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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Tonsoku-like, DNA repair protein

IkappaBR, NFKBIL2, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor like-2
The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, FACT, NF-kappaB, TGF-beta, Chk1
Papers on IkappaBR
DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study.
Chronic Renal Insufficiency Cohort (CRIC) Study et al., Washington, D.C., United States. In Nephrol Dial Transplant, 2014
Other CKD-related genes that were differentially methylated are NOS3, NFKBIL2, CLU, NFKBIB, TGFB3 and TGFBI, which are involved in oxidative stress and inflammatory pathways (P-values of 4.5E-03 to 0.046).
Identification of a novel oncogene, MMS22L, involved in lung and esophageal carcinogenesis.
Daigo et al., Tokyo, Japan. In Int J Oncol, 2012
MMS22L protein was translocated to the nucleus and stabilized by binding to C-terminal portion of NFKBIL2 [nuclear factor of kappa (NFKB) light polypeptide gene enhancer in B-cells inhibitor-like 2].
RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.
GeneRIF
Peter et al., Z├╝rich, Switzerland. In Embo J, 2011
Results strongly suggest that the Mms22L-Nfkbil2 complex contributes to genome stability by regulating the chromatin state at stalled replication forks.
Identification of the MMS22L-TONSL complex that promotes homologous recombination.
GeneRIF
Rouse et al., Dundee, United Kingdom. In Mol Cell, 2010
MMS22L and TONSL are required for the maintenance of genome stability.
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.
GeneRIF
Durocher et al., Toronto, Canada. In Mol Cell, 2010
These results indicate that MMS22L and TONSL are genome caretakers that stimulate the recombination-dependent repair of stalled or collapsed replication forks.
A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.
GeneRIF
Harper et al., Boston, United States. In Mol Cell, 2010
This study identifies MMS22L-NFKBIL2 as components of the replication stress control pathway.
Comparative proteomics of human embryonic stem cells and embryonal carcinoma cells.
Pandey et al., Bengaluru, India. In Proteomics, 2010
Several proteins that were highly expressed in ECCs such as heat shock 27 kDa protein-1, mitogen-activated protein kinase kinase-1, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor like-2, and S100 calcium-binding protein-A4 have also been attributed to malignancy in other systems.
Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study.
GeneRIF
Hill et al., Oxford, United Kingdom. In Crit Care, 2009
Common NFKBIL2 polymorphisms are associated with susceptibility to invasive pneumococcal infection.
Isolation, sequence, and chromosomal localisation of the human IkappaBR gene (NFKBIL2).
Barton et al., London, United Kingdom. In Ann Hum Genet, 2000
We also report the chromosomal localisation of the human IkappaBR gene (approved gene symbol NFKBIL2) to 8q24.3 using PCR-based somatic cell hybrid panel analysis and fluorescence in situ hybridization (FISH) mapping.
Selective up-regulation of cytokine-induced RANTES gene expression in lung epithelial cells by overexpression of IkappaBR.
Ray et al., New Haven, United States. In J Biol Chem, 1997
We previously reported the cloning of a cDNA for IkappaBR (for IkappaB-related) from human lung alveolar epithelial cells.
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