belgium) MIF (R ...
