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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Jul 2015.

Interleukin 10

IL-10, Interleukin-10
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: Interleukin-6, CAN, IL-4, HAD, V1a
Papers using IL-10 antibodies
Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.
Supplier
Dieli Francesco, In PLoS ONE, 2008
... or PE-Cy5-conjugated anti-CD3, CD4, CD8, CD25, F4/80, CD206, IgG2b and IgG2a mAb, IFNγ, IL-12p70, IL-4, IL-10 and TGF-β1 ELISA kits were purchased from eBioscience (San Diego, CA) ...
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia
Supplier
Bian Zhao-Xiang et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... , IL-6, and IL-10 ELISA kits were purchased from eBioscience (San Diego, USA) ...
Multiplexed immunoassays for proteins using magnetic luminescent nanoparticles for internal calibration
Supplier
Preininger Claudia et al., In Sensors (Basel, Switzerland), 2006
... protein, biotinylated anti IL-6 (MQ2-39C3) as well as anti IL-10 (JES3-9D7), recombinant IL-10, biotinylated anti IL-10 (JES3-12G8), anti TNF alpha (MAb1), recombinant TNF alpha and biotinylated TNF alpha (MAbF6C5) were purchased from eBioscience (San Diego, CA, USA) ...
Translocation pathway of the intratracheally instilled ultrafine particles from the lung into the blood circulation in the mouse
Supplier
Lee Moo-Yeol et al., In Safety and Health at Work, 2005
... ELISA kits for interleukin-6 (IL-6), IL-1b, IL-4, IL-10, tumor necrosis factor-α (TNF-α), and interferon-gamma (IFN-γ) were supplied by BD Biosciences (San Diego, CA, USA) ...
4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy.
Supplier
Fallon Padraic G., In PLoS ONE, 2004
... The mAbs against mouse CD3, CD28, IL-4, IL-5, IL-13, TNFα, IL-6, IL-8, IFN-γ and IL-10 ELISA kits were purchased from Biolegend (California, USA) ...
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Papers on IL-10
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
New
Impact
Kaech et al., New Haven, United States. In Nat Immunol, 31 Aug 2015
We found that interleukin 10 (IL-10) derived from CD4(+) regulatory T cells (Treg cells) was necessary for the maturation of memory CD8(+) T cells following acute infection with lymphocytic choriomeningitis virus (LCMV).
Meta-Analysis of Associations Between Interleukin-10 Polymorphisms and Susceptibility to Vasculitis.
New
Lee et al., Seoul, South Korea. In Immunol Invest, 27 Aug 2015
OBJECTIVE: This study determined whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to vasculitis.
Predicting survival using clinical risk scores and non-HLA immunogenetics.
New
Bickeböller et al., Göttingen, Germany. In Bone Marrow Transplant, 27 Aug 2015
When viewed in addition to an already established clinical risk score (EBMT-score), three polymorphisms: rs8177374 in the gene for MyD88-adapter-like (MAL; P=0.026), rs9340799 in the oestrogen receptor gene (ESR; P=0.003) and rs1800795 in interleukin-6 (IL-6; P=0.007) were found to be associated with reduced overall survival, whereas the haplo-genotype (ACC/ACC) in IL-10 was protective (P=0.02).
Cytokine profile in drug-naïve, first episode patients with psychosis.
New
Mavreas et al., Ioánnina, Greece. In J Psychosom Res, 17 Aug 2015
Our aim is to compare the levels of interleukin (IL) IL-2, IL-6, IL-10, IL-17 and transforming growth factor -β2 (TGF-β2) between drug-naïve-first episode patients with psychosis and healthy controls matched for age, sex, BMI and smoking.
Serum hepcidin concentrations and type 2 diabetes.
Review
New
Tuomainen et al., Kuopio, Finland. In World J Diabetes, 10 Aug 2015
Some of the suggested pathways are via transcription modulator of hepcidin (STAT3); ferroportin 1 expression on the cells involved in iron transport; transmembrane protease 6 enzyme; and pro-inflammatory cytokines, interleukin (IL)-1, IL-6, tumor necrosis factor-α and IL-10.
Antibody-independent functions of B cells: a focus on cytokines.
New
Impact
Fillatreau et al., Berlin, Germany. In Nat Rev Immunol, 31 Jul 2015
Finally, B cells can regulate inflammatory immune responses, primarily through their provision of IL-10 and IL-35.
Differential roles of Porphyromonas gingivalis lipopolysaccharide and Escherichia coli lipopolysaccharide in maturation and antigen-presenting functions of dentritic cells.
New
Hu et al., Nanjing, China. In Eur Rev Med Pharmacol Sci, 31 Jul 2015
MATERIALS AND METHODS: Flow cytometry was used to detect CD11c, MHC-II, CD80, CD86 and CD40 expression on DCs which were stimulated by P. gingivalis-LPS or E. coli-LPS and ELISA was used to detect IL-12, IFN-γ, IL-10 and IL-13 secreted by DCs.
Diversity and plasticity of microglial cells in psychiatric and neurological disorders.
Review
New
Chiba et al., Yokohama, Japan. In Pharmacol Ther, 27 Jul 2015
On the other hand, M2 polarized microglia can produce anti-inflammatory cytokine, IL-10 and express several receptors that are implicated in inhibiting inflammation and restoring homeostasis.
Complex host genetic susceptibility to Staphylococcus aureus infections.
Review
New
Schrodi et al., Marshfield, United States. In Trends Microbiol, 22 Jul 2015
Mouse models show variable susceptibility to S. aureus infections across mouse strains and disease models with roles for signaling pathways involving Toll-like receptors (TLR-1, TLR-2, and TLR-6), interleukins (IL-4, IL-6, IL-10, and IL-13), chemokines [CXC ligand (CXCL)-1 and CXCL-2], and T helper (Th)1/Th2 responses.
Th1/Th2 cytokines and their genotypes as predictors of hepatitis B virus related hepatocellular carcinoma.
Review
New
Kaur et al., Chandīgarh, India. In World J Hepatol, 18 Jul 2015
In this regard, this review will detail the substantial role of key Th1: interleukin 1 (IL-1), IL-2, IL-12, tumor necrosis factor-α, interferon-γ; Th2: IL-4, IL-10 and non Th1/Th2: IL-6, transforming growth factor-β1 cytokines genotypes in analyzing the variability in the clinical manifestations in an HBV-afflicted individual, which might finally, culminates into HCC.
DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance.
New
Impact
Ochando et al., New York City, United States. In Immunity, 16 Jul 2015
Mechanistically, that simultaneous DC-SIGN engagement by fucosylated ligands and TLR4 signaling was required for production of immunoregulatory IL-10 associated with prolonged allograft survival.
Regulatory B cells: origin, phenotype, and function.
Review
New
Impact
Mauri et al., London, United Kingdom. In Immunity, May 2015
Through the production of interleukin-10 (IL-10), IL-35, and transforming growth factor β (TGF-β), Breg cells suppress immunopathology by prohibiting the expansion of pathogenic T cells and other pro-inflammatory lymphocytes.
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family.
Review
New
Vannay et al., Budapest, Hungary. In Mediators Inflamm, Dec 2014
In the present review we provide an overview of the common key mediators of organ fibrosis highlighting the role of interleukin-10 (IL-10) cytokine family members (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26), which recently came into focus as tissue remodeling-related inflammatory cytokines.
The immunobiology of interleukin-27.
New
Impact
Hunter et al., Saga, Japan. In Annu Rev Immunol, Dec 2014
Although it was initially linked with the development of Th1 responses, it is now recognized as a potent antagonist of different classes of inflammation through its ability to directly modify CD4(+) and CD8(+) T cell effector functions, to induce IL-10, and to promote specialized T regulatory cell responses.
Relationship between UV-irradiated HaCaT cell cytokines and Th1/Th2 imbalance.
New
Deng et al., Jinan, China. In Genet Mol Res, Dec 2014
However, the expression of IL-10R and IL-10 was upregulated 12 h following UVB irradiation, as well as following lower dose UVA irradiation.
Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population.
GeneRIF
Chowdhury et al., Calcutta, India. In Gene, 2012
identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population
IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
GeneRIF
Plevy et al., Chapel Hill, United States. In J Immunol, 2012
These results suggest that histone deacetylation on the Il12b promoter by histone deacetylase 3 mediates homeostatic effects of IL-10 in macrophages.
A protective role for human IL-10-expressing CD4+ T cells in colitis.
GeneRIF
Bream et al., Baltimore, United States. In J Immunol, 2012
CD4-positive T cells represent a protective source of transgenic IL-10 in the mouse colon.
A regulatory role for IL-10 receptor signaling in development and B cell help of T follicular helper cells in mice.
GeneRIF
Shen et al., Shanghai, China. In J Immunol, 2012
Blockade of IL-10 promotes the B-cell help function of activated T helper (Th) cells.
Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation.
GeneRIF
Zhao et al., Beijing, China. In J Immunol, 2012
Mouse embryonic fibroblasts-mesenchymal stem cells secrete IL-10 and control regulatory dendritic cell production by activating SOCS (suppressor of cytokine)3 through the JAK-STAT signaling pathway.
More papers using IL-10 antibodies
Obesity does not alter the pharmacokinetics of drotrecogin alpha (activated) in severe sepsis
Supplier
Schneider Francis et al., In Critical Care, 2004
... For cytokines transcriptional expression (TNF-α, IL-10 and IFN-γ) QuantiTect Primer Assays primers (Qiagen, Courtaboeuf, France) were used ...
Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription
Supplier
Jope Richard S et al., In Journal of Neuroinflammation, 2004
... Mouse IL-1β, TNFα, IL-6, IL-10 and IFNγ were measured with ELISA kits according to the manufacturer's instructions (eBioscience).
A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
Supplier
Moser Bernhard et al., In The Journal of Experimental Medicine, 2002
... OptEIA ELISA kits for the detection of IL-4, IL-10, IFN-γ, TNF-α, and TGF-β in supernatants were obtained from BD Biosciences.
Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production
Supplier
Blanchard Thomas G. et al., In Frontiers in Immunology, 2001
... Mice double deficient in Rag1 and IL-10 were generated by crossing the respective transgenic strains and subsequent progeny ...
Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells
Supplier
Sviland Lisbet et al., In Virchows Archiv, 1998
... IL-10, TNF-α and IFN-γ were detected with antibodies from ImmunoTools, Friesoythe, Germany, TGF-β with antibodies from Santa Cruz Biotechnology, Santa Cruz, CA, USA ...
T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function.
Supplier
Sarkar Devanand, In PLoS ONE, 1998
... IL-2, IFNγ, IL-12, IL-10 and TNFα were quantified with cytokine specific ELISA kits (eBioScience).
Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis
Supplier
Kawai Shinichi et al., In Arthritis Research & Therapy, 1997
... Recombinant human IL-1β, TNF-α, IL-4, IL-6, IL-8, IL-10, and interferon-γ were from BD Biosciences (San Diego, CA) ...
Plasma nitrate concentrations in neutropenic and non-neutropenic patients with suspected septicaemia
Supplier
Burke-Gaffney Anne et al., In Intensive Care Medicine, 1994
... sandwich enzyme-linked immunosorbent assay (ELISA) kits were used to measure IL-6, -8 (Hycult, Uden, Netherlands), IL-10 (BD Biosciences, Erembodegem, Belgium) MIF (R ...
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