GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 08 Dec 2016.
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011] (from
This study demonstrated that IKK/NF-kappaB activation is sufficient to induce hydrocephalus formation and provides a potential mechanistic explanation for the frequent association of neuroinflammation and hydrocephalus formation during brain development
Fishelson et al., Tel Aviv-Yafo, Israel. In J Immunol, 2012
Embryonic fibroblasts lacking either the p65 subunit of NF-kappaB or the IkappaB kinase alpha or IkappaB beta subunits of the NF-kappaB activator complex are more sensitive to complement-dependent cytotoxicity.