Nfkbiz regulates the proliferation and differentiation of keratinocytes.
In Jpn J Vet Res, Aug 2015
Nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-κB) inhibitor zeta (Nfkbiz) is a nuclear inhibitor of NF-κB (IκB) protein that is also termed as molecule possessing ankyrin repeats induced by lipopolysaccharide, interleukin-1-inducible nuclear ankyrin repeat protein, or IκBζ.
Ocular surface inflammation mediated by innate immunity.
Kyoto, Japan. In Eye Contact Lens, 2010
Furthermore, we show that IkappaBzeta KO mice exhibit severe, spontaneous ocular surface inflammation accompanied by the eventual loss of almost all goblet cells and spontaneous perioral inflammation.
Innate immunity of the ocular surface.
Kyoto, Japan. In Brain Res Bull, 2010
IkappaBzeta is important for TLR signaling, in mice, its knock-out produced severe, spontaneous ocular surface inflammation, the eventual loss of goblet cells, and spontaneous perioral inflammation, suggesting that dysfunction/abnormality of innate immunity can lead to ocular surface inflammation.
NF-kappaB regulation: the nuclear response.
Dublin, Ireland. In J Cell Mol Med, 2009
A number of novel nuclear regulators of NF-kappaB such as IkappaB-zeta and PDZ and LIM domain 2 (PDLIM2) have now been identified, adding another layer to the mechanics of NF-kappaB regulation.