[Battle with herpes for 37 years].
In Nihon Ganka Gakkai Zasshi, Mar 2015
IkappaB kinase-β (IKK2) inhibitors, which inhibit the activity of NF-κB, were used to examine gene expression during HSV reactivation in a mouse model.
A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.
Oss, Netherlands. In Br J Pharmacol, 2012
In addition, we recommend which inhibitors to use for studying the biology of the 20 most investigated kinases that are clinically relevant: Abl (ABL1), AKT1, ALK, Aurora A/B, CDKs, MET, CSF1R (FMS), EGFR, FLT3, ERBB2 (HER2), IKBKB (IKK2), JAK2/3, JNK1/2/3 (MAPK8/9/10), MEK1/2, PLK1, PI3Ks, p38α (MAPK14), BRAF, SRC and VEGFR2 (KDR).
Critical roles of IĸB kinase subunits in mast cell degranulation.
Chiba, Japan. In Int Arch Allergy Immunol, 2011
Recently, we showed that IKK2 (also called IKKβ), a catalytic subunit of the IKK complex, induces immunoglobulin E-mediated degranulation in mast cells by phosphorylating SNAP-23, the target-membrane soluble N-ethylmaleimide-sensitive fusion factor attachment protein receptor (SNARE).