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Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

IKKbeta, IKK2
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: NF-kappaB, IkappaBalpha, I-kappa B Kinase, p65, V1a
Papers using IKKbeta antibodies
The IKK2/NF-{kappa}B pathway suppresses MYC-induced lymphomagenesis
Siegmund D et al., In Cell Death & Disease, 2008
... The IKK2 inhibitor TPCA-1 was from Tocris Bioscience (Ellisville, MO, USA) ...
Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein.
Agarwal Sudha, In PLoS ONE, 2002
... Antibodies for TRAF1 (H-125), TRAF2 (H-249), IKK2 (H-470) and HA (HA-probe Y-11) were from Santa Cruz Biotechnology Inc; antibodies against the ...
Papers on IKKbeta
NF-κB and androgen receptor variant expression correlate with human BPH progression.
Hayward et al., Nashville, United States. In Prostate, Jan 2016
To further investigate these pathways, human prostatic stromal and epithelial cell lines were transduced with constitutively active or kinase dead forms of IKK2 to regulate canonical NF-κB activity.
Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet activation and aggregation.
Chen et al., Taiwan. In Blood, Jan 2016
In human platelets, L5 but not L1 (the least electronegative LDL subfraction) induced Aβ release via IκB kinase 2 (IKK2).
Inhibitor of NFκB Kinase Subunit 2 Blockade Hinders the Initiation but Aggravates the Progression of Crescentic GN.
Thaiss et al., Bonn, Germany. In J Am Soc Nephrol, Dec 2015
Here, we investigated whether inhibiting the NFκB-inducing kinase IKK2 can attenuate crescentic GN, a severe DC- and Th cell-dependent kidney inflammatory disease.
NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.
Pasparakis et al., Köln, Germany. In Cancer Cell, Dec 2015
Here, we show that complete NF-κB inhibition by combined LPC-specific ablation of RelA, c-Rel, and RelB did not phenocopy NEMO deficiency, but constitutively active IKK2-mediated NF-κB activation prevented hepatocellular damage and HCC in NEMO(LPC-KO) mice.
IKK-related genetic diseases: probing NF-κB functions in humans and other matters.
Courtois et al., Grenoble, France. In Cell Mol Life Sci, Apr 2015
Its activation is tightly controlled by a kinase complex, IκB kinase (IKK), composed of three core proteins: IKK1/IKKα, IKK2/IKKβ and NEMO/IKKγ.
[Battle with herpes for 37 years].
Shimomura, In Nihon Ganka Gakkai Zasshi, Mar 2015
IkappaB kinase-β (IKK2) inhibitors, which inhibit the activity of NF-κB, were used to examine gene expression during HSV reactivation in a mouse model.
Cardiac-Specific Activation of IKK2 Leads to Defects in Heart Development and Embryonic Lethality.
Wirth et al., Ulm, Germany. In Plos One, 2014
We expressed a constitutively active (CA) mutant of IKK2, the kinase activating canonical NF-κB signaling, specifically in cardiomyocytes under the control of the α-myosin heavy chain promoter.
Necrosis-Induced Sterile Inflammation Mediated by Interleukin-1α in Retinal Pigment Epithelial Cells.
Sonoda et al., Ube, Japan. In Plos One, 2014
ANCE-induced IL-6, IL-8, and MCP-1 release was inhibited by IL-1 receptor antagonist and by an IKK2 inhibitor (a blocker of NF-κB signaling) in a concentration-dependent manner, but was not affected by a pan-caspase inhibitor (Z-VAD-FMK).
Deficiency of innate and acquired immunity caused by an IKBKB mutation.
Schwarz et al., Freiburg, Germany. In N Engl J Med, 2014
All patients carried a homozygous duplication--c.1292dupG in exon 13 of IKBKB, which encodes IκB kinase 2 (IKK2, also known as IKKβ)--leading to loss of expression of IKK2, a component of the IKK-nuclear factor κB (NF-κB) pathway.
Silencing of IkBβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo.
Avadhani et al., Philadelphia, United States. In Carcinogenesis, 2012
findings demonstrate that IkBbeta is a master regulator of mitochondrial retrograde signaling pathway and that the retrograde signaling plays a role in tumor growth in vivo
Nuclear factor κB activation impairs ependymal ciliogenesis and links neuroinflammation to hydrocephalus formation.
Baumann et al., Ulm, Germany. In J Neurosci, 2012
This study demonstrated that IKK/NF-kappaB activation is sufficient to induce hydrocephalus formation and provides a potential mechanistic explanation for the frequent association of neuroinflammation and hydrocephalus formation during brain development
Chronic activation of the kinase IKKβ impairs T cell function and survival.
Zhong et al., Durham, United States. In J Immunol, 2012
Uncontrolled IKKbeta activation promotes T cell apoptosis and attenuates responsiveness to T cell receptor stimulation and bacterial infection in vivo.
Cardiomyocyte-specific IκB kinase (IKK)/NF-κB activation induces reversible inflammatory cardiomyopathy and heart failure.
Wirth et al., Ulm, Germany. In Proc Natl Acad Sci U S A, 2012
IKK/NF-kappaB activation in cardiomyocytes is sufficient to cause cardiomyopathy and heart failure by inducing an excessive inflammatory response and myocyte atrophy.
A role for the NF-κB pathway in cell protection from complement-dependent cytotoxicity.
Fishelson et al., Tel Aviv-Yafo, Israel. In J Immunol, 2012
Embryonic fibroblasts lacking either the p65 subunit of NF-kappaB or the IkappaB kinase alpha or IkappaB beta subunits of the NF-kappaB activator complex are more sensitive to complement-dependent cytotoxicity.
p38 MAPK inhibitors, IKK2 inhibitors, and TNFα inhibitors in COPD.
Panettieri et al., Philadelphia, United States. In Curr Opin Pharmacol, 2012
In this review, we discuss signaling pathways involved in COPD pathogenesis and review clinical studies of p38 MAPK inhibitors, TNFα inhibitors, and IKK2 inhibitors as potential COPD therapies.
A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.
Zaman et al., Oss, Netherlands. In Br J Pharmacol, 2012
In addition, we recommend which inhibitors to use for studying the biology of the 20 most investigated kinases that are clinically relevant: Abl (ABL1), AKT1, ALK, Aurora A/B, CDKs, MET, CSF1R (FMS), EGFR, FLT3, ERBB2 (HER2), IKBKB (IKK2), JAK2/3, JNK1/2/3 (MAPK8/9/10), MEK1/2, PLK1, PI3Ks, p38α (MAPK14), BRAF, SRC and VEGFR2 (KDR).
Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model.
Verma et al., Los Angeles, United States. In Nat Cell Biol, 2012
Results suggest the possible application of IKK2 and Timp-1 inhibitors in treating lung cancer.
KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.
Chiao et al., Houston, United States. In Cancer Cell, 2012
Here, we report that pancreas-targeted IKK2/β inactivation inhibited NF-κB activation and PDAC development in Kras(G12D) and Kras(G12D);Ink4a/Arf(F/F) mice, demonstrating a mechanistic link between IKK2/β and Kras(G12D) in PDAC inception.
Critical roles of IĸB kinase subunits in mast cell degranulation.
Nakajima et al., Chiba, Japan. In Int Arch Allergy Immunol, 2011
Recently, we showed that IKK2 (also called IKKβ), a catalytic subunit of the IKK complex, induces immunoglobulin E-mediated degranulation in mast cells by phosphorylating SNAP-23, the target-membrane soluble N-ethylmaleimide-sensitive fusion factor attachment protein receptor (SNARE).
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.
Wang et al., Houston, United States. In Cell, 2010
NLRC5 inhibited NF-kappaB-dependent responses by interacting with IKKalpha and IKKbeta and blocking their phosphorylation.
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