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Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

IKKepsilon, IKKi, inducible IkappaB kinase, IKBKE
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009] (from NCBI)
Top mentioned proteins: TBK1, NF-kappaB, Interferon Regulatory Factor-3, IRF, RIG-I
Papers on IKKepsilon
The critical role of Akt in cardiovascular function.
Review
New
Su et al., Augusta, United States. In Vascul Pharmacol, Nov 2015
Ack1, Src, PTK6, TBK1, IKBKE and IKKε are some of the non-canonical pathways which affect the Akt activity.
17β-Estradiol enhances the activation of IFN-α signaling in B cells by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p that target IKKε.
New
Hou et al., Nanjing, China. In Biochim Biophys Acta, Aug 2015
These microRNAs could target the 3'UTR of the IKKε-encoding gene IKBKE directly and regulate the expression of IKKε, which can promote the activation of IFN-α signaling.
MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits.
New
Deckert et al., Würzburg, Germany. In Am J Med Genet B Neuropsychiatr Genet, Jun 2015
Hsa-miR-4717-5p showed the most robust effect on RGS2 and regulated two other candidate genes of anxiety disorders (CNR1 and IKBKE) as well.
Polymorphisms of IKBKE gene are associated with major depressive disorder and panic disorder.
New
Vasar et al., Tartu, Estonia. In Brain Behav, Apr 2015
Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon (IKBKE) gene encodes IKKε protein that is involved in innate immunity, predominantly antiviral response generation.
Tumor-suppressing effect of miR-4458 on human hepatocellular carcinoma.
Zhu et al., Weifang, China. In Cell Physiol Biochem, 2014
IKBKE is amplified and over-expressed in a large percentage of human breast tumors and identified as an oncogene of human breast tumor.
IKBKE Upregulation is Positively Associated with Squamous Cell Carcinoma of the Lung In Vivo and Malignant Transformation of Human Bronchial Epithelial Cells In Vitro.
Lv et al., Bengbu, China. In Med Sci Monit, 2014
BACKGROUND: The IκB kinase inhibitor of κB kinase epsilon (IKBKE) is overexpressed in several human cancers.
Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance.
Impact
Li et al., Cleveland, United States. In Immunity, 2012
Via biochemical and genetic approaches, the kinases IKKi and GSK3α were identified as the critical intermediate signaling components for IL-1-induced AKT activation, which in turn activated mTOR.
ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.
GeneRIF
Zhu et al., Tallahassee, United States. In J Virol, 2012
phosphorylation of IRF7 on Ser477 and Ser479 by IKKepsilon or TBK1 is inhibited by KSHV ORF45
PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics.
Review
Mahajan et al., Tampa, United States. In J Cell Physiol, 2012
Although phosphatidylinositol-3-OH kinase (PI3K), a lipid kinase, is well characterized as a major regulator of AKT activation in response to a variety of ligands, recent studies highlight a diverse group of tyrosine (Ack1/TNK2, Src, PTK6) and serine/threonine (TBK1, IKBKE, DNAPKcs) kinases that activate AKT directly to promote its pro-proliferative signaling functions.
Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKε.
GeneRIF
Kunz et al., Lausanne, Switzerland. In J Virol, 2012
NP-IKKepsilon interaction likely plays a crucial role in arenavirus-host interaction.
Silencing of IKKε using siRNA inhibits proliferation and invasion of glioma cells in vitro and in vivo.
GeneRIF
Huang et al., Tianjin, China. In Int J Oncol, 2012
deregulation of IKKepsilon plays a pivotal role in the uncontrolled proliferation and malignant invasion of glioma cells
Kinome expression profiling identifies IKBKE as a predictor of overall survival in clear cell renal cell carcinoma patients.
GeneRIF
Wu et al., Houston, United States. In Carcinogenesis, 2012
IKBKE and gene expression patterns for other members of the NF-kappaB pathway were not associated with survival, suggesting that IKBKE gene expression may be an independent marker of variation in overall survival
FOXO3 as a new IKK-ε-controlled check-point of regulation of IFN-β expression.
GeneRIF
Udalova et al., London, United Kingdom. In Eur J Immunol, 2012
identify FOXO3 as a new IKK-epsilon-controlled check-point of IRF activation and regulation of IFN-beta expression, providing new insight into the role of FOXO3 in immune response control.
The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation.
Impact
Li et al., Cleveland, United States. In Nat Immunol, 2011
Here we report that Act1, the key adaptor for the IL-17 receptor (IL-7R), formed a complex with the inducible kinase IKKi after stimulation with IL-17.
Crystal structure of inhibitor of κB kinase β.
Impact
Wu et al., New York City, United States. In Nature, 2011
Other IKK family members, IKKα, TBK1 and IKK-i, may have a similar trimodular architecture and function.
IKKepsilon: a kinase at the intersection of signaling and membrane traffic.
Review
Gould, Glasgow, United Kingdom. In Sci Signal, 2010
The ability to coordinate membrane trafficking events in space and time is of fundamental importance in biology.
TRAF-mediated regulation of immune and inflammatory responses.
Review
Cheng et al., Los Angeles, United States. In Sci China Life Sci, 2010
They subsequently engage other signaling proteins to activate inhibitor of kappaB kinase (IKK) complex, TRAF family member-associated NF-kappaB activator (TANK)-binding kinase 1 (TBK1) and inducible I kappaB kinase (IKK-i) (also known as IKKepsilon), ultimately leading to activation of transcription factors such as NF-kappaB and interferon-regulatory factor (IRF) to induce immune and inflammatory responses.
IKKepsilon: a bridge between obesity and inflammation.
Impact
Olefsky, San Diego, United States. In Cell, 2009
Chiang et al. (2009) now show that the IkappaB kinase IKKepsilon is an important link between obesity and inflammation and may be a new therapeutic target for treating obesity-related metabolic diseases.
The protein kinase IKKepsilon regulates energy balance in obese mice.
Impact
GeneRIF
Saltiel et al., Ann Arbor, United States. In Cell, 2009
Gene expression analyses indicate that IKKepsilon knockout reduces expression of inflammatory cytokines, and changes expression of certain regulatory proteins and enzymes involved in glucose and lipid metabolism
The IKK-related kinases: from innate immunity to oncogenesis.
Review
Servant et al., Montréal, Canada. In Cell Res, 2008
Over the past four years, the field of the innate immune response has been highly influenced by the discovery of the IkappaB kinase (IKK)-related kinases, TANK Binding Kinase 1 (TBK1) and IKKi, which regulate the activity of interferon regulatory factor (IRF)-3/IRF-7 and NF-kappaB transcription factors.
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