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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 07 Oct 2015.

Interleukin 10

IL-10, Interleukin-10
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: Interleukin-6, HAD, CAN, IL-4, IL-17
Papers using IL-10 antibodies
Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.
Dieli Francesco, In PLoS ONE, 2008
... or PE-Cy5-conjugated anti-CD3, CD4, CD8, CD25, F4/80, CD206, IgG2b and IgG2a mAb, IFNγ, IL-12p70, IL-4, IL-10 and TGF-β1 ELISA kits were purchased from eBioscience (San Diego, CA) ...
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia
Bian Zhao-Xiang et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... , IL-6, and IL-10 ELISA kits were purchased from eBioscience (San Diego, USA) ...
Multiplexed immunoassays for proteins using magnetic luminescent nanoparticles for internal calibration
Preininger Claudia et al., In Sensors (Basel, Switzerland), 2006
... protein, biotinylated anti IL-6 (MQ2-39C3) as well as anti IL-10 (JES3-9D7), recombinant IL-10, biotinylated anti IL-10 (JES3-12G8), anti TNF alpha (MAb1), recombinant TNF alpha and biotinylated TNF alpha (MAbF6C5) were purchased from eBioscience (San Diego, CA, USA) ...
Translocation pathway of the intratracheally instilled ultrafine particles from the lung into the blood circulation in the mouse
Lee Moo-Yeol et al., In Safety and Health at Work, 2005
... ELISA kits for interleukin-6 (IL-6), IL-1b, IL-4, IL-10, tumor necrosis factor-α (TNF-α), and interferon-gamma (IFN-γ) were supplied by BD Biosciences (San Diego, CA, USA) ...
4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy.
Fallon Padraic G., In PLoS ONE, 2004
... The mAbs against mouse CD3, CD28, IL-4, IL-5, IL-13, TNFα, IL-6, IL-8, IFN-γ and IL-10 ELISA kits were purchased from Biolegend (California, USA) ...
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Papers on IL-10
Regulatory B cells mediate tolerance to apoptotic self in health: implications for disease.
Gray et al., Edinburgh, United Kingdom. In Int Immunol, 30 Nov 2015
B cells are able to regulate immune responses through the secretion of IL-10 and other inhibitory cytokines, though no transcription factor that can define 'regulatory B cells' as a separate lineage has yet been found.
Regulatory B10 cell development and function.
Tedder et al., Durham, United States. In Int Immunol, 30 Nov 2015
However, a rare but potent B-cell subset in both humans and mice is capable of inhibiting immune responses through the production of the anti-inflammatory cytokine IL-10.
Cytokine modulation (IL-6, IL-8, IL-10) by human breast milk lipids on intestinal epithelial cells (Caco-2).
Sánchez et al., Venezuela. In J Matern Fetal Neonatal Med, 06 Nov 2015
We measured the concentrations and mRNA levels of IL-6, IL-8 and IL-10 cytokines by immunoassay (ELISA) and quantitative-PCR (qRT-PCR) technique, respectively.
Exploring the role of interleukin-22 in neurological and autoimmune disorders.
Zhang et al., Suzhou, China. In Int Immunopharmacol, 31 Oct 2015
Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that has recently gained attention in regard to its recognized pathogenic role in neurological and autoimmune disorders.
Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses.
Correale et al., Buenos Aires, Argentina. In Cell, 10 Oct 2015
Melatonin induces the expression of the repressor transcription factor Nfil3, blocking the differentiation of pathogenic Th17 cells and boosts the generation of protective Tr1 cells via Erk1/2 and the transactivation of the IL-10 promoter by ROR-α.
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Kaech et al., New Haven, United States. In Nat Immunol, Aug 2015
We found that interleukin 10 (IL-10) derived from CD4(+) regulatory T cells (Treg cells) was necessary for the maturation of memory CD8(+) T cells following acute infection with lymphocytic choriomeningitis virus (LCMV).
Antibody-independent functions of B cells: a focus on cytokines.
Fillatreau et al., Berlin, Germany. In Nat Rev Immunol, Jul 2015
Finally, B cells can regulate inflammatory immune responses, primarily through their provision of IL-10 and IL-35.
DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance.
Ochando et al., New York City, United States. In Immunity, Jul 2015
Mechanistically, that simultaneous DC-SIGN engagement by fucosylated ligands and TLR4 signaling was required for production of immunoregulatory IL-10 associated with prolonged allograft survival.
Regulatory B cells: origin, phenotype, and function.
Mauri et al., London, United Kingdom. In Immunity, May 2015
Through the production of interleukin-10 (IL-10), IL-35, and transforming growth factor β (TGF-β), Breg cells suppress immunopathology by prohibiting the expansion of pathogenic T cells and other pro-inflammatory lymphocytes.
Activated regulatory T cell regulates neural stem cell proliferation in the subventricular zone of normal and ischemic mouse brain through interleukin 10.
Yang et al., Shanghai, China. In Front Cell Neurosci, Dec 2014
The mechanism was examined by inhibiting interleukin 10 (IL-10) and transforming growth factor (TGF-β) signaling.
Thyroid dysfunction: an autoimmune aspect.
Tabassum et al., Riyadh, Saudi Arabia. In Int J Clin Exp Med, Dec 2014
Various cytokines IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-14, TNF-α and IFN-γ are found in thyroid follicular cells which enhance inflammatory response with nitric oxide (NO) and prostaglandins.
Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review.
Ignotti et al., João Monlevade, Brazil. In Mediators Inflamm, Dec 2014
Of the 27 studied inflammatory mediators, the main proinflammatory mediators were IL-6, IFN-γ, TNF-α, IL-1β, and IL-17; the main anti-inflammatory mediators were IL-10 and IL-4.
Association of IFN-γ : IL-10 Cytokine Ratio with Nonsegmental Vitiligo Pathogenesis.
Jahan et al., Hyderābād, India. In Autoimmune Dis, Dec 2014
The present study aimed to estimate the serum levels of pro- and anti-inflammatory cytokines, IFN-γ and IL-10, and their ratios in nonsegmental vitiligo patients and healthy individuals from India.
Pathologic and Protective Roles for Microglial Subsets and Bone Marrow- and Blood-Derived Myeloid Cells in Central Nervous System Inflammation.
Owens et al., Odense, Denmark. In Front Immunol, Dec 2014
These subsets differ in their expression of Arg-1, YM1, iNOS, IL-10, and IGF-1.
Synergy between CD40 and MyD88 Does Not Influence Host Survival to Salmonella Infection.
Wick et al., Göteborg, Sweden. In Front Immunol, Dec 2014
In contrast to infected wildtype and CD40(-/-) mice, both MyD88(-/-) mice and DKO mice lack detectable serum IFN-γ and have elevated IL-10.
Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population.
Chowdhury et al., Calcutta, India. In Gene, 2012
identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population
IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
Plevy et al., Chapel Hill, United States. In J Immunol, 2012
These results suggest that histone deacetylation on the Il12b promoter by histone deacetylase 3 mediates homeostatic effects of IL-10 in macrophages.
A protective role for human IL-10-expressing CD4+ T cells in colitis.
Bream et al., Baltimore, United States. In J Immunol, 2012
CD4-positive T cells represent a protective source of transgenic IL-10 in the mouse colon.
A regulatory role for IL-10 receptor signaling in development and B cell help of T follicular helper cells in mice.
Shen et al., Shanghai, China. In J Immunol, 2012
Blockade of IL-10 promotes the B-cell help function of activated T helper (Th) cells.
Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation.
Zhao et al., Beijing, China. In J Immunol, 2012
Mouse embryonic fibroblasts-mesenchymal stem cells secrete IL-10 and control regulatory dendritic cell production by activating SOCS (suppressor of cytokine)3 through the JAK-STAT signaling pathway.
More papers using IL-10 antibodies
Obesity does not alter the pharmacokinetics of drotrecogin alpha (activated) in severe sepsis
Schneider Francis et al., In Critical Care, 2004
... For cytokines transcriptional expression (TNF-α, IL-10 and IFN-γ) QuantiTect Primer Assays primers (Qiagen, Courtaboeuf, France) were used ...
Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription
Jope Richard S et al., In Journal of Neuroinflammation, 2004
... Mouse IL-1β, TNFα, IL-6, IL-10 and IFNγ were measured with ELISA kits according to the manufacturer's instructions (eBioscience).
A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
Moser Bernhard et al., In The Journal of Experimental Medicine, 2002
... OptEIA ELISA kits for the detection of IL-4, IL-10, IFN-γ, TNF-α, and TGF-β in supernatants were obtained from BD Biosciences.
Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production
Blanchard Thomas G. et al., In Frontiers in Immunology, 2001
... Mice double deficient in Rag1 and IL-10 were generated by crossing the respective transgenic strains and subsequent progeny ...
Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells
Sviland Lisbet et al., In Virchows Archiv, 1998
... IL-10, TNF-α and IFN-γ were detected with antibodies from ImmunoTools, Friesoythe, Germany, TGF-β with antibodies from Santa Cruz Biotechnology, Santa Cruz, CA, USA ...
T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function.
Sarkar Devanand, In PLoS ONE, 1998
... IL-2, IFNγ, IL-12, IL-10 and TNFα were quantified with cytokine specific ELISA kits (eBioScience).
Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis
Kawai Shinichi et al., In Arthritis Research & Therapy, 1997
... Recombinant human IL-1β, TNF-α, IL-4, IL-6, IL-8, IL-10, and interferon-γ were from BD Biosciences (San Diego, CA) ...
Plasma nitrate concentrations in neutropenic and non-neutropenic patients with suspected septicaemia
Burke-Gaffney Anne et al., In Intensive Care Medicine, 1994
... sandwich enzyme-linked immunosorbent assay (ELISA) kits were used to measure IL-6, -8 (Hycult, Uden, Netherlands), IL-10 (BD Biosciences, Erembodegem, Belgium) MIF (R ...
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