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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PDZ domain containing 3

IKEPP, PDZK2, NHERF4, intestinal and kidney enriched PDZ protein, NaPi-Cap2, PDZ domain-containing protein 2
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: PDZK1, CAN, Cystic Fibrosis Transmembrane Conductance Regulator, V1a, PSD-95
Papers on IKEPP
USP2-45 Is a Circadian Clock Output Effector Regulating Calcium Absorption at the Post-Translational Level.
New
Staub et al., Lausanne, Switzerland. In Plos One, Dec 2015
Usp2-KO mice show hyperabsorption of dietary Ca2+ in small intestine, likely due to strong overexpression of the membrane scaffold protein NHERF4, a regulator of the Ca2+ channel TRPV6 mediating dietary Ca2+ uptake.
Prostacyclin receptors: Transcriptional regulation and novel signalling mechanisms.
New
Kinsella et al., Dublin, Ireland. In Prostaglandins Other Lipid Mediat, Sep 2015
Moreover, the functional implications of the interactions between the IP with PDZK1, a multi PDZ-domain containing protein essential for reverse-cholesterol transport and endothelialization, and the IP with IKEPP, the intestinal and kidney enriched PDZ protein, for the role of the prostacyclin-IP axis within the vasculature are reviewed.
Luteolin potentiates the sensitivity of colorectal cancer cell lines to oxaliplatin through the PPARγ/OCTN2 pathway.
Zhou et al., Changsha, China. In Anticancer Drugs, 2014
This finding is likely because of the increase of PDZ domain containing 1 (PDZK1) and PDZ domain containing 3 (PDZK2), which are known to facilitate the expression of OCTN2 on the cell surface and/or enhance transporter activity.
MiR-134/487b/655 cluster regulates TGF-β-induced epithelial-mesenchymal transition and drug resistance to gefitinib by targeting MAGI2 in lung adenocarcinoma cells.
Gemma et al., Tokyo, Japan. In Mol Cancer Ther, 2014
MAGI2 (membrane-associated guanylate kinase, WW, and PDZ domain-containing protein 2), a predicted target of these miRNAs and a scaffold protein required for PTEN, was diminished in A549 cells with EMT after the TGF-β1 stimulation.
Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs).
Azhar et al., Palo Alto, United States. In J Biol Chem, 2013
NHERF1 and NHERF2 mRNA and protein are expressed at varying levels in model steroidogenic cell lines and the adrenal, with only low expression of PDZK1 (NHERF3) and NHERF4.
Interaction of the human prostacyclin receptor and the NHERF4 family member intestinal and kidney enriched PDZ protein (IKEPP).
GeneRIF
Kinsella et al., Dublin, Ireland. In Biochim Biophys Acta, 2012
IKEPP was also found to be expressed in vascular endothelial cells where it co-localizes and complexes with the hIP
Regulation of SLC26A3 activity by NHERF4 PDZ-mediated interaction.
Yoon et al., Seoul, South Korea. In Cell Signal, 2012
NHERF4 is an epithelial-enriched PDZ domain scaffold protein that has attracted attention because of its enriched tissue expression in the intestine and kidney.
In vitro analysis of PDZ-dependent CFTR macromolecular signaling complexes.
Li et al., Wayne, United States. In J Vis Exp, 2011
So far, several different PDZ scaffold proteins have been reported to bind to the carboxyl terminal tail of CFTR with various affinities, such as NHERF1, NHERF2, PDZK1, PDZK2, CAL (CFTR-associated ligand), Shank2, and GRASP(20-27).
Activity and PI3-kinase dependent trafficking of the intestinal anion exchanger downregulated in adenoma depend on its PDZ interaction and on lipid rafts.
Lamprecht et al., Tübingen, Germany. In Am J Physiol Gastrointest Liver Physiol, 2010
Furthermore, DRA interacts with PDZK1, E3KARP, and IKEPP in LR, although their localization within lipid rafts is independent of DRA.
Role of NHERF and scaffolding proteins in proximal tubule transport.
Review
Weinman et al., Baltimore, United States. In Urol Res, 2010
PDZK1 (NHERF-3) and IKEPP (NHERF-4) were later identified and found to have similar homology domains, leading to their recent reclassification.
Increased basal insulin secretion in Pdzd2-deficient mice.
Yao et al., Hong Kong, Hong Kong. In Mol Cell Endocrinol, 2010
Expression of the multi-PDZ protein Pdzd2 (PDZ domain-containing protein 2) is enriched in pancreatic islet beta cells, but not in exocrine or alpha cells, suggesting a role for Pdzd2 in the regulation of pancreatic beta-cell function.
Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.
GeneRIF
Donowitz et al., Baltimore, United States. In Cell Physiol Biochem, 2007
Regulation of NHE3 depends on the nature of the NHERF family member associating with NHE3 and the accompanying NHE3 complexes.[IKEPP]
PDZ domain-containing protein as a physiological modulator of TRPV6.
GeneRIF
So et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2007
PDZK2 is an essential TRPV6 interacting protein as a physiological modulator of TRPV6.
The emerging role of PDZ adapter proteins for regulation of intestinal ion transport.
Review
Seidler et al., Tübingen, Germany. In Am J Physiol Gastrointest Liver Physiol, 2006
This article reviews recent advances in our understanding of the role of the PDZ adapter proteins NHERF, E3KARP, PDZK1, IKEPP (NHERF-1 to NHERF-4), CAL, and Shank-2 that bind to CFTR, NHE3, and the intestinal SLC26 members in the regulation of intestinal fluid transport.
Beyond the brush border: NHERF4 blazes new NHERF turf.
Review
Milgram et al., Chapel Hill, United States. In J Physiol, 2005
The work summarized in this review suggests the most recently identified family member, NHERF4, is the most divergent.
NHERF family and NHE3 regulation.
Review
Li et al., Baltimore, United States. In J Physiol, 2005
These are four proteins (current most used names include NHERF1, NHERF2, PDZK1 and IKEPP) which are related to each other, are present in locations in or close to the BB, and scaffold a variable series of proteins in NHE3-containing complexes in a dynamic manner that is altered by changes in signal transduction which affects NHE3 activity.
A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor.
GeneRIF
Milgram et al., Chapel Hill, United States. In J Biol Chem, 2002
A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor.
Molecular mechanisms in proximal tubular and small intestinal phosphate reabsorption (plenary lecture).
Review
Biber et al., Zürich, Switzerland. In Mol Membr Biol, 2001
For the COOH-terminal tail of the IIa Na/Pi-cotransporter, several interacting PDZ-domain proteins have been identified which may contribute to either its apical expression (NaPi-Cap1) or to its subapical/lysosomal traffic (NaPi-Cap2).
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