Prostacyclin receptors: Transcriptional regulation and novel signalling mechanisms.
Dublin, Ireland. In Prostaglandins Other Lipid Mediat, Sep 2015
Moreover, the functional implications of the interactions between the IP with PDZK1, a multi PDZ-domain containing protein essential for reverse-cholesterol transport and endothelialization, and the IP with IKEPP, the intestinal and kidney enriched PDZ protein, for the role of the prostacyclin-IP axis within the vasculature are reviewed.
In vitro analysis of PDZ-dependent CFTR macromolecular signaling complexes.
Wayne, United States. In J Vis Exp, 2011
So far, several different PDZ scaffold proteins have been reported to bind to the carboxyl terminal tail of CFTR with various affinities, such as NHERF1, NHERF2, PDZK1, PDZK2, CAL (CFTR-associated ligand), Shank2, and GRASP(20-27).
Increased basal insulin secretion in Pdzd2-deficient mice.
Hong Kong, Hong Kong. In Mol Cell Endocrinol, 2010
Expression of the multi-PDZ protein Pdzd2 (PDZ domain-containing protein 2) is enriched in pancreatic islet beta cells, but not in exocrine or alpha cells, suggesting a role for Pdzd2 in the regulation of pancreatic beta-cell function.
Regulation of the intestinal anion exchanger DRA (downregulated in adenoma).
Tübingen, Germany. In Ann N Y Acad Sci, 2009
All three transport proteins possess PDZ domain binding motifs that facilitate binding to members of the NHERF (Na/H exchanger regulatory factor) family of adapter proteins [NHERF, E3KARP (NHE3 kinase A regulatory protein), PDZK1 (PDZ protein kidney 1) and IKEPP (intestinal and kidney enriched PDZ protein)].
NHERF family and NHE3 regulation.
Baltimore, United States. In J Physiol, 2005
These are four proteins (current most used names include NHERF1, NHERF2, PDZK1 and IKEPP) which are related to each other, are present in locations in or close to the BB, and scaffold a variable series of proteins in NHE3-containing complexes in a dynamic manner that is altered by changes in signal transduction which affects NHE3 activity.